Article
Cell Biology
Yanlong Song, Weiting Chen, Bo Zhu, Wei Ge
Summary: Folliculogenesis is regulated by the communication between oocytes and follicle cells, with EGF signaling playing a critical role in the early stages of follicle development. Knockout mutants of Egf and Egfr in zebrafish revealed that Egfr is essential for follicle activation, while Egf mutation primarily affects fertilization rate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuan Yang, Ruizeng Luo, Shengyu Chao, Jiangtao Xue, Dongjie Jiang, Yun Hao Feng, Xin Dong Guo, Dan Luo, Jiaping Zhang, Zhou Li, Zhong Lin Wang
Summary: This article introduces a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS), which can improve the pharmacodynamics of epidermal growth factor and overcome the pharmacodynamic challenges associated with its conventional administration strategies.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R. Montfort, Joyce Schroeder
Summary: Targeting the retrotranslocation of EGFR may be a potent therapeutic approach for RTK-active cancer.
CANCER GENE THERAPY
(2023)
Article
Pathology
Po-Chun Chen, Chien-Peng Hsu, Sheng-Ya Wang, Tsai-Yen Wu, Yu-Jyun Lin, You-Tzung Chen, Shu-Hao Hsu
Summary: miR-194 is highly expressed in hepatocytes and its depletion increases hepatic resistance to acetaminophen-induced acute injuries. This study investigated the role of miR-194 in cholestatic liver injury using miR-194/miR-192 cluster liver-specific knockout mice. The results showed that the loss of miR-194 improved cholestatic liver injury and suppressed CYP7A1 expression through CTNNB1 signaling.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Multidisciplinary Sciences
Pengxiang Chen, Wei Wang, Rui Liu, Jiahui Lyu, Lei Zhang, Baizhou Li, Biying Qiu, Anhao Tian, Wenhong Jiang, Honggang Ying, Rui Jing, Qianqian Wang, Keqing Zhu, Ruiliang Bai, Linghui Zeng, Shumin Duan, Chong Liu
Summary: Animals receive sensory stimuli from the environment, which are essential for survival but can also impact physiological status and disease development. This study demonstrates that olfaction directly regulates the development of malignant glioma through olfactory neuronal circuits.
Article
Chemistry, Multidisciplinary
Jing Zhao, Siying Li, Xuelei Pang, Yuping Shan
Summary: The therapeutic efficacy of nano-drugs targeting EGFR was evaluated in terms of cell entry efficiency and induced cell mechanical properties at the single particle/cell level in real time.
CHEMICAL COMMUNICATIONS
(2022)
Article
Cell Biology
Ching-Chia Cheng, Chih-Feng Lin, Yong-Chong Lin, Tai-Horng Young, Pei-Jen Lou
Summary: The study modified gene expression of ACs by transfection of the GnT-V-overexpression plasmid, leading to increased proliferation and stemness properties of ACs. High levels of GnT-V were positively correlated with ALDH1A3 expression by increasing phosphorylation of cell surface receptors and activating downstream signaling transduction. This indicates that GnT-V plays a significant role in cell immortalization through the EGFR/ERK/ALDH1A3 signaling pathway in the ACs model.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tamara Weiss, Sabine Taschner-Mandl, Lukas Janker, Andrea Bileck, Fikret Rifatbegovic, Florian Kromp, Helena Sorger, Maximilian O. Kauer, Christian Frech, Reinhard Windhager, Christopher Gerner, Peter F. Ambros, Inge M. Ambros
Summary: The study found that Schwann cells exhibit a similar adaptive response in peripheral nerve injury and tumor development, with stromal SCs expressing nerve repair genes in ganglioneuromas. Neuroblastoma cells respond to repair-related SCs by increasing neuronal differentiation and reducing proliferation, mainly through the action of EGFL8.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Julian Roos, Meike Dahlhaus, Jan-Bernd Funcke, Monika Kustermann, Gudrun Strauss, Daniel Halbgebauer, Elena Boldrin, Karlheinz Holzmann, Peter Moeller, Bernadette M. Trojanowski, Bernd Baumann, Klaus-Michael Debatin, Martin Wabitsch, Pamela Fischer-Posovszky
Summary: The study revealed that miR-146a regulates adipose tissue inflammation by suppressing the NPR3 gene, thereby impacting the development of obesity and insulin resistance.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Veterinary Sciences
Rui Ma, Sijiu Yu, Yan Cui, Yangyang Pan, Meng Wang, Libin Wang, Jinglei Wang, Ling Zhao, Hui Zhang
Summary: This study found that epidermal growth factor (EGF) inhibits autophagy in yak cumulus cells by down-regulating the expression of Atg5, Beclin1, and LC3, and promotes endocytosis by regulating the expression of Cav1 and Cav2. These results provide a reference for further exploring the effects of growth factors on livestock germ cells and the regulatory role of the autophagy-endocytosis crosstalk mechanism in follicle development and oocyte maturation, to improve the fecundity of yaks.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Dong Hoon Shin, Sun Ha Kim, Minyoung Choi, Young-Ki Bae, Chungyong Han, Beom K. Choi, Sang Soo Kim, Ji-Youn Han
Summary: The study demonstrates that KRAS mutation can increase the cleavage of NRG1 from the S-N fusion protein, enhancing various signaling pathways. The coexistence of KRAS mutant and S-N fusion in lung tumors makes them more vulnerable to MEK1/2 and ADAM17 inhibitors.
Article
Dermatology
Musin Kelel, Ruey-Bing Yang, Tsen-Fang Tsai, Pi-Hui Liang, Fu-Yu Wu, Yu-Tien Huang, Ming-Fong Yang, Yu-Ping Hsiao, Li-Fang Wang, Chen-Fen Tu, Fu-Tong Liu, Yungling L. Lee
Summary: The study reveals that FUT8 remodeling of EGFR plays a critical role in the development of psoriasis phenotypes and is associated with disease severity. FUT8 gain of function promotes cell proliferation, while short hairpin FUT8 reduces proliferation and alters the cell cycle.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biology
Chi-Chuan Lin, Lukasz Wieteska, Guillaume Poncet-Montange, Kin Man Suen, Stefan T. Arold, Zamal Ahmed, John E. Ladbury
Summary: Interactions between the peripheral juxtamembrane and C-terminal tail regions and the phosphorylation state of the kinase domain of FGFR2 fine tunes its signaling outputs.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Zhongqiu Zhou, Zhuojun Zhang, Han Chen, Wenhao Bao, Xiangqin Kuang, Ping Zhou, Zhiqing Gao, Difeng Li, Xiaoyi Xie, Chunxiao Yang, Xuhong Chen, Jinyuan Pan, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Lan Wang, Jianan Yang, Lili Jiang
Summary: This study demonstrates that SBSN and secreted SBSN promote bladder cancer metastasis through activation of the EGFR/SRC/STAT3 pathway, identifying SBSN as a potential diagnostic and therapeutic target for bladder cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Immunology
Yu Chen, Jie Mei, Ping Zhang, Jiayu Liu, Lingyan Chen, Liwei Wu, Yan Zhang
Summary: This research discovered that IQGAP1 is upregulated in most cancer types and correlates with poor prognosis in ovarian cancer. It is also associated with immune-related genes and tumor-infiltrating lymphocytes. IQGAP1 functions as a novel EGF-response gene, mediating EGF-induced tumor cell proliferation, migration, and invasion through interaction with STATs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Sachin V. Surve, Paul J. Myers, Samantha A. Clayton, Simon C. Watkins, Matthew J. Lazzara, Alexander Sorkin
MOLECULAR BIOLOGY OF THE CELL
(2019)
Article
Biology
Mads Breum Larsen, Mireia Perez Verdaguer, Brigitte F. Schmidt, Marcel P. Bruchez, Simon C. Watkins, Alexander Sorkin
Article
Neurosciences
Mary Hongying Cheng, Luca Ponzoni, Tatiana Sorkina, Ji Young Lee, She Zhang, Alexander Sorkin, Ivet Bahar
Review
Developmental Biology
Yoel Sadovsky, Yingshi Ouyang, Juliana S. Powell, Hui Li, Jean-Francois Mouillet, Adrian E. Morelli, Alexander Sorkin, Leonid Margolis
Review
Cell Biology
Irene Estadella, Oriol Pedros-Gamez, Magali Colomer-Molera, Manel Bosch, Alexander Sorkin, Antonio Felipe
Article
Immunology
Yingshi Ouyang, Jean-Francois Mouillet, Alexander Sorkin, Yoel Sadovsky
Summary: Cells produce cytoplasmic vesicles to facilitate the processing and transport of molecules, while releasing extracellular vesicles for intercellular communication. Understanding the biological functions and potential diagnostic/therapeutic applications of EVs, especially exosomes, is a current focus. EVs and viruses share similarities in biogenesis, size distribution, cargo, and cell-targeting mechanisms, with potential impacts on viral replication and infectivity revealed by research.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Neurosciences
Tarique R. Bagalkot, Ethan R. Block, Kristen Bucchin, Judith Joyce Balcita-Pedicino, Michael Calderon, Susan R. Sesack, Alexander Sorkin
Summary: The study reveals that membrane diffusion is the main mode of long-range transport of DAT through the medial forebrain bundle (MFB). However, vesicular traffic can also play a significant role in a subset of MFB axons. The turnover rate of plasma membrane DAT in MFB axons is estimated to be approximately 20 days.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Mark von Zastrow, Alexander Sorkin
Summary: This review outlines the intricate relationships between endocytosis and cellular signaling, particularly focusing on tyrosine kinase and G protein-coupled receptors. The examples provided offer an insight into the current consensus, uncertainties, and controversies in this rapidly advancing field of cell biology.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 90, 2021
(2021)
Article
Biochemistry & Molecular Biology
Tatiana Sorkina, Mary Hongying Cheng, Tarique R. Bagalkot, Callen Wallace, Simon C. Watkins, Ivet Bahar, Alexander Sorkin
Summary: A series of small molecules have been discovered to stabilize trimers and induce high-order oligomers of DAT, ultimately promoting its endocytosis. The small molecule-induced DAT oligomerization and endocytosis are favored by the inward-facing DAT conformation and involve interactions of four hydrophobic residues at the interface between TM helices TM4 and TM9.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Microbiology
Yingshi Ouyang, Tarique Bagalkot, Wendy Fitzgerald, Elena Sadovsky, Tianjiao Chu, Ana Martinez-Marchal, Miguel Brieno-Enriquez, Emily J. Su, Leonid Margolis, Alexander Sorkin, Yoel Sadovsky
Summary: Research has shown that the main entry factors for SARS-CoV-2 are expressed in human placental trophoblasts, but not in other placental villous cells. The placental defense against SARS-CoV-2 infection likely involves post-entry processing mechanisms.
Article
Cell Biology
Sachin Surve, Simon C. Watkins, Alexander Sorkin
Summary: The study demonstrated that endogenous KRAS and NRAS are predominantly localized to the plasma membrane and do not colocalize with endosomal EGFR upon EGF stimulation. It was suggested that a small pool of surface EGFRs sustain signaling within the RAS-ERK1/2 pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Mireia Perez Verdaguer, Tian Zhang, Joao A. Paulo, Steven Gygi, Simon C. Watkins, Hiroaki Sakurai, Alexander Sorkin
Summary: This study dissects the mechanisms of p38-induced endocytosis of EGFR using a pH-sensitive model, proposing a unifying model of crosstalk between multiple endocytosis pathways. The research reveals that p38-dependent EGFR endocytosis is essential for the interaction with the sigma 2 subunit of clathrin adaptor AP2, and is additive to CME induced by cytokines but constrained to internalizing ligand-free EGFRs due to Grb2 recruitment by ligand-activated EGFRs.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mirella Mourad, Taylor Jacob, Elena Sadovsky, Shai Bejerano, Glicella Salazar-De Simone, Tarique Rajasaheb Bagalkot, Jason Zucker, Michael T. Yin, Jennifer Y. Chang, Lihong Liu, Larisa Debelenko, Carrie J. Shawber, Morgan Firestein, Yingshi Ouyang, Cynthia Gyamfi-Bannerman, Anna Penn, Alexander Sorkin, Ronald Wapner, Yoel Sadovsky
Summary: The severity of COVID-19 in pregnant women is associated with the processing of SARS-CoV-2 in the placenta and antiviral pathways, suggesting a role for these proteins in the placental response to SARS-CoV-2.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Hui Li, Itziar Pinilla-Macua, Yingshi Ouyang, Elena Sadovsky, Kazuhiro Kajiwara, Alexander Sorkin, Yoel Sadovsky
JOURNAL OF EXTRACELLULAR VESICLES
(2020)
Article
Neurosciences
Cihan Kaya, Mary H. Cheng, Ethan R. Block, Tom M. Bartol, Terrence J. Sejnowski, Alexander Sorkin, James R. Faeder, Ivet Bahar