Bi-specific Aptamers Mediating Tumor Cell Lysis

Discovery of Fully Human Anti-MET Monoclonal Antibodies with Antitumor Activity against Colon Cancer Tumor Models In Vivo

(2015) Edward Htun van der Horst et al.   NEOPLASIA

Delivering cargoes into cancer cells using DNA aptamers targeting internalized surface portals

(2010) Erik W. Orava et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Modulating the pharmacokinetics of therapeutic antibodies

(2010) A. Constantinou et al.   BIOTECHNOLOGY LETTERS

A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting

(2010) Markus Kügler et al.   BRITISH JOURNAL OF HAEMATOLOGY

Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen

(2010) Claudia Bluemel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Monovalency Unleashes the Full Therapeutic Potential of the DN-30 Anti-Met Antibody

(2010) Giovanni Pacchiana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective Elimination of Acute Myeloid Leukemic Cells by Recombinant Bispecific Antibody Derivatives Directed Against CD33 and CD16

(2010) Heiko Singer et al.   JOURNAL OF IMMUNOTHERAPY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Strategies to Extend Plasma Half-Lives of Recombinant Antibodies

(2009) Roland E. Kontermann   BIODRUGS

Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells

(2009) Andrés López-Albaitero et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Bispecific T-Cell Engaging Antibodies for Cancer Therapy

(2009) P. A. Baeuerle et al.   CANCER RESEARCH

Novel Therapeutic Inhibitors of the c-Met Signaling Pathway in Cancer

(2009) J. P. Eder et al.   CLINICAL CANCER RESEARCH

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Cancer-selective antiproliferative activity is a general property of some G-rich oligodeoxynucleotides

(2009) Enid W. Choi et al.   NUCLEIC ACIDS RESEARCH

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

The Met tyrosine kinase receptor in development and cancer

(2008) Alessandra Gentile et al.   CANCER AND METASTASIS REVIEWS

FcγRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck

(2008) Rodney J. Taylor et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

MET receptor tyrosine kinase as a therapeutic anticancer target

(2008) Christine M. Stellrecht et al.   CANCER LETTERS

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

(2008) H. Jin et al.   CANCER RESEARCH

Assembling OX40 Aptamers on a Molecular Scaffold to Create a Receptor-Activating Aptamer

(2008) Claudia M. Dollins et al.   CHEMISTRY & BIOLOGY

SELEX with modified nucleotides

(2008) Anthony D Keefe et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Immunogenicity of anti-tumor necrosis factor antibodies—toward improved methods of anti-antibody measurement

(2008) Lucien Aarden et al.   CURRENT OPINION IN IMMUNOLOGY

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice

(2008) James O. McNamara et al.   JOURNAL OF CLINICAL INVESTIGATION

A Novel CD19-directed Recombinant Bispecific Antibody Derivative With Enhanced Immune Effector Functions for Human Leukemic Cells

(2008) Christian Kellner et al.   JOURNAL OF IMMUNOTHERAPY

Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase

(2008) J. MÜLLER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel bimodular DNA aptamers with guanosine quadruplexes inhibit phylogenetically diverse HIV-1 reverse transcriptases

(2008) D. Michalowski et al.   NUCLEIC ACIDS RESEARCH

Molecular assembly for high-performance bivalent nucleic acid inhibitor

(2008) Y. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA