期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 27, 页码 24385-24393出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.212191
关键词
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资金
- European Union [LSHM-CT-2005-512012]
- Bundesministerium fur Bildung und Forschung [0315512]
- Medical Research Council [G0501258, G0800498]
- Hertie-Institute for Clinical Brain Research
- Medical Research Council [G0800498, G0501258] Funding Source: researchfish
- MRC [G0800498, G0501258] Funding Source: UKRI
Cell adhesion molecules regulate synapse formation and maintenance via transsynaptic contact stabilization involving both extracellular interactions and intracellular postsynaptic scaffold assembly. The cell adhesion molecule neurofascin is localized at the axon initial segment of granular cells in rat dentate gyrus, which is mainly targeted by chandelier cells. Lentiviral shRNA-mediated knockdown of neurofascin in adult rat brain indicates that neurofascin regulates the number and size of postsynaptic gephyrin scaffolds, the number of GABA(A) receptor clusters as well as presynaptic glutamate decarboxylase-positive terminals at the axon initial segment. By contrast, overexpression of neurofascin in hippocampal neurons increases gephyrin cluster size presumably via stimulation of fibroblast growth factor receptor 1 signaling pathways.
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