Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding

Crystal Structure and Functional Analysis of the Glutaminyl Cyclase from Xanthomonas campestris

(2010) Wei-Lin Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Glutaminyl Cyclases Display Significant Catalytic Proficiency for Glutamyl Substrates

(2009) Franziska Seifert et al.   BIOCHEMISTRY

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

(2009) Anett Stephan et al.   FEBS Journal

Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement

(2009) Mirko Buchholz et al.   JOURNAL OF MEDICINAL CHEMISTRY

A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis

(2008) Kai-Fa Huang et al.   BIOCHEMICAL JOURNAL

Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β†

(2008) Holger Cynis et al.   BIOCHEMISTRY

Alternative pathways for production of β-amyloid peptides of Alzheimer's disease

(2008) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery

(2008) Holger Cynis et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of glutaminyl cyclase prevents pGlu-A formation after intracorticalhippocampal microinjectionin vivoin situ

(2008) Stephan Schilling et al.   JOURNAL OF NEUROCHEMISTRY

Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology

(2008) Stephan Schilling et al.   NATURE MEDICINE