Combined X-ray, NMR, and Kinetic Analyses Reveal Uncommon Binding Characteristics of the Hepatitis C Virus NS3-NS4A Protease Inhibitor BI 201335

Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target

(2010) Maxwell D. Cummings et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease

(2010) P. W. White et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potency, safety, and pharmacokinetics of the NS3/4A protease inhibitor BI201335 in patients with chronic HCV genotype-1 infection

(2010) Michael P. Manns et al.   JOURNAL OF HEPATOLOGY

Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)

(2010) Montse Llinàs-Brunet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Tautomeric states of the active-site histidines of phosphorylated and unphosphorylated IIIGlc, a signal-transducing protein from escherichia coli, using two-dimensional heteronuclear NMR techniques

(2010) J.G. Pelton et al.   PROTEIN SCIENCE

Hepatitis C Virus NS3 Protease Is Activated by Low Concentrations of Protease Inhibitors

(2009) Göran Dahl et al.   BIOCHEMISTRY

Use of the Fused NS4A Peptide−NS3 Protease Domain To Study the Importance of the Helicase Domain for Protease Inhibitor Binding to Hepatitis C Virus NS3-NS4A

(2009) Diane Thibeault et al.   BIOCHEMISTRY

Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior

(2009) Ravi Rajagopalan et al.   BIOCHEMISTRY

Telaprevir: A Promising Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

(2009) I. Gentile et al.   CURRENT MEDICINAL CHEMISTRY

Halogen BondingA Novel Interaction for Rational Drug Design?

(2009) Yunxiang Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

The global burden of hepatitis C

(2009) Daniel Lavanchy   LIVER INTERNATIONAL

FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Diagnosis, management, and treatment of hepatitis C: An update

(2008) Marc G. Ghany et al.   HEPATOLOGY

Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor

(2008) Mariana Gallo et al.   JOURNAL OF MOLECULAR BIOLOGY