Article
Endocrinology & Metabolism
Qiongyu Lu, Ziting Liu, Luyao Zhao, Linru Xu, Chu Liu, Ling Li, Yiren Cao, Fengchan Li, Lili Wu, Lei Wang, Ting Chen, Tao You, Lijie Ren, Guixue Wang, Chaojun Tang, Li Zhu
Summary: The study found that Sema7A plays an inhibitory role in obesity and hepatic steatosis, suggesting it as a potential new therapeutic target for obesity and metabolic diseases.
MOLECULAR METABOLISM
(2023)
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Article
Cell Biology
Demin Cai, Yanwei Li, Kexin Zhang, Bo Zhou, Feilong Guo, Lena Holm, Hao-Yu Liu
Summary: The study demonstrates that conjugated linoleic acid (CLA) can induce liver abnormalities in mice, while a PPARα antagonist called GW6471 can reverse the progression of NAFLD and insulin resistance by controlling gene expression related to fatty acid oxidation and synthesis. This highlights the potential druggable nature of PPARα in regulating lipid homeostasis in NAFLD.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Gulisudumu Maitiabula, Feng Tian, Peng Wang, Li Zhang, Xuejin Gao, Songlin Wan, Haifeng Sun, Jianbo Yang, Yupeng Zhang, Tingting Gao, Bin Xue, Chaojun Li, Jieshou Li, Xinying Wang
Summary: PP2A-Cα plays an important role in the pathogenesis of PNAHS, acting as a protective factor by improving hepatic steatosis and liver function. A decrease in PP2A-Cα leads to activation of Akt2 and inhibition of AMPK, exacerbating hepatic steatosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuri Hayashi, Hyeon-Cheol Lee-Okada, Eri Nakamura, Norihiro Tada, Takehiko Yokomizo, Yoko Fujiwara, Ikuyo Ichi
Summary: This study found that >= C20 PUFAs synthesized by FADS2 are crucial in regulating hepatic triacylglycerol and cholesterol accumulation during PUFA deficiency.
Article
Food Science & Technology
Cheng Cheng, Xiao-Huan Liu, Jing He, Jing Gao, Jin-Ting Zhou, Jing-Na Fan, Xi Jin, Jianbo Zhang, Liao Chang, Zijun Xiong, Jun Yu, Shengbin Li, Xiaoming Li
Summary: ApoA4 restricts hepatic steatosis by inhibiting SREBF1-mediated lipogenesis and improves insulin sensitivity and glucose uptake via IRS-PI3K-Akt signaling in the liver. These findings indicate that ApoA4 may serve as a therapeutic target for obesity-associated NAFLD.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jiaqi Chen, Shihui Lei, Yueye Huang, Xiaojuan Zha, Lei Gu, Donglei Zhou, Jun Li, Feng Liu, Nannan Li, Lei Du, Xiu Huang, Ziwei Lin, Le Bu, Shen Qu
Summary: This study investigated the serum LCN2 levels of obese patients with NAFLD and found that decreased LCN2 levels were associated with improvement in hepatic steatosis.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Pharmacology & Pharmacy
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang
Summary: This study found that FGF9 expression was increased in the livers of diet-induced obese mice, and knockdown exacerbated the fatty liver phenotype while overexpression alleviated hepatic steatosis and improved insulin sensitivity. Mechanistically, FGF9 inhibits genes involved in lipogenesis and increases genes involved in fatty acid oxidation, reducing cellular lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhenbang Qin, Ping Wang, Weiwen Chen, Jue-Rui Wang, Xianhua Ma, Hai Zhang, Weiping J. Zhang, Chunchun Wei
Summary: This study reveals that hepatic ELOVL3 is not essential for lipid metabolism and does not play a significant role in maintaining lipid homeostasis or the development of obesity and hepatic steatosis. Liver-specific knockout of Elovl3 does not result in abnormalities in body weight, liver mass and morphology, liver triglyceride content, or glucose tolerance under normal or low-fat diet conditions. Moreover, the deletion of hepatic Elovl3 does not significantly affect body weight gain or hepatic steatosis induced by high-fat diet. Lipidomic analysis shows that the loss of hepatic Elovl3 does not cause substantial changes in lipid profiles. Unlike global knockouts, mice lacking Elovl3 specifically in the liver exhibit normal expression of genes involved in hepatic de novo lipogenesis, lipid uptake, or beta-oxidation at the mRNA and protein levels. Overall, our data indicate that hepatic ELOVL3 is dispensable for metabolic homeostasis or diet-induced metabolic disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty
Summary: In addition to severe mitochondrial dysfunction, drug-induced steatosis may also be triggered by mild-to-moderate inhibition of mitochondrial fatty acid oxidation, increased de novo lipogenesis, and impairment of very low-density lipoprotein (VLDL) secretion. Among these mechanisms, impairment of VLDL secretion seems to be more frequently involved, possibly as a consequence of endoplasmic reticulum stress.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Toxicology
Shuanghui Lu, Zhiyuan Ma, Yong Gu, Ping Li, Yingchun Chen, Mengru Bai, Hui Zhou, Xi Yang, Huidi Jiang
Summary: Fluoxetine downregulates hepatic G6Pase expression, subsequently enhances the transformation of glucose to lipid, ultimately resulting in hepatic steatosis, but with no impact on fatty acid uptake.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Correction
Biochemistry & Molecular Biology
Irma Hernandez-Velazquez, Monica Sanchez-Tapia, Guillermo Ordaz-Nava, Nimbe Torres, Armando R. Tovar, Amanda Galvez
Summary: The study showed that black bean protein concentrate can ameliorate hepatic steatosis in rats by reducing lipogenesis and increasing fatty acid oxidation.
Article
Chemistry, Multidisciplinary
Xiang Wei, Li Lin, Qian-qian Yuan, Xiu-yun Wang, Qing Zhang, Xiao-min Zhang, Ke-chao Tang, Man-yu Guo, Ting-yu Dong, Wei Han, Da-ke Huang, Yin-liang Qi, Mei Zhang, Hua-bing Zhang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global health concern associated with metabolic disorders and obesity. There is a lack of approved drugs for the prevention or treatment of NAFLD. Recent evidence suggests that bavachin, a flavonoid derived from Psoralea corylifolia L., has potential effects on insulin sensitivity and fatty acid metabolism. This study investigates the effects of bavachin on obesity-associated NAFLD in vivo and in vitro.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Food Science & Technology
Keisuke Hamada, Ping Wang, Yangliu Xia, Nana Yan, Shogo Takahashi, Kristopher W. Krausz, Haiping Hao, Tingting Yan, Frank J. Gonzalez
Summary: WA has therapeutic effects on alcoholic liver disease by inhibiting hepatic lipogenesis to reduce liver injury caused by alcohol.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tiange Li, Han Gong, Biyuan Zhan, Xueying Mao
Summary: Chitosan oligosaccharides (COS) attenuate hepatic steatosis by suppressing lipid synthesis and enhancing fatty acid oxidation. AMP-activated protein kinase (AMPK) is involved in the beneficial effects of COS on hepatic steatosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Zheng Chen, Hong Shen, Chengxin Sun, Lei Yin, Fei Tang, Pan Zheng, Yang Liu, Robert Brink, Liangyou Rui
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Bijie Jiang, Hong Shen, Zheng Chen, Lei Yin, Linsen Zan, Liangyou Rui
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Cell Biology
Chengxin Sun, Lin Jiang, Yan Liu, Hong Shen, Stephen J. Weiss, Yifa Zhou, Liangyou Rui
Article
Endocrinology & Metabolism
Yan Liu, Liang Sheng, Yi Xiong, Hong Shen, Yong Liu, Liangyou Rui
Article
Gastroenterology & Hepatology
Hong Shen, Liang Sheng, Yi Xiong, Yeung-Hyen Kim, Lin Jiang, Zheng Chen, Yong Liu, Kalyani Pyaram, Cheong-Hee Chang, Liangyou Rui
JOURNAL OF HEPATOLOGY
(2017)
Article
Endocrinology & Metabolism
Hong Shen, Mengle Shao, Kae Won Cho, Suqing Wang, Zheng Chen, Liang Sheng, Ting Wang, Yong Liu, Liangyou Rui
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2012)
Article
Endocrinology & Metabolism
Zheng Chen, Liang Sheng, Hong Shen, Yujun Zhao, Shaomeng Wang, Robert Brink, Liangyou Rui
Article
Gastroenterology & Hepatology
Hong Shen, Liang Sheng, Zheng Chen, Lin Jiang, Haoran Su, Lei Yin, M. Bishr Omary, Liangyou Rui
Article
Biochemistry & Molecular Biology
Liang Sheng, Yingjiang Zhou, Zheng Chen, Decheng Ren, Kae Won Cho, Lin Jiang, Hong Shen, Yoshiteru Sasaki, Liangyou Rui
Article
Medicine, Research & Experimental
Hong Shen, Lin Jiang, Jiandie D. Lin, M. Bishr Omary, Liangyou Rui
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Hong Shen, Yewei Ji, Yi Xiong, Hana Kim, Xiao Zhong, Michelle G. Jin, Yatrik M. Shah, M. Bishr Omary, Yong Liu, Ling Qi, Liangyou Rui
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Yuan Li, Martin G. Myers, Chung Owyang, Liangyou Rui
NATURE COMMUNICATIONS
(2020)
Correction
Multidisciplinary Sciences
Lin Jiang, Haoran Su, Xiaoyin Wu, Hong Shen, Min-Hyun Kim, Yuan Li, Martin G. Myers, Chung Owyang, Liangyou Rui
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Haibin Zhou, Jianfeng Lu, Krishnapriya Chinnaswamy, Jeanne A. Stuckey, Liu Liu, Donna McEachern, Chao-Yie Yang, Denzil Bernard, Hong Shen, Liangyou Rui, Yi Sun, Shaomeng Wang
Summary: The study identifies two potent and selective covalent DCN1 inhibitors that selectively inhibit cullin-3 neddylation in cells, leading to increased NRF2 protein levels and protection of mice from liver damage.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Qiuyu Wang, Vishal P. Sharma, Hong Shen, Yuanyuan Xiao, Qi Zhu, Xuelian Xiong, Liang Guo, Lin Jiang, Kunimasa Ohta, Siming Li, Haifei Shi, Liangyou Rui, Jiandie D. Lin