Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Infectious Diseases
Tomomi Kobatake, Keiki Ogino, Hiroyuki Sakae, Kazuyoshi Gotoh, Akari Watanabe, Osamu Matsushita, Hiroyuki Okada, Kenji Yokota
Summary: The study found that disulfiram has bactericidal effects on Helicobacter pylori at low concentrations, suggesting it can serve as a supplement to current H. pylori eradication drugs.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Microbiology
Leilei Wu, Fei Jiang, Xiaobing Shen
Summary: CagA potentially regulates the biological function of GC cells through the miR-155-5p/SMAD2/SP1 axis. miR-155-5p could be a therapeutic target for GC related to CagA.
Article
Medicine, Research & Experimental
Zong-Bao Yan, Jin-Yu Zhang, Yi-Pin Lv, Wen-Qing Tian, Zhi-Guo Shan, Fang-Yuan Mao, Yu-Gang Liu, Wan-Yan Chen, Pan Wang, Yun Yang, Ping Cheng, Liu-Sheng Peng, Ya-Ling Liao, Geng-Yu Yue, Xiao-Lin Xu, Yong-Liang Zhao, Mu-Han Lu, Yuan Zhuang
Summary: The study found that REDD1 is increased in the gastric mucosa of H. pylori-infected patients and mice. H. pylori induced GECs to express REDD1 via the phosphorylated cagA, activating the MAPKp38 pathway. In Redd1-/- mice, gastric inflammation, MHCII+ monocyte infiltration, IL-23, and IL-17A were all attenuated.
Article
Food Science & Technology
Sebastian Diechler, Bianca E. Chichirau, Gernot Posselt, Dionyssios N. Sgouras, Silja Wessler
Summary: Research has shown that the diverse structure of CagA regulates B cell physiology, while B cell survival is independent of CagA.
Article
Gastroenterology & Hepatology
Sungil Jang, Lori M. Hansen, Hanfu Su, Jay Solnick, Jeong-Heon Cha
Summary: This study found that the number of cagA copies in Helicobacter pylori is higher in mice with less intense immune response and lower in mice with more intense immune response. Additionally, cagY recombination is also associated with H. pylori virulence.
Article
Cell Biology
Na Wang, Faying Zhou, Caiyu Chen, Hao Luo, Jingwen Guo, Wei Wang, Jian Yang, Liangpeng Li
Summary: Infection, particularly involving H. pylori, is believed to play a role in the development of atherosclerosis. Studies have shown that OMVs secreted by H. pylori accelerate atherosclerosis plaque formation by damaging endothelial cells. Components like CagA and LPS in H. pylori OMVs are implicated in this process, potentially through activation of the ROS/NF-kappa B signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
So Dam Lee, Haengdueng Jeong, Bo Ram Hwang, Byeong Min Yu, Yejin Cho, Ki Teak Nam, Hyunki Kim, Yong Chan Lee
Summary: Strains of Helicobacter pylori positive for CagA may contribute to the development of gastric cancer through the induction of CK2 activation and CK28 degradation. The downregulation of CK28 and subsequent activation of AKT and Snail signaling pathways may play a crucial role in the epithelial-to-mesenchymal transition (EMT) in gastric cancer. CK2 could be a potential molecular target for the treatment of H. pylori-infected gastric cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Ryo Kinoshita-Daitoku, Kotaro Kiga, Masatoshi Miyakoshi, Ryota Otsubo, Yoshitoshi Ogura, Takahito Sanada, Zhu Bo, Tuan Vo Phuoc, Tokuju Okano, Tamako Iida, Rui Yokomori, Eisuke Kuroda, Sayaka Hirukawa, Mototsugu Tanaka, Arpana Sood, Phawinee Subsomwong, Hiroshi Ashida, Tran Thanh Binh, Lam Tung Nguyen, Khien Vu Van, Dang Quy Dung Ho, Kenta Nakai, Toshihiko Suzuki, Yoshio Yamaoka, Tetsuya Hayashi, Hitomi Mimuro
Summary: This study reveals that a small non-coding RNA of H. pylori plays a crucial role in regulating bacterial adaptation to the host environment and production of an oncoprotein, highlighting its potential role in gastric carcinogenesis.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Judit Alarcon-Millan, Jose Bonilla-Delgado, Gloria Fernandez-Tilapa, Nayeli Goreti Nieto-Velazquez, Monica Sierra-Martinez, Victor Manuel Alvarado-Castro, Enoc Mariano Cortes-Malagon
Summary: This study investigated the prevalence of clarithromycin resistance-associated mutations in Mexican patients infected with Helicobacter pylori. The results showed a high prevalence of H. pylori infection (84.3%) among patients with gastric diseases, with the vacA s1m1/cagA+ genotype being the most frequent (44.8%). The prevalence of clarithromycin resistance-associated mutations was 19.8%, with the A2143G and A2142C mutations being the most common. Furthermore, a significant association was found between the A2142G mutation and the vacA s1m1/cagA+ genotype.
Article
Plant Sciences
Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li
Summary: The study aimed to find the most effective alkaloid against Helicobacter pylori in Rhizoma Coptidis and illustrate the probable mechanisms. The results showed that coptisine was the most effective alkaloid against H. pylori and could eradicate the bacteria through multiple mechanisms while reducing inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)