Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Neetu Kushwah, Kevin Woeppel, Vaishnavi Dhawan, Delin Shi, Xinyan Tracy Cui
Summary: The study demonstrates that L1 coating can reduce superoxide production from cultured microglia through direct reduction reaction and signaling pathways, and increase anti-inflammatory cytokine release and phagocytosis in response to PMA or LPS stimulation. Additionally, surface roughening with nanoparticles prior to L1 immobilization further enhances the beneficial effects of L1 in reducing microglia activation and oxidative stress.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Kheerthana Duraivelan, Dibyendu Samanta
Summary: This review provides a detailed account of the roles of nectin family members in various tumors, highlighting the seemingly opposing roles of some members in tumor-associated pathways where they function as both tumor suppressors and oncogenes. Understanding the functional duality of nectin family in tumors can advance our knowledge of molecular mechanisms regulating tumor development and progression, leading to improved tumor diagnosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biophysics
Kouki Abe, Kentarou Baba, Liguo Huang, Koay Teng Wei, Kazunori Okano, Yoichiroh Hosokawa, Naoyuki Inagaki
Summary: The mechanical properties of the extracellular environment play a role in modulating axon outgrowth, with axons growing longer on stiffer substrates under conditions that replicate the soft brain environments. This stiffness-dependent axon outgrowth is mediated by actin-adhesion coupling involving shootin1a, L1, and laminin on the substrate. L1 at the growth cone membrane switches between two adhesive states, with a longer duration of immobilization on stiffer substrates leading to increased actin-adhesion coupling and traction force exerted on the substrate. This enhanced interaction between L1 and laminin on stiffer substrates promotes force generation for axon outgrowth.
BIOPHYSICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Hang Lam Li, Simei Go, Jung-Chin Chang, Arthur Verhoeven, Ronald Oude Elferink
Summary: This review highlights the distinct characteristics and crucial role of soluble adenylyl cyclase (sAC) in cellular processes, as well as recent significant advancements in the field of sAC research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Cell Biology
Shaobo Zhang, Timothy Saunders
Summary: During the development of complex multicellular organisms, the robust formation of specific cell-cell connections is essential for precise tissue structure generation. Various mechanical cues, including differential adhesion and cell contractility, play a role in regulating cell-cell recognition and contact.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Subramani Manigandan, Sulagna Mukherjee, Jong Won Yun
Summary: The study identified FAM107A as a factor that interferes with fat browning in white adipocytes. Deficiency of FAM107A promoted mitochondrial biogenesis and significantly upregulated core fat-browning marker proteins, as well as beige-specific genes. The data revealed a previously unknown mechanism of FAM107A in the regulation of lipid metabolism and its significant role in metabolic homeostasis.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Behavioral Sciences
Jianjiang Wang, Jie Yin, Xi Zheng
Summary: This study investigates the effects of artemisinin (ART) on neurological recovery in a mouse model of intracerebral hemorrhage (ICH) induced by collagenase. The results show that ART can upregulate L1 expression to alleviate brain edema, reduce oxidative stress, and inhibit inflammation, thus improving the neurological outcome in mice with ICH.
BRAIN AND BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Lauren Taylor, Miriam Wankell, Pankaj Saxena, Craig McFarlane, Lionel Hebbard
Summary: Skeletal muscles are responsible for voluntary body movements and undergo a complex process of myogenesis for formation, maintenance, regeneration, and repair. This process involves satellite cells, transcription factors, cell adhesion molecules, and signaling cascades for effective muscle growth and function.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Plant Sciences
Shuai Sun, Xiaotian Wang, Zhiqiang Liu, Jingwei Bai, Jia Song, Ren Li, Xia Cui
Summary: Inflorescence architecture directly impacts yield potential in most crops. This study investigates the genetic regulatory network of inflorescence architecture in tomato and discovers a regulator called TARGET OF EAT1 (SlTOE1), which is primarily expressed in the floral meristem and represses the transcription of key genes involved in inflorescence development. The study also finds that SlTOE1 and ENHANCER OF JOINTLESS 2 (EJ2) act additively to regulate inflorescence branching in tomato.
Article
Biochemistry & Molecular Biology
Byeong Gwan Song, Su Yeon Kwon, Jae Won Kyung, Eun Ji Roh, Hyemin Choi, Chang Su Lim, Seong Bae An, Seil Sohn, Inbo Han
Summary: Synaptic cell adhesion molecules (SynCAMs), specifically SynCAM3, play a crucial role in synapse formation and maintenance as well as synaptic plasticity regulation. Through its involvement in the connection between axons and astrocytes, SynCAM3 has been found to be associated with astrocytic scar formation following central nervous system (CNS) injuries. This study explores the impact of selective removal of SynCAM3 on spinal cord injury (SCI) outcomes, highlighting its role in the prevention of scar-forming astrocytes and promoting extracellular matrix (ECM) reconstitution, ultimately leading to improved functional recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Kae-Jiun Chang, Ira Agrawal, Anna Vainshtein, Wan Yun Ho, Wendy Xin, Greg Tucker-Kellogg, Keiichiro Susuki, Elior Peles, Shuo-Chien Ling, Jonah R. Chan
Summary: TDP-43 is crucial for proper nerve conduction in Schwann cells by directly binding to Neurofascin mRNA, which is essential for assembling and maintaining paranodes. This study highlights the significance of TDP-43 in glial cells and provides insights into the mechanisms underlying nerve conduction dysfunction caused by TDP-43 loss-of-function.
Article
Plant Sciences
Yanxin Jiang, Anran Zhang, Wenjing He, Qingqing Li, Bosi Zhao, Hongjiao Zhao, Xubo Ke, Yalu Guo, Piaoyun Sun, Tongwen Yang, Zheng Wang, Biao Jiang, Junjun Shen, Zheng Li
Summary: This study reveals the genetic controls underlying lateral organ initiation and morphogenesis in watermelon. The LATERAL SUPPRESSOR gene regulates the formation and morphology of lateral organs in watermelon. The protein-protein interaction assays demonstrated that ClLs interacts directly with ClTEN, ClPID, and ClAP1. These findings provide potential gene targets for transforming the architecture of watermelon.
Article
Medicine, Research & Experimental
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David Eo Knight, Ronan O'Dwyer, David X. Overton, Christina M. Lucato, Nicola Mg Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Summary: The study developed PD-1 agonist ImmTAAI molecules that can inhibit T cell function by mimicking the action of PD-L1. These molecules specifically bind to target cells and effectively activate the PD-1 receptor on interacting T cells, achieving immune suppression.
Review
Cell Biology
Bo Wu, Qian Wang, Xiang Shi, Meixi Jiang
Summary: The existence of multiple endocytic pathways and their effects on tumor cells and immune cells have been intensively investigated. Understanding these pathways can lead to new candidates for cancer treatment and regulation of the tumor immune microenvironment.
CELL COMMUNICATION AND SIGNALING
(2022)