Histone Deacetylase Inhibitor Valproic Acid Inhibits Cancer Cell Proliferation via Down-regulation of the Alzheimer Amyloid Precursor Protein

High sensitivity to carcinogens in the brain of a mouse model of Alzheimer's disease

(2010) J Serrano et al.   ONCOGENE

HDAC inhibitors: Magic bullets, dirty drugs or just another targeted therapy

(2009) Olaf Witt et al.   CANCER LETTERS

Neuroprotective Secreted Amyloid Precursor Protein Acts by Disrupting Amyloid Precursor Protein Dimers

(2009) Matthias Gralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Terminal Differentiation in Melanoma Cells on Downregulation of β-Amyloid Precursor Protein

(2009) Michelle G. Botelho et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Transcriptional induction of GRP78/BiP by histone deacetylase inhibitors and resistance to histone deacetylase inhibitor-induced apoptosis

(2009) P. Baumeister et al.   MOLECULAR CANCER THERAPEUTICS

Cancer linked to Alzheimer disease but not vascular dementia

(2009) C. M. Roe et al.   NEUROLOGY

Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice

(2008) Ditte Zerlang Christensen et al.   ACTA NEUROPATHOLOGICA

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors

(2008) Nagma Khan et al.   BIOCHEMICAL JOURNAL

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

(2008) K.-i. Takayama et al.   CANCER RESEARCH

Valproic acid as epigenetic cancer drug: Preclinical, clinical and transcriptional effects on solid tumors

(2008) Alfonso Duenas-Gonzalez et al.   CANCER TREATMENT REVIEWS

A Closer Look at α-Secretase

(2008) Rolf Postina   Current Alzheimer Research

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

(2008) Hong Qing et al.   JOURNAL OF EXPERIMENTAL MEDICINE