Article
Cell Biology
Douja Chamseddine, Siraje A. Mahmud, Aundrea K. Westfall, Todd A. Castoe, Rance E. Berg, Mark W. Pellegrino
Summary: ATF5 protects the host from enteric pathogens by maintaining the integrity of the intestinal barrier and preventing dysregulated glucose metabolism associated with obesity and hyperglycemia. It supports intestinal barrier function by promoting a satiety response through transcriptional regulation of cholecystokinin.
Article
Cell Biology
Changchun Cao, Kang He, Shaoxun Li, Qianqian Ge, Lei Liu, Zhengwei Zhang, Hui Zhang, Xinwen Wang, Xiaoyang Sun, Lianshu Ding
Summary: The study identified the complex of ITPRIP-DAPK1-MYL9 in malignant glioma cells, revealing the crucial role of ITPRIP in the inhibition of DAPK1 and enhancement of tumorigenic properties. The interaction of ITPRIP with DAPK1 and recruitment of MYL9 to the kinase domain of DAPK1 play key roles in promoting glioma progression.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Xiaoyang Zheng, Yuguang Wang, Dongxu Wang, Jingru Wan, Xiangying Qin, Zhuang Mu, Nan Hu
Summary: The high expression of PSMC2 is associated with poor prognosis in glioma patients. PSMC2 promotes glioma cell proliferation and inhibits apoptosis. PSMC2 may serve as a potential therapeutic target for glioma.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhou Xu, Xingruo Zeng, Mingchang Li, Jianming Liao, Qianxue Chen
Summary: The study demonstrated that downregulation of PRDX3 by miR-383 induced cell apoptosis and mitochondrial ROS production in U87 cells, thereby promoting oxidative stress-induced autophagy.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Sejeong Shin, Min-Joon Han, Mark P. Jedrychowski, Ziyang Zhang, Kevan M. Shokal, David R. Plas, Noah Dephoure, Sang-Oh Yoon
Summary: Cells change their proteomes according to their environment and needs, and the key regulator of this process is mTOR. Dysregulation of mTOR leads to changes in proteostasis and the progression of diseases, including cancer.
Article
Cell Biology
Bin Sheng, Zichao Wei, Xiaowei Wu, Yi Li, Zhihua Liu
Summary: This study identified USP12 as a key deubiquitinating enzyme for breast cancer metastasis, promoting angiogenesis and leading to metastasis. Overexpression of USP12 decreased DMFS, while high MDK expression predicted lower DMFS and overall survival in breast cancer patients. The USP12-MDK axis may serve as a potential therapeutic target for breast cancer metastasis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Matthew J. Taylor, Adam M. Thompson, Sharif Alhajlah, Richard Tuxworth, Zubair Ahmed
Summary: DNA double-strand breaks play a crucial role in neurological conditions, and targeting the ATM-Chk2 pathway can slow down neural decline and promote neuroprotection by inhibiting nonhomologous end-joining.
Article
Neurosciences
Liang Liu, Xuelan Zhou, Shan Cheng, Yuyuan Ge, Baomin Chen, Jia Shi, Haoran Li, Suwen Li, Yongdong Li, Jiaqi Yuan, Anyi Wu, Xinglei Liu, Shilu Huang, Zhipeng Xu, Jun Dong
Summary: This study identified the role of the DHX9/TCF12/CSF1 axis in glioma progression, showing its ability to promote infiltration and polarization of macrophages, thereby promoting malignant progression of glioma. This finding provides a new potential target for future immune therapies against gliomas.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Yan Li, Jiansheng Chen, Zetao Chen, Xiangdong Xu, Jun Weng, Yuxuan Zhang, Yunzhao Mo, Yang Liu, Jihui Wang, Yiquan Ke
Summary: The research identified an upregulation of circGLIS3 in high-grade glioma, which promoted glioma cell migration and invasion, and induced angiogenesis through modulating Ezrin T567 phosphorylation. This suggests that circGLIS3 plays a role in the invasion and angiogenesis of glioma in high-grade glioma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Claire Maudet, Marouane Kheloufi, Sylvain Levallois, Julien Gaillard, Lei Huang, Charlotte Gaultier, Yu-Huan Tsai, Olivier Disson, Marc Lecuit
Summary: This study reveals a specific mechanism by which the bacterial pathogen Listeria monocytogenes confers an increased lifespan to infected cells by rendering them resistant to cell-mediated immunity, facilitating its persistence within the host, dissemination to the central nervous system, and transmission.
Article
Neurosciences
Alireza P. Shabanzadeh, Jason Charish, Nardos G. Tassew, Nahal Farhani, Jinzhou Feng, Xinjue Qin, Shuzo Sugita, Andrea J. Mothe, Thomas Walchli, Paulo D. Koeberle, Philippe P. Monnier
Summary: The inhibition of cholesterol synthesis has been shown to promote axonal regeneration and survival, offering a potential therapeutic approach for neuronal regeneration in the central nervous system. Altering the association of cell surface receptors with lipid rafts can neutralize inhibitory functions and provide opportunities for promoting CNS regeneration and survival. Late stage cholesterol synthesis inhibition alters Neogenin association with lipid rafts, thereby offering a novel approach for promoting regeneration and survival following injuries.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Oncology
Tao Luo, Kaikai Ding, Jianxiong Ji, Xin Zhang, Xiaobing Yang, Anjing Chen, Bin Huang, Di Zhang, Jian Wang, Xingang Li
Summary: The study suggests that CKAP4 is highly upregulated in glioma, and high expression of CKAP4 is associated with poor patient survival. CKAP4 promotes malignant progression of gliomas by inhibiting Hippo signaling. Therefore, CKAP4 has the potential to serve as a promising biomarker for predicting patient prognosis and targeting CKAP4 expression may be an effective therapeutic strategy for the treatment of human gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Mariel F. Schwietzer, Sonja Thoelmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thuering, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet
Summary: Entosis is a cell competition process where tumor cells engulf other tumor cells. Depletion of the cell adhesion receptor JAM-A increases the rate of entosis and is associated with dysregulation of CIL.
Article
Biochemistry & Molecular Biology
Kamalakshi Deka, Sougata Saha
Summary: This study identified arginylation of HuR as a factor affecting its stability and RNA binding activity, leading to alternative polyadenylation of Hsp70.3 mRNA and playing a role in early heat stress response.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Yu'e Liu, Shu Zhao, Yi Chen, Wencong Ma, Shiping Lu, Le He, Jie Chen, Xi Chen, Xiaoling Zhang, Yufeng Shi, Xuan Jiang, Kaijun Zhao
Summary: This study aims to decipher the role of vimentin (VIM) in glioma, especially its role in OXPHOS-inhibition sensitivity, which may provide a promising therapeutic target for glioma treatment. By analyzing RNA-sequencing data, the researchers found that VIM is highly expressed in OXPHOS-inhibition resistant cancer cells, particularly in glioma cancer cells. Further study revealed that VIM plays important roles in cancer progression, immunotherapy suppression, cancer stemness, and drug resistance.
Article
Oncology
Yariswamy Manjunath, Sathisha V. Upparahalli, Kanve N. Suvilesh, Diego M. Avella, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Guangfu Li, Jussuf T. Kaifi
Article
Multidisciplinary Sciences
Xiaoqiang Qi, Emily Schepers, Diego Avella, Eric T. Kimchi, Jussuf T. Kaifi, Kevin F. Staveley-O'Carroll, Guangfu Li
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Article
Cell Biology
Rui Tang, Yung-Chun Wang, Xiaohan Mei, Ning Shi, Chengming Sun, Ran Ran, Gui Zhang, Wenjing Li, Kevin F. Staveley-O'Carroll, Guangfu Li, Shi-You Chen
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Yariswamy Manjunath, David Porciani, Jonathan B. Mitchem, Kanve N. Suvilesh, Diego M. Avella, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Donald H. Burke, Guangfu Li, Jussuf T. Kaifi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Yariswamy Manjunath, Jonathan B. Mitchem, Kanve N. Suvilesh, Diego M. Avella, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Chelsea B. Deroche, Klaus Pantel, Guangfu Li, Jussuf T. Kaifi
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Oncology
Diego M. Avella, Yariswamy Manjunath, Amolak Singh, Chelsea B. Deroche, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Jonathan B. Mitchem, Eric Kwon, Guangfu Li, Jussuf T. Kaifi
TRANSLATIONAL LUNG CANCER RESEARCH
(2020)
Review
Gastroenterology & Hepatology
Xiaoqiang Qi, Ming Yang, Joseph Stenberg, Rahul Dey, Leslie Fogwe, Muhammad Shawkat Alam, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Guangfu Li
WORLD JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Cell Biology
Xinjian Liu, Hao Yuan, Jing Zhou, Qiongling Wang, Xiaoqiang Qi, Catharine Bernal, Diego Avella, Jussuf T. Kaifi, Eric T. Kimchi, Parrett Timothy, Kun Cheng, Yi Miao, Kuirong Jiang, Guangfu Li
Summary: The study identified LIM domain only 7 (LMO7) as a potential target for developing targeted therapy for pancreatic cancer, as loss of LMO7 function significantly suppresses tumor growth and metastasis. This suggests that LMO7 could be an important unrecognized druggable factor in impacting pancreatic cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Sashi Kandel, Pratik Adhikary, Guangfu Li, Kun Cheng
Summary: The blockade of the TIM3/Gal9 pathway shows promising therapeutic potential in cancer treatment, by enhancing immune response and overcoming immune resistance. TIM3 and Gal9 may also serve as prognostic and predictive biomarkers in different types of cancers.
Article
Oncology
Diego M. Avella Patino, Vijay Radhakrishnan, Kanve N. Suvilesh, Yariswamy Manjunath, Guangfu Li, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Wesley C. Warren, Jussuf T. Kaifi, Jonathan B. Mitchem
Summary: This review article summarizes the role of epigenetic regulation in immune response in a wide range of cancers, including the epigenetic changes in immune cells such as T cells, macrophages, and natural killer cells.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dilip Venugopal, Nanda Kasani, Yariswamy Manjunath, Guangfu Li, Jussuf T. Kaifi, Jae W. Kwon
Summary: A novel method using multifunctional hybrid functional microposts was developed to address the limitations of low flow rates and device clogging in processing rare tumor cells from blood as liquid biopsies. The method integrated a swift by-passing route for non-tumor cells to prevent clogging problems, leading to highly efficient separation of rare cells from biological fluids. Improved designs showed higher capture efficiencies for both microbeads and cancer cells.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Jing Zhou, Nan Lyu, Qiongling Wang, Ming Yang, Eric T. Kimchi, Kun Cheng, Trupti Joshi, Adama R. Tukuli, Kevin F. Staveley-O'Carroll, Guangfu Li
Summary: Tumor-associated macrophages (TAMs) play a critical role in pancreatic cancer tumorigenesis and their function is regulated by TGFBI. Disruption of TGFBI not only inhibits TAM polarization and their stimulating effect on pancreatic cancer growth, but also improves anti-tumor immunity and sensitizes pancreatic cancer to chemotherapy.
Article
Medicine, Research & Experimental
Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng
Summary: This study investigated silencing the PCBP2 gene through siRNA to reverse the accumulation of type I collagen in PDAC tumor stroma. The use of nanocomplex significantly reduced ECM production and enhanced drug penetration through desmoplastic tumor stroma. In a mouse model, the combination of PCBP2 siRNA nanocomplex with gemcitabine effectively suppressed tumor progression.
Article
Oncology
Xiaoqiang Qi, Ming Yang, Lixin Ma, Madeline Sauer, Diego Avella, Jussuf T. Kaifi, Jeffrey Bryan, Kun Cheng, Kevin F. Staveley-O'Carroll, Eric T. Kimchi, Guangfu Li
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Multidisciplinary Sciences
Hao Yuan, Joseph Stenberg, Guangfu Li