Review
Biochemical Research Methods
Stephen Safe, Rupesh Shrestha, Kumaravel Mohankumar
Summary: The NR superfamily of transcription factors encodes important genes for maintaining cellular homeostasis and pathophysiology. The orphan receptor NR4A1 and its sub-family members play key roles in immune function and have potential clinical applications for treating various diseases. Various compounds have been identified as NR4A1 ligands, showing promise in cancer, endometriosis, metabolic, and inflammatory diseases.
EXPLORING NUCLEAR RECEPTORS
(2021)
Review
Endocrinology & Metabolism
Livia Odagiu, Julia May, Salix Boulet, Troy A. Baldwin, Nathalie Labrecque
Summary: The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes induced by various signals, acting as transcription factors in T cells. Their activity is regulated by expression levels rather than ligand binding, impacting aspects of thymic differentiation and peripheral T cell responses.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Marie-Charlotte Meinsohn, Camilla H. K. Hughes, Anthony Estienne, Hatice D. Saatcioglu, David Pepin, Raj Duggavathi, Bruce D. Murphy
Summary: The study found that NR5A2 plays an important role in follicular development, with its depletion leading to changes in follicle numbers and development. The expression of NR5A2 prepares primordial follicles for entry into the developing pool.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xudan Li, Quancheng Chen, Jie Liu, Shenjin Lai, Minda Zhang, Tidong Zhen, Hongyu Hu, Xiang Gao, Alice S. T. Wong, Jin-Zhang Zeng
Summary: In this study, Bkh126 is shown to have therapeutic efficacy in HCC by activating the silenced Nur77 and aggravating the pre-activated UPR. Mechanistically, Bkh126 induces Nur77 to sense IRE1 alpha-ASK1-JNK signaling and translocate to the mitochondria, leading to cell death.
Article
Chemistry, Medicinal
Daniel Zaienne, Silvia Arifi, Julian A. Marschner, Jan Heering, Daniel Merk
Summary: This research identified potential pharmacological modulation of NOR-1, with one drug exhibiting agonist or antagonist potency and altering NOR-1 regulated gene expression in a cellular setting.
Article
Multidisciplinary Sciences
Elise W. Wolf, Zachary P. Howard, Lihui Duan, Hanson Tam, Ying Xu, Jason G. Cyster
Summary: GPR174 plays a role in activating B cells and modulating B cell gene expression. The findings suggest a potential pathway for improving in vitro study of B cell responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Juan Pablo Rigalli, Dirk Theile, Julie Nilles, Johanna Weiss
Summary: PXR interacts with RXRα to regulate drug metabolism, immune function, and cancer pathogenesis; its activity is regulated by coactivator and corepressor proteins; studies indicate cell- and ligand-specific differences in PXR activation.
Article
Immunology
David E. Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J. Hall, Jacob I. Sznajder, Evelyn P. Murphy, Daniel Crean, Eoin P. Cummins
Summary: The NR4A family members NR4A2 and NR4A3 have distinct and common roles in transcriptional regulation in monocytes, with NR4A2 associated with antigen presentation and MHC genes, and NR4A3 linked to viral response pathways. Functional studies suggest preferential roles for NR4A2 in antigen processing and common roles for both NR4A2 and NR4A3 in cell migration. This study provides new insights into the mechanisms of action of NR4A2 and NR4A3 in monocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lejla Medzikovic, Hylja Heese, Pieter B. van Loenen, Cindy P. A. A. van Roomen, Ingeborg B. Hooijkaas, Vincent M. Christoffels, Esther E. Creemers, Carlie J. M. de Vries, Vivian de Waard
Summary: Nur77 regulates cardiac fibrosis by promoting CF-to-MyoFB transition intrinsically and inhibiting cardiomyocyte-driven paracrine TGF-beta-mediated MyoFB differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mi Cheong Cheong, Zhu Wang, Tegegn G. Jaleta, Xinshe Li, James B. Lok, Steven A. Kliewer, David J. Mangelsdorf
Summary: The nematode-specific nuclear receptor DAF-12 interacts with a parasite-specific coactivator DIP-1 in Strongyloides spp., crucial for development and infectious stage reactivation. CRISPR/Cas9 mutagenesis studies confirm the essential role of DAF-12 and DIP-1 in governing parasite development. This reveals a distinct nuclear receptor/coactivator signaling pathway in parasite development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Katherine M. Delaney, Alexa Barad, Luisa F. Castillo, Chloe M. Hasund, Ronnie Guillet, Eva K. Pressman, Philip J. Katzman, Tomas Ganz, Elizabeta Nemeth, Kimberly O. O'Brien
Summary: This study investigates the expression of iron regulatory proteins ERFE, EPO, and NCOA4 in the placenta and their associations with maternal and neonatal iron status. The results show that ERFE, EPO, and NCOA4 mRNA are expressed in the placenta as early as 25 weeks of gestation. However, the expression of ERFE and EPO is not associated with iron status, while NCOA4 is associated with poor iron status in both mothers and newborns.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Eiichi Kusagawa, Chiharu Okuda, Rikako Yamaguchi, Kaori Nakano, Yasunobu Miyake, Takao Kataoka
Summary: Cucurbitacin B down-regulates TNF-alpha-induced ICAM-1 expression and inhibits the inflammatory response in lung adenocarcinoma cells by modulating the TNF-R1 expression in the NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Guanxin Zhang, Qing Qin, Chen Zhang, Xiaobo Sun, Kyosuke Kazama, Bing Yi, Fang Cheng, Zhi-Fu Guo, Jianxin Sun
Summary: The study finds that NDRG1 plays an essential role in cell differentiation, proliferation, and stress responses. The expression of NDRG1 significantly increases in cytokine-stimulated endothelial cells and atherosclerotic lesions. Inhibition of NDRG1 not only suppresses the expression of procoagulant molecules but also exerts antithrombotic effects in endothelial cells, highlighting its potential as a therapeutic target for vascular diseases.
CIRCULATION RESEARCH
(2023)
Article
Oncology
Minda Zhang, Zeyu Shi, Shuaishuai Zhang, Xudan Li, Sally Kit Yan To, Yijia Peng, Jie Liu, Siming Chen, Hongyu Hu, Alice Sze Tsai Wong, Jin-Zhang Zeng
Summary: English Summary: Compound K (CK) derived from ginseng binds and modulates Nur77 phosphorylation to inhibit cancer stem-cell-like cells (CSCs) and suppress colorectal cancer (CRC) metastasis. CK disrupts the Nur77-Akt feed-forward loop, inactivates PI3K/Akt, and reactivates the silenced Dicer transcription under a hypoxic microenvironment. CK shows potential as a nutraceutical against CRC and offers an alternative strategy for PI3K/Akt inactivation by targeting Nur77, overcoming concerns aboutdrug selectivity and safety.
Article
Biochemistry & Molecular Biology
Andrew D. Huber, William C. Wright, Wenwei Lin, Kinjal Majumder, Jonathan A. Low, Jing Wu, Cameron D. Buchman, David J. Pintel, Taosheng Chen
Summary: This study found that mutating a single residue in the PXR receptor can convert the antagonist SPA70 into an agonist. Molecular dynamics simulations revealed that in certain cases, the action of SPA70 is similar to that of agonists, further elucidating the relationship between the structure and activity of the PXR receptor.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Correction
Cell Biology
Aurore L'honore, Pierre-Henri Commere, Jean-Francois Ouimette, Didier Montarras, Jacques Drouin, Margaret Buckingham
DEVELOPMENTAL CELL
(2016)
Article
Neurosciences
Panojot Bifsha, Aurelio Balsalobre, Jacques Drouin
MOLECULAR NEUROBIOLOGY
(2017)
Article
Oncology
Laura C. Hernandez-Ramirez, Ryhem Gam, Nuria Valdes, Maya B. Lodish, Nathan Pankratz, Aurelio Balsalobre, Yves Gauthier, Fabio R. Faucz, Giampaolo Trivellin, Prashant Chittiboina, John Lane, Denise M. Kay, Aggeliki Dimopoulos, Stephan Gaillard, Mario Neou, Jerome Bertherat, Guillaume Assie, Chiara Villa, James L. Mills, Jacques Drouin, Constantine A. Stratakis
ENDOCRINE-RELATED CANCER
(2017)
Article
Developmental Biology
Stephen Nemec, Aurelie Huang Sung, Jacques Drouin
DEVELOPMENTAL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Alexandre Mayran, Jacques Drouin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Genetics & Heredity
Alexandre Mayran, Konstantin Khetchoumian, Fadi Hariri, Tomi Pastinen, Yves Gauthier, Aurelio Balsalobre, Jacques Drouin
Article
Biology
Aurore L'honore, Pierre-Henri Commere, Elisa Negroni, Giorgia Pallafacchina, Bertrand Friguet, Jacques Drouin, Margaret Buckingham, Didier Montarras
Article
Multidisciplinary Sciences
Alexandre Mayran, Kevin Sochodolsky, Konstantin Khetchoumian, Juliette Harris, Yves Gauthier, Amandine Bemmo, Aurelio Balsalobre, Jacques Drouin
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
Konstantin Khetchoumian, Aurelio Balsalobre, Alexandre Mayran, Helen Christian, Valerie Chenard, Julie St-Pierre, Jacques Drouin
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Blandine Ponroy Bally, W. Todd Farmer, Emma V. Jones, Selin Jessa, J. Benjamin Kacerovsky, Alexandre Mayran, Huashan Peng, Julie L. Lefebvre, Jacques Drouin, Arnold Hayer, Carl Ernst, Keith K. Murai
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Ines Desanlis, Yacine Kherdjemil, Alexandre Mayran, Yasser Bouklouch, Claudia Gentile, Rushikesh Sheth, Rolf Zeller, Jacques Drouin, Marie Kmita
NATURE COMMUNICATIONS
(2020)
Review
Endocrinology & Metabolism
Juliette Harris, Arthur Gouhier, Jacques Drouin
Summary: Pioneer transcription factors play crucial roles in cell fate specification by accessing closed heterochromatin, remodeling chromatin, and activating new gene subsets. Pax7 is the only well-documented pioneer factor in pituitary development, specifying the fate of melanotrope cells in the intermediate lobe. The potent activity of pioneer factors in reprogramming gene expression has been associated with tumor development, with overexpression or chromosomal translocations leading to the production of chimeric pioneers in different cancers.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Audrey Pelletier, Alexandre Mayran, Arthur Gouhier, James G. Omichinski, Aurelio Balsalobre, Jacques Drouin
Summary: The pioneer transcription factor Pax7 contains two DNA binding domains, both of which are required for efficient binding to composite DNA target sites. Unique protein:DNA interactions are necessary for Pax7 pioneer action on heterochromatin sites.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Irene Delgado, Giovanna Giovinazzo, Susana Temino, Yves Gauthier, Aurelio Balsalobre, Jacques Drouin, Miguel Torres
Summary: Meis1 and Meis2 are homeodomain transcription factors that regulate organogenesis by cooperating with Hox proteins. Inactivation of Meis1/2 in the lateral plate mesoderm leads to limb agenesis in mouse embryos, with Meis and Tbx factors co-binding and co-regulating enhancers of Fgf10. Limbs with deleted Meis alleles show skeletal hypoplasia and agenesis of posterior elements due to their early role in establishing limb antero-posterior prepattern.
NATURE COMMUNICATIONS
(2021)
Article
Developmental Biology
Stephen Nemec, Maeva Luxey, Deepak Jain, Aurelie Huang Sung, Tomi Pastinen, Jacques Drouin