Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Immunology
Shelby M. Knoche, Alaina C. Larson, Gabrielle L. Brumfield, Steven Cate, William H. Hildebrand, Joyce C. Solheim
Summary: Pancreatic cancer cells can evade the immune system by downregulating MHC class I expression, and EGFR inhibitors can increase MHC class I surface expression. Therefore, the combination of EGFR inhibitors and immunotherapy may be beneficial in combating pancreatic cancer.
IMMUNOLOGIC RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober, Donghun Shin
Summary: The differentiation of liver progenitor cells (LPCs) into hepatocytes is crucial for reducing inflammation and fibrosis in chronic liver diseases. Inhibition of the epidermal growth factor receptor (EGFR) signaling pathway promotes LPC-to-hepatocyte differentiation and may serve as a proregenerative therapeutic approach for patients with advanced liver disease. This study provides insights into the mechanisms underlying LPC-mediated liver regeneration and suggests the potential of EGFR inhibitors as a treatment option.
Article
Cell Biology
Jeng-Chang Chen, Wendy Yang, Li-Yun Tseng, Hsueh-Ling Chang
Summary: This study explores the effects of neurosphere medium (NSM) and self-renewal medium (SRM) on the development of enteric neural stem cells (ENSCs) in vitro. The results show that the different compositions of NSM and SRM lead to distinct outcomes, with epidermal growth factor inhibiting enteric neuronal wiring in NSM, while basic fibroblast growth factor promotes neurogenesis and gangliogenesis in ENSCs.
Article
Biochemistry & Molecular Biology
Tasmia Ahmed, Paola Cruz Flores, Christopher C. Pan, Hannah R. Ortiz, Yeon S. Lee, Paul R. Langlais, Karthikeyan Mythreye, Nam Y. Lee
Summary: Insulin signaling in blood vessels stimulates angiogenesis and maintains vascular homeostasis. We discovered a crosstalk between the insulin receptor and ALK1, which activates Smad1/5 and induces EPDR1 expression, promoting angiogenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yi Zhou, Jack P. K. Bravo, Hannah N. Taylor, Jurre A. Steens, Ryan N. Jackson, Raymond H. J. Staals, David W. Taylor
Summary: The cryo-electron microscopy structure of a type IV-B CRISPR ribonucleoprotein complex was revealed at 3.9-angstrom resolution, showing a resemblance to type III-A CRISPR Csm effector complex but lacking subunits for RNA processing and target DNA cleavage. Surprisingly, the complex does not assemble around a CRISPR-derived RNA, but instead assembles around heterogeneous RNA in a pseudo-A-form configuration. These findings provide insight into the assembly and function of enigmatic type IV CRISPR systems, expanding our understanding of class I CRISPR-Cas system architecture.
Article
Chemistry, Multidisciplinary
Priyanka Dhakane, Varun Sai Tadimarri, Shrikrishnan Sankaran
Summary: Regenerative medicine aims to restore damaged cells, tissues, and organs by using growth factors to stimulate regenerative cellular transformations. However, the clinical application of growth factors is limited due to stability issues and the need for precise regulation. This study explores the use of engineered living materials (ELMs) containing live microorganisms as a strategy to overcome these limitations. The development of an ELM that releases a pro-angiogenic protein in a light-regulated manner is described.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Suzuki, Koji Sakamoto, Yoshio Nakahara, Atsushi Enomoto, Jun Hino, Akira Ando, Masahide Inoue, Yukihiro Shiraki, Norihito Omote, Masahiro Kusaka, Jun Fukihara, Naozumi Hashimoto
Summary: In this study, a novel subpopulation of lung fibroblasts expressing meflin was found to have antifibrotic properties by regulating TGF-beta signaling. Growth differentiation factor 10 (Gdf10) encoding bone morphogenic protein 3b (BMP3b) was identified as a downstream molecule regulated by meflin, which played an antifibrotic role in lung fibroblasts. Supplementation of recombinant BMP3B could be a potential therapeutic strategy for fibrotic lung diseases.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Oncology
E. Zhou, Feng Wu, Mengfei Guo, Zhengrong Yin, Yumei Li, Minglei Li, Hui Xia, Jingjing Deng, Guanghai Yang, Yang Jin
Summary: The established ERS in this study can predict a poor prognosis for LUAD patients and has the potential to predict drug responses.
FRONTIERS IN ONCOLOGY
(2022)
Review
Dermatology
Sun Hye Shin, Young Gue Koh, Woo Geon Lee, Joon Seok, Kui Young Park
Summary: Epidermal growth factor (EGF) is essential for wound healing and tissue homeostasis. Recombinant human EGF (rhEGF) has been proven to promote skin wound healing and has potential clinical applications in dermatological conditions beyond wound healing. However, there is a scarcity of studies on its use in these conditions. In this article, we searched PubMed/Medline and Google Scholar databases to summarize the effects of rhEGF in various skin problems.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Proma Bhattacharya, Moumita Kundu, Subhayan Das, Yash Verma, Mahitosh Mandal, Sudarsan Neogi
Summary: This study developed a nanocomposite hydrogel for wound healing by incorporating magnesium oxide nanoparticles, which significantly improved the properties of the hydrogel and demonstrated good biocompatibility and stimulated cell growth.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Faris Alrumaihi
Summary: A bioinformatic approach was used to screen compounds that can bind to the kinase domain of HER2. Three compounds with good binding affinity were identified, namely LAS_51187157, LAC_51217113, and LAC_51390233.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Christopher Nardone, Brad A. Palanski, Daniel C. Scott, Richard T. Timms, Karl W. Barber, Xin Gu, Aoyue Mao, Yumei Leng, Emma V. Watson, Brenda A. Schulman, Philip A. Cole, Stephen J. Elledge
Summary: The TFE3 and MITF master transcription factors regulate lysosomal, melanocytic, and autophagy genes to maintain metabolic homeostasis. Previous studies suggested that their cytosolic retention mediated by the Rag GTPases-mTORC1 was essential for suppressing transcriptional activity in the presence of nutrients. However, our experiments in mammalian cells demonstrate that regulated protein stability plays a fundamental role in their control.