Nonamyloid Aggregates Arising from Mature Copper/Zinc Superoxide Dismutases Resemble Those Observed in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

(2010) Aaron Kerman et al.   ACTA NEUROPATHOLOGICA

Disrupted Zinc-Binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R

(2010) Sai V. Seetharaman et al.   BIOCHEMISTRY

Mutation-dependent Polymorphism of Cu,Zn-Superoxide Dismutase Aggregates in the Familial Form of Amyotrophic Lateral Sclerosis

(2010) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Profiling in the Lumbar Spinal Cord of a Mouse Model of Amyotrophic Lateral Sclerosis: A Role for Wild-Type Superoxide Dismutase 1 in Sporadic Disease?

(2010) Antonello D’Arrigo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis

(2009) Hsueh-Ning Liu et al.   ANNALS OF NEUROLOGY

Branching in Amyloid Fibril Growth

(2009) Christian Beyschau Andersen et al.   BIOPHYSICAL JOURNAL

Immature Copper-Zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis

(2009) Sai V. Seetharaman et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Common Property of Amyotrophic Lateral Sclerosis-associated Variants

(2009) Kathleen S. Molnar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Metal Ions, Disulfide Reduction and Mutations Related to Familial ALS Promote Formation of Amyloid-Like Aggregates from Superoxide Dismutase

(2009) Zeynep A. Oztug Durer et al.   PLoS One

Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation

(2009) N. Carulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional features cause misfolding of the ALS-provoking enzyme SOD1

(2009) A. Nordlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein aggregation kinetics, mechanism, and curve-fitting: A review of the literature

(2008) Aimee M. Morris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis

(2008) Xiaohang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete Loss of Post-translational Modifications Triggers Fibrillar Aggregation of SOD1 in the Familial Form of Amyotrophic Lateral Sclerosis

(2008) Yoshiaki Furukawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme

(2008) Mercedes Prudencio et al.   JOURNAL OF NEUROCHEMISTRY

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

(2008) Masayuki Yamasaki et al.   NATURE

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization

(2008) Lucia Banci et al.   PLoS One

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

(2008) M. Chattopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY

Protein Aggregation and Protein Instability Govern Familial Amyotrophic Lateral Sclerosis Patient Survival

(2008) Qi Wang et al.   PLOS BIOLOGY

Folding versus aggregation: Polypeptide conformations on competing pathways

(2007) Thomas R. Jahn et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Sonication of proteins causes formation of aggregates that resemble amyloid

(2004) Peter B. Stathopulos et al.   PROTEIN SCIENCE