Article
Chemistry, Physical
Dorota Stary, Jedrzej Kukulowicz, Izabella Goral, Hanna Baltrukevich, Marharyta Barbasevich, Justyna Gody, Marek Bajda
Summary: Thymidine phosphorylase (TP) inhibitors were discovered using multilevel virtual screening, with three compounds showing micromolar biological activity. The study contributes to the development of novel anticancer agents by identifying promising ligands through molecular modeling and in vitro testing.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Medicine, General & Internal
Yixin Zou, Hanning Tang, Yi Miao, Huayuan Zhu, Li Wang, Lei Fan, Jianxin Fu, Wei Xu, Jianyong Li, Yi Xia
Summary: NOTCH1 mutation is a significant molecular abnormality in chronic lymphocytic leukemia (CLL), which leads to an unfavorable prognosis and poor response to chemoimmunotherapy. This study investigates the mechanism of adverse prognosis caused by NOTCH1 mutation from the perspective of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), a splicing factor. The results demonstrate that RNA splicing plays a vital role in NOTCH1-mutated CLL cells, and the overexpression of c-Myc-dependent hnRNPA1 promotes cell proliferation and inhibits apoptosis, contributing to the poor prognosis of patients with NOTCH1 mutation.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Shalini Bajaj, Maushmi S. Kumar, Hussain Tinwala, Y. C. Mayur
Summary: A series of novel 1,3,4-oxadiazole derivatives were designed and synthesized with substituted phenyl ring, aiming to discover potential anti-cancer agents targeting thymidine phosphorylase enzyme. Experimental results showed that two molecules displayed promising anti-cancer activity by partly inhibiting thymidine phosphorylation.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, General & Internal
Wei Li, Hong Yue
Summary: COVID-19 causes thrombotic events related to inflammation and organ damage, with TYMP playing a key role in these processes. TYMP could serve as a sensitive marker for COVID-19 diagnosis, and targeting TYMP with tipiracil, a selective inhibitor, may be a novel approach for treating COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Lucillia Bezu, Alejandra Wu Chuang, Allan Sauvat, Juliette Humeau, Wei Xie, Giulia Cerrato, Peng Liu, Liwei Zhao, Shuai Zhang, Julie Le Naour, Jonathan Pol, Peter van Endert, Oliver Kepp, Fabrice Barlesi, Guido Kroemer
Summary: This study investigates the anticancer effects of six local anesthetics used in clinical practice. The results suggest that local anesthetics induce immunogenic stress responses in cancer cells, leading to antitumor effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Ryutaro Mori, Junko Ukai, Yoshihisa Tokumaru, Yoshimi Niwa, Manabu Futamura
Summary: This study investigated the changes in 5-FU metabolism and the mechanism of 5-FU resistance in different cell lines. The inhibition of TP reversed the resistance to 5-FU, suggesting a potential cancer therapy.
Article
Medicine, General & Internal
Karolina Gawrys, Aleksandra Turek-Jakubowska, Jakub Gawrys, Maciej Jakubowski, Janusz Debski, Ewa Szahidewicz-Krupska, Malgorzata Trocha, Arkadiusz Derkacz, Adrian Doroszko
Summary: The aim of this dynamic LC-MS proteomic study in human platelets was to identify potential protein candidates for biomarkers of acute ischemic stroke (AIS), assess their changes during the acute phase of stroke, and define new drug targets. The study found differences in platelet proteins between AIS patients and healthy controls, and identified Thymidine Phosphorylase 4 (TYMP-4) as a promising drug target for the management or prevention of ischemic stroke.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Physical
P. Venkata Ramana
Summary: Cancer is a deadly disease that is difficult to treat due to various factors. Scientific research has led to advancements in medications and treatments, but the study of medical repercussions remains important. This research contributes to the understanding of the atomic-level mechanisms of antiemetic and anticancer medications, improving their effectiveness and potentially leading to the development of innovative treatments.
THEORETICAL CHEMISTRY ACCOUNTS
(2023)
Article
Oncology
Wei Guo, Qilin Huai, Guochao Zhang, Lei Guo, Peng Song, Xuemin Xue, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He
Summary: High expression of HNRNPC is significantly associated with poor overall survival in patients with LUAD, indicating that HNRNPC may be a cancer-promoting factor and a potential prognostic biomarker in LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Courtney J. J. McCann, Nesrin M. M. Hasan, Teresita Padilla-Benavides, Shubhrajit Roy, Svetlana Lutsenko
Summary: Copper is an essential micronutrient that plays a critical role in mammalian growth and development. The study reveals that hnRNPA2/B1 acts as a negative regulator of ATP7A abundance by modulating its mRNA and protein levels, thus maintaining copper homeostasis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Immunology
Jingming Wang, Di Sun, Mingshu Wang, Anchun Cheng, Yukun Zhu, Sai Mao, Xuming Ou, Xinxin Zhao, Juan Huang, Qun Gao, Shaqiu Zhang, Qiao Yang, Ying Wu, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu
Summary: Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA binding proteins that play diverse roles in RNA metabolism. Depending on their cellular localization, hnRNPs can bind to viral RNA or proteins during virus infection, and regulate viral translation, genome replication, and virion release. This review highlights the common features and distinct roles of hnRNPs in the life cycle of positive single-stranded RNA viruses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Sayoni Maitra Roy, Vrinda Garg, Sushmitha Pedugu Sivaraman, Sourav Barman, Chitrita Ghosh, Pousali Bag, Palanivelmurugan Mohanasundaram, Partha Sona Maji, Arnab Basu, Anjaneyulu Dirisala, Surya K. Ghosh, Amit Ranjan Maity
Summary: Targeted drug delivery is crucial for improving the efficacy of anticancer drugs. Mathematical modeling can aid in the design of nuclear drug delivery systems and optimize the factors that affect drug penetration and targeting.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Selvaraj Sengottiyan, Alicja Mikolajczyk, Tomasz Puzyn
Summary: The lack of knowledge about the uptake of NPs by biological cells is a significant problem for drug delivery. In order to address this problem, molecular modeling studies have been conducted to describe the mechanism of cellular uptake of drug-loaded nanoparticles. In this study, three different models were developed to predict the cellular uptake mechanism of drug-loaded nanoparticles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Jiangwei Song, Rong Quan, Dan Wang, Jue Liu
Summary: This study demonstrates that Seneca Valley virus (SVV) infection leads to cleavage, degradation, and cytoplasmic redistribution of heterogeneous nuclear ribonucleoprotein K (hnRNP K). The viral 3C(pro) protease is responsible for the degradation of hnRNP K through the caspase pathway. A cleavage fragment of hnRNP K promotes SVV replication, while hnRNP K inhibits viral replication. hnRNP K interacts with the viral 5' untranslated region (UTR) and knockdown of hnRNP K inhibits SVV replication.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Jun-ichi Takino, Takuma Sato, Isamu Hiraishi, Kentaro Nagamine, Takamitsu Hori
Summary: Pancreatic cancer has a poor prognosis compared to other cancer types, largely due to its resistance to hypovascular environments. Recent studies have shown that decreased expression of HNRNPM in PDA tissues may contribute to the adaptation of cancer cells to hypovascular conditions.
Review
Pharmacology & Pharmacy
Xin Cao, Jiayun Hou, Quanlin An, Yehuda G. Assaraf, Xiangdong Wang
DRUG RESISTANCE UPDATES
(2020)
Article
Immunology
Idan Yelin, Noga Aharony, Einat Shaer Tamar, Amir Argoetti, Esther Messer, Dina Berenbaum, Einat Shafran, Areen Kuzli, Nagham Gandali, Omer Shkedi, Tamar Hashimshony, Yael Mandel-Gutfreund, Michael Halberthal, Yuval Geffen, Moran Szwarcwort-Cohen, Roy Kishony
CLINICAL INFECTIOUS DISEASES
(2020)
Review
Nutrition & Dietetics
Yarden Golan, Yehuda G. Assaraf
Article
Oncology
David G. J. Cucchi, Costa Bachas, Marry M. van den Heuvel-Eibrink, Susan T. C. J. M. Arentsen-Peters, Zinia J. Kwidama, Gerrit J. Schuurhuis, Yehuda G. Assaraf, Valerie de Haas, Gertjan J. L. Kaspers, Jacqueline Cloos
Article
Cell Biology
Michal Stark, Tomas F. D. Silva, Guy Levin, Miguel Machuqueiro, Yehuda G. Assaraf
Article
Oncology
Giovanna Li Petri, Btissame El Hassouni, Rocco Sciarrillo, Niccola Funel, Giulia Mantini, Eveline A. Zeeuw van der Laan, Stella Cascioferro, Amir Avan, Paolo Andrea Zucali, Nadia Zaffaroni, Tonny Lagerweij, Barbara Parrino, Kees Smid, Marcello Deraco, Carlotta Granchi, Alicja Braczko, Ryszard T. Smolenski, Larry H. Matherly, Gerrit Jansen, Yehuda G. Assaraf, Patrizia Diana, Jacqueline Cloos, Godefridus J. Peters, Filippo Minutolo, Elisa Giovannetti
BRITISH JOURNAL OF CANCER
(2020)
Review
Pharmacology & Pharmacy
Michele Dal Bo, Elena De Mattia, Lorena Baboci, Silvia Mezzalira, Erika Cecchin, Yehuda G. Assaraf, Giuseppe Toffoli
DRUG RESISTANCE UPDATES
(2020)
Article
Cell Biology
Matan Soll, Qiu-Cheng Chen, Benny Zhitomirsky, Punnajit P. Lim, John Termini, Harry B. Gray, Yehuda G. Assaraf, Zeev Gross
CELL DEATH DISCOVERY
(2020)
Article
Rheumatology
Ittai B. Muller, Marry Lin, Willem F. Lems, Marieke M. ter Wee, Anna Wojtuszkiewicz, Michael T. Nurmohamed, Jacqueline Cloos, Yehuda G. Assaraf, Gerrit Jansen, Robert de Jonge
Summary: This study investigated the association between FPGS 8PR levels and lack of responsiveness to MTX treatment in RA patients, finding a correlation between high baseline 8PR/8WT ratios and disease activity scores as well as treatment outcomes.
Article
Neurosciences
Dejan B. Budimirovic, Annette Schlageter, Stela Filipovic-Sadic, Dragana D. Protic, Eran Bram, E. Mark Mahone, Kimberly Nicholson, Kristen Culp, Kamyab Javanmardi, Jon Kemppainen, Andrew Hadd, Kevin Sharp, Tatyana Adayev, Giuseppe LaFauci, Carl Dobkin, Lili Zhou, William Ted Brown, Elizabeth Berry-Kravis, Walter E. Kaufmann, Gary J. Latham
Article
Oncology
May Levin, Michal Stark, Yishai Ofran, Yehuda G. Assaraf
Summary: The study explored chemoresistance mechanisms in AML patients and found that each patient displayed unique resistance mechanisms following similar treatment protocols. Standardized evaluation of key drug transport and metabolism genes is necessary as an integral component of routine AML management for selecting treatment of choice for individual patients.
CANCER CELL INTERNATIONAL
(2021)
Review
Pharmacology & Pharmacy
Bowen Li, Jingwen Jiang, Yehuda G. Assaraf, Hengyi Xiao, Zhe-Sheng Chen, Canhua Huang
DRUG RESISTANCE UPDATES
(2020)
Article
Biochemical Research Methods
Michal Stark, Shachar Raz, Yehuda G. Assaraf
Summary: The study reveals that cytoplasmic FPGS is associated with the cytoskeleton and unconventional myosin-1c, supporting the dynamic channeling of polyglutamylated folates to metabolon compartments. This novel finding enhances folate-dependent de novo biosynthesis of nucleotides and DNA/protein methylation.
JOURNAL OF PROTEOMICS
(2021)
Article
Chemistry, Medicinal
Vinay K. Sharma, Michal Stark, Natalia Fridman, Yehuda G. Assaraf, Zeev Gross
Summary: PC-Im is a theranostic agent with pH-sensitive properties that selectively targets and kills tumor cells through endogenous and exogenous stimuli, ensuring its cytotoxicity occurs upon lysosomal accumulation and light activation.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biology
Michal Stark, May Levin, Igor Ulitsky, Yehuda G. Assaraf
Summary: This study reveals that the localization of cFPGS mRNA and protein at cell protrusions is mediated by two G-quadruplex (GQ) motifs in the 3 ' UTR of FPGS. Upon folate stimulation, the FPGS 3 ' UTR GQ motifs induce an invasive phenotype in cancer cell migration and invasion.