Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Medicine, General & Internal
Marta Mellai, Omar Porrini Prandini, Aurora Mustaccia, Valentina Fogazzi, Marta Allesina, Marco Krengli, Renzo Boldorini
Summary: pTERT mutations were significantly associated with histologic grade and prognosis in malignant meningiomas, supporting their use in prognostic classification. The mutation rate was higher in anaplastic meningiomas compared to atypical tumors, indicating their potential as adverse prognostic factors.
Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Article
Biotechnology & Applied Microbiology
Zhiwen Liu, Li Zhang, Wen Chen, Fenqian Yuan, Zhi Yang, Sheng Liu, Fei Le
Summary: In this study, it was found that miR-195-5p regulates cell proliferation, apoptosis, and invasion in human thyroid cancer by interacting with TERT. Overexpression of miR-195-5p inhibits proliferation and invasion, and promotes apoptosis, effects that can be reversed by the overexpression of TERT. This suggests that miR-195-5p may serve as a potential therapeutic target for human thyroid cancer.
Review
Biochemistry & Molecular Biology
Anna A. Plyasova, Dmitry D. Zhdanov
Summary: Alternative splicing of hTERT pre-mRNA regulates telomerase activity and determines cell functions. In addition to telomerase activity regulation, alternative splicing provides cells with splice variants that may have alternative biological activities.
Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Article
Multidisciplinary Sciences
Jiao Li, Yi Feng, Jing Zhao, Zhi Fang, Haiting Liu
Summary: This study found that telomerase reverse transcriptase promotes angiogenesis and maintains the integrity of the blood-brain barrier after neonatal hypoxic-ischemic brain damage. Furthermore, the Notch-1 signaling pathway appears to contribute to the angiogenic function of telomerase reverse transcriptase.
Article
Biochemistry & Molecular Biology
Takahiro Suzuki, Jeremy Cheret, Fernanda Dinelli Scala, Aysun Akhundlu, Jennifer Gherardini, Dana-Lee Demetrius, James D. B. O'Sullivan, Gorana Kuka Epstein, Alan J. Bauman, Constantinos Demetriades, Ralf Paus
Summary: Dysregulation of mTORC1 activity is closely related to aging, cancer, and genetic disorders. In this study, the role of mTORC1 in human hair follicles was investigated, revealing its negative regulation on hair growth and pigmentation. Inhibition of mTORC1 stimulated hair follicle growth and pigmentation, while knockdown of the TSC2 gene reduced pigmentation. These findings suggest that pharmacological inhibition of mTORC1 could be a potential strategy for managing hair loss and depigmentation disorders.
Article
Oncology
Olivier Adotevi, Dewi Vernerey, Pascale Jacoulet, Aurelia Meurisse, Caroline Laheurte, Hamadi Almotlak, Marion Jacquin, Vincent Kaulek, Laura Boullerot, Marine Malfroy, Emeline Orillard, Guillaume Eberst, Aurelie Lagrange, Laure Favier, Marie Gainet-Brun, Ludovic Doucet, Luis Teixeira, Zineb Ghrieb, Anne-Laure Clairet, Yves Guillaume, Marie Kroemer, Didier Hocquet, Melanie Moltenis, Samuel Limat, Elisabeth Quoix, Celine Mascaux, Didier Debieuvre, Christine Fagnoni-Legat, Christophe Borg, Virginie Westeel
Summary: The purpose of this study was to test the safety, immunogenicity, and efficacy of UCPVax vaccine in patients with metastatic non-small-cell lung cancer. The results showed that UCPVax vaccine was highly immunogenic and safe, and achieved interesting 1-year survival rate in advanced NSCLC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Shujing Li, Bin Jiang, Haiyang Yu, Dongqing Song
Summary: The study demonstrated that PINX1 and TERT play important roles in lung injury during both acute and convalescent phases, and regulation of PINX1 expression can ameliorate cell senescence and improve lung function.
Article
Endocrinology & Metabolism
Jiongwei Pan, Zaiting Ye, Xiaoping Cai, Hao Zheng, Yiwei Jiang, Xin Wang, Zhuo Cao
Summary: This study investigated the relationship between miR-491-5p and telomerase activity. It was found that miR-491-5p inhibits telomerase reverse transcriptase activity, leading to reduced migration, viability, invasion, and angiogenesis of TIVE cells. Targeting miR-491-5p may regulate the development of tumors by controlling the invasion, migration, and angiogenesis of endothelial cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Ji Hye Moon, Ilias P. Nikas, Kyung Chul Moon, Bohyun Kim, Han Suk Ryu
Summary: This study demonstrates that hTERT immunocytochemistry (ICC) can be used as an ancillary test in routine cytology practice to improve the sensitivity and specificity of urine cytology for urothelial carcinoma diagnosis and surveillance.
Article
Chemistry, Multidisciplinary
Debao Fang, Hao Hu, Kailiang Zhao, Aman Xu, Changjun Yu, Yong Zhu, Ning Yu, Bo Yao, Suyun Tang, Xianning Wu, Yide Mei
Summary: MLF2 is a new negative regulator of p53 that interacts with both p53 and USP7. It inhibits USP7-mediated deubiquitination of p53, leading to p53 destabilization and promoting colorectal cancer. Clinically, MLF2 is elevated in colorectal cancer and its high expression is associated with poor prognosis.
Article
Biochemistry & Molecular Biology
Shuang Li, Qian Xin, Guangyao Fang, Yi Deng, Fengyuan Yang, Chenming Qiu, Yongjian Yang, Cong Lan
Summary: Physical exercise can prevent cardiac hypertrophy by upregulating mitochondrial TERT expression. Overexpression of mitochondrial-targeted TERT improves mitochondrial dysfunction and reduces oxidative stress, leading to the attenuation of cardiac hypertrophy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Chemistry, Physical
Jae Won Song, Jungyo Suh, Seok Won Lee, Jung Ki Yoo, Uijeong Lee, Jang Hee Han, Cheol Kwak, Minyong Kang, Yi Rang Kim, Chang Wook Jeong, Jin Woo Choi
Summary: In this study, an adenovirus was designed and tested for the detection of circulating tumor cells (CTCs). The adenovirus is able to bind to desmoglein-2, which is highly expressed in most cancer cells. By comparing the number of CTCs before and after surgery in patients with renal cell carcinoma and prostate cancer, the researchers found that the cancer cell-specific infection of the adenovirus can efficiently detect CTCs.
Article
Biochemical Research Methods
Munui Kim, Seung Han Baek, Min Song
BMC BIOINFORMATICS
(2018)
Article
Biochemistry & Molecular Biology
Homa Rahnamoun, Juyeong Hong, Zhengxi Sun, Jihoon Lee, Hanbin Lu, Shannon M. Lauberth
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Homa Rahnamoun, Jihoon Lee, Zhengxi Sun, Hanbin Lu, Kristen M. Ramsey, Elizabeth A. Komives, Shannon M. Lauberth
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2018)
Article
Genetics & Heredity
Min Song, Seung Han Baek, Go Eun Heo, Jeong-Hoon Lee
Article
Biochemistry & Molecular Biology
Arda Halu, Shikang Liu, Seung Han Baek, Brian D. Hobbs, Gary M. Hunninghake, Michael H. Cho, Edwin K. Silverman, Amitabh Sharma
HUMAN MOLECULAR GENETICS
(2019)
Article
Multidisciplinary Sciences
Enrico Maiorino, Seung Han Baek, Feng Guo, Xiaobo Zhou, Parul H. Kothari, Edwin K. Silverman, Albert-Laszlo Barabasi, Scott T. Weiss, Benjamin A. Raby, Amitabh Sharma
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Mei Yang, Ji Hoon Lee, Zhao Zhang, Richard De La Rosa, Mingjun Bi, Yuliang Tan, Yiji Liao, Juyeong Hong, Baowen Du, Yanming Wu, Jessica Scheirer, Tao Hong, Wei Li, Teng Fei, Chen-Lin Hsieh, Zhijie Liu, Wenbo Li, Michael G. Rosenfeld, Kexin Xu
Article
Health Care Sciences & Services
Seung Han Baek, Dinah Foer, Katherine N. Cahill, Elliot Israel, Enrico Maiorino, Annika Rohl, Joshua A. Boyce, Scott T. Weiss
Summary: The study found that strong responders to imatinib (FEV1 increase >20%) shared multiple downregulated mitochondrial-related pathways, while weak responders (5-10% FEV1 increase) and non-responders did not have these pathways in common.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ji Hoon Lee, Juyeong Hong, Zhao Zhang, Barbara de la Pena Avalos, Cecilia J. Proietti, Agustina Roldan Deamicis, Pablo G. Guzman, Hung-Ming Lam, Jose Garcia, Martine P. Roudier, Anthony E. Sisk, Richard De la Rosa, Kevin Vu, Mei Yang, Yiji Liao, Jessica Scheirer, Douglas Pechacek, Pooja Yadav, Manjeet K. Rao, Siyuan Zheng, Teresa L. Johnson-Pais, Robin J. Leach, Patricia Elizalde, Eloise Dray, Kexin Xu
Summary: The role of RNA methylation in cancer, specifically m(6)A, was studied in relation to HMBOX1 mRNA degradation, leading to telomere dysfunction and p53 signaling inactivation, ultimately causing chromosome abnormalities and aggressive phenotypes. Further exploration with CRISPR-based m(6)A-editing tools showed that the methyl groups on HMBOX1 contribute to altered cancer genome generation. The study also found negative correlation between RNA methyltransferase METTL3 expression and telomere length, while HMBOX1 mRNA levels exhibited opposite patterns, suggesting potential rectification of cancer-driving genomic alterations through specific epitranscriptomic programs.
Article
Multidisciplinary Sciences
Yiji Liao, Chen-Hao Chen, Tengfei Xiao, Barbara de la Pena Avalos, Eloise Dray, Changmeng Cai, Shuai Gao, Neel Shah, Zhao Zhang, Avery Feit, Pengya Xue, Zhijie Liu, Mei Yang, Ji Hoon Lee, Han Xu, Wei Li, Shenglin Mei, Roodolph S. Pierre, Shaokun Shu, Teng Fei, Melissa Duarte, Jin Zhao, James E. Bradner, Kornelia Polyak, Philip W. Kantoff, Henry Long, Steven P. Balk, X. Shirley Liu, Myles Brown, Kexin Xu
Summary: Drugs that block the activity of the methyltransferase EZH2 have shown potential for treating non-Hodgkin lymphomas with EZH2 gain-of-function mutations. This study reveals that EZH2 inhibitors can also inhibit the growth of castration-resistant prostate cancer (CRPC) cells by blocking the transactivation activity of EZH2 and down-regulating DNA damage repair (DDR) genes. The expression of DDR genes is correlated with EZH2 dependency and cellular sensitivity to EZH2 inhibitors in various types of solid tumors. These findings provide insights into the mechanism of action of EZH2 inhibitors and have implications for combination cancer therapies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cardiac & Cardiovascular Systems
Seung-Han Baek, Enrico Maiorino, Hyunbum Kim, Kimberly Glass, Benjamin A. Raby, Ke Yuan
Summary: By analyzing single-cell RNA sequencing data, we have identified specific pericyte markers among lung, heart, kidney, and bladder, and revealed differentially expressed genes and functional relationships between mural cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Juyeong Hong, Ji Hoon Lee, Zhao Zhang, Yanming Wu, Mei Yang, Yiji Liao, Richard de la Rosa, Jessica Scheirer, Douglas Pechacek, Nu Zhang, Zhenming Xu, Tyler Curiel, Xi Tan, Tim H. -M. Huang, Kexin Xu
Summary: Inhibition of cancer-intrinsic EZH2 promotes antitumor immunity in breast cancer, requiring specific activation of type I IFN signaling. High levels of EZH2 and low levels of STAT2 in breast cancer patients are associated with the worst antitumor immune responses.
Article
Biochemistry & Molecular Biology
Leonardo Martini, Seung Han Baek, Ian Lo, Benjamin A. Raby, Edwin K. Silverman, Scott T. Weiss, Kimberly Glass, Arda Halu
Summary: The versatility of cellular response arises from the communication and crosstalk of signaling pathways in a complex network. This study presents a network-based statistical approach called MuXTalk that models the unique ways in which signaling and regulatory interactions can interface. Using statistically over-represented multilinks as proxies of crosstalk, crosstalk among 60 signaling pathways is inferred, expanding currently available crosstalk databases significantly.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Juyeong Hong, Kexin Xu, Ji Hoon Lee
Summary: This study reviews the function of m(6)A modification in cancer and its association with DNA damage response and genomic stability, proposing potential therapeutic strategies.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Respiratory System
Annika Rohl, Seung Han Baek, Priyadarshini Kachroo, Jarrett D. Morrow, Kelan Tantisira, Edwin K. Silverman, Scott T. Weiss, Amitabh Sharma, Kimberly Glass, Dawn L. DeMeo
Summary: This study explores the fetal origins of chronic obstructive pulmonary disease (COPD) by analyzing lung DNA methylation marks and studying the network relationships between methylomic and transcriptomic signatures associated with adult lung tissue from former smokers with and without COPD. The study identifies potential pathobiological mechanisms linking fetal lung smoke exposure to adult COPD through protein-protein interaction networks.
RESPIRATORY RESEARCH
(2022)