Review
Oncology
Ye Gu, Xiaofeng Zhang, Weiping Yu, Weifeng Dong
Summary: This article reviews the methylation function of SET7/9 and discusses its important impact mechanisms on cancer initiation and development. The article also explores the function of SET7/9 in regulating the expression and stability of protein targets and discusses its potential role as an oncogene or tumor suppressor in different cancer types.
Article
Biology
Alexandra Daks, Elena Vasileva, Olga Fedorova, Oleg Shuvalov, Nickolai A. Barlev
Summary: In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.
Review
Oncology
Lili Gao, Weiping Yu, Peng Song, Qing Li
Summary: SET7/9 is an important lysine methyltransferase involved in regulating various biological processes, playing a key role in tumorigenesis and development.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2022)
Review
Pharmacology & Pharmacy
Samarth Dwivedi, Atharva Chavan, Atish T. Paul
Summary: This review focuses on the role of SET7 in the onset and progression of diabetic nephropathy (DN), and its potential as a therapeutic target to combat renal disorders.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Daks, Victoria Mamontova, Olga Fedorova, Alexey Petukhov, Oleg Shuvalov, Sergey Parfenyev, Sofia Netsvetay, Aigul Venina, Alena Kizenko, Evgeny Imyanitov, Nickolai Barlev
Summary: Set7/9 regulates cell proliferation, cancer progression, and DNA damage response by post-translationally modifying critical transcription factors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dmitry Myadelets, Sergey Parfenyev, Julia Vasileva, Oleg Shuvalov, Alexey Petukhov, Olga Fedorova, Nickolai Barlev, Alexandra Daks
Summary: The protein-specific methyltransferase Set7/9 plays a crucial role in various cellular processes, including histone modification and transcription factor regulation. It has been linked to tumor growth and the transformation of normal cells. The impact of Set7/9 on cancer progression is complex and dependent on the type of cancer. This study reveals the potential involvement of Set7/9 in DNA damage signaling and repair processes in breast cancer cells. The downregulation of Set7/9 is associated with decreased expression of PARP1 and increased resistance to cisplatin. The combination of cisplatin and the FDA approved PARP1 inhibitor niraparib shows promising synergistic effects in overcoming cisplatin resistance in Set7/9 deficient breast cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alexander D. Roth, Dasan M. Thamattoor
Summary: Three polymorphs of the hydrocarbon 9-[(9H-fluoren-9-ylidene)methyl]phenanthrene have been isolated and characterized. One form displays conformational polymorphism, which is less common in simple hydrocarbons. The synthesis process led to the formation of the β-5 form instead of the α-5 form. The differences in molecular interactions between the polymorphs were observed.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Ji-Qiang Fan, Kehui Cen, Hua-Jun Xu, Hai-Yang Wang, Ying Yang, Ze-Min Zhu, Hao Liu, Dengyu Chen, Weigang Fan, Man-Bo Li
Summary: This study synthesized four carbonyl metal nanoclusters through a photochemical reduction-oxidation cascade process and compared their catalytic performance. The results showed that these nanoclusters have oxidative resistance and structural stability, and their catalytic activity is dependent on the ring size.
Review
Microbiology
Florian Kremp, Volker Mueller
Summary: The production of bulk chemicals from petroleum sources leads to greenhouse gas emissions. The development of bio-based processes, particularly using acetogenic bacteria, has gained attention as an alternative. These anaerobic organisms produce acetate and ethanol from CO2, CO, and H2, with methanol also being a suitable substrate. The biochemistry and bioenergetics of methanol conversion in anaerobic bacteria is discussed, along with the possibility of biochemical production from methanol.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Zining Zhang, Qi Zhu, Daniel Pyle, Xukai Zhou, Guangbin Dong
Summary: This study reports a deacylative halogenation approach to convert various methyl ketones to alkyl halides by forming an aromatic byproduct. The method is applicable to a wide range of methyl ketones and can be used for one-pot conversions and annulations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Himanshu Sankrityayan, Ajinath Kale, Vishwadeep Shelke, Anil Bhanudas Gaikwad
Summary: The study demonstrated that the novel SET7/9 inhibitor, Cyproheptadine, has renoprotective potential by reducing H3K4Me1 expression and ER stress to prevent diabetic kidney disease.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Spartak S. Yarovoy, Irina Mirzaeva, Yuri Mironov, Natalia Pervukhina, Konstantin A. Brylev
Summary: Azide cluster complexes were obtained by reacting Re3X9 with sodium azide. These complexes represent the first case of metal cluster polyazide complexes and exhibit high explosiveness.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Ersen Mete, Sinasi Ellialtioglu, Oguz Gulseren, Deniz Uner
Summary: In this study, the concentration and coordination of surface oxygen vacancies were found to be critical for the direct water-splitting reaction on PbTiO3 and TiO2 (001) surfaces. Two neighboring O vacancies are necessary for water-splitting on TiO2-terminated surfaces, while only two oxygen vacancies are required for molecular hydrogen formation on the PbO-terminated surface of PbTiO3. However, the formation of molecular hydrogen is hindered by the presence of a third vacancy on TiO2-terminated surfaces.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Article
Crystallography
Aysenur Limon, Dustin N. Jordan, Till Strothmann, Laure P. Cuignet, Yann Garcia, Christoph Janiak
Summary: Three novel iron(II) coordination polymers were synthesized using the linker 1,3,5-tris((1H-1,2,4-triazol-1-yl)methyl)benzene (ttmb). The single-crystal structures revealed that all three compounds form a double-chain structure with the iron atoms being bridged by two ttmb linkers. The iron(II) ions are surrounded by N4 donor atoms from the triazole groups of ttmb, along with coordinating water or isothiocyanato ligands.
Article
Chemistry, Organic
Ming La, Dandan Liu, Xuerong Chen, Fang-Lin Zhang, Yirong Zhou
Summary: A novel palladium-catalyzed direct o-C-H iodination of benzaldehydes was successfully developed using a commercially available 2,5-bis(trifluoromethyl)aniline as the optimal Monodentate Transient Directing Group (MonoTDG), achieving moderate to excellent yields and good selectivity. Importantly, a concise two-step total synthesis of the natural product hernandial was demonstrated by merging this new MonoTDG-assisted C-H iodination with subsequent copper-catalyzed cross-coupling.
Article
Biochemistry & Molecular Biology
Robert J. Fick, Grace M. Kroner, Binod Nepal, Roberta Magnani, Scott Horowitz, Robert L. Houtz, Steve Scheiner, Raymond C. Trievel
ACS CHEMICAL BIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Philipp Koldewey, Frederick Stull, Scott Horowitz, Raoul Martin, James C. A. Bardwell
Article
Biochemistry & Molecular Biology
Kristoffer E. Johansson, Nicolai Tidemand Johansen, Signe Christensen, Scott Horowitz, James C. A. Bardwell, Johan G. Olsen, Martin Willemoes, Kresten Lindorff-Larsen, Jesper Ferkinghoff-Borg, Thomas Hamelryck, Jakob R. Winther
JOURNAL OF MOLECULAR BIOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Philipp Koldewey, Scott Horowitz, James C. A. Bardwell
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Scott Horowitz, Philipp Koldewey, Frederick Stull, James C. A. Bardwell
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Loic Salmon, Frederick Stull, Sabrina Sayle, Claire Cato, Serife Akgul, Linda Foit, Logan S. Ahlstrom, Elan Z. Eisenmesser, Hashim M. Al-Hashimi, James C. A. Bardwell, Scott Horowitz
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Lorna Dsilva, Shubhi Mittal, Brian Koepnick, Jeff Flatten, Seth Cooper, Scott Horowitz
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION
(2019)
Article
Biochemistry & Molecular Biology
Firas Khatib, Ambroise Desfosses, Foldit Players, Brian Koepnick, Jeff Flatten, Zoran Popovic, David Baker, Seth Cooper, Irina Gutsche, Scott Horowitz
Article
Biochemical Research Methods
Serena Rocchio, Ramona Duman, Kamel El Omari, Vitaliy Mykhaylyk, Christian Orr, Zhen Yan, Loic Salmon, Armin Wagner, James C. A. Bardwell, Scott Horowitz
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Ahyun Son, Scott Horowitz, Baik L. Seong
Summary: The RNA world concept suggests that RNA played a dual role as genetic material and catalyst, enriching the early RNA world with proteins. The folding activity of proteins residing in ribozymes likely facilitated the transition of the RNA world into the present protein-based biological systems.
Article
Biochemistry & Molecular Biology
Adam Begeman, Ahyun Son, Theodore J. Litberg, Tadeusz H. Wroblewski, Thane Gehring, Veronica Huizar Cabral, Jennifer Bourne, Zhenyu Xuan, Scott Horowitz
Letter
Biochemistry & Molecular Biology
Josh Aaron Miller, Firas Khatib, Haley Hammond, Seth Cooper, Scott Horowitz
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Bryan B. Guzman, Ahyun Son, Theodore J. Litberg, Zijue Huang, Daniel Dominguez, Scott Horowitz
Summary: This state-of-the-art review explores the interaction between nucleic acids and proteins, specifically focusing on the G-quadruplex structure of RNA and DNA. It discusses how G-quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and highlights unanswered questions in this scientific field.
Article
Multidisciplinary Sciences
Ahyun Son, Veronica Huizar Cabral, Zijue Huang, Theodore J. Litberg, Scott Horowitz
Summary: Recent research has found that G-quadruplex (G4) nucleic acids are effective in preventing protein aggregation and improving protein folding in Escherichia coli. Through in vitro protein folding experiments, it was discovered that G4s can accelerate protein folding by rescuing kinetically trapped intermediates. Time-course folding experiments in E. coli further showed that G4s primarily enhance protein folding quality instead of preventing protein aggregation. This study suggests that nucleic acids and ATP-independent chaperones may play important roles in determining the folding fate of proteins.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Theodore J. Litberg, Rajesh Kumar Reddy Sannapureddi, Zijue Huang, Ahyun Son, Bharathwaj Sathyamoorthy, Scott Horowitz
Summary: Maintaining a healthy protein folding environment is essential for cellular function. Recently, nucleic acids, especially G-quadruplexes, were found to be effective chaperones for preventing protein aggregation. Through structure-function and NMR analyses, several factors that affect the ability of G-quadruplexes to prevent protein aggregation, such as structural topology, accessibility and dynamics of G-quadruplexes, and their oligomerization state, were identified. Understanding these factors will help elucidate the possible roles of G-quadruplexes in neurodegenerative disease.