期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 52, 页码 44457-44466出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M111.255364
关键词
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资金
- Spanish Ministry of Science and Innovation (MICINN) [BIO2007-60066, SAF2010 15512]
- European Regional Development Fund
- MICINN [CSD2008-00005C]
- National Autonomous University of Mexico
- Consejo Superior de Investigaciones Cientificas, Spain (UNAM-CSIC)
- CSIC
The caspase recruitment domain (CARD) is present in a large number of proteins. Initially, the CARD was recognized as part of the caspase activation machinery. CARD-CARD interactions play a role in apoptosis and are responsible for the Apaf-1-mediated activation of procaspase-9 in the apoptosome. CARD-containing proteins mediate the inflammasome-dependent activation of proinflammatory caspase-1. More recently, new roles for CARD-containing proteins have been reported in signaling pathways associated with immune responses. The functional role of CARD-containing proteins and CARDs in coordinating apoptosis and inflammatory and immune responses is not completely understood. We have explored the putative cross-talk between apoptosis and inflammation by analyzing the modulatory activity on both the Apaf-1/procaspase-9 interaction and the inflammasome-mediated procaspase-1 activation of CARD-derived polypeptides. To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display.
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