Article
Endocrinology & Metabolism
Martha Hanschkow, Nathalie Boulet, Elena Kempf, Anne Bouloumie, Wieland Kiess, Robert Stein, Antje Korner, Kathrin Landgraf
Summary: MSCA1 and CD36 are associated with obesity-related alterations in children's adipose tissue, with CD36 expression predicting the adipogenic potential of SVF cells.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Qian Li, Kirsty L. Spalding
Summary: Adipocytes undergo extensive cytoskeletal remodeling to accommodate their dramatic morphological changes. Cell growth-related signaling pathways are activated to meet the increasing cellular needs. Continued expansion of adipocytes can lead to metabolic dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Said Lhamyani, Adriana-Mariel Gentile, Rosa M. Giraldez-Perez, Monica Feijoo-Cuaresma, Silvana Yanina Romero-Zerbo, Mercedes Clemente-Postigo, Hatem Zayed, Wilfredo Oliva Olivera, Francisco Javier Bermudez-Silva, Julian Salas, Carlos Lopez Gomez, Abdelkrim Hmadcha, Nabil Hajji, Gabriel Olveira, Francisco J. Tinahones, Rajaa El Bekay
Summary: The study found higher levels of miR-21 in WAT of non-diabetic obese individuals and mice and in 3T3-L1 adipocytes, miR-21 mimic affected genes involved in WAT functionality regulation and significantly increased genes related to browning and thermogenesis. In vivo treatment with miR-21 mimic blocked weight gain induced by high-fat diet in obese mice, associated with metabolic enhancement, WAT browning, and brown AT thermogenic programming through specific signaling pathways.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Dan Xu, Ye Gong, Xiaojun Xiang, Yongtao Liu, Kangsen Mai, Qinghui Ai
Summary: This study discovered for the first time perirenal adipose tissue (PAT) in large yellow croaker, and observed its morphological and cytological characteristics. Compared with liver and muscle, PAT highly expressed marker genes of white adipose tissue. Preadipocytes were isolated from PAT and their differentiation process was investigated, revealing the regulation mechanism.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Johanna Bruder, Tobias Fromme
Summary: Within the first month after birth, mice undergo a drastic but transient remodeling process in their adipose tissue depots. This process involves the sudden emergence and subsequent reversal of beige adipocytes in white fat depots, along with an opposite phenomenon in brown fat depots. The remodeling process is influenced by various environmental and genetic factors and may contribute to the lasting adaptive capacity in adult animals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Changbao Sun, Ang Li, Huan Wang, Jiage Ma, Juncai Hou
Summary: Acetate is associated with adipocyte differentiation and lipid deposition. In a study on obese mice and mouse adipose mesenchymal stem cells, it was found that acetate significantly increased body weight, food intake, and fatty lesions, while decreasing anti-inflammatory factors levels and liver function. The mRNA expression levels of several genes in adipose tissue and stem cells were also significantly altered.
Article
Agriculture, Multidisciplinary
Yaofeng Chen, Sujuan Zhao, Ran Ding, Hui Li, Cai-Xia Yang, Zhi-Qiang Du
Summary: Long noncoding RNAs play important roles in chicken growth and disease progression. This study identified functional elements of the long noncoding RNA lncPRDM16, which have potential importance in inhibiting preadipocyte proliferation. These findings provide the foundation for further exploration of lncPRDM16 function and potential improvement of chicken muscle quality.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Giles E. Duffield, Maricela Robles-Murguia, Tim Y. Hou, Kathleen A. McDonald
Summary: The disruption of Id4 gene resulted in mice with abnormal circadian clock characteristics, such as shorter circadian period length and advanced phase angle of entrainment under different lighting conditions. Anatomical analysis revealed smaller suprachiasmatic nucleus (SCN) in Id4-/- mice, suggesting a possible influence on retinal afferents. The absence of ID4 protein may lead to changes in interactions with other Id gene family members, resulting in abnormal properties of the circadian clock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Haidong Zhao, Mingli Wu, Xiaoqin Tang, Qi Li, Xiaohua Yi, Wanxia Zhao, Xiuzhu Sun
Summary: This study reveals the metabolic mechanism of subcutaneous adipose tissue in chicks, demonstrates the crucial role of FFA-induced Ccl2 (chicken CCL26) secretion in lipid transportation, and identifies the significant involvement of macrophages in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Chen, Si Min Lai, Shaohai Xu, Yingrou Tan, Keith Leong, Dehua Liu, Jia Chi Tan, Roshan Ratnakar Naik, Anna M. Barron, Sunil S. Adav, Jinmiao Chen, Shu Zhen Chong, Lai Guan Ng, Christiane Ruedl
Summary: Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to metabolic changes and play a protective role against pathological remodeling during obesity. They control vascular integrity, adipocyte function, lipid metabolism, extracellular matrix accumulation, and fibrosis in WAT. The protective role of ATMs in obesity-driven WAT dysfunction challenges the traditional assumption of them as foes.
Article
Pharmacology & Pharmacy
Zhenlu Xu, Dongyun Liu, Dong Liu, Xue Ren, Haibo Liu, Guihong Qi, Yue Zhou, Chongming Wu, Kui Zhu, Zhongmei Zou, Jing Yuan, Wenhan Lin, Peng Guo
Summary: EQST, a meroterpenoid derived from a marine sponge-derived fungus, displays anti-obesity effects by inhibiting adipogenesis and regulating the enzyme activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). It shows better inhibitory intensity and efficacy on anti-obesity than known 11 beta-HSD1 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Editorial Material
Biochemistry & Molecular Biology
Gisela Geoghegan, Judith Simcox
Summary: Body temperature regulation plays a crucial role in maintaining glucose homeostasis. In a recent study published in Cell, Meng et al. identified a regulatory pathway in which light activates retinal ganglion cells to inhibit thermogenesis in brown adipose tissue, leading to impaired glucose homeostasis. This finding provides an explanation for the metabolic effects of chronic exposure to light.
Article
Biochemistry & Molecular Biology
Kathrin Landgraf, Andreas Kuhnapfel, Maria Schlanstein, Ronald Biemann, Berend Isermann, Elena Kempf, Holger Kirsten, Markus Scholz, Antje Korner
Summary: This study found that childhood obesity is associated with dysfunction and early signs of metabolic disease in adipose tissue. By analyzing gene expression profiles in adipose tissue samples from obese children, the researchers identified genes that are associated with obesity and related parameters. They also discovered that EGFL6 gene may play a role in the pathogenesis of metabolic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Anna Goddi, Alanis Carmona, Soo-Young Park, Gokhan Dalgin, Maria A. Gonzalez Porras, Eric M. Brey, Ronald N. Cohen
Summary: This study found that LAMA4 negatively regulates thermogenic phenotype and pathways involving mitochondrial biogenesis in adipocytes through the suppression of AMPK alpha.
Article
Biochemistry & Molecular Biology
Giles E. Duffield, Nathan P. Watson, Akio Mantani, Stuart N. Peirson, Maricela Robles-Murguia, Jennifer J. Loros, Mark A. Israel, Jay C. Dunlap
Article
Biochemistry & Molecular Biology
Tim Y. Hou, Sarah M. Ward, Joana M. Murad, Nathan P. Watson, Mark A. Israel, Giles E. Duffield
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Clinical Neurology
T Tada, JB Nguyen, Y Hitoshi, NP Watson, JF Dunn, S Ohara, S Nagano, K Kosai, MA Israel
NEUROLOGICAL RESEARCH
(2005)
Article
Multidisciplinary Sciences
Y Liang, M Diehn, N Watson, AW Bollen, KD Aldape, MK Nicholas, KR Lamborn, MS Berger, D Botstein, PO Brown, MA Israel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2005)
Article
Biochemical Research Methods
T Tada, M Wendland, N Watson, N Kuriyama, H Kuriyama, T Roberts, M Burns, W Weiss, MA Israel
JOURNAL OF NEUROSCIENCE METHODS
(2002)