Article
Biochemistry & Molecular Biology
Elsa Franco-Echevarria, Trevor J. Rutherford, Marc Fiedler, Caroline Dean, Mariann Bienz
Summary: The study investigates the function of VEL PHD fingers in plant vernalization and reveals its unique structure. The VEL PHD finger forms a larger superdomain similar to the OBERON family. Interestingly, unlike other PHD fingers, the VEL PHD superdomain interacts with negatively charged polymers instead of histone H3 tails.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Hematology
Zachary C. Murphy, Kristin Murphy, Jacquelyn Myers, Michael Getman, Tyler Couch, Vincent P. Schulz, Kimberly Lezon-Geyda, Cal Palumbo, Hongxia Yan, Narla Mohandas, Patrick G. Gallagher, Laurie A. Steiner
Summary: The terminal maturation of human erythroblasts involves significant changes in histone marks associated with active transcription elongation, rather than heterochromatin accumulation. Regulation of RNA polymerase II activity and gene expression at the transcriptional level play a critical role in controlling the maturation process of erythroblasts.
Editorial Material
Plant Sciences
Hazem S. Elshafie
Summary: This article summarizes the chemical composition and biological-pharmaceutical activities of plant essential oils (PEOs), and discusses their possible modes of action and influencing factors. It provides valuable insights into the application of PEOs.
Article
Biochemistry & Molecular Biology
Savita Yadav, Ranajit Nivrutti Shinde, Suruchi Singh, Subramanian Karthikeyan, Balvinder Singh
Summary: The unstructured C-terminal residues of GCHII are crucial for its enzymatic activity, genetic deletion results in loss of enzyme activity, and His-190 may play an important role in the catalysis process.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Editorial Material
Plant Sciences
Hazem S. Elshafie, Ippolito Camele
Summary: Essential oils, derived from plants, are concentrated liquids containing bioactive chemicals and volatile substances. They have been used in folk medicine for their antibacterial properties and have potential applications in the food and cosmetics industries. This Special Issue provides in-depth research on different plant essential oils and their chemical constituents and pharmaceutical functions.
Review
Biochemistry & Molecular Biology
Joshua C. Black, Tatiana G. Kutateladze
Summary: This review explores the molecular mechanisms and structural features of plant homeodomain (PHD) fingers, which have been shown to selectively bind specific regions of histones. It discusses the biological implications of these atypical interactions and highlights the therapeutic potential of PHD fingers, as well as comparing inhibition strategies.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Saori Shibuya, Mitsushiro Nakatomi, Kaori Kometani-Gunjigake, Kayoko Nakao-Kuroishi, Kae Matsuyama, Shinji Kataoka, Takashi Toyono, Yuji Seta, Tatsuo Kawamoto
Summary: Optimal Msx1 gene is crucial for mandibular tip development, and its deficiency leads to rare abnormalities in the median cleft of the lower lip and cleft chin. The study found that the expression of Msx1 gene is reduced in the mandibular tip, resulting in incomplete fusion of the mandibular processes and failure to restore during development. In addition, the absence of the Msx1 gene also causes division of Meckel's cartilage and surrounding soft tissues. The results suggest that the Msx1 gene is indispensable for proper mandibular tip development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Nitika Gaurav, Tatiana G. Kutateladze
Summary: Plant homeodomain (PHD) fingers are a well-known family of epigenetic readers that can recognize histone H3. They typically bind to the unmodified or methylated amino-terminal tail of H3, but recent studies have shown that some PHD fingers can also bind to non-histone proteins, H3 mimetics, and DNA. This review highlights the molecular mechanisms of PHD fingers' interactions with ligands other than the amino terminus of H3 and discusses the similarities and differences in their engagement with histone and non-histone binding partners.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Joe McKellar, Mary Arnaud-Arnould, Laurent Chaloin, Marine Tauziet, Charlotte Arpin-Andre, Oriane Pourcelot, Mickael Blaise, Olivier Moncorge, Caroline Goujon
Summary: The N-terminal domain of HsMX1 protein is essential for its antiviral activity against influenza A virus, Vesicular Stomatitis Virus, and La Crosse virus, as demonstrated by mutagenesis, imaging, and biochemical approaches. A highly conserved leucine within this region is crucial for the antiviral activity of human, mouse, and bat MX1 proteins. Mutation of this leucine does not affect GTPase activity or oligomerization capabilities, but alters MX1 protein subcellular localization.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yali Li, Huayuan Tang, Fengling Chen, Jiewen Chen, Hong Wang, Zee Chen, Yaoyun Duan, Xinru Wang, Li Li, Kunfu Ouyang
Summary: SET domain-containing 2 (SETD2), the primary methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3), is essential for fetal erythropoiesis. Loss of Setd2 leads to anemia and impairs erythroblast differentiation. Several embryonic erythropoiesis-related genes are identified as likely downstream targets of SETD2 regulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Plant Sciences
Ao Duan, Rui Liu, Changchang Liu, Fei Wu, Hang Su, Shuangzhen Zhou, Min Huang, Xiaohai Tian, Haitao Jia, Ya Liu, Manfei Li, Hewei Du
Summary: The study reveals that submergence is a major constraint on rice production in South and Southeast Asia. A gene called SAB23 is found to negatively regulate submergence tolerance in rice by modulating the expression of CYP714B2. The study also shows that a mutant of SAB23 displays reduced plant height and delayed seed maturation, but enhanced submergence tolerance.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Ruibin Xu, Yufeng Li, Zhipeng Sui, Tianyu Lan, Wanjun Song, Ming Zhang, Yirong Zhang, Jiewen Xing
Summary: C-terminal encoded peptides (CEPs) serve as mobile signals coordinating developmental programs in plants, with ZmCEP1 playing a crucial role in maize development and growth. Overexpression of ZmCEP1 leads to reduced plant and seed size, while knockout of ZmCEP1 results in improved plant height, kernel size, and weight. Transcriptome analysis reveals that ZmCEP1 regulates genes related to nitrogen metabolism, nitrate transport, sugar transport, and auxin response in maize.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Lipi Parikh, Bright O. Agindotan, Mary E. Burrows
Summary: Plant-derived essential oils have shown effective inhibitory effects on important pathogenic fungi, suggesting their potential for disease management in both organic and conventional production systems.
Article
Chemistry, Multidisciplinary
Qian Jia, Hui Zeng, Huanxi Li, Nan Xiao, Jing Tang, Shangfang Gao, Jinbing Zhang, Wei Xie
Summary: In this study, the researchers determined the structures of GSDA in plants, revealing its catalytic mechanism and structural rearrangements during reactions. The identification of additional substrates and comparison with other deaminases helped uncover recognition differences for specific substrates. These findings may contribute to the development of deaminase-based gene-editing tools.
CHEMICAL COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Anuja A. George, Nancy C. Walworth
Review
Genetics & Heredity
Anuja A. George, Nancy C. Walworth
Article
Multidisciplinary Sciences
Carmela Palermo, Justin C. Hope, Greg A. Freyer, Hui Rao, Nancy C. Walworth
Article
Multidisciplinary Sciences
Susanne Cranz-Mileva, Melissa C. Pamula, Bipasha Barua, Brinda Desai, Yaejee Hannah Hong, Jacquelyn Russell, Richard Trent, Jianqiu Wang, Nancy C. Walworth, Sarah E. Hitchcock-DeGregori
Article
Multidisciplinary Sciences
Carrie Belfield, Craig Queenan, Hui Rao, Kenji Kitamura, Nancy C. Walworth
Article
Genetics & Heredity
Shakil Ahmed, Barbara Dul, Xinxing Qiu, Nancy C. Walworth
Article
Biochemistry & Molecular Biology
Barbara E. Dul, Nancy C. Walworth
JOURNAL OF BIOLOGICAL CHEMISTRY
(2007)
Article
Biochemical Research Methods
S Dunaway, NC Walworth
Article
Biochemistry & Molecular Biology
S Ahmed, C Palermo, SH Wan, NC Walworth
MOLECULAR AND CELLULAR BIOLOGY
(2004)
Article
Cell Biology
H Capasso, C Palermo, SH Wan, H Rao, UP John, MJ O'Connell, NC Walworth
JOURNAL OF CELL SCIENCE
(2002)
Article
Biochemistry & Molecular Biology
HY Liu, BS Nefsky, NC Walworth
JOURNAL OF BIOLOGICAL CHEMISTRY
(2002)
Review
Cell Biology
NC Walworth
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2001)
Article
Cell Biology
S Dunaway, HY Liu, NC Walworth
JOURNAL OF CELL SCIENCE
(2005)
Article
Genetics & Heredity
S Wan, NC Walworth