Article
Chemistry, Multidisciplinary
Ken-ichi Shinohara, Yuu Makida, Takashi Oohashi, Ryoga Hori
Summary: In this study, the observation of a molecule walking along a synthetic helical polymer chain is reported. The movement is driven by van der Waals interactions and the tapping effect of an atomic force microscopy tip. The phenomenon is recorded using a fast-scanning atomic force microscope and simulated through molecular dynamics calculations. Based on these findings, the principle of a polymer molecular motor is proposed.
Article
Chemistry, Multidisciplinary
Hao Li, Pu Wang, Chen Zhu, Wei Zhang, Meng Zhou, San Zhang, Chunfeng Zhang, Yapei Yun, Xi Kang, Yong Pei, Manzhou Zhu
Summary: This study presents intercluster hierarchical triple-helical structures of all-thiol-stabilized Au6Cu6(4-MeOBT)12 nanoclusters from both molecular and supramolecular perspectives. Abundant intermolecular interactions were found to be beneficial for the organization of the triple-helical superstructure of metal clusters. Additionally, different electronic structures between nanocluster monomers and helical aggregates were observed through DFT calculations and experimental measurements.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Hui Wang, Xiaohua Liu, Lifeng Tan
Summary: A new ruthenium(II) polypyridyl complex [Ru(dmb)(2)dppz-idzo](2+)(dmb = 4,4'-dimethyl-2,2'-bipyridine, dppz-idzo = dppz-imidazolone) has been synthesized and characterized in this study for developing new luminescent probes for RNA. The binding properties of this complex to RNA duplex and triplex structures have been investigated, revealing intercalation as the binding mode. Moreover, the fluorescence titrations show that this complex can serve as a molecular light switch for both duplex and triplex structures. Thermal denaturation studies demonstrate that this complex can significantly stabilize RNA duplex and triplex structures. These findings provide valuable insights into the understanding of Ru(II) complex binding with different structural RNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Christopher A. Ryan, Vladislavs Baskevics, Martins Katkevics, Eriks Rozners
Summary: In triplex-forming peptide nucleic acid, a novel 2-guanidyl pyridine nucleobase (V) can recognize up to two cytosine interruptions in polypurine tracts of dsRNA by engaging the entire Hoogsteen face of C-G base pair. Insights from ab initio and molecular dynamics simulations revealed the H-bonding interactions that stabilize V · C-G triplets. Our findings provide guidance for future design of improved nucleobases, advancing the goal of recognizing any sequence of dsRNA.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Xindong Xu, Qing Wang, Siya Xue, Yuxue Pan, Shan Chen
Summary: The study found that alkali-neutralization treatment can effectively reduce the size of curdlan's triple-helical aggregates while increasing the relative amount of independent triple helices. The treatment does not alter the primary structure of curdlan chains, but affects the crystalline structure and hydrogen bonding of curdlan.
CARBOHYDRATE POLYMERS
(2021)
Review
Biochemistry & Molecular Biology
Kathleen E. Orrell, Roman A. Melnyk
Summary: Large clostridial toxins (LCTs) are a family of disease-causing proteins characterized by their large size and conserved multidomain architectures; the discovery of LCT-like T domains in diverse bacteria has provided new insights into LCT translocation.
TRENDS IN BIOCHEMICAL SCIENCES
(2021)
Review
Engineering, Biomedical
Jean -Daniel Malcor, Frederic Mallein-Gerin
Summary: This review article discusses the use of triple-helical peptides as efficient tools to improve cell-biomaterial interactions in tissue engineering. Triple-helical peptides are bioactive molecules that mimic the architectural and biological properties of collagen. They have been successfully used to specifically recognize cell-surface receptors and provide cells seeded on biomaterials with controlled biological cues. Functionalization with triple-helical peptides has enabled researchers to improve cell function for regenerative medicine applications, such as tissue repair. However, this approach still remains under-explored and most functionalization strategies reported in the literature are unable to address collagen-binding receptors.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Physical
Chih-Hao Huang, Ya-Chiao Lee, Tetsuhiro Kudo, Xu Shi, Kosei Ueno, Teruki Sugiyama, Hiroaki Misawa, Hiroshi Masuhara
Summary: In this study, optical trapping with fabricated gold nanodisk arrangement was used to observe the trapping and arrangement of gold nanoparticles between the nanodisks, as well as the bidirectional and unidirectional swarming behavior of the nanoparticles. These findings provide valuable insights into optical manipulation techniques coupled with fabricated nanostructures, expanding the possibilities for optical trapping and related research.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Mohammad Kianezhad, Mehrdad Youzi, Mehran Vaezi, Hossein Nejat Pishkenari
Summary: With molecular dynamics simulations and potential energy analysis, this study evaluates the motion characteristics of C-60 and C-60-based nanovehicles on graphene and hexagonal boron-nitride (BN) surfaces. It is found that C-60 is more stable on boron-nitride impurity regions and its motion is restricted by an energy barrier. A boron-nitride nanoroad with graphene is designed to confine the surface motion of C-60 and nanovehicles. Furthermore, a temperature gradient is applied to achieve unidirectional transport on the surface.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Naoki Hosokawa, Masahiro Kuragano, Atsuki Yoshino, Keitaro Shibata, Taro Q. P. Uyeda, Kiyotaka Tokuraku
Summary: The study focuses on the cooperative interaction between fimbrin and actin filaments in forming parallel bundles. It was found that the actin-binding domain of fimbrin promotes the well-ordered arrangement of actin filaments, while its interaction with the glass surface affects bundle formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Guanglei Dong, Zhonghua Pan, Baoliang Han, Yunwen Tao, Xin Chen, Geng-Geng Luo, Panpan Sun, Cunfa Sun, Di Sun
Summary: This study presents an atom-precise 18-copper nanocluster (Cu18H) with a pseudo D-3-symmetrical triple-helical Cu-15 core. Cu18H exhibits unique multi-layered 3D chirality and forms an infinite double-stranded helix through intra-strand and inter-strand interactions. The hierarchical assemblies of Cu18H not only resemble the structure of DNA but also exhibit crystallization-induced emission enhancement and aggregation-induced emission enhancement effects, as well as efficient catalysis of electron transfer reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Manufacturing
Shun Zhang, Feng Jiao, Xue Wang, Ying Niu
Summary: A novel predictive cutting force model of helical milling for unidirectional CFRP was established in this study, which was validated through experiments to effectively predict the cutting force.
JOURNAL OF MANUFACTURING PROCESSES
(2021)
Article
Mechanics
Naresh Jada, Sambasiva Rao Ganneboyina, Soubhik Kumar Bhaumik
Summary: This study investigates two-phase flow in a triple-helical microchannel (THM) and identifies different parallel flow regimes. The stability and flow intensification of these regimes are evaluated based on experimental results, revealing novel phenomena and physics.
Article
Chemistry, Organic
Fengbo Liu, Shagor Chowdhury, Roselyne Rosas, Valerie Monnier, Laurence Charles, Hakim Karoui, Didier Gigmes, Olivier Ouari, Floris Chevallier, Christophe Bucher, Anthony Kermagoret, Simin Liu, David Bardelang
Summary: A viologen-phenylene-imidazole (VPI) conjugate can form antiparallel triple stacks in water with cucurbit[10]uril (CB[10]), pairwise complexing the guest trimer. The quinary host:guest 2:3 complex displays features assignable to charge-transfer interactions, and under reductive conditions, CB[10] can solubilize a VPI radical.
Article
Materials Science, Textiles
Milad Razbin, Roohollah Bagherzadeh
Summary: In this work, the longitudinal modulus of helical auxetic yarn (HAY) reinforced unidirectional composite is predicted using lamina theories through elasticity and rule of the mixture approach. The proposed model is able to recognize the effect of wrapping angle on the longitudinal modulus of HAY reinforced unidirectional composite.
JOURNAL OF THE TEXTILE INSTITUTE
(2023)
Article
Materials Science, Paper & Wood
Kalavathy Rajan, Angele Djioleu, Gurshagan Kandhola, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
Article
Nutrition & Dietetics
Namika Miya, Asuka Uratani, Keita Chikamoto, Yuki Naito, Keiji Terao, Yutaka Yoshikawa, Hiroyuki Yasui
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)
Article
Polymer Science
Bakul Akter, Ariful Islam Khan, Subarna Karmaker, Pollob Ghosh, Soma Saha, Shakil Ahmed Polash, Zinia Islam, Satya Ranjan Sarker, Md Sharif Hossain, Hiroyuki Yasui, Tapan Kumar Saha
Summary: The study revealed a strong interaction between Zinc(II) ions and γ-PGA at pH 5, with binding kinetic data following a pseudo-second-order kinetic model and maximum binding capacity varying with temperature. Zn(γ-PGA) complex exhibited antimicrobial activity against both gram-negative and gram-positive bacteria.
Article
Chemistry, Medicinal
Kenji Arimitsu, Yusuke Yagi, Kazuhiro Koshino, Yukina Nishito, Takahiro Higuchi, Hiroyuki Yasui, Hiroyuki Kimura
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Kenji Arimitsu, Hiroki Iwasaki, Hiroyuki Kimura, Hiroyuki Yasui
Summary: The study found that the rare sugar D-allulose forms high-affinity complexes with boronic acids, with the interaction mainly occurring through the 2,3-hydroxy groups of alpha-allulofuranose in aqueous solution and the 3,5-hydroxy groups of beta-allulopyranose in organic solvents.
Article
Biochemical Research Methods
Yuto Kondo, Hiroyuki Kimura, Chiaki Fukumoto, Yusuke Yagi, Yasunao Hattori, Hidekazu Kawashima, Hiroyuki Yasui
Summary: This study discussed the advantages and potential of copper-mediated radioiodination using aryl boronic precursors in radiochemistry, with a focus on the impact of protecting groups on radiolabeling efficiency.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2021)
Article
Chemistry, Medicinal
Takenori Furukawa, Hiroyuki Kimura, Hanae Torimoto, Yusuke Yagi, Hidekazu Kawashima, Kenji Arimitsu, Hiroyuki Yasui
Summary: Erythropoietin-producing hepatocellular (Eph) receptors, particularly EphA2, are involved in cancer proliferation and migration. The synthesized imaging tracer [I-123]ETB shows potential for cancer diagnosis by specifically targeting EphA2 receptors using SPECT imaging technology.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Nutrition & Dietetics
Yuki Hashimoto, Katsuhiko Yoshizawa, Yuka Kaido, Akiko Takenouchi, Keiji Terao, Hiroyuki Yasui, Yutaka Yoshikawa
Summary: Studies have shown that the antioxidant capacity of the complex of gamma-cyclodextrin (CD) and alpha-lipoic acid (ALA) is higher than that of free ALA. Supplementation with CD/ALA can improve antioxidant activity and performance during high-intensity exercise.
Article
Biochemistry & Molecular Biology
Fumie Hamano, Suzumi M. Tokuoka, Megumi Ishibashi, Yasuto Yokoi, Dieter M. Tourlousse, Yoshihiro Kita, Yuji Sekiguchi, Hiroyuki Yasui, Takao Shimizu, Yoshiya Oda
Summary: This study explored the relationship between stool condition and various omics data in captive monkeys, focusing on the phenotype of stool water content. By analyzing the monkeys' food intake and evaluating their stool, urine, and plasma, the researchers aimed to understand the health status of individual monkeys comprehensively. The metabolomic, lipidomic, metallomic, and intestinal microbiota analyses suggested correlations between lipid-related metabolites, selenium, bacterial species, and stool water content, raising the hypothesis of redox imbalance causing minor health problems.
Article
Materials Science, Paper & Wood
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Joseph Batta-Mpouma, Nicole Labbe, Joshua Sakon, Benjamin A. Babst, Anindya Ghosh, Danielle Julie Carrier, Jin-Woo Kim
Summary: Cellulose nanocrystals (CNCs) are renewable and biocompatible nanomaterials with unique properties. The production and properties of CNCs from different wood species were investigated. The results showed that the type of wood species had an impact on the yield, purity, and properties of CNCs. This study provides insights into optimizing CNC production and usage for different applications.
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Joseph Batta-Mpouma, Gurshagan Kandhola, Joshua Sakon
Summary: Cellulose nanocrystals (CNCs) can be crosslinked to form nanoparticle-based hydrogels with tunable physicochemical properties, which improves the instability issue of CNCs in moist environments. The strength of intermolecular hydrogen bonding can be controlled by the type and concentration of crosslinkers as well as the CNC concentration. By changing the crosslinking conditions, the surface chemistry of CNCs can be transformed from hydrophilic to hydrophobic, and the topology and aqueous stability of self-assembled structures can be tuned.
Article
Chemistry, Medicinal
K. Yamashita, T. Ogihara, M. Hayashi, T. Nakagawa, Y. Ishizaki, M. Kume, L. Yano, R. Niigata, J. Hiraoka, H. Yasui, T. Nakamura
Article
Infectious Diseases
Yukako Yasui, Hiroyuki Yasui, Kumiko Suzuki, Takako Saitou, Yoshiki Yamamoto, Toshihiko Ishizaka, Kouji Nishida, Shingo Yoshihara, Iwao Gohma, Yoshihiko Ogawa
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2020)
Article
Nutrition & Dietetics
Namika Miya, Yuki Naito, Keita Chikamoto, Keiji Terao, Yutaka Yoshikawa, Hiroyuki Yasui
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)
Article
Biotechnology & Applied Microbiology
Gurshagan Kandhola, Angele Djioleu, Kalavathy Rajan, Nicole Labbe, Joshua Sakon, Danielle Julie Carrier, Jin-Woo Kim
BIORESOURCES AND BIOPROCESSING
(2020)