期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 285, 期 44, 页码 34240-34249出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M110.159152
关键词
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资金
- National Institutes of Health [AI50050, HL094463, HL62244, HL096972, GM38060]
- American Heart Association, MidAtlantic Affiliate [0855424E]
Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides. Chemical synthesis of large heparan sulfate oligosaccharides remains challenging. We report the synthesis of oligosaccharides with different sulfation patterns and sizes from a disaccharide building block using glycosyl-transferases, heparan sulfate C-5-epimerase, and sulfotransferases. This method offers a generic approach to prepare heparan sulfate oligosaccharides possessing predictable structures.
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