期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 286, 期 41, 页码 35922-35932出版社
ELSEVIER
DOI: 10.1074/jbc.M111.261172
关键词
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资金
- Canadian Institutes of Health Research
- Howard Hughes Medical Institute
- Michael Smith Foundation for Health Research
- Canada Foundation for Innovation
- B.C. Knowledge Development Fund
- Kwanjeong Educational Foundation (Republic of Korea)
- University of British Columbia
Background: The transfer of sialic acids is catalyzed by a set of sialyltransferases with defined specificities. Results: We solved the ternary complex of the sialyltransferase Cst-II and kinetically characterized its mechanism. Conclusion: Our analysis gives insights into the acceptor specificity and proposes the iso-ordered Bi Bi mechanism. Significance: This work improves our understanding of sialyltransferase structure/function.
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