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Medicine, General & Internal
Daniel Almeida do Valle, Mara Lucia S. Ferreira Santos, Monica J. Spinosa, Bruno A. Telles, Carolina Prando, Mara L. Cordeiro
Summary: This case study describes a 6-year-old boy hospitalized with super-refractory status epilepticus related to autoimmune encephalitis associated with B19 infection. Following immunosuppressive therapy, the patient achieved complete symptom remission, normal neurological examination, and appropriate neuropsychomotor development, highlighting the importance of early clinical suspicion and treatment.
Article
Multidisciplinary Sciences
Angela L. Whittsette, Ya-Juan Wang, Ting-Wei Mu
Summary: This study reveals that the endoplasmic reticulum membrane complex (EMC) plays a positive regulatory role in the surface trafficking and function of endogenous gamma-aminobutyric acid type A (GABA(A)) receptors. The EMC3 and EMC6 subunits of EMC have the most significant impact and can restore the function of epilepsy-associated GABA(A) receptor variants. Furthermore, EMC3 and EMC6 interact with major neuroreceptors, suggesting a general role of the EMC in the biogenesis of neuroreceptors.
Article
Cell Biology
Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono
Summary: The study found that OT acts as a positive allosteric modulator of KOR and MOR, enhancing G protein signaling without affecting beta-arrestin signaling.
Article
Multidisciplinary Sciences
Jin Ye, Guichang Zou, Ruichi Zhu, Chao Kong, Chenjian Miao, Mingjie Zhang, Jianchao Li, Wei Xiong, Chao Wang
Summary: GABARAP and GABARAPL1 stabilize GABA(A) receptors by directly binding to the γ 2 subunit, promoting receptor trafficking pathways, and modulating receptor localization at synapses.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Qier Zhou, Zhiwei Zhang, Songkai Long, Wanjun Li, Baiyun Wang, Na Liang
Summary: The kappa-opioid receptor (KOR) is associated with various types of cancer and understanding this association may facilitate the development of new antitumor therapies.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Neus Pedraza, Ma Ventura Monserrat, Francisco Ferrezuelo, Jordi Torres-Rosell, Neus Colomina, Federico Miguez-Cabello, Javier Picanol Parraga, David Soto, Esperanza Lopez-Merino, Celia Garcia-Vilela, Jose A. Esteban, Joaquim Egea, Eloi Gari
Summary: In this study, Nuclear Cyclin D1 is found to interact with and phosphorylate the α4 subunit of GABA A receptors, increasing the surface levels of α4-containing GABA A receptors and enhancing their response. This molecular link between D1-Cdk4 and GABA A receptors activity highlights a novel role for this G1 cyclin in neuronal signalling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Neurosciences
Yu Yang, Haijie Yu, Reji Babygirija, Bei Shi, Weinan Sun, Xiaojiao Zheng, Jun Zheng
Summary: Stress can elevate CRF release in the hypothalamus, which inhibits gastric motor functions, while central NPY can counteract the actions of CRF to weaken stress responses. Electroacupuncture at ST-36 increases central NPY mRNA expression and reduces central CRF mRNA expression, restoring gastric motor function. NPY may antagonize overexpressed CRF through the GABA(A) receptor to attenuate HPA axis activities in CCS conditions.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Medicinal
Wei-Jie Fang, Thomas F. Murray, Jane Aldrich
Summary: The study investigates the cyclization of Dyn A analog arodyn to limit conformational flexibility and enhance affinity and selectivity for kappa opioid receptors. Both cis and trans isomers of cyclized peptides exhibit competitive antagonism of kappa opioid receptors similar to arodyn, providing important information for the design of next-generation cyclic arodyn analogs.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Medicinal
Lalit K. Golani, Md Yeunus Mian, Taukir Ahmed, Kamal P. Pandey, Prithu Mondal, Dishary Sharmin, Sepideh Rezvanian, Jeffrey M. Witkin, James M. Cook
Summary: This study investigates the pharmacological actions of benzodiazepines on the GABA(A) receptor and reveals key binding interaction domains through cryo-EM structure analysis. By designing and synthesizing structural analogs, compounds with improved efficacy and selectivity were discovered. Modeling and binding data demonstrate the potential of these compounds for improved medical treatments.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biology
Karen L. Bales, Forrest D. Rogers
Summary: This paper reviews the literature on the neuroendocrine mechanisms for the emotional consequences of partner loss, with a special focus on hypothesized interactions between oxytocin, corticotropin-releasing hormone and the kappa opioid system.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ya-Juan Wang, Xiao-Jing Di, Ting-Wei Mu
Summary: This study identified the interactomes of GABAA receptors and revealed potential components and pathways involved in the biogenesis and degradation of GABAA receptors. TRIM21 was found to positively regulate the degradation of misfolding-prone GABAA receptor subunits. This research provides insights into the molecular mechanisms of GABAA receptor proteostasis and offers possibilities for the treatment of neurological diseases.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Craig A. Sexton, Reka Penzinger, Martin Mortensen, Damian P. Bright, Trevor G. Smart
Summary: This study reveals that spontaneous gating of GABA(A) receptors requires incorporation of beta 3 subunits, which is modulated by protein kinases and neurosteroids. This spontaneous activity alters neural network activity by regulating tonic inhibition.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ibtissem Nabti, Babu J. N. Reddy, Rachid Rezgui, Wenqi Wang, Steven P. Gross, George T. Shubeita
Summary: This study demonstrates that phosphorylated MAP4 can bias organelle transport towards the microtubule minus-ends by impairing the force generation of kinesin-1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Ya-Juan Wang, Xiao-Jing Di, Ting-Wei Mu
Summary: This study systematically identified the interactomes of GABA(A) receptors using a proteomics-based approach. The findings shed light on the proteostasis network components involved in GABA(A) receptor biogenesis and suggest a potential regulatory mechanism for the degradation of misfolding-prone subunits.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Yamaguchi, Kanako Miyano, Shigeto Hirayama, Yusuke Karasawa, Kaori Ohshima, Eiko Uezono, Akane Komatsu, Miki Nonaka, Hideaki Fujii, Keisuke Yamaguchi, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Summary: This study evaluated the structural requirements for the selectivity of nalfurafine in activating G-protein-mediated and β-arrestin-mediated pathways. The findings suggest that nalfurafine analogs with a 3S-hydroxy group may be G-protein-biased κ OR agonists.