Review
Biochemistry & Molecular Biology
Kenta Yoh, Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue
Summary: Estrogen is an essential hormone that primarily functions in the female reproductive system and has pleiotropic effects in various tissues and organs. Low estrogen levels, such as in postmenopausal women, can lead to disorders like cardiovascular disease, dementia, metabolic syndrome, osteoporosis, sarcopenia, and frailty. Estrogen receptors (ERs) and estrogen-related receptors (ERRs) play crucial roles in muscle physiology, including muscle mass maintenance, exercise physiology, and regeneration, particularly in relation to mitochondrial function and metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Martin Picard, Orian S. Shirihai
Summary: Mitochondria, as living and dynamic organelles, play a crucial role in processing and transmitting signals to regulate cellular and organismal functions and adaptation. Understanding mitochondrial signal transduction is of great significance for studying mitochondrial biology and human health.
Article
Orthopedics
Alicia L. Black, James Haskins, Ambra Pozzi, Andrea L. Clark
Summary: This study demonstrates that there is a higher abundance of ROS-producing chondrocytes in female itga1-null mice. Additionally, itga1 has limited influence on the percentage of chondrocytes stained positively for 3-nitrotyrosine or pEGFR. Furthermore, itga1 influences the expression of ER alpha and ER beta in femoral cartilage from female mice, and these receptors are coexpressed and colocalized in chondrocytes. Finally, sexual dimorphism is observed in ROS and 3-nitrotyrosine production, but not in pEGFR expression.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wei Zhao, Yue Hou, Qiwei Zhang, Haiyang Yu, Meichen Meng, Hanting Zhang, Yanmeng Zhou
Summary: This study demonstrates that the activation of ERβ can support learning and memory, and alleviate symptoms of postmenopausal AD model by regulating neuronal mitochondrial biogenesis and mitophagy.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Whitney L. Stuard, Rossella Titone, Danielle M. Robertson
Summary: This study reveals a novel role for IGFBP-3 in regulating mitochondrial homeostasis through the regulation of mitophagy receptors in corneal epithelial cells. Additionally, IGFBP-3 affects mitochondrial morphology and respiration.
Article
Biochemistry & Molecular Biology
Agnieszka Anna Rawluszko-Wieczorek, Julia Lipowicz, Marta Nowacka, Kamila Ostrowska, Paulina Pietras, Malgorzata Blatkiewicz, Marcin Rucinski, Pawel Piotr Jagodzinski, Michal Nowicki
Summary: The presence of estrogen receptor beta (ER beta) is inversely correlated with the occurrence of colorectal cancer (CRC), and low expression of ER beta is associated with poorer overall survival of CRC patients. ER beta can inhibit tumorigenesis through various molecular pathways and also has an impact on the hypoxic response in CRC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Cell Biology
Bin Yuan, Jing Yang, Louis Dubeau, Yanfen Hu, Rong Li
Summary: The study identified the crucial role of an ER beta-specific phosphotyrosine residue in mouse ovarian development and function, with mutant mice showing reduced fertility and decreased ovarian cell proliferation. These findings provide strong genetic and molecular evidence for the impact of isotype-specific ER beta phosphorylation in ovarian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Susanne Schueler-Toprak, Maciej Skrzypczak, Carsten Gruendker, Olaf Ortmann, Oliver Treeck
Summary: Ovarian cancer is the most lethal gynecological cancer mainly diagnosed in advanced stages, while endometrial cancer is often detected in early stages. Treatment options for recurrent or advanced disease are limited. Estrogens and their receptors play a role in both ovarian and endometrial cancers. This article provides an update on the current understanding of the roles of estrogen receptors in these cancers and highlights the need for further research.
Article
Environmental Sciences
Xue Wen, Man Zhu, Zehua Li, Tao Li, Xuewen Xu
Summary: This study explores the effects of BPA on wound repair and finds that dietary intake of BPA delays wound healing, while wound application of BPA accelerates skin regeneration. This is because BPA up-regulates the expression of ERβ in the wound area, and enhances the function of fibroblasts to promote wound repair. For diabetic patients, application of BPA on wounds significantly speeds up wound healing without significant adverse effects on ovarian hormone levels.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Peibin Lin, Xiaojing Zhang, Baoyi Zhu, Jun Gao, Dazhong Yin, Jianwen Zeng, Zhanfang Kang
Summary: Naringenin specifically activates ER beta to improve insulin secretion, protects beta cell function, and reverses glucose dysregulation in diabetic rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Oncology
Shulan Xie, Xuanwei Wang, Shuyuan Gan, Xiaodong Tang, Xianhui Kang, Shengmei Zhu
Summary: TRAP1, a member of the Hsp90 chaperone family, plays a crucial role in tumor progression by regulating metabolism and apoptotic pathways. It is an important therapeutic target for cancer, and combining TRAP1 inhibitors with chemotherapy may represent a new treatment strategy. This review discusses the molecular mechanisms of TRAP1 in tumor progression and recent advances in selective, targeted TRAP1 and Hsp90 inhibitors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dario P. Anobile, Iris C. Salaroglio, Fabrizio Tabbo, Sofia La Vecchia, Muhlis Akman, Francesca Napoli, Maristella Bungaro, Federica Benso, Elisabetta Aldieri, Paolo Bironzo, Joanna Kopecka, Francesco Passiglia, Luisella Righi, Silvia Novello, Giorgio V. Scagliotti, Chiara Riganti
Summary: This study aims to elucidate the molecular circuitries explaining the differential gender-related response to anti-PD-1/anti-PD-L1 agents in non-small cell lung cancer (NSCLC). The results revealed that estrogen receptor alpha (ER alpha) is a predictive factor of response to pembrolizumab, particularly in female patients. Additionally, aromatase inhibitors are proposed as new gender-tailored immune-adjuvants in NSCLC.
CLINICAL CANCER RESEARCH
(2023)
Review
Cell Biology
Edmund Charles Jenkins, Mrittika Chattopadhyay, Doris Germain
Summary: Mitochondrial stress can induce cytosolic proteostasis, but the exact mechanisms are still unclear. The interaction between mitochondria and cytosolic proteostasis is crucial for treating proteopathies, and there is potential for stimulating mitochondrial-mediated cytosolic proteostasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Tsialtas, Achilleas Georgantopoulos, Maria E. Karipidou, Foteini D. Kalousi, Aikaterini G. Karra, Demetrios D. Leonidas, Anna-Maria G. Psarra
Summary: Estrogens play a crucial role in regulating both reproductive and non-reproductive system physiology, with a particular impact on the nervous system. The presence of mitochondrial estrogen receptor beta (mtER beta) has been shown to directly participate in neuronal physiology maintenance. Overexpression of mtER beta in N2A cells enhances resistance to apoptotic stimuli, suggesting its potential as a therapeutic target for degenerative diseases associated with mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Masato Ishizuka, Mutsuo Harada, Seitaro Nomura, Toshiyuki Ko, Yuichi Ikeda, Jiaxi Guo, Satoshi Bujo, Haruka Yanagisawa-Murakami, Masahiro Satoh, Shintaro Yamada, Hidetoshi Kumagai, Yoshihiro Motozawa, Hironori Hara, Takayuki Fujiwara, Tatsuyuki Sato, Norifumi Takeda, Norihiko Takeda, Kinya Otsu, Hiroyuki Morita, Haruhiro Toko, Issei Komuro
Summary: Cxcr7, abundantly expressed in cardiomyocytes, may act as a beta-arrestin-biased receptor to contribute to heart protection. Fibroblast-specific Cxcr7 knockout did not significantly impact cardiac phenotypes post-myocardial infarction, suggesting a potential therapeutic target for myocardial infarction.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Wei-Xing Ma, Chun-Yan Li, Ran Tao, Xin-Ping Wang, Liang-Jun Yan
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Toxicology
Xiaorong Yang, Xuefei Sun, Jinzi Wu, Jinteng Ma, Peipei Si, Litian Yin, Yu Zhang, Liang-Jun Yan, Ce Zhang
TOXICOLOGY LETTERS
(2020)
Article
Cell Biology
Victor J. T. Lin, Jiangnan Hu, Ashwini Zolekar, Liang-Jun Yan, Yu-Chieh Wang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Liang-Jun Yan
Summary: Diabetic kidney disease (DKD) is a common and severe complication of diabetes, mainly driven by NADH/NAD(+) redox imbalance and mitochondrial dysfunction. The review discusses strategies to counteract DKD, including the use of mitochondria-targeted antioxidants and caloric restriction.
Editorial Material
Biochemistry & Molecular Biology
Liang-Jun Yan
Article
Pharmacology & Pharmacy
Yan-Li Li, Xin-Rui Chang, Jin-Teng Ma, Xin Zhao, Li-Tian Yin, Liang-Jun Yan, Jun-Hong Guo, Ce Zhang, Xiao-Rong Yang
Summary: This study investigated the role of peripheral group III metabotropic glutamate receptors in formalin-evoked nociception, showing that agonists of these receptors can reduce pain by inhibiting pro-inflammatory cytokines in the spinal cord.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Liang-Jun Yan, Daniel C. Allen
Summary: Cadmium, a nonessential metal heavily polluting the environment, can cause chronic damage to the kidneys, mainly accumulating in and damaging the proximal tubule of nephrons. Oxidative damage serves as a unifying mechanism for cadmium-induced renal toxicity, with antioxidants potentially ameliorating the injury.
Editorial Material
Biochemistry & Molecular Biology
Liang-Jun Yan
Review
Biochemistry & Molecular Biology
Amany Iskander, Liang-Jun Yan
Summary: Cisplatin is an FDA-approved anti-cancer drug widely used for solid tumor treatment, but its severe side effects, particularly kidney toxicity, restrict its clinical applications. This review covers the mechanisms of cisplatin-induced kidney injury, including oxidative stress, inflammation, and renal fibrosis. It also explores the potential roles of NAD(+)-dependent redox enzymes in ameliorating cisplatin-induced kidney injury and the protective effects of natural products derived from plants. The general procedures for creating animal models of cisplatin-induced kidney injury involving mice and rats are also discussed.
Review
Biochemistry & Molecular Biology
Liang-Jun Yan
Summary: Diabetic nephropathy (DN) is a common complication of diabetes mellitus, and there are currently no effective treatments available. Understanding the biochemical and molecular mechanisms of DN requires the use of animal models, and one widely used model is the non-obese type 2 diabetes induced by nicotinamide and streptozotocin in rodents.
Article
Biochemistry & Molecular Biology
Liang-Jun Yan, Yucheng Wang
Summary: This article reviews the various roles of DLDH in different pathological conditions, including its deficiency in humans, its role in stroke and neuroprotection, skin photoaging, Alzheimer's disease, and DLDH as a nondehydrogenating protein, as well as the construction of genetically modified animal models to study the role of DLDH in specific pathological conditions. Understanding the redox and nonredox features of DLDH may lead to the discovery of druggable targets for disease interventions.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Multidisciplinary Sciences
Zhao Liu, Mengjie Liu, Gongwei Jia, Jiani Li, Lingchuan Niu, Huiji Zhang, Yunwen Qi, Houchao Sun, Liang-Jun Yan, Jingxi Ma
Summary: Intermittent fasting (IF) is a form of time restricted eating with potential neuroprotective effects. This study investigated the effect of IF on cerebral angiogenesis in ischemic rats. The results showed that long-term IF improved neurological outcomes, increased microvessel density (MVD), and activated the GDF11/ALK5 signaling pathway.
Review
Nutrition & Dietetics
Sulin F. Kamt, Jiankang Liu, Liang-Jun Yan
Summary: The kidney is a crucial organ functioning in waste elimination and nutrient reabsorption, as well as blood pressure regulation, electrolyte balance, blood pH homeostasis, erythropoiesis, and vitamin D maturation. However, due to its heavy workload and constant exposure to insults, both acute kidney injury (AKI) and chronic kidney disease (CKD) can develop. Unfortunately, there are currently no effective therapeutic managements for AKI or CKD, highlighting the urgent need for novel approaches in treating kidney injury.
Review
Biochemistry & Molecular Biology
Liang-Jun Yan
Summary: The kidneys are vulnerable to both acute kidney injury (AKI) and chronic kidney disease (CKD), with animal models being crucial for studying the pathological mechanisms of kidney disease. This article reviews a widely used animal model of kidney disease induced by folic acid (FA), discussing the major mechanisms of FA-induced kidney injury and its application in testing therapeutic approaches.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Si-Qun Jing, Sai-Sai Wang, Rui-Min Zhong, Jun-Yan Zhang, Jin-Zi Wu, Yi-Xian Tu, Yan Pu, Liang-Jun Yan
NEURAL REGENERATION RESEARCH
(2020)