Article
Health Care Sciences & Services
Hee Young Cho, Han Sung Park, Eun Hee Ahn, Eun Ju Ko, Hyeon Woo Park, Young Ran Kim, Ji Hyang Kim, Woo Sik Lee, Nam Keun Kim
Summary: The study revealed that PAI-1 rs1050955 and REN 10795 rs5707 alleles may decrease the risk of RPL, while the tPA rs4646972 genotype may increase the risk of RPL.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Yukiko Asano, Takayuki Iwaki, Kazuo Umemura, Naohiro Kanayama, Hiroaki Itoh
Summary: The study showed that fibrin had no effect on mouse blastocysts, but significantly suppressed trophoblast growth in human blastocysts. However, trophoblasts in human blastocysts then switched to growth promotion through increased fibrinolysis with urokinase-type plasminogen activator (uPA) activity.
HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Rawan Altalhi, Nikoletta Pechlivani, Ramzi A. Ajjan
Summary: Hypofibrinolysis is a key abnormality in diabetes, with elevated levels of PAI-1 playing a significant role. Strategies to inhibit PAI-1 function may lead to new antithrombotic agents that reduce vascular complications in diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kiyotaka Okada, Naoyuki Kawao, Daisho Nakai, Rei Wakabayashi, Yoshitaka Horiuchi, Katsumi Okumoto, Shinji Kurashimo, Yoshimasa Takafuji, Osamu Matsuo, Hiroshi Kaji
Summary: This study demonstrated that glucocorticoids decrease the number of macrophages at the injured site during early bone repair after femoral bone injury partly through PAI-1 and M-CSF in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Yun-Jong Park, David Acosta, Russell Vassell, Juanjie Tang, Surender Khurana, Carol D. Weiss, Hana Golding, Marina Zaitseva
Summary: This study investigates the pathological mechanisms of severe COVID-19 and reveals that D-dimer and immune complexes have a synergistic effect in amplifying the inflammatory response of monocytes. This finding provides valuable insights for the treatment and prognosis of severe COVID-19.
Article
Medicine, General & Internal
Esra'a Abudouleh, Fatimah Alhamlan, Arwa A. Al-Qahtani, Marie Fe Bohol, Amal Al Hazzani, Khadija Khorfan, Morad Alkaff, Tarek Owaidah, Ahmed A. Al-Qahtani
Summary: This study investigated coagulation and fibrinolysis parameters in COVID-19 patients and their association with disease severity. The results showed significantly elevated levels of thrombin activatable fibrinolysis inhibitor, fibrinogen, and tissue plasminogen activator in severe patients. Additionally, patients in the ICU had significantly higher levels of plasminogen activator inhibitor-1, tissue plasminogen activator, and thrombin activatable fibrinolysis inhibitor. These coagulation markers can serve as suitable prognostic indicators for hypofibrinolysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maria D. Valls, Maria Soldado, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Montesinos
Summary: Activation of adenosine A(2A) receptor can promote angiogenesis by increasing the expression of annexin A2 in human dermal microvascular endothelial cells, which enhances fibrinolysis and contributes to wound healing and tissue revascularization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Florence Boissiere-Michot, Caroline Mollevi, Volker Baecker, Evelyne Crapez, William Jacot
Summary: Urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) have been identified as prognostic and predictive biomarkers in breast cancer, but their clinical use is limited due to the need for fresh-frozen or fresh tumor samples for quantification. This study compared the expression levels of PLAU and SERPINE1 mRNA (corresponding to uPA and PAI-1 proteins) using in situ hybridization with immunometric assay in breast tumor samples. The results showed that in situ hybridization cannot replace the immunometric assay for quantification of uPA and PAI-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Kirstin Meiners, Prisca Hamm, Marcus Gutmann, Jan Niedens, Agnieszka Nowak-Krol, Salvador Pane, Tessa Luehmann
Summary: The study developed three polyethylene glycol (PEG)ylated tPA bioconjugates based on the recombinant human tPA drug Alteplase using site-specific conjugation strategies. These bioconjugates showed improved proteolytic activity, slower inhibition kinetics by PAI-1, and increased hydrodynamic size.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Oncology
Bofang Wang, Baohong Gu, Tao Zhang, Xuemei Li, Na Wang, Chenhui Ma, Lin Xiang, Yunpeng Wang, Lei Gao, Yang Yu, Kewei Song, Puyi He, Yueyan Wang, Jingyu Zhu, Hao Chen
Summary: The fibrinolytic system is involved in various physiological functions and plays a significant role in the pathogenesis of many diseases. Plasminogen activator inhibitor 1 (PAI-1) is a crucial element of this system and acts as an anti-fibrinolytic agent in the normal blood clotting process. PAI-1 is involved in blood diseases, inflammation, obesity, metabolic syndrome, and tumor pathology, exhibiting a paradoxical role in different digestive system tumors.
Article
Dermatology
Yu-Ju Tseng, Chih-Hung Lee, Wei-Yu Chen, Jenq-Lin Yang, Hong-Tai Tzeng
Summary: The study demonstrates that PAI-1 activity regulates immune checkpoints by promoting lysosomal degradation of PD-L1. Inhibition of PAI-1 combined with anti-PD-L1 immunotherapy shows promise as a therapeutic regimen for melanoma treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kaito Harada, Takashi Yahata, Makoto Onizuka, Abd Aziz Ibrahim, Eri Kikkawa, Toshio Miyata, Kiyoshi Ando
Summary: The study highlights the inhibitory role of plasminogen activator inhibitor type-1 (PAI-1) in hematopoietic regeneration in bone marrow microenvironments with abundant bone marrow adipocytes (BMAs), suggesting that blocking PAI-1 activity could be a novel therapeutic approach. PAI-1 inhibitor treatment significantly increases stem cell factor concentration in obese patients, contributing to improved hematopoietic regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Victor M. Schuettfort, Benjamin Pradere, David D'Andrea, Nico C. Grossmann, Fahad Quhal, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Michael Rink, Pierre I. Karakiewicz, Reza Sari Motlagh, Satoshi Katayama, Yair Lotan, Douglas Scherr, Mohammad Abufaraj, Harun Fajkovica, Eva Comperat, Dmitry Enikeev, Shahrokh F. Shariat
Summary: Elevated preoperative plasma levels of uPA, SuPAR, and PAI-one were confirmed to be associated with aggressive disease features and worse survival outcomes in patients treated with RC for UCB. These biomarkers have the potential to identify patients who may benefit from intensified/multimodal therapy and improve the discriminatory power of predictive/prognostic models.
JOURNAL OF UROLOGY
(2021)
Article
Hematology
Tae Ito, Yuko Suzuki, Hideto Sano, Naoki Honkura, Francis J. Castellino, Tetsumei Urano
Summary: The study demonstrates the existence of three distinct forms of high-molecular-weight complexes between tPA and PAI-1. Peptide sequence analysis revealed that these complexes consist of nonacylated-enzyme inhibitor complexes, with only a fraction of the population releasing free tPA under physiological conditions.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Clinical Neurology
Sebastian A. Lewandowski, Ingrid Nilsson, Linda Fredriksson, Peter Lonnerberg, Lars Muhl, Manuel Zeitelhofer, Milena Z. Adzemovic, Susanne Nichterwitz, Daniel A. Lawrence, Eva Hedlund, Ulf Eriksson
ACTA NEUROPATHOLOGICA
(2016)
Article
Medicine, General & Internal
N. Wahlgren, M. Thoren, B. Hojeberg, T. -B. Kall, A. -C. Laska, C. Sjostrand, J. Hoijer, H. Almqvist, S. Holmin, A. Lilja, L. Fredriksson, D. Lawrence, U. Eriksson, N. Ahmed
JOURNAL OF INTERNAL MEDICINE
(2017)
Article
Hematology
Linda Fredriksson, Daniel A. Lawrence, Robert L. Medcalf
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2017)
Article
Physiology
Kevin P. Bohannon, Mary A. Bittner, Daniel A. Lawrence, Daniel Axelrod, Ronald W. Holz
JOURNAL OF GENERAL PHYSIOLOGY
(2017)
Article
Pathology
Asmita Pant, Anna K. Kopec, Kevin S. Baker, Holly Cline-Fedewa, Daniel A. Lawrence, James P. Luyendyk
AMERICAN JOURNAL OF PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Jintao Wang, Enming Su, Hui Wang, Chiao Guo, Daniel A. Lawrence, Daniel T. Eitzman
SCIENTIFIC REPORTS
(2018)
Article
Immunology
Virginie Bondu, Casey Bitting, Valerie L. Poland, Joshua A. Hanson, Michelle S. Harkins, Sarah Lathrop, Kurt B. Nolte, Daniel A. Lawrence, Tione Buranda
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ashley A. Reinke, Shih-Hon Li, Mark Warnock, Maxim E. Shaydakov, Naga Sandhya Guntaka, Enming J. Su, Jose A. Diaz, Cory D. Emal, Daniel A. Lawrence
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Microbiology
Ursula Waack, Mark Warnock, Andrew Yee, Zachary Huttinger, Sara Smith, Ayush Kumar, Alban Deroux, David Ginsburg, Harry L. T. Mobley, Daniel A. Lawrence, Maria Sandkvist
Article
Cell Biology
Gerard E. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, Jacqueline Perrigoue, Aleksandar Stojmirovic, Katherine Li, Brian D. Muegge, Umang Jain, Kelli L. VanDussen, Bridie J. Goggins, Simon Keely, Jessica Weaver, Paul S. Foster, Daniel A. Lawrence, Ta-Chiang Liu, Thaddeus S. Stappenbeck
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Hematology
Adam Miszta, Anna K. Kopec, Asmita Pant, Lori A. Holle, James R. Byrnes, Daniel A. Lawrence, Kirk C. Hansen, Matthew J. Flick, James P. Luyendyk, Bas de laat, Alisa S. Wolberg
Article
Biochemistry & Molecular Biology
Mary Migliorini, Shih-Hon Li, Anqi Zhou, Cory D. Emal, Daniel A. Lawrence, Dudley K. Strickland
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Hematology
Hekmat B. Khoukaz, Yan Ji, Drew J. Braet, Manisha Vadali, Ahmed A. Abdelhamid, Cory D. Emal, Daniel A. Lawrence, William P. Fay
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Neurosciences
Tamara K. Stevenson, Daniel A. Lawrence
Article
Clinical Neurology
Enming Joseph Su, Chunzhang Cao, Linda Fredriksson, Ingrid Nilsson, Christina Stefanitsch, Tamara K. Stevenson, Juanjuan Zhao, Margret Ragsdale, Yu-Yo Sun, Manuel Yepes, Chia-Yi Kuan, Ulf Eriksson, Dudley K. Strickland, Daniel A. Lawrence, Li Zhang
ACTA NEUROPATHOLOGICA
(2017)