Article
Dentistry, Oral Surgery & Medicine
Naoto Ohkura, Kunihiko Yoshiba, Nagako Yoshiba, Yohei Oda, Naoki Edanami, Hayato Ohshima, Shoji Takenaka, Takashi Okiji, Yuichiro Noiri
Summary: This study investigated the localization of components of the PGE2-transporting pathway in human dental pulp and their relevance to angiogenesis and dentinogenesis. The results showed that EP2/EP4 agonists promoted the generation of endothelial cell filopodia and upregulated the expression of angiogenesis and odontoblast differentiation-related genes.
JOURNAL OF ENDODONTICS
(2023)
Article
Multidisciplinary Sciences
Changxiu Qu, Chunyou Mao, Peng Xiao, Qingya Shen, Ya-Ni Zhong, Fan Yang, Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, Ru-Jia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, Peng-Ju Zhang, Guige Hou, Zijian Li, Xiao Yu, Ren-Jie Chai, You-Fei Guan, Jin-Peng Sun, Yan Zhang
Summary: Selective modulation of the EP2 subtype of the prostaglandin E-2 (PGE(2)) receptor has potential therapeutic implications for various diseases, with recent structural studies shedding light on its unconventional activation mechanisms and ligand selectivity motifs.
Article
Immunology
Ward Vleeshouwers, Koen van den Dries, Sandra de Keijzer, Ben Joosten, Diane S. Lidke, Alessandra Cambi
Summary: This study highlights the modulation of myeloid immune cell function by Prostaglandin E2 (PGE2) through the activation of EP2 and EP4 receptors. EP4 plays a key role in podosome loss in DCs, while both EP2 and EP4 signaling lead to different cAMP production profiles and reciprocal control of signaling pathways. Efficient signaling of both EP2 and EP4 relies on an intact microtubule network, enhancing our understanding of early signaling events in myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Stephen J. Assinder, Badwi B. Boumelhem
Summary: Oxytocin stimulates lipolysis in 3T3-L1 adipocytes, mediated by autocrine/paracrine actions of PGE2 and leptin.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Aikaterini Kourpa, Angela Schulz, Eva Mangelsen, Debora Kaiser-Graf, Nils Koppers, Monika Stoll, Michael Rothe, Michael Bader, Bettina Purfuerst, Severine Kunz, Thomas Gladytz, Thoralf Niendorf, Sebastian Bachmann, Kerim Mutig, Juliane Bolbrinker, Daniela Panakova, Reinhold Kreutz
Summary: This study explored the renoprotective effects of pharmacological blockade of EP2 and EP4 receptors in the development of albuminuria. The results showed that separate and combined blockade of EP2 and EP4 receptors reduced albuminuria. This finding provides a basis for further research on the therapeutic potential of this treatment option and the possible role of circadian clock genes.
Article
Cell Biology
Yi-Lin Zhang, Wen Liu, Jian-Bang Xu, Qing Sun, Zhuo-Er Qiu, Lei Chen, Jiehong Huang, Yun-Xin Zhu, Wen-Liang Zhou
Summary: The study revealed that PGE(2) induces anion secretion in rat vaginal epithelial cells via the EP-adenylate cyclase-cAMP signaling pathway and facilitates fluid secretion in the vagina. Additionally, LPS stimulation enhances cyclooxygenase-dependent PGE(2) synthesis and vaginal fluid secretion.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Oncology
Maria Khan, Cecilia Engstrom, Johan Bourghardt Fagman, Ulrika Smedh, Kent Lundholm, Britt-Marie Iresjo
Summary: Inflammatory signaling through EP2 receptors is associated with tumor growth. Knocking out EP2 receptors in host tissues reduces tumor growth and systemic inflammation by inducing gene expression changes in tumor-stroma compartments. The absence of EP2 receptor signaling reduces tumor microenvironment remodeling and increases local immunity.
Article
Cardiac & Cardiovascular Systems
Yaqiong Wang, Ting Zhang, Xuesen Cao, Jianzhou Zou, Xiaoqiang Ding, Bo Shen, Wenlv Lv
Summary: The study showed that both EP2 and EP4 receptors were up-regulated in PGE2-treated cardiomyocyte cells, and the inhibition of EP2 receptor could suppress PGE2-induced cardiomyocyte hypertrophy and cardiac fibrosis. Additionally, EP2 receptor inhibitor administration significantly improved cardiac function and fibrosis in the 5/6NT rat model.
Article
Cell Biology
Yujing Wang, Hang Li, Chu Xue, Hao Chen, Yanning Xue, Fang Zhao, Zhengyu Cao, Michael X. Zhu
Summary: Transient receptor potential vanilloid 3 (TRPV3) is highly expressed in skin keratinocytes and plays a crucial role in regulating keratinocyte proliferation. Moderate activation of TRPV3 promotes cell proliferation, while strong activation may lead to cell death. The proliferative effect is mediated through the Ca2+/CaMKII -> TGF alpha/EGFR -> PI3K -> NF-kappa B signaling pathway.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Immunology
Nitin Kamble, Angila Gurung, Benedikt B. Kaufer, Ansar Ahmed Pathan, Shahriar Behboudi
Summary: MDV infection induces activation of COX-2 and production of PGE2, leading to inhibition of T cell proliferation via EP2 and EP4 receptors on day 21 post infection. Oral administration of the COX-2 inhibitor meloxicam during MDV infection suppresses COX-2 activation and rescues T cell proliferation on day 21 post infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Lee Peng Karen-Ng, Usama Sharif Ahmad, Luis Gomes, Keith David Hunter, Hong Wan, Eleni Hagi-Pavli, Eric Kenneth Parkinson
Summary: Early treatment of oral cancer is crucial for better cure rates and reduced disability. Oral cancer is difficult to detect early as it develops unseen. Two types of epithelial cells in oral tissue may contribute to the progression to malignancy. Regulators of prostaglandin secretion in premalignant oral cells have been identified as potential targets for future therapies.
Article
Cell Biology
Hsin-Hsin Peng, Cheng-Yeu Wu, Yuan-Chao Hsiao, Jan Martel, Po-Yuan Ke, Chen-Yaw Chiu, Jian-Ching Liau, I-Te Chang, Yu-Hsiu Su, Yun-Fei Ko, John D. Young, David M. Ojcius
Summary: Mycelium water extract of Ganoderma lucidum extends longevity in Caenorhabditis elegans by reducing FIB-1 levels, increasing LGG-1 expression, and activating autophagy and stress resistance pathways. Low molecular weight compounds isolated from G. lucidum also prolong lifespan and induce autophagy in human cells.
Article
Endocrinology & Metabolism
Karin J. Bosma, Spencer R. Andrei, Liora S. Katz, Ashley A. Smith, Jennifer C. Dunn, Valerie F. Ricciardi, Marisol A. Ramirez, Sharon Baumel-Alterzon, William A. Pace, Darian T. Carroll, Emily M. Overway, Elysa M. Wolf, Michelle E. Kimple, Quanhu Sheng, Donald K. Scott, Richard M. Breyer, Maureen Gannon
Summary: EP3 blockade promotes an increase in beta cell mass in db/db mice with type 2 diabetes, without affecting alpha cell proliferation. This effect may be mediated through the regulation of Nrf2, which plays a key role in protection against oxidative damage.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Na-Lee Ka, Ga Young Lim, Seung-Su Kim, Sewon Hwang, Juhyeong Han, Yun-Hee Lee, Mi-Ock Lee
Summary: This study revealed a novel function of type I interferons in inducing aromatase expression in adipose tissues surrounding breast cancer, which potentiates the growth of estrogen receptor-positive breast cancer. The findings provide insights into the crosstalk between type I interferons and estrogen signaling in the progression of ER-positive BC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Hong Wang, Yangchun Xu, Meishan Jin, Hongxia Li, Shanshan Li
Summary: The study revealed the inhibitory effect of miR-383 in a rat psoriasis model, suppressing the pathological process by regulating LCN2 and the JAK/STAT signaling pathway to alleviate inflammation and promote keratinocyte apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)