Article
Infectious Diseases
Maria Helena Rigatto, Fabiano Ramos, Andressa Barros, Silvia Pedroso, Isabelli Guasso, Luciana Goncalves, Pedro Bergo, Alexandre P. Zavascki
Summary: This study investigated the effects of double-, single-, and none-carbapenem-containing antimicrobial regimens on the treatment of patients with carbapenem-resistant Enterobacterales bloodstream infections. The results showed that single-carbapenem regimens were associated with a lower risk of mortality compared to regimens without carbapenem, while double-carbapenem regimens did not show any significant benefit.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Xiaoxue Liang, Ping Chen, Baoguo Deng, Feng-Hui Sun, Yongqiang Yang, Yanxian Yang, Ruowen He, Mingyang Qin, Yiping Wu, Fan Yang, Guo-Bao Tian, Min Dai
Summary: This study compared the antimicrobial resistance, virulence, clinical characteristics, and risk factors between carbapenem-resistant K. pneumoniae (CRKP) and carbapenem-susceptible K. pneumoniae (CSKP) isolates from patients with bloodstream infections (BSIs) in China. The results demonstrated that CRKP isolates were more drug-resistant, more virulent, and associated with poorer outcomes compared to CSKP isolates.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Xiaoyu Zhao, Shirong Li, Yixin Zhang, Jue Wang, Chuning Wang, Xiaohua Qin, Fupin Hu, Minggui Wang
Summary: This retrospective study evaluated the clinical efficacy of ceftazidime-avibactam (CZA) for the treatment of central nervous system (CNS) infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). The results showed that CZA-based combination therapy is an effective treatment option for CNS infections caused by CRKP.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Medicine, General & Internal
Wioletta Medrzycka-Dabrowska, Sandra Lange, Katarzyna Zorena, Sebastian Dabrowski, Dorota Ozga, Lucyna Tomaszek
Summary: The study highlights the importance of paying attention to carbapenem-resistant Klebsiella pneumoniae infections in patients with COVID-19. Rational antibiotic therapy should be used to prevent the increase of bacterial resistance, along with continuous monitoring and surveillance of hospital infections caused by multidrug-resistant organisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wei Yu, Yunbo Chen, Ping Shen, Jinru Ji, Chaoqun Ying, Zhiying Liu, Luying Xiong, Yunqing Qiu, Yonghong Xiao
Summary: This study investigated the activity and optimal treatments of CZA and AZA against bloodstream infections caused by carbapenem resistant Klebsiella pneumoniae. The results showed that both drugs had good therapeutic efficacy, especially when using two-step infusion therapy. The study also identified new sequence types, which helps to understand the spread and resistance mechanisms of the strains.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Dakang Hu, Wenjie Chen, Qi Zhang, Meng Li, Zehua Yang, Yong Wang, Yunkun Huang, Gang Li, Dongxing Tian, Pan Fu, Weiwen Wang, Ping Ren, Qing Mu, Lianhua Yu, Xiaofei Jiang
Summary: This study investigated the epidemiology of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) and hypervirulent carbapenem-resistant Klebsiella pneumoniae (Hv-CRKP) in mainland China. Molecular determination of CR-HvKP and Hv-CRKP showed biases compared to mouse lethality test, with the exact prevalence of CR-HvKP being less than 1.0% and that of Hv-CRKP even lower.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Courtney L. Luterbach, Liang Chen, Lauren Komarow, Belinda Ostrowsky, Keith S. Kaye, Blake Hanson, Cesar A. Arias, Samit Desai, Jason C. Gallagher, Elizabeth Novick, Stephen Pagkalinawan, Ebbing Lautenbach, Glenn Wortmann, Robert C. Kalayjian, Brandon Eilertson, John J. Farrell, Todd McCarty, Carol Hill, Vance G. Fowler, Barry N. Kreiswirth, Robert A. Bonomo, David van Duin
Summary: This study evaluated the clustering of carbapenem-resistant Klebsiella pneumoniae (CRKp) among patients in US hospitals and identified widespread intrasystem and intersystem transmission. Different methods for assessing genetic similarity resulted in only minor differences in interpretation.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Irina Magdalena Dumitru, Mirela Dumitrascu, Nicoleta Dorina Vlad, Roxana Carmen Cernat, Carmen Ilie-Serban, Aurelia Hangan, Raluca Elena Slujitoru, Aura Gherghina, Corina Mitroi-Maxim, Licdan Curtali, Dalia Sorina Carp, Anca Dumitrescu, Romelia Mitan, Rodica Lesanu, Sorin Rugina
Summary: Infections with carbapenem-resistant Enterobacteriaceae pose a significant challenge in healthcare settings, especially with CRKP being resistant to the majority of available antimicrobial agents and leading to high rates of morbidity and mortality. A recent report of patients in an ICU with COVID-19 who developed invasive infections due to CP-Kp strains highlights the importance of rigorous antibiotic administration programs in intensive care units, especially for high-risk populations like the elderly.
Article
Microbiology
Feiyang Zhang, Qin Li, Jiawei Bai, Manlin Ding, Xiangjin Yan, Guangxi Wang, Baoli Zhu, Yingshun Zhou
Summary: This study revealed that 8.39% of Klebsiella pneumoniae strains were amikacin-heteroresistant, with potential association with increased expression of aminoglycoside resistance genes. The majority of heteroresistant phenotypes were unstable, with partial or full reversion of minimal inhibitory concentrations to the level of susceptibility.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Xinqian Ma, Shining Fu, Yifan Wang, Lili Zhao, Wenyi Yu, Yukun He, Wentao Ni, Zhancheng Gao
Summary: This study used proteomics analysis to investigate the impact and mechanism of tigecycline and aminoglycoside combination therapy on carbapenem-resistant Klebsiella pneumoniae (CRKP). The study found that the proteomic responses to tigecycline and aminoglycosides were different in monotherapy, with tigecycline dominating the proteomic alterations in combination therapy. Adaptive responses to tigecycline were associated with the upregulation of oxidative phosphorylation and translation-related proteins, while tigecycline might perturb adaptive responses to aminoglycosides through inhibition of heat shock response.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Fanbo Lu, Luwen Zhang, Juanjuan Ji, Yuanhong Xu, Bo Wang, Jinxing Xia
Summary: This study aimed to investigate the epidemiological and antimicrobial resistant patterns, clinical characteristics and risk factors of critically ill patients infected with carbapenem-resistant Klebsiella pneumoniae (CRKP) from intensive care units (ICUs). The study found that CRKP strains exhibited significantly strong resistance against major antimicrobial agents, and the risk of CRKP infection was associated with recent exposure to certain antibiotics and prior treatment with invasive interventions.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Kosuke Kamio, J. Luis Espinoza
Summary: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) poses a significant global public health concern due to their potential for widespread dissemination, limited treatment options, and high mortality rates. Active surveillance, early diagnosis, and contact isolation are important strategies for controlling and preventing the occurrence and spread of CRE bacteria. This study provides an overview of the epidemiology of CRE infections in Japan from 2015 to 2019, highlighting the stable but increasing number of reported cases. The majority of CRE infections were observed in patients over the age of 65, with men representing 60% of the cases and a mortality rate of approximately 3.5%. Notably, Enterobacter cloacae and Klebsiella aerogenes were the most common pathogens responsible for CRE infections, with Klebsiella aerogenes becoming the leading pathogen since 2017. The IMP carbapenemase type was the most commonly isolated carbapenemase. Further research is needed to determine the prevalence and mechanisms behind the local predominance of Klebsiella aerogenes and Enterobacter cloacae, particularly in healthcare settings.
Review
Microbiology
Gabriel Mendes, Maria Leonor Santos, Joao F. Ramalho, Aida Duarte, Catia Caneiras
Summary: Hypervirulent and carbapenem-resistant pathotypes of Klebsiella pneumoniae have emerged as distinct evolutionary types with significant impact on public health. However, there is concern over the convergence of high-risk clones that pose a challenge to available therapeutic options. This review aims to describe the worldwide distribution of virulence factors among carbapenem-resistant highly virulent or hypervirulent K. pneumoniae strains and their interactions with carbapenemase production and sequence types. Urgent understanding of these strains is necessary for effective response as they increasingly replace classical strains in healthcare settings.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Athira Pattolath, Prabha Adhikari, Vidya Pai
Summary: The purpose of this study was to detect the presence of Carbapenemase-producing genes in Klebsiella pneumoniae, identify the risk factors for acquiring them, and understand their impact on clinical outcomes. The study found a high prevalence of Carbapenem-resistant K. pneumoniae (CRKP), with surgery and parenteral nutrition significantly associated with the infection. Patients with CRKP had a higher risk of mortality and poor clinical outcomes.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Xuemei Yang, Qiaoling Sun, Jiaping Li, Yu Jiang, Yi Li, Jianping Lin, Kaichao Chen, Edward Wai-Chi Chan, Rong Zhang, Sheng Chen
Summary: The epidemiological features and potential threat to human health of the newly emerged carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) are currently unknown. This study analyzed 784 CRKP strains collected from three hospitals in China and found that the proportion of CRKP strains among clinical K. pneumoniae strains increased sharply. A significant number of these CRKP strains carried a virulence-encoding plasmid, but only a small percentage exhibited a hypervirulent phenotype. Genetic markers were not strongly correlated with hypervirulent phenotypes, indicating that additional factors may contribute to the hypervirulence of CRKP. The transmission of these CRKP strains in China likely involved multiple clones of ST11 and the major mechanism of carbapenem resistance was the carriage of IncFII pSWU01-like, bla (KPC-2)-bearing plasmids. These findings highlight the rapid increase in prevalence of CRKP strains carrying virulence plasmids in China and the need for better definition and screening of truly hypervirulent CR-HvKP strains in clinical settings.
EMERGING MICROBES & INFECTIONS
(2022)
