Article
Neurosciences
Qingqing Bai, Shuoyang Wang, Dongmei Rao, Zhiming Zhou, Jianfei Wang, Qi Wang, Yu Qin, Zhaohu Chu, Shoucai Zhao, Dijing Yu, Yang Xu
Summary: In this study, the researchers investigated the impact of RIPK3 activation on neuronal necroptosis and the involvement of DAXX in the nuclear necroptosis pathway after ICH. The results showed that RIPK3 promoted neuronal necroptosis in ICH mice, partially through the DAXX signaling pathway. RIPK3 and AIF interacted with nuclear DAXX to aggravate ICH injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Sung-Min Kim, Won-Hee Hur, Byung-Yoon Kang, Sung-Won Lee, Pu-Reun Roh, Dong-Jun Park, Pil-Soo Sung, Seung-Kew Yoon
Summary: The study revealed that the expression of Daxx was significantly decreased in fibrotic liver tissues, and overexpression of Daxx inhibited the EMT process by interfering with TGF-beta-induced phosphorylation of Smad2. Daxx was found to reduce the transcriptional activity of Smad2 by binding to its MH1 domain and interfering with Smad2 acetylation, suggesting its potential as a therapeutic target for liver fibrosis.
Article
Engineering, Biomedical
Lizebona August Ambattu, Callum Knight, Keng-hui Lin, Amy Gelmi, Leslie Y. Yeo
Summary: This study investigates the effects of short-duration mechanostimulation on endothelial junction stability and barrier capacity. The study found that the integrity of the endothelial barrier can not only recover but also enhance considerably after transient disruption, thanks to the role of calcium and cAMP signaling. Such enhancement in barrier capacity is useful for developing in vitro models that resemble in vivo conditions.
Article
Oncology
Ana P. Kutschat, Feda H. Hamdan, Xin Wang, Alexander Q. Wixom, Zeynab Najafova, Christine S. Gibhardt, Waltraut Kopp, Jochen Gaedcke, Philipp Strobel, Volker Ellenrieder, Ivan Bogeski, Elisabeth Hessmann, Steven A. Johnsen
Summary: Gemcitabine-resistant PDAC tumors show coamplification of RRM1 and STIM1, where RRM1 is required for resistance while high STIM1 levels lead to increased cytosolic calcium levels. This calcium influx impairs ER stress response and activates NFAT signaling, revealing a potential target for therapy in PDAC.
Article
Cell Biology
Beibei Wu, Jin Seok Woo, Pamela Vila, Marcus Jew, Jennifer Leung, Zuoming Sun, Sonal Srikanth, Yousang Gwack
Summary: In effector T cells, the pore subunit of CRAC channels, ORAI1, is limited in plasma membrane localization with a significant fraction trapped in intracellular vesicles. NKD2, an essential component of ORAI1(+) vesicles activated by signaling pathways downstream of T cell receptors, orchestrates trafficking and insertion of ORAI1(+) vesicles to the plasma membrane. T cell receptor (TCR)-stimulation-dependent insertion of ORAI1 into the plasma membrane is essential for sustained calcium signaling and cytokine production in T cells.
Article
Cell Biology
Yuxiong Lu, Qing Yang, Yubin Su, Yin Ji, Guobang Li, Xianzhi Yang, Liyan Xu, Zhaoliang Lu, Jiajun Dong, Yi Wu, Jin-Xin Bei, Chaoyun Pan, Xiaoqiong Gu, Bo Li
Summary: MYCN amplification in pediatric neuroblastoma cells increases sensitivity to GPX4-targeting ferroptosis inducers by upregulating TFRC expression, leading to enhanced iron metabolism and lipid peroxidation, suggesting potential therapeutic strategies for treating MYCN-amplified NB.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Chitra Bhatia, Subhash Reddy Gaddam, Ashutosh Pandey, Prabodh Kumar Trivedi
Summary: Flavonols, a type of protective compounds, are regulated by light and other environmental factors. MYB12 has been identified as a key gene in Arabidopsis that regulates flavonol accumulation in response to light.
Article
Medicine, Research & Experimental
Olga A. Mareninova, Eszter T. Vegh, Natalia Shalbueva, Carli J. M. Wightman, Dustin L. Dillon, Sudarshan Malla, Yan Xie, Toshimasa Takahashi, Zoltan Rakonczay, Samuel W. French, Herbert Y. Gaisano, Fred S. Gorelick, Stephen J. Pandol, Steven J. Bensinger, Nicholas O. Davidson, David W. Dawson, Ilya Gukovsky, Anna S. Gukovskaya
Summary: The study reveals the essential role of the M6P pathway in maintaining exocrine pancreas homeostasis and function, with Gnptab(-/-) mice developing spontaneous pancreatitis. Normalization of cholesterol metabolism by pharmacologic means alleviated responses of experimental pancreatitis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Yi-qian Feng, Heng Zhang, Jing-xia Han, Bi-jia Cui, Lu-ning Qin, Lei Zhang, Qing-qing Li, Xin-ying Wu, Nan-nan Xiao, Yan Zhang, Ting-ting Lin, Hui-juan Liu, Tao Sun
Summary: Intense UV exposure causes DNA damage and the cellular response to this damage is not well understood. Transcriptome analysis of UV-irradiated and non-irradiated skin revealed the involvement of transcription-related proteins HSF4 and COIL in mediating the cellular response to UV irradiation. Under UV irradiation, HSF4 and COIL form a complex and preferentially bind to target genes due to the presence of R-loops. This complex alters the regulation of target genes, leading to enhanced expression of inflammation and ageing-related genes, such as Atg7, Tfpi, and Lims1. A drug screening identified N6-(2-hydroxyethyl)-adenosine as a competitive inhibitor of COIL binding to R-loops, thereby inhibiting the activation of downstream inflammation-related genes and inflammatory skin injury.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Namrata Shukla, Ullas Kolthur-Seetharam
Summary: Organisms in the wild experience unpredictable and diverse food availability throughout their lifespan. Over-/under-nutrition during development and in adulthood is known to dictate organismal survival and fitness. This study demonstrates the essential role of Sirtuin 6 in regulating larval developmental kinetics, physiological homeostasis, physical activity, and organismal lifespan, providing new insights into gene-diet interactions and nutrient-dependent life-history traits.
Article
Biochemistry & Molecular Biology
Jennifer Allouche, Inbal Rachmin, Kaustubh Adhikari, Luba M. Pardo, Ju Hee Lee, Alicia M. McConnell, Shinichiro Kato, Shaohua Fan, Akinori Kawakami, Yusuke Suita, Kazumasa Wakamatsu, Vivien Igras, Jianming Zhang, Paula P. Navarro, Camila Makhlouta Lugo, Haley R. Noonan, Kathleen A. Christie, Kaspar Itin, Nisma Mujahid, Jennifer A. Lo, Chong Hyun Won, Conor L. Evans, Qing Yu Weng, Hequn Wang, Sam Osseiran, Alyssa Lovas, Istvan Nemeth, Antonio Cozzio, Alexander A. Navarini, Jennifer J. Hsiao, Nhu Nguyen, Lajos Kemeny, Othon Iliopoulos, Carola Berking, Thomas Ruzicka, Rolando Gonzalez-Jose, Maria-Catira Bortolini, Samuel Canizales-Quinteros, Victor Acuna-Alonso, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, Shosuke Ito, Maria Vittoria Schiaffino, Luke H. Chao, Benjamin P. Kleinstiver, Sarah Tishkoff, Leonard Zon, Tamar Nijsten, Andres Ruiz-Linares, David E. Fisher, Elisabeth Roider
Summary: This study reveals a mechanism of skin pigmentation that is independent of UV light and MITF, involving the regulation of melanosome maturation through targeting the mitochondrial enzyme NNT. Inhibition of NNT leads to increased pigmentation, as shown in human skin and mice experiments, and genetic modifications of NNT affect melanocytic pigmentation in zebrafish. Analysis of human cohorts also suggests significant associations between skin color and various single-nucleotide polymorphisms within NNT.
Article
Multidisciplinary Sciences
Syed Raza Mahmood, Xin Xie, Nadine Hosny El Said, Tomas Venit, Kristin C. Gunsalus, Piergiorgio Percipalle
Summary: The study demonstrates that changes in beta-actin levels can influence chromatin structure and 3D genome architecture, as well as the chromatin remodeling activities of BAF and polycomb proteins in mouse embryonic fibroblasts.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Qihong Yu, Jin-Xin Liu, Xichuan Zheng, Xueke Yan, Peng Zhao, Chuanzheng Yin, Wei Li, Zifang Song
Summary: This study reveals the significant role of Sox9 in mediating autophagy-dependent vSMC phenotypic modulation and the development of TA. Inhibition of Sox9 expression can attenuate neointimal formation, providing a potential therapeutic approach for vascular pathologies.
Article
Immunology
Sam Blanchett, Yves Dondelinger, Alessandro Barbarulo, Mathieu J. M. Bertrand, Benedict Seddon
Summary: The IKK complex plays a critical role in regulating NF-kappa B activation. It has been found that IKK can also repress RIPK1 dependent cell death pathways by phosphorylating RIPK1 at serine 25. This phosphorylation event promotes the survival of T cells and is essential for normal development in the thymus.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuangzhan Huang, Lanjuan Hu, Shihan Zhang, Mingxing Zhang, Wenzhu Jiang, Tao Wu, Xinglin Du
Summary: The study identified and characterized a WRKY transcription factor, OsWRKY50, in rice which acts as a transcriptional repressor and plays crucial roles in plant responses to salt stress. Overexpression of OsWRKY50 enhances salt stress tolerance and reduces sensitivity to ABA-regulated seed germination and seedling growth. Protoplast-based transient expression system and yeast hybrid assay demonstrated that OsWRKY50 directly binds to the promoter of OsNCED5, further inhibiting its transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yoshitaka Hasegawa, Yasushi Hojo, Hiroki Kojima, Muneki Ikeda, Keisuke Hotta, Rei Sato, Yuuki Ooishi, Miyuki Yoshiya, Bon-Chu Chung, Takeshi Yamazaki, Suguru Kawato
Article
Endocrinology & Metabolism
Jen-Chieh Lin, Shing Hu, Pei-Hung Ho, Hwei-Jan Hsu, John H. Postlethwait, Bon-chu Chung
Article
Environmental Sciences
Caroline Vignet, Lucette Joassard, Laura Lyphout, Tiphaine Guionnet, Manon Goubeau, Karyn Le Menach, Francois Brion, Olivier Kah, Bon-Chu Chung, Helene Budzinski, Marie-Laure Begout, Xavier Cousin
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2015)
Editorial Material
Endocrinology & Metabolism
Walter L. Miller, Bon-chu Chung
Article
Chemistry, Medicinal
Yi-Hsuan Chen, Hua-Yi Hsu, Ming-Tyng Yeh, Chen-Cheng Chen, Chang-Yu Huang, Ying-Hsuan Chung, Zee-Fen Chang, Wei-Chen Kuo, Nei-Li Chan, Jui-Hsia Weng, Bon-chu Chung, Yu-Ju Chen, Cheng-Bang Jian, Ching-Chieh Shen, Hwan-Ching Tai, Sheh-Yi Sheu, Jim-Min Fang
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Jui-Hsia Weng, Bon-chu Chung
Article
Cell Biology
Yu Chien, Karen Rosal, Bon-chu Chung
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Guo-Wei Jheng, Sung Sik Hur, Chia-Ming Chang, Chun-Chieh Wu, Jia-Shing Cheng, Hsiao-Hui Lee, Bon-Chu Chung, Yang-Kao Wang, Keng-Hui Lin, Juan C. del Alamo, Shu Chien, Jin-Wu Tsai
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Endocrinology & Metabolism
Chen-wei Hsu, You-Jiun Pan, Yan-Wei Wang, Sok-Keng Tong, Bon-chu Chung
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Biochemistry & Molecular Biology
C-Y Wang, E. Y-H Huang, S-c Huang, B-c Chung
Article
Multidisciplinary Sciences
Ming-Wei Kuo, Show-Wan Lou, Bon-chu Chung
Article
Endocrinology & Metabolism
Tulay Guran, Cengiz Kara, Melek Yildiz, Eda C. Bitkin, Goncagul Haklar, Jen-Chieh Lin, Mehmet Keskin, Lise Barnard, Ahmet Anik, Gonul Catli, Ayla Guven, Birgul Kirel, Filiz Tutunculer, Hasan Onal, Serap Turan, Teoman Akcay, Zeynep Atay, Gulay C. Yilmaz, Jamala Mamadova, Azad Akbarzade, Onder Sirikci, Karl-Heinz Storbeck, Tugba Baris, Bon-Chu Chung, Abdullah Bereket
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Editorial Material
Cell Biology
Yann Gibert, Bon-Chu Chung
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Cell Biology
Chen-wei Hsu, Bon-chu Chung
Summary: Fish gonads develop differently from mammalian gonads, mainly due to species-specific factors such as the presence of the gsdf gene in teleosts but its absence in many tetrapods. The gsdf transcript is primarily expressed in gonadal somatic cells, with variable functions related to germ cell proliferation, testicular formation, ovarian development, and sex determination in different fish species. The common and diverse expression, regulation, and functions of gsdf among different fish species are summarized with respect to evolution.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Meng-Chun Monica Shih, Chen-Che Jeff Huang, Hsueh-Ping Chu, Nai-Chi Hsu, Bon-Chu Chung
Summary: The study reveals that fetal energy homeostasis is established before birth, and fetal steroids are necessary for regulating glycogen synthesis, hepatic gluconeogenesis, and insulin secretion during the fetal stage.