Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

Hepatocyte Growth Factor and Its Receptor Signalling Complex as Targets in Cancer Therapy

(2012) Tracey Martin et al.   Anti-Cancer Agents in Medicinal Chemistry

c-Met inhibitors with different binding modes: Two is better than one

(2011) Isabelle Dussault et al.   CELL CYCLE

C-MET as a new therapeutic target for the development of novel anticancer drugs

(2010) Israel Cañadas et al.   Clinical & Translational Oncology

The 2010 Meeting of the American Society of Clinical Oncology

(2010) David J. Lee et al.   Clinical Lung Cancer

Non-ATP Competitive Protein Kinase Inhibitors

(2010) L. Garuti et al.   CURRENT MEDICINAL CHEMISTRY

ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity

(2010) N. Munshi et al.   MOLECULAR CANCER THERAPEUTICS

Enzymatic Characterization of c-Met Receptor Tyrosine Kinase Oncogenic Mutants and Kinetic Studies with Aminopyridine and Triazolopyrazine Inhibitors

(2009) Sergei L. Timofeevski et al.   BIOCHEMISTRY

Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

(2009) John Porter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Analysis of c-Met Kinase Domain Complexes: A New Specific Catalytic Site Receptor Model for Defining Binding Modes of ATP-Competitive Ligands

(2009) Yasmine Asses et al.   Chemical Biology & Drug Design

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Single-Agent Laromustine, A Novel Alkylating Agent, Has Significant Activity in Older Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia

(2009) Gary J. Schiller et al.   JOURNAL OF CLINICAL ONCOLOGY

Developing c-MET pathway inhibitors for cancer therapy: progress and challenges

(2009) Xiangdong Liu et al.   TRENDS IN MOLECULAR MEDICINE

Biochemical Basis for the Functional Switch That Regulates Hepatocyte Growth Factor Receptor Tyrosine Kinase Activation†

(2008) Payal R. Sheth et al.   BIOCHEMISTRY

Affinity Selection-Mass Spectrometry and its Emerging Application to the High Throughput Screening of G Protein-Coupled Receptors

(2008) Charles Whitehurst et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition

(2008) AC Backes et al.   Expert Opinion on Drug Discovery

Type-II Kinase Inhibitor Docking, Screening, and Profiling Using Modified Structures of Active Kinase States

(2008) Irina Kufareva et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase†

(2008) Brian K. Albrecht et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Drug development of MET inhibitors: targeting oncogene addiction and expedience

(2008) Paolo M. Comoglio et al.   NATURE REVIEWS DRUG DISCOVERY