Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Peripheral Vascular Disease
Rui Lu, Takahiro Ishikawa, Mamoru Tanaka, Tomoe Tsuboi, Shinji Yokoyama
Summary: This study demonstrates that Zn++ can increase ABCA1 stability by enhancing calmodulin binding to ABCA1, leading to increased HDL biogenesis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fengqing Zhu, Guanglei Chang, Xiaoqiong Tang, Lingyun Gao, Nan Zhang
Summary: Doxorubicin (DOX) is used for cancer treatment but can cause cardiovascular toxicity. This study examined whether DOX promotes atherosclerosis by impairing cardiac function. The results showed that DOX increased miR-33 expression and reduced the protein level of ATP binding cassette transporter A1 (ABCA1). DOX also suppressed cholesterol efflux, especially under high-cholesterol conditions. Transfection of miR-33 mimics or inhibitors into cells respectively decreased or increased ABCA1 protein expression and regulated intracellular lipid accumulation. Overall, DOX upregulates miR-33 to suppress ABCA1 expression, leading to intracellular lipid deposition in macrophages, which is an early sign of atherosclerosis. This study provides new insights for the clinical observation and evaluation of DOX side effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Ling Liang, Qiang Xie, Changqing Sun, Yuanhui Wu, Wei Zhang, Weihua Li
Summary: The study revealed a positive association between circulating sPLA2-IIA and HDL-C levels, suggesting that sPLA2-IIA may enhance cholesterol efflux through regulation of PPAR-gamma/LXR-alpha/ABCA1.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Nanoscience & Nanotechnology
Yan Zhu, Yanni Xu, Dong Han, Xiujin Zhang, Cheng Qin, Jing Liu, Lei Tian, Mengqi Xu, Yan Fang, Yang Zhang, Yabin Wang, Feng Cao
Summary: In this study, a scavenger receptors AI (SR-AI) targeted theranostic nanoparticles were constructed to target foam cells and atherosclerotic plaques via ABCA1 activation. The SAU-NPs showed more active targeting to plaque lesions compared to non-SR-AI targeted nanoparticles. SAU-NPs carrying 5242331 inhibited the transformation to foam cells and effectively reduced cholesterol deposition through activating the LXR & alpha;-ABCA1/ABCG1/SR-BI pathway.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yu-Ting Wu, Jiang-Bin Li, Hui-Qin Lin, Guo-Xin Zhang, Cong-Min Hong, Ming Li, Zhi-Jun Guo, Yan-Bing Yang
Summary: The study demonstrated that overexpression of miR-200b-3p and downregulation of ABCA1 can promote lipid accumulation and inhibit cholesterol efflux, while inhibiting miR-200b-3p may alleviate these effects.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest
Summary: Comparison of THP-1 macrophage subtypes with varying degrees of differentiation provided new insights into cholesterol metabolism and identified DSC1 as a viable target for promoting cholesterol efflux in differentiated macrophages. Pharmacological strategies targeting DSC1, such as docetaxel, may hold significant potential for reducing atherogenic cholesterol deposition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Plant Sciences
Ting Qian, Xiaoshan Wang, Jingjing Liu, Mengyun Shi, Jing Zhao, Peipei Sun, Guanghui Zheng, Congbing Fang, Xingbin Xie
Summary: This study uncovered that anthocyanin transport in strawberry fruits may be mediated by ABCC transporter ABCC8 and its expression is regulated by MYB10, bHLH33, and MYC1 transcription factors.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Michael J. Haas, Arshag D. Mooradian
Summary: ABCA and apo A1 play crucial roles in reverse-cholesterol transport process. Research focuses on enhancing RCT to reduce cardiovascular disease risk by understanding the regulatory pathways of their expression and activity.
Article
Plant Sciences
Xiaoyun Li, Guofang Zhang, Yahong Liang, Lin Hu, Bonan Zhu, Dongmei Qi, Sujuan Cui, Hongtao Zhao
Summary: The study identified Class I TCP7 as a positive regulator of flowering time and showed that it synergistically interacts with NF-Ys to activate the transcriptional expression of the flowering integrator gene SOC1.
Article
Neurosciences
Min Zhu, Longfei Jia, Jianping Jia
Summary: The study identified miR-96-5p as the upstream miRNA for ABCA1, and inhibition of miR-96-5p in AD models could reduce A beta(42)/A beta(40) ratios by upregulating the expression of ABCA1, indicating an important role of miR-96-5p in regulating A beta content.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Oncology
Zhijuan Liang, Wei Jiao, Liping Wang, Yuanbin Chen, Dan Li, Zhao Zhang, Zhilei Zhang, Ye Liang, Haitao Niu
Summary: CYP27A1 plays a regulatory role in the proliferation and migration of ccRCC, by activating LXRs/ABCA1 to regulate cholesterol homeostasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Takaaki Kawanobe, Naoko Shiranaga, Noriyuki Kioka, Yasuhisa Kimura, Kazumitsu Ueda
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Shiho Ito, Noriyuki Kioka, Kazumitsu Ueda
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Yusuke Okamoto, Maiko Tomioka, Fumihiko Ogasawara, Kota Nagaiwa, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Takuma Kishimoto, Nario Tomishige, Motohide Murate, Reiko Ishitsuka, Hubert Schaller, Yves Mely, Kazumitsu Ueda, Toshihide Kobayashi
Article
Biochemistry & Molecular Biology
Fumihiko Ogasawara, Atsushi Kodan, Kazumitsu Ueda
Review
Biochemistry & Molecular Biology
Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda
Summary: ABCB1, also known as MDR1 or P-glycoprotein, plays a crucial role in exporting various hydrophobic compounds and serving as a protective physiological barrier in several organs. The mechanism involves an aromatic hydrophobic network triggering a conformational change in ABCB1, leading to a twist-and-squeeze motion that exports hydrophobic substrates directly to the extracellular space, distinct from other transporters.
Article
Biochemistry & Molecular Biology
Fumihiko Ogasawara, Kazumitsu Ueda
Summary: Cholesterol is a major component of the cell plasma membrane and its balance is essential for cellular functions. This study reveals that ABCA1 and Aster-A play important roles in maintaining the asymmetrical distribution of cholesterol in the plasma membrane. ABCA1 translocates cholesterol from the inner leaflet to the outer leaflet of the plasma membrane to maintain a low inner leaflet cholesterol level. When the cholesterol level increases, Aster-A is recruited to transfer cholesterol to the endoplasmic reticulum. These findings provide insights into the regulation of intracellular cholesterol homeostasis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ryota Futamata, Masato Kinoshita, Katsueki Ogiwara, Noriyuki Kioka, Kazumitsu Ueda
Summary: In this study, the researchers found that ABCA1 deficiency in the Japanese medaka fish inhibits successful ovulation through cholesterol accumulation in the ovarian follicle. ABCA1A in the theca cells regulates cholesterol content in the ovarian follicles.
Article
Biochemistry & Molecular Biology
Mitsuhiro Nakato, Naoko Shiranaga, Maiko Tomioka, Hitomi Watanabe, Junko Kurisu, Mineko Kengaku, Naoko Komura, Hiromune Ando, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
Summary: Mutations in the ABCA13 gene may increase susceptibility to psychiatric disorders. The protein encoded by this gene accelerates cholesterol internalization in neurons, which is associated with the pathophysiology of psychiatric disorders.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kyoko Takata, Tsuyoshi Goto, Mito Kuroda, Yasuhisa Kimura, Ichiro Harada, Kazumitsu Ueda, Teruo Kawada, Noriyuki Kioka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Fumihiko Ogasawara, Fumi Kano, Masayuki Murata, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda
SCIENTIFIC REPORTS
(2019)