The N-terminal Domain of NPC1L1 Protein Binds Cholesterol and Plays Essential Roles in Cholesterol Uptake

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

(2011) Jing-Jie Tang et al.   Cell Metabolism

The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation

(2011) Hyock Joo Kwon et al.   PLoS One

Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes

(2010) Michael L. Wang et al.   Cell Metabolism

Molecular Characterization of the NPC1L1 Variants Identified from Cholesterol Low Absorbers

(2010) Li-Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake

(2010) L. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Mj1640/DUF358 Protein Reveals a Putative SPOUT-Class RNA Methyltransferase

(2010) H.-Y. Chen et al.   Journal of Molecular Cell Biology

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Requirement of Myosin Vb·Rab11a·Rab11-FIP2 Complex in Cholesterol-regulated Translocation of NPC1L1 to the Cell Surface

(2009) Bei-Bei Chu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane topology of human NPC1L1, a key protein in enterohepatic cholesterol absorption

(2009) Jiang Wang et al.   JOURNAL OF LIPID RESEARCH

The Cholesterol Absorption Inhibitor Ezetimibe Acts by Blocking the Sterol-Induced Internalization of NPC1L1

(2008) Liang Ge et al.   Cell Metabolism

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

(2008) A. B. Weinglass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA