Article
Virology
Lu Dai, Bock-Gie Jung, Jungang Chen, Buka Samten, James Craig Forrest, Steven R. Post, Zhiqiang Qin
Summary: KSHV-associated cancers are common in immunocompromised patients, while tuberculosis remains one of the deadliest infectious diseases globally; people living with HIV are at significantly higher risk of developing tuberculosis compared to those without HIV infection; the pathogenic factor ESAT-6 from Mtb can influence the biology of KSHV-infected cells.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Microbiology
V Dirix, N. Dauby, M. Hites, E. Watelet, A. Van Praet, A. Godefroid, E. Petit, M. Singh, C. Locht, F. Mascart, V Corbiere
Summary: Optimal detection of latent tuberculosis infection (LTBI) is crucial for achieving tuberculosis elimination. A user-friendly whole-blood interferon gamma release assay (IGRA) was developed to improve the detection of LTBI. Clinical evaluation showed a sensitivity of 93% for detecting LTBI among asymptomatic individuals. Individuals with responses to both antigens are likely at risk for reactivating the infection and should be prioritized for prophylactic treatment.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Chun-Hai Gao, Yan-An Zhang, Mao-Shui Wang
Summary: The performance of interferon-gamma release assays (IGRAs) was evaluated in patients with Mycobacterium kansasii infection. The positivity rates of IGRAs in patients with M. kansasii isolates were relatively low. More efforts are required to improve the performance of IGRAs in diagnosing M. kansasii infection.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Cell Biology
Edgardo Madrid-Paulino, Dulce Mata-Espinosa, Juan Carlos Leon-Contreras, Isela Serrano-Fujarte, Sol de Diaz de Leon-Guerrero, Tomas Villasenor, Lucero Ramon-Luing, Jose L. Puente, Leslie Chavez-Galan, Rogelio Hernandez-Pando, Leonor Perez-Martinez, Gustavo Pedraza-Alva
Summary: The transcription factor Klf10 plays a critical role in the survival and infection of Mycobacterium tuberculosis by negatively modulating IFN-gamma levels. Klf10 prevents the reprogramming of macrophages from phagocytosis to macropinocytosis, enhancing bacterial engulfment and bactericidal activity.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Microbiology
Gang Sheng, Hongqian Chu, Huijuan Duan, Wenjing Wang, Na Tian, Dingyi Liu, Hong Sun, Zhaogang Sun
Summary: This study reveals that LRRC25 acts as a negative regulator in microglia infected with Mycobacterium tuberculosis, enhancing the anti-bacterial immunity by degrading ISG15 and inhibiting the secretion of IFN-gamma.
Article
Multidisciplinary Sciences
Dale R. Balce, Ya-Ting Wang, Michael R. McAllaster, Bria F. Dunlap, Anthony Orvedahl, Barry L. Hykes, Lindsay Droit, Scott A. Handley, Craig B. Wilen, John G. Doench, Robert C. Orchard, Christina L. Stallings, Herbert W. Virgin
Summary: The study identified an important role of UFMylation in inhibiting responses to IFN-gamma and lipopolysaccharide, as deficiency in this system led to excessive activation of IFN-gamma and increased transcriptional responses. Additionally, UFMylation in myeloid cells is necessary for resistance to influenza infection in mice, indicating its modulation of in vivo infection responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agriculture, Dairy & Animal Science
Xin Li, Aihong Xia, Zhengzhong Xu, Jiaying Liu, Shasha Fu, Zhaoli Cao, Yechi Shen, Yuqing Xie, Chuang Meng, Xiang Chen, Xinan Jiao
Summary: This study aimed to develop an efficient assay for the diagnosis of bovine tuberculosis based on the ELISpot technique. The M. bovis IFN-eta ELISpot assay demonstrated a high level of agreement and had the ability to detect infected cattle earlier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Medicine, Research & Experimental
Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yuping Wang, Xiaoji Luo, Jinyong Luo
Summary: The study demonstrates that Cardamonin inhibits proliferation, migration, and invasion of osteosarcoma cells, inducing cell cycle arrest. It has minimal effects on normal cells and represses tumor growth in a xenograft mouse model. Mechanistically, Cardamonin activates the P38 and JNK MAPK signaling pathway to promote apoptosis in osteosarcoma cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Aditi Chatterjee
Summary: Tuberculosis is a common infectious disease and drug resistance is hindering treatment progress. The virulence factors of Mycobacterium tuberculosis, such as phosphatases (PTPs), play a crucial role in the survival of bacteria in the host. This review focuses on the current development of drugs targeting mPTPs.
Article
Chemistry, Analytical
Manjoosha R. Yerrapragada, Dileep Mampallil
Summary: This review focuses on sensing methods for interferon-gamma (IFN-gamma) using optical, electrochemical, and mechanical principles. The article explains the use of specific biorecognition molecules and surface functionalization methods in these sensing methods and suggests that the same strategies can be applied to sensing other analytes.
Article
Immunology
Ana Raquel Maceiras, Diogo Silverio, Rute Goncalves, Marcos S. Cardoso, Margarida Saraiva
Summary: During infection, bone marrow hematopoiesis is reprogrammed to produce myeloid cells, a mechanism called emergency myelopoiesis. However, studies using the mouse model of infection and laboratory reference strain M. tuberculosis H37Rv have shown limited emergency myelopoiesis and trained immunity. This study used a hypervirulent M. tuberculosis isolate HN878 to infect mice and found increased frequencies of LSK cells and the GMP population, as well as an increase in monocytes and neutrophils in the blood and lung. However, there was no trained immunity observed in the bone marrow.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hongxia Niu, Qianqian Cao, Tingting Zhang, Yunjie Du, Pu He, Lei Jiao, Bingxiang Wang, Bingdong Zhu, Lina Hu, Ying Zhang
Summary: A novel multi-antigen fusion protein vaccine was developed and combined with another vaccine, showing promising results in mice infected with tuberculosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Priyanka Talukdar, Beth F. Junecko, Daniel S. Lane, Pauline Maiello, Joshua T. Mattila
Summary: IFN-λ is expressed in granulomas and may influence myeloid cell function and immunity in tuberculosis. The expression of IFN-λ varies in different granuloma microenvironments, primarily expressed by macrophages and neutrophils, with differences in subcellular localization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Umi Zulaikha Mohd Azmi, Nor Azah Yusof, Jaafar Abdullah, Shahrul Ainliah Alang Ahmad, Fatin Nabilah Mohd Faudzi, Nurul Hanun Ahmad Raston, Siti Suraiya, Poh Shing Ong, Devandran Krishnan, Nur Khairunnisa Sahar
Summary: A portable, rapid, and simple sandwich-type immunosensor reader was developed to detect the presence of Mycobacterium tuberculosis in sputum samples. The sensor showed high sensitivity and specificity, providing a practical screening tool for tuberculosis detection.
Article
Chemistry, Analytical
Piaopiao Chen, Wu Peng, Runlian Qu, Yaqin He, Tangyuheng Liu, Jin Huang, Binwu Ying
Summary: Researchers developed an IFN-gamma aptasensor using pyrophosphate-cerium coordination polymeric nanoparticles as signal reporters and a double-stranded DNA as a probe for tuberculosis diagnosis. The sensor showed high detection sensitivity and target protein specificity and was validated in clinical samples, providing a new sensitive tool for early TB diagnosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Li Xu, Huan Ning, Ling Gu, Qinghong Wang, Wenbao Lu, Hui Peng, Weiguang Cui, Baoling Ying, Christina R. Ross, Gerald M. Wilson, Lin Wei, William S. M. Wold, Jianguo Liu
Article
Oncology
Wenbao Lu, Huan Ning, Ling Gu, Hui Peng, Qinghong Wang, Rong Hou, Mingui Fu, Daniel F. Hoft, Jianguo Liu
Article
Multidisciplinary Sciences
Hui Peng, Qixian Zhang, Xiaojuan Li, Zhen Liu, Jia Shen, Rui Sun, Jie Wei, Jia Zhao, Xiaoying Wu, Feng Feng, Shuping Zhong, Xi Sun, Zhongdao Wu
SCIENTIFIC REPORTS
(2016)
Article
Allergy
Hui Peng, Huan Ning, Qinghong Wang, Wenbao Lu, Yingzi Chang, Tony T. Wang, Jinping Lai, Pappachan E. Kolattukudy, Rong Hou, Daniel F. Hoft, Mark S. Dykewicz, Jianguo Liu
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft, Jianguo Liu
NATURE COMMUNICATIONS
(2017)
Article
Engineering, Biomedical
Cuifeng Wang, Xin Luo, Yuefang Zhao, Lina Han, Xin Zeng, Min Feng, Shirong Pan, Hui Peng, Chuanbin Wu
ACTA BIOMATERIALIA
(2012)
Article
Pharmacology & Pharmacy
Yuan Shen, Hui Peng, Jingjing Deng, Yuting Wen, Xin Luo, Shirong Pan, Chuanbin Wu, Min Feng
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2009)
Article
Immunology
Hui Peng, Rui Sun, Qixian Zhang, Jia Zhao, Jie Wei, Xin Zeng, Huanqin Zheng, Zhongdao Wu
JOURNAL OF INFECTIOUS DISEASES
(2013)
Article
Nanoscience & Nanotechnology
Yuan Shen, Hui Peng, Shirong Pan, Min Feng, Yuting Wen, Jingjing Deng, Xin Luo, Chuanbin Wu
Article
Parasitology
Hejun Zhou, Xi Sun, Zhiyue Lv, Yujuan Shen, Hui Peng, Lingling Yang, Huanquin Zheng, Ming Chiu Fung, Jianping Cao, Zhongdao Wu
PARASITOLOGY RESEARCH
(2012)
Article
Parasitology
Xi Sun, ZhiYue Lv, Hui Peng, MingQiu Fung, Linlin Yang, Jie Yang, Huanqin Zheng, JinYi Liang, ZhongDao Wu
PARASITOLOGY RESEARCH
(2012)
Article
Chemistry, Multidisciplinary
Ling Guo, Ye Zhang, Zeping Yang, Hui Peng, Runxiu Wei, Cuifeng Wang, Min Feng
Article
Biotechnology & Applied Microbiology
Litao Yang, Hui Peng, Zhaoling Zhu, Gang Li, Zitong Huang, Zhixin Zhao, Richard A. Koup, Robert T. Bailer, Changyou Wu
JOURNAL OF GENERAL VIROLOGY
(2007)
Article
Immunology
Li-Tao Yang, Hui Peng, Zhao-Ling Zhu, Gang Li, Zi-Tong Huang, Zhi-Xin Zhao, Richard A. Koup, Robert T. Bailer, Chang-You Wu
CLINICAL IMMUNOLOGY
(2006)