Article
Cell Biology
Shanting Gao, Xiaomin Bu, Yongyue Gao, Zengtao Bao, Wenchao Shi, Lipeng Luan, Huiyu Chen, Baoming Zhang, Qingshui Tian, Wenxian Guan, Liuqing Yang
Summary: This study reveals the significant roles of the E2F1-miR-532 double-negative feedback loop in gastric cancer progression. E2F1 is highly upregulated in gastric cancer tissues and correlates with tumor malignancy. MiR-532 is decreased and negatively correlated with E2F1 in gastric cancer tissues. MiR-532 directly targets and inhibits E2F1 expression, affecting proliferation, cell cycle, apoptosis, and DNA damage in gastric cancer cells. Moreover, E2F1 serves as a transcriptional repressor to suppress miR-532 expression, forming a double-negative feedback loop.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Xiangmei Cao, Xinzhao Li, Yike Su, Chi Zhang, Chunyan Wei, Kunsong Chen, Donald Grierson, Bo Zhang
Summary: The transcription factor PpNAC1 and DNA demethylase PpDML1 play important roles in regulating the ripening process of peach fruit. PpNAC1 directly activates the expression of multiple ripening-related genes, while the increased transcription of PpDML1 is associated with decreased DNA methylation levels.
Article
Biochemistry & Molecular Biology
Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Long Sun, Fengjiao Zhu, Chengfu Xu, Chaoju Gong
Summary: E2F1 promotes the cell cycle of CRC by enhancing spindle assembly through the transactivation of stathmin1 and TACC3. PKA-mediated phosphorylation of stathmin1 at Ser16 is essential for the phosphorylation of TACC3 at Ser558, facilitating the assembly of TACC3/clathrin/alpha-tubulin complexes. Dysregulation of stathmin1 and TACC3 leads to abnormal spindle pole formation, including disorganized and multipolar spindles. Overexpression of wild-type stathmin1 promotes cell proliferation and tumor growth, and high levels of E2F1, stathmin1, or TACC3 are associated with poor survival in CRC patients.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Horticulture
Mudassar Ahmad, Ahmed Alabd, Yuhao Gao, Wenjie Yu, Wajeeha Jamil, Xuxu Wang, Jia Wei, Junbei Ni, Yuanwen Teng, Songling Bai
Summary: NAC proteins are important regulators in plant development and stress tolerance. In this study, the authors investigated the transcriptional regulation of PpNACs during abiotic stress signaling in pear. They identified three differentially expressed NAC genes, PpNAC88, PpNAC92, and PpNAC130, which belong to the stress-responsive NAC subgroup in pear. The authors also found that these PpNACs, named Pp-SNACs, have high expression levels under salt stress and ABA treatment. Further experiments revealed the transcriptional regulation of Pp-SNACs on stress-responsive genes and the formation of protein complexes by PpNAC88 and PpNAC130, suggesting their multidirectional roles in abiotic stress response in pear.
SCIENTIA HORTICULTURAE
(2022)
Article
Biology
Eun Jae Yang, Ji Hwan Park, Hyun-Ji Cho, Jeong-A Hwang, Seung-Hwa Woo, Chi Hyun Park, Sung Young Kim, Joon Tae Park, Sang Chul Park, Daehee Hwang, Young-Sam Lee
Summary: Inhibition of ATM and ROCK kinases synergistically increases the proliferation of human diploid fibroblasts undergoing replicative senescence, promoting cell cycle progression through activation of transcription factors E2F1 and FOXM1.
COMMUNICATIONS BIOLOGY
(2022)
Article
Plant Sciences
Ruiyang Wang, Xiaoqian Liu, Hongqing Zhu, Yuming Yang, Ruifan Cui, Yukun Fan, Xuhao Zhai, Yifei Yang, Shanshan Zhang, Jinyu Zhang, Dandan Hu, Dan Zhang
Summary: The expression of transcription factor GmERF1 is closely related to phosphorus use efficiency in soybean under low phosphorus stress. GmERF1 promotes phosphorus absorption in soybean by regulating hormone levels and affecting root development. Favorable GmERF1 genotypes from wild soybean can be used for breeding high phosphorus use efficiency in soybean.
Article
Cell Biology
Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Fei Li, Aiqin Niu, Kangjun Zhao, Jianbing Feng, Ying Chen
Summary: This study aimed to investigate the expression of gene-associated with retinoid-interferon-induced mortality 19 (GRIM-19) in asthenozoospermia patients and its regulation of GC-2 spd cell proliferation, apoptosis, and migration. The results showed that GRIM-19 expression was significantly lower in the sperm of asthenozoospermia patients compared to normal individuals. Overexpression of GRIM-19 promoted cell proliferation and migration and reduced apoptosis, while silencing of GRIM-19 had the opposite effects.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Alyssa M. Klein, Lynn Biderman, David Tong, Bita Alaghebandan, Sakina A. Plumber, Helen S. Mueller, Anne van Vlimmeren, Chen Katz, Carol Prives
Summary: This study suggests that MDM2 and MDMX may play a p53-independent role in maintaining cell-cycle progression by affecting the activity of E2F family members and p73, making them a potential target of interest in cancers lacking wild-type p53.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Jianming Zhang, Jing Zhang, Zhongmao Fu, Yuan Zhang, Zai Luo, Pengshan Zhang, Yitian Xu, Chen Huang
Summary: Accumulating evidence suggests that downregulation of carbohydrate response element binding protein (CHREBP) is associated with gastric cancer (GC) development and progression. CHREBP acts as an independent diagnostic marker of GC and its downregulation promotes cell proliferation and inhibits apoptosis. Furthermore, CHREBP transcriptionally inhibits cyclin D1 expression in GC cells, suggesting its involvement in GC growth and apoptosis through targeting the cyclin D1-Rb-E2F1 pathway.
CELL DEATH DISCOVERY
(2022)
Article
Cardiac & Cardiovascular Systems
Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D. Littlewood, Gerard I. Evan, James E. Hudson, Catherine H. Wilson
Summary: The study reveals that Myc and HRas can cooperate to induce proliferation in adult mammalian cardiomyocytes, but the activity of HRas also leads to cell death, limiting its potential as a regenerative therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Siming Chen, Zhiwen He, Tianchen Peng, Fenfang Zhou, Gang Wang, Kaiyu Qian, Lingao Ju, Yu Xiao, Xinghuan Wang
Summary: PRR11 functions as an oncogene in ccRCC, reducing the stability of E2F1 protein and can be activated by c-Myc.
Article
Oncology
Cheemala Ashok, Neha Ahuja, Subhashis Natua, Jharna Mishra, Atul Samaiya, Sanjeev Shukla
Summary: ESRP1 plays a significant role in cancer progression, with elevated expression in carcinoma in situ and reduced expression in hypoxic cancer cells. The transcription factor E2F1 and CpG hydroxymethylation are key factors in upregulating ESRP1 expression, while hypoxia-induced TET3 downregulation leads to E2F1 repression, contributing to diminished ESRP1 expression in hypoxic conditions.
Article
Developmental Biology
Shaked Bar-Cohen, Mria Lorena Martinez Quiles, Alexey Baskin, Ruba Dawud, Barbara H. Jennings, Ze'ev Paroush
Summary: The cell cycle is regulated by the synthesis and degradation of phase-specific transcripts and proteins. Groucho, the orthologue of TLE1 in Drosophila, is shown to regulate normal cell cycle progression by selectively inactivating its activity through phosphorylation. This study suggests that Cdk1 is involved in phosphorylation of Groucho during the cell cycle, and Groucho may play a role in the development of human cancer.
Article
Oncology
Jing Xu, Lei Liu, Ranran Ma, Yawen Wang, Xu Chen, Haiting Liu, Youxin Ji, Tiantian Liu, Peng Gao
Summary: This study revealed that elevated KIF26A expression in breast cancer tissues is associated with lymph node metastasis. KIF26A promotes cell proliferation and cell cycle progression in breast cancer cells. The core promotor region of human KIF26A gene is located at position -395 to -385, upstream of the transcription start site. The transcriptional factor E2F1 activates KIF26A expression, leading to cell cycle progression through the CDK-RB-E2Fs pathway.
FRONTIERS IN ONCOLOGY
(2021)