Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Functionin Vitroand Increase Bone Massin Vivo
出版年份 2010 全文链接
标题
Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Functionin Vitroand Increase Bone Massin Vivo
作者
关键词
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出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 285, Issue 51, Pages 40135-40147
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2010-10-08
DOI
10.1074/jbc.m110.166892
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Dickkopf-1 as a potential therapeutic target in Paget's disease of bone
- (2010) Helen S McCarthy et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- IgG2m4, an engineered antibody isotype with reduced Fc function
- (2010) Zhiqiang An et al. mAbs
- Wnt Proteins Promote Bone Regeneration
- (2010) S. Minear et al. Science Translational Medicine
- Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma
- (2009) M. Fulciniti et al. BLOOD
- Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells
- (2009) Stefan Bajada et al. BONE
- Future therapeutic targets in osteoporosis
- (2009) Chad Deal CURRENT OPINION IN RHEUMATOLOGY
- Dickkopf-1: a suitable target for the management of myeloma bone disease
- (2009) Maria Gavriatopoulou et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease
- (2009) Maria Cristina Rosi et al. JOURNAL OF NEUROCHEMISTRY
- Promising bone-related therapeutic targets for rheumatoid arthritis
- (2009) Yongwon Choi et al. Nature Reviews Rheumatology
- Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6
- (2009) Damien Fleury et al. PROTEIN EXPRESSION AND PURIFICATION
- The role of Dickkopf-1 in bone development, homeostasis, and disease
- (2008) J. J. Pinzone et al. BLOOD
- Monoclonal Antibody Pharmacokinetics and Pharmacodynamics
- (2008) W Wang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
- (2008) Martin Kaiser et al. EUROPEAN JOURNAL OF HAEMATOLOGY
- Large-Scale Analysis of Association Between LRP5 and LRP6 Variants and Osteoporosis
- (2008) Joyce B. J. van Meurs JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism
- (2008) Ke Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Insight into the Mechanisms of Wnt Signaling Antagonism by Dkk
- (2008) Lijun Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
- (2008) Deborah J Heath et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair
- (2008) Carmen E. Macsai et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
- (2008) K. Ellwanger et al. MOLECULAR AND CELLULAR BIOLOGY
- Translating insights from development into regenerative medicine: The function of Wnts in bone biology
- (2008) P. Leucht et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
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