Article
Immunology
Sergio M. Borghi, Victor Fattori, Thacyana T. Carvalho, Vera L. H. Tatakihara, Tiago H. Zaninelli, Felipe A. Pinho-Ribeiro, Camila R. Ferraz, Larissa Staurengo-Ferrari, Rubia Casagrande, Wander R. Pavanelli, Fernando Q. Cunha, Thiago M. Cunha, Phileno Pinge-Filho, Waldiceu A. Verri
Summary: The study reveals the contribution of spinal cord and ganglia cellular and molecular events to pain in T. cruzi infection, providing a better understanding of CD pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shengwei Li, Zhibing Li, Ran Yin, Jungang Nie, Yongnan Fu, Ru Ying
Summary: The study showed that DUOX1-induced ROS production and pyroptosis play a crucial role in the development of cardiac fibrosis, with high levels of ROS and pyroptosis being associated with cardiac fibrosis. Interventions targeting DUOX1 can effectively inhibit the development of fibrosis in cardiomyocytes.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel Pardo-Rodriguez, Paola Lasso, Jose Mateus, John Mendez, Concepcion J. Puerta, Adriana Cuellar, Jorge Robles, Claudia Cuervo
Summary: This study evaluated the trypanocidal effect and cytokine production induction of extracts obtained from Clethra fimbriata, a plant traditionally used as a febrifuge, on Trypanosoma cruzi. The hexane extract showed the highest activity against the parasite and low cytotoxicity, and it also induced the production of cytokines IFN-γ and TNF.
Article
Immunology
Lucia Lopez, Maria Laura Chiribao, Magali C. Girard, Karina A. Gomez, Paula Carasi, Marisa Fernandez, Yolanda Hernandez, Carlos Robello, Teresa Freire, Maria Dolores Pineyro
Summary: The study showed that c-TXNPx induces the recruitment of IL-12/23p40-producing innate antigen-presenting cells and promotes a strong specific Th1 immune response, while c-TXNPxC52S does not. The presence of peroxidatic cysteine is essential for the peroxidase activity and quaternary structure of the protein.
Article
Multidisciplinary Sciences
Ivan Menendez-Montes, Salim Abdisalaam, Feng Xiao, Nicholas T. Lam, Shibani Mukherjee, Luke I. Szweda, Aroumougame Asaithamby, Hesham A. Sadek
Summary: Mitochondrial utilization of fatty acids induces a significant increase in ROS detection at the chromatin level, indicating that mitochondrial metabolic perturbations directly alter the nuclear redox status, with chromatin being particularly sensitive to the prooxidant effect of FA utilization by the mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Raquel S. Negreiros, Noelia Lander, Miguel A. Chiurillo, Anibal E. Vercesi, Roberto Docampo
Summary: Pyruvate, the end product of glycolysis, is transported into the mitochondria through the mitochondrial pyruvate carriers MPC1 and MPC2. Knockout of MPC1 and MPC2 in Trypanosoma cruzi affects pyruvate-driven respiration, host cell invasion, and intracellular replication of amastigotes.
Article
Biochemistry & Molecular Biology
Sumit Das, Puja Panja, Gaurab Chowdhury, Saroj Biswas, Yuthika Dholey, Subrata Adak
Summary: This study reports two members of the ChaC family of gamma-glutamyl cyclotransferases in Leishmania, showing their roles in GSH degradation and cell growth.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Sara Teixeira de Macedo-Silva, Gonzalo Visbal, Gabrielle Frizzo Souza, Mayara Roncaglia dos Santos, Simon B. Cammerer, Wanderley de Souza, Juliany Cola Fernandes Rodrigues
Summary: This study found that benzylamines have anti-parasitic activity against Leishmania amazonensis and affect the structure of the cell membrane and mitochondria by blocking the sterol synthesis pathway. These results suggest that benzylamines may be promising pharmaceutical leads for the treatment of leishmaniasis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Su Bu, Anran Xiong, Zhiying Yang, Faycal Aissa-Brahim, Ying Chen, Yichun Zhang, Xunyong Zhou, Fuliang Cao
Summary: Bilobalide exhibits beneficial bioactivities such as neuroprotection, anti-inflammation, and antioxidant effects. The study demonstrates that bilobalide can induce apoptosis in mature adipocytes through the ROS-mediated mitochondrial pathway.
Article
Cell Biology
Yanhong Wang, Xinyu Mang, Xuran Li, Zhengyu Cai, Fei Tan
Summary: This study investigated the effect and mechanism of cold atmospheric plasma (CAP) on the proliferation and apoptosis of lung cancer and colon cancer cells. The results showed that CAP treatment inhibited tumor cell proliferation and induced apoptosis through the activation of the mitochondrial pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiajie Tan, Yuling Xiang, Yuanguo Xiong, Yaoyuan Zhang, Boyang Qiao, Hong Zhang
Summary: In this study, crebanine, a bioactive compound derived from Stephania, was found to effectively inhibit the growth and migration capacity of hepatocellular carcinoma cells. It induces apoptosis through increasing reactive oxygen species levels and disrupting mitochondrial membrane potential. Additionally, crebanine affects the biological function of hepatocellular carcinoma cells through the ROS-AKT-FoxO3a signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Lizhen Si, Jing Gu, Mi Wen, Ruiqi Wang, Joy Fleming, Jinyue Li, Jintian Xu, Lijun Bi, Jiaoyu Deng
Summary: This study revealed the previously unknown bactericidal effects of sulfonamides, deepening our understanding of their mechanisms of action and potentially aiding in the design of new potentiators.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Lucas Vellasco, Erik Svensjo, Carlos Alberto Bulant, Pablo Javier Blanco, Fabio Nogueira, Gilberto Domont, Natalia Pinto de Almeida, Clarissa Rodrigues Nascimento, Danielle Silva-dos-Santos, Carla Eponina Carvalho-Pinto, Emiliano Horacio Medei, Igor C. Almeida, Julio Scharfstein
Summary: Microangiopathy may worsen the clinical outcome of Chagas disease. This study used intravital microscopy to investigate microcirculatory alterations in the hamster cheek pouch infected by GFP-expressing T. cruzi. The findings suggest that intracellular amastigotes stimulate angiogenesis and enhance the delivery of plasma-borne nutrients and factors, benefiting the host-parasite relationship.
Article
Immunology
Fabiola Gonzalez-Herrera, Natasha S. Clayton, Daniela Guzman-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalan, Renatto Anfossi, Helena Quintero-Pertuz, Maria Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raul Vivar, Juan Diego Maya
Summary: This study demonstrates that statins can inhibit ROCK activity, reduce inflammation, and promote anti-inflammatory cytokine expression, suggesting that statins may be a potential pharmacological strategy for preventing cardiac inflammation in CCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Lingshan Xu, Liang Zhu, Ping Liu, Zhouquan Wu, Zhiqing Zou
Summary: Ozone therapy at low concentrations protects the myocardium from OGD/R-induced injury by inhibiting autophagy. Ozone can reverse the harmful effects of OGD/R on cardiomyocytes and prevent OGD/R-induced oxidative stress dose-dependently.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Huifang Shi, Juechao Zhang, Xiaoqing Han, Huihan Li, Mingshu Xie, Yingying Sun, Wenguang Liu, Xueqing Ba, Xianlu Zeng
INTERNATIONAL JOURNAL OF CANCER
(2017)
Article
Cell Biology
Peter German, David Saenz, Peter Szaniszlo, Leopoldo Aguilera-Aguirre, Lang Pan, Muralidhar L. Hegde, Attila Bacsi, Gyorgy Hajas, Zsolt Radak, Xueqing Ba, Sankar Mitra, John Papaconstantinou, Istvan Boldogh
MECHANISMS OF AGEING AND DEVELOPMENT
(2017)
Article
Multidisciplinary Sciences
Yueshuang Ke, Yanlong Han, Xiaolan Guo, Jitao Wen, Ke Wang, Xue Jiang, Xue Tian, Xueqing Ba, Istvan Boldogh, Xianlu Zeng
NATURE COMMUNICATIONS
(2017)
Article
Biochemical Research Methods
Yueshuang Ke, Ke Wang, Hui Xu, Chenxin Wang, Jing Zhang, Xianlu Zeng, Ruoxi Wang, Istvan Boldogh, Xueqing Ba
MOLECULAR AND CELLULAR PROBES
(2018)
Article
Cell Biology
Ruoxi Wang, Chunshuang Li, Ping Qiao, Yaoyao Xue, Xu Zheng, Hongyu Chen, Xianlu Zeng, Wenguang Liu, Istvan Boldogh, Xueqing Ba
CELL DEATH & DISEASE
(2018)
Article
Cell Biology
Liangping Su, Hongyuan Li, Cheng Huang, Tingting Zhao, Yongjun Zhang, Xueqing Ba, Zhongwei Li, Yu Zhang, Baiqu Huang, Jun Lu, Yanmei Zhao, Xiaoxue Li
Article
Biochemistry & Molecular Biology
Wenjing Hao, Tianyang Qi, Lang Pan, Ruoxi Wang, Bing Zhu, Leopoldo Aguilera-Aguirre, Zsolt Radak, Tapas K. Hazra, Spiros A. Vlahopoulos, Attila Bacsi, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
Review
Biochemistry & Molecular Biology
Xueqing Ba, Istvan Boldogh
Article
Oncology
Huifang Shi, Xiaoqing Han, Yingying Sun, Chao Shang, Min Wei, Xueqing Ba, Xianlu Zeng
Review
Biochemistry & Molecular Biology
Ruoxi Wang, Wenjing Hao, Lang Pan, Istvan Boldogh, Xueqing Ba
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Multidisciplinary Sciences
Torkild Visnes, Armando Cazares-Korner, Wenjing Hao, Olov Wallner, Geoffrey Masuyer, Olga Loseva, Oliver Mortusewicz, Elisee Wiita, Antonio Sarno, Aleksandr Manoilov, Juan Astorga-Wells, Ann-Sofie Jemth, Lang Pan, Kumar Sanjiv, Stella Karsten, Camilla Gokturk, Maurice Grube, Evert J. Homan, Bishoy M. F. Hanna, Cynthia B. J. Paulin, Therese Pham, Azita Rasti, Ulrika Warpman Berglund, Catharina von Nicolai, Carlos Benitez-Buelga, Tobias Koolmeister, Dag Ivanic, Petar Iliev, Martin Scobie, Hans E. Krokan, Pawel Baranczewski, Per Artursson, Mikael Altun, Annika Jenmalm Jensen, Christina Kalderen, Xueqing Ba, Roman A. Zubarev, Pal Stenmark, Istvan Boldogh, Thomas Helleday
Review
Biochemistry & Molecular Biology
Yueshuang Ke, Jing Zhang, Xueping Lv, Xianlu Zeng, Xueqing Ba
CELLULAR AND MOLECULAR LIFE SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Yueshuang Ke, Xueping Lv, Xingyue Fu, Jing Zhang, Ameer Ali Bohio, Xianlu Zeng, Wenjing Hao, Ruoxi Wang, Istvan Boldogh, Xueqing Ba
Summary: PARylation is an important post-translational modification that increases the formation of HuR oligomer/multimer, which in turn promotes the disassociation of miRISC and stabilizes pro-inflammatory gene mRNAs.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lang Pan, Wenjing Hao, Yaoyao Xue, Ke Wang, Xu Zheng, Jixian Luo, Xueqing Ba, Yang Xiang, Xiaoqun Qin, Jesper Bergwik, Lloyd Tanner, Arne Egesten, Allan R. Brasier, Istvan Boldogh
Summary: This study reveals that reactive oxygen species (ROS) can induce epithelial cell-state transition and ECM deposition during airway injury. They found that oxidative DNA damage, specifically the formation of 8-oxoG lesions, functions as a pioneer factor in transcriptional reprogramming of airway epithelial cells. These findings provide important insights into the role of oxidative DNA damage in mediating profibrotic processes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Physiology
Leopoldo Aguilera-Aguirre, Wenging Hao, Lang Pan, Xiaoxue Li, Alfredo Saavedra-Molina, Attila Bacsi, Zsolt Radak, Sanjiv Sur, Allan R. Brasier, Xueqing Ba, Istvan Boldogh
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2017)