Article
Biochemistry & Molecular Biology
Chunqun Wang, Wenjie Gao, Shi Yan, Xing-Quan Zhu, Xun Suo, Xin Liu, Nishith Gupta, Min Hu
Summary: N-glycosylation is a physiologically vital post-translational modification in eukaryotic organisms, and Haemonchus contortus has exclusive chitobiose modifications in its N-glycans. Immunogenic proteins like peptidases are N-glycosylated in the parasite, with glycan-rich conjugates primarily located in the intestine and gonads of adult worms, evading host immune responses. This comprehensive atlas of N-glycosylation in the prevalent parasitic nematode highlights its importance for infection, immunity, and prevention.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Immunology
Caixian Zhou, Yao Zhang, Simin Wu, Zhiheng Wang, Waresi Tuersong, Chunqun Wang, Feng Liu, Min Hu
Summary: CircRNAs are a novel class of non-coding RNA family involved in various biological processes in plants and animals, but little is known about their presence in parasitic helminths. In this study, a comprehensive exploration of circRNAs in the blood-sucking parasitic nematode H. contortus revealed that a majority were derived from exonic regions of protein-coding genes, with a higher expression in third-stage larvae compared to adult stages. Differential expression analysis showed circRNAs were significantly enriched in biological processes like signaling and metabolism, and could potentially regulate gene expression at the post-transcriptional level. The study lays a foundation for understanding circRNA regulatory mechanisms in H. contortus and other parasitic nematodes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nikola Palevich, Paul H. Maclean, Vincenzo Carbone, Ruy Jauregui, Saleh Umair
Summary: The emergence of drug-resistant parasitic nematodes in both humans and livestock necessitates the development of alternative and cost-effective control strategies. Barbervax((R)) is the only registered vaccine for the economically important ruminant strongylid Haemonchus contortus. In this study, the microbiome, genome-wide diversity, and transcriptome of H. contortus adult male populations that survived vaccination were compared to identify potential vaccine evasion genes.
Review
Parasitology
Tapoka T. Mkandawire, Richard K. Grencis, Matthew Berriman, Maria A. Duque-Correa
Summary: Although the process of hatching from eggs in nematodes is of fundamental importance, our understanding of this process is limited. In particular, progress in studying animal-parasitic nematodes has been slow since the 1980s. Enhancing our understanding of this crucial life-cycle process would greatly benefit parasitic nematode research, treatment, and control. This review examines the role of eggs in the nematode life cycle, current knowledge of the hatching cascade, and specific areas that remain unknown. Strategies to address these knowledge gaps and their potential impact in nematode parasite research, treatment, and control are discussed.
TRENDS IN PARASITOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Z. J. Quintero-Elena, L. Aguilar-Marcelino, G. S. Castaneda-Ramirez, O. Gomez-Rodriguez, E. Villar-Luna, G. Lopez-Guillen, S. G. Ramirez-Rojas
Summary: The study evaluated the in vitro and micro-plot predatory activity of the mite Caloglyphus mycophagus against Haemonchus contortus (L3) and Nacobbus aberrans (J2). Results showed that the mite had in vitro predation activity against both nematodes, with significant reduction percentages. Additionally, mortality of mites in micro-plots containing ivermectin was 100%.
BIOLOGICAL CONTROL
(2022)
Article
Biotechnology & Applied Microbiology
Ricardo Jose Comans-Perez, Jose E. Sanchez, Laith Khalil Tawfeeq Al-Ani, Manases Gonzalez-Cortazar, Gloria Sarahi Castaneda-Ramirez, Pedro Mendoza-de Gives, Alma Delia Sanchez-Garcia, Jair Millan-Orozco, Liliana Aguilar-Marcelino
Summary: This study evaluated the morphology of ten strains of edible mushrooms and their anthelmintic activity against Haemonchus contortus larvae in vitro. The results showed that some fungi exhibited high toxicity against nematodes, making them potential candidates for future in vivo tests.
BIOLOGICAL CONTROL
(2021)
Article
Immunology
Zhaohai Wen, Yue Zhang, Jiajun Feng, Kalibixiati Aimulajiang, Muhammad Tahir Aleem, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
Summary: This study found that HcESPs inhibit the adaptive immune response of goats through various mechanisms, helping H. contortus evade immunity. Furthermore, HcESPs reverse the LPS-induced immune inflammatory response. The findings contribute to a better understanding of the evasion mechanisms of H. contortus and provide a new approach for preventing infection by this parasite.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junhao Zhuge, Xiang Zhou, Lifeng Zhou, Jiafu Hu, Kai Guo
Summary: This study developed the Plant Parasitic Nematodes Database (PPND), a platform that provides genomic, transcriptomic, protein, and functional annotation data for plant parasitic nematode research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Hui Liu, Zhuolin Tao, Yifan Wang, Xin Liu, Chunqun Wang, Lu Liu, Min Hu
Summary: This study investigates the role of a CAP protein member, Hc-CAP-15, in regulating the developmental process of the parasitic nematode Haemonchus contortus. Hc-CAP-15 is found to be localized in the cuticle, intestine, and oocyte of adult worms and shows the highest transcription level in the parasitic fourth-stage larvae (L4s). Silencing Hc-CAP-15 gene results in a significant increase in the body length of L4s.
PARASITES & VECTORS
(2023)
Article
Multidisciplinary Sciences
Jeba R. J. Jesudoss Chelladurai, Katy A. Martin, Pam Vardaxis, Craig Reinemeyer, Paramasivan Vijayapalani, Alan P. Robertson, Matthew T. Brewer
Summary: In this study, the researchers investigated the role of permeability glycoproteins (P-gps) in Toxocara canis drug tolerance. They found that T. canis has 13 annotated P-gp genes, with at least 10 expressed in adults and hatched larvae, and at least 8 expressed in somatic larvae. However, treatment with macrocyclic lactones did not significantly increase P-gp expression. Further studies are needed to understand the contribution of P-gps to macrocyclic lactone tolerance in T. canis.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Anabel Ortiz Caltempa, Marisela Hernandez, Ana Lilia Perez, Liliana Aguilar, Cynthia Guzman, Dolores Adriana Ayon-Nunez, Gladis Fragoso, Raul J. Bobes, Maria Eugenia Lopez, Edda Sciutto, Maria Luisa Villareal
Summary: Parasitic diseases have a significant impact on human and animal health globally. The excessive use of anti-parasitic drugs has led to the emergence of drug resistance, necessitating the development of environmentally friendly treatments. This study genetically modified Carica papaya to develop an oral anti-cysticercosis vaccine. Additionally, suspension cultures of transformed and untransformed C. papaya were produced and optimized to explore their potential as natural antiparasitic products.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Entomology
Hai Yan Wu, Juliana de Oliveira Silva, Jennifer Smith Becker, J. Ole Becker
Summary: Plant-parasitic nematodes are significant pests for many crops worldwide. Fluazaindolizine, a fluorinated nematicide, shows strong toxic activity against certain nematode species with low mammalian toxicity. The compound impacts nematode parasitism at non-lethal concentrations and short-term exposure.
JOURNAL OF PEST SCIENCE
(2021)
Article
Parasitology
Camille Beaumelle, Elizabeth M. Redman, Jill de Rijke, Janneke Wit, Slimania Benabed, Francois Debias, Jeanne Duhayer, Sylvia Pardonnet, Marie-Therese Poirel, Gilles Capron, Stephane Chabot, Benjamin Rey, Glenn Yannic, John S. Gilleard, Gilles Bourgoin
Summary: The study found that gastrointestinal nematode communities in roe deer vary in different hosts, regions, and circumstances, with some livestock parasite species unexpectedly present. Young roe deer host the highest diversity of gastrointestinal nematodes, with age having a more pronounced effect in Trois Fontaines.
PARASITES & VECTORS
(2021)
Article
Immunology
Kavita Rawat, Aruna Pal, Samiddha Banerjee, Abantika Pal, Subhas Chandra Mandal, Subhasis Batabyal
Summary: CD14 plays a crucial role in parasitic immunology in sheep, with genetic variations affecting susceptibility to Haemonchus contortus infections. Evolutionary analysis suggests sheep have closer genetic relationship with humans, potentially making them suitable model organisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hengzhi Shi, Xiaocui Huang, Xueqiu Chen, Yi Yang, Fei Wu, Chaoqun Yao, Guangxu Ma, Aifang Du
Summary: A secretory transthyretin-like protein, Hc-ttr-31, in H. contortus shows high transcription levels in the egg and early larval stages, with potential roles in regulating post-embryonic larval development and protecting gonads from oxidative stress. Knockdown of Hc-ttr-31 in C. elegans leads to shortened lifespan, decreased brood size, slowed pumping rate, and activation of apoptosis signalling pathway, indicating its importance in nematode development and reproduction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nasir H. Bhanpuri, Sarah J. Hallberg, Paul T. Williams, Amy L. McKenzie, Kevin D. Ballard, Wayne W. Campbell, James P. McCarter, Stephen D. Phinney, Jeff S. Volek
CARDIOVASCULAR DIABETOLOGY
(2018)
Correction
Endocrinology & Metabolism
Sarah J. Hallberg, Amy L. McKenzie, Paul T. Williams, Nasir H. Bhanpuri, Anne L. Peters, Wayne W. Campbell, Tamara L. Hazbun, Brittanie M. Volk, James P. McCarter, Stephen D. Phinney, Jeff S. Volek
Article
Endocrinology & Metabolism
Sarah J. Hallberg, Amy L. McKenzie, Paul T. Williams, Nasir H. Bhanpuri, Anne L. Peters, Wayne W. Campbell, Tamara L. Hazbun, Brittanie M. Volk, James P. McCarter, Stephen D. Phinney, Jeff S. Volek
Article
Multidisciplinary Sciences
Rachel Fellows, Christopher M. Russo, Catarina S. Silva, Soon Goo Lee, Joseph M. Jez, John D. Chisholm, Chloe Zubieta, Max H. Nanao
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Ashley M. Sherp, Soon Goo Lee, Evelyn Schraft, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Clinical Neurology
Morgan J. Siegmann, Shaminie J. Athinarayanan, Sarah J. Hallberg, Amy L. McKenzie, Nasir H. Bhanpuri, Wayne W. Campbell, James P. McCarter, Stephen D. Phinney, Jeff S. Volek, Christa J. Van Dort
Article
Medicine, General & Internal
Eduardo Vilar-Gomez, Shaminie J. Athinarayanan, Rebecca N. Adams, Sarah J. Hallberg, Nasir H. Bhanpuri, Amy L. McKenzie, Wayne W. Campbell, James P. McCarter, Stephen D. Phinney, Jeff S. Volek, Naga Chalasani
Article
Biochemistry & Molecular Biology
Roshan Kumar, Soon Goo Lee, Rehna Augustine, Micheal Reichelt, Daniel G. Vassao, Manoj H. Palavalli, Aron Allen, Jonathan Gershenzon, Joseph M. Jez, Naveen C. Bisht
Article
Multidisciplinary Sciences
Soon Goo Lee, Eitan Salomon, Oliver Yu, Joseph M. Jez
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Endocrinology & Metabolism
Shaminie J. Athinarayanan, Rebecca N. Adams, Sarah J. Hallberg, Amy L. McKenzie, Nasir H. Bhanpuri, Wayne W. Campbell, Jeff S. Volek, Stephen D. Phinney, James P. McCarter
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Michelle S. Chung, Antea J. DeMarsilis, Cynthia K. Holland, Rohit Jaswaney, Cherry Jiang, Jakob H. P. Kroboth, Kevin Kulshrestha, Raymundo Z. W. Marcelo, Vidhya M. Meyyappa, Grant B. Nelson, Janki K. Patel, Alex J. Petronio, Samantha K. Powers, Peter R. Qin, Mythili Ramachandran, Divya Rayapati, John A. Rincon, Andreia Rocha, Joan Gabriel Rodinho Nunes Ferreira, Micah K. Steinbrecher, Kaisen Yao, Eric J. Zhang, Angela J. Zou, Margery Gang, Melanie Sparks, Barrie Cascella, Wilhelm Cruz, Joseph M. Jez
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Soon Goo Lee, Kate Harline, Orchid Abar, Sakirat O. Akadri, Alexander G. Bastian, Hui-Yuan S. Chen, Michael Duan, Caroline M. Focht, Amanda R. Groziak, Jesse Kao, Jagdeesh S. Kottapalli, Matthew C. Leong, Joy J. Lin, Regina Liu, Joanna E. Luo, Christine M. Meyer, Albert F. Mo, Seong Ho Pahng, Vinay Penna, Chris D. Raciti, Abhinav Srinath, Shwetha Sudhakar, Joseph D. Tang, Brian R. Cox, Cynthia K. Holland, Barrie Cascella, Wilhelm Cruz, Sheri A. McClerkin, Barbara N. Kunkel, Joseph M. Jez
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Microbiology
Rachel L. Edwards, Isabel Heueck, Soon Goo Lee, Ishaan T. Shah, Justin J. Miller, Andrew J. Jezewski, Marwa O. Mikati, Xu Wang, Robert C. Brothers, Kenneth M. Heidel, Damon M. Osbourn, Carey-Ann D. Burnham, Sophie Alvarez, Stephanie A. Fritz, Cynthia S. Dowd, Joseph M. Jez, Audrey R. Odom John
Article
Biochemistry & Molecular Biology
Kaleena Zhang, Josephine S. Lee, Regina Liu, Zita T. Chan, Trenton J. Dawson, Elisa S. De Togni, Chris T. Edwards, Isabel K. Eng, Ashley R. Gao, Luis A. Goicouria, Erin M. Hall, Kelly A. Hu, Katherine Huang, Alexander Kizhner, Kelsie C. Kodama, Andrew Z. Lin, Jennifer Y. Liu, Alan Y. Lu, Owen W. Peng, Erica P. Ryu, Sophia Shi, Maria L. Sorkin, Patricia L. Walker, Grace J. Wang, Mark C. Xu, Rebecca S. Yang, Barrie Cascella, Wilhelm Cruz, Cynthia K. Holland, Sheri A. McClerkin, Barbara N. Kunkel, Soon Goo Lee, Joseph M. Jez
BIOSCIENCE REPORTS
(2020)
Article
Nutrition & Dietetics
Amy L. McKenzie, Shaminie J. Athinarayanan, Jackson J. McCue, Rebecca N. Adams, Monica Keyes, James P. McCarter, Jeff S. Volek, Stephen D. Phinney, Sarah J. Hallberg
Summary: This study aimed to assess an alternative approach to type 2 diabetes prevention through a two-year carbohydrate restricted nutrition therapy intervention for 96 prediabetes patients. Results showed the potential utility of this alternate approach in normalizing blood sugar and improving related comorbidities.