期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 285, 期 26, 页码 19921-19926出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.127480
关键词
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资金
- DFG (Deutsche Forschungsgemeinschaft) [SCHR512/11-1]
- Clusters of Excellence Inflammation at Interfaces and The Future Ocean
- German Federal Ministry of Education and Research BMBF through the NGFN plus Network on Environment-related diseases
Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.
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