Article
Cell Biology
Erna Marija Meskyte, Laura Pezze, Laura Bartolomei, Mattia Forcato, Irene Adelaide Bocci, Giovanni Bertalot, Mattia Barbareschi, Leticia Oliveira-Ferrer, Alessandra Bisio, Silvio Bicciato, Daiva Baltriukiene, Yari Ciribilli
Summary: The oncoprotein ETV7 is up-regulated in all types of breast cancer and promotes cancer progression by increasing cell proliferation and stemness. In this study, it was found that ETV7 plays a role in breast cancer inflammation by suppressing innate immune and inflammatory responses. The down-regulation of TNFRSF1A by ETV7 reduces NF-kappa B signaling activation and there is a potential crosstalk between ETV7 and STAT3, resulting in the repression of TNFRSF1A transcription.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Ae Ryang Jung, Ga Eun Kim, Mee Young Kim, U-Syn Ha, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Yong Hyun Park
Summary: The study found that increased expression of HMGB1 in prostate cancer is associated with aggressive cancer and poor survival outcomes, while inhibiting HMGB1 expression significantly reduces cell proliferation and invasion. The interaction between HMGB1 and TNFR1 can promote tumor progression in prostate cancer through the NF-kappa B signaling pathway.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Haokun Liu, Ying Zhao, Yanfang Wu, Yutong Yan, Xiaoe Zhao, Qiang Wei, Baohua Ma
Summary: Mastitis is a common and important clinical disease in ruminants, which may lead to inflammatory fibrosis if not promptly treated. This study found that Snail plays a critical role in LPS-induced EMT in GMECs, and the mechanism is dependent on the activation of the TLR4/NF-kappa B signaling pathway.
Article
Biotechnology & Applied Microbiology
Rui Li, Lingxing Zeng, Hongzhe Zhao, Junge Deng, Ling Pan, Shaoping Zhang, Guandi Wu, Ying Ye, Jialiang Zhang, Jiachun Su, Yanfen Zheng, Shuang Deng, Ruihong Bai, Lisha Zhuang, Mei Li, Zhixiang Zuo, Dongxin Lin, Jian Zheng, Xudong Huang
Summary: The m(6)A-TNFRSF1A axis plays a critical role in the development of esophageal squamous cell carcinoma (ESCC), and may serve as a potential drug target.
Article
Medicine, Research & Experimental
Jing-Qiang Huang, He-Feng Li, Jing Zhu, Jun-Wei Song, Xian-Bin Zhang, Peng Gong, Qiu-Yu Liu, Chun-Hui Zhou, Liang Wang, Li-Yun Gong
Summary: SRPK1 is overexpressed in colon cancer and correlated with clinical stage and TNM classifications. High levels of SRPK1 are associated with poor prognosis. Mechanistically, SRPK1 enhances the anti-apoptosis ability of colon cancer cells under oxaliplatin treatment by promoting NF-κB pathway activation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Darshika J. Udawatte, Diane M. M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman
Summary: Dengue virus, a prevalent arthropod-borne virus, targets the human protein RIPK1 to evade the innate immune response. This interaction inhibits the activation of NF-kappa B, a key player in inflammation and cell death. The NS3 protein of DENV is responsible for this suppression, independent of its protease activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Eugenia Roupakia, Evangelia Chavdoula, Georgia Karpathiou, Giannis Vatsellas, Dimitrios Chatzopoulos, Angeliki Mela, Jennifer M. Gillette, Katharina Kriegsmann, Mark Kriegsmann, Anna Batistatou, Anna Goussia, Kenneth B. Marcu, Emmanouil Karteris, Apostolos Klinakis, Evangelos Kolettas
Summary: Canonical NF-kappa B signaling pathway promotes NSCLC by downregulating the metastasis suppressor CD82/KAI1, leading to cell migration, EMT, and tumour growth.
Article
Biochemistry & Molecular Biology
Ping Li, Yang Yang, Xinyu Yang, Yifei Wang, Chon-Kit Chou, Mengmeng Jiang, Jingbin Zheng, Fengyang Chen, Xin Chen
Summary: The study found that TNF receptor type II (TNFR2) is expressed in a wide range of tumor cells. Knocking out TNFR2 in mouse colon cancer cells MC38 and CT26 using CRISPR/Cas9 technology inhibited in vitro proliferation and colony formation of cancer cells through inhibition of AKT phosphorylation and promotion of autophagy-induced cell death. In addition, TNFR2 deficiency significantly impaired the in vivo growth of MC38 or CT26 tumors in mice, accompanied by a decrease in soluble TNFR2 levels in the circulation and an increase in the number of tumor-infiltrating IFN gamma+ CD8 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bin Li, Lei Zhang, Lei Zhu, Yongqiang Cao, Zhimin Dou, Qin Yu
Summary: The study revealed the significant role of HDAC5 in intestinal sepsis by inhibiting Ghrelin and related signaling pathways to promote intestinal inflammation and cell apoptosis.
Article
Cell Biology
Qingqing Sun, Yijuan Cao, Yonglian Lan, Lingling Lei, Bei Zhang, Shuyu Wang
Summary: The study found that the S100A7/NF-κB signaling pathway plays a crucial role in the pathogenesis of endometriosis, with S100A7 overexpression promoting the disease by increasing cell proliferation and inflammation, while decreasing cell apoptosis. This provides new insights into future therapeutic strategies.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Weijun Wu, Jinghuan Wang, Chenxi Xiao, Zhenghua Su, Haibi Su, Wen Zhong, Jianchun Mao, Xinhua Liu, Yi Zhun Zhu
Summary: This study confirmed that cytoplasmic protein TRAF2 can be methylated by SMYD2 and contribute to the continuous activation of NF-kappa B signaling pathway. Knocking down SMYD2 showed varying degrees of mitigation in acute and chronic inflammation mouse models. Moreover, lysine-specific demethylase LSD1 was found to resist the methylation of TRAF2 induced by SMYD2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Runyi Ye, Dongwei Liu, Hongyu Guan, NiJiati AiErken, Zeng Fang, Yawei Shi, Yunjian Zhang, Shenming Wang
Summary: The study showed that upregulation of AHNAK2 in thyroid carcinoma tissues, especially in metastatic ones, is associated with poor prognosis. Knockdown of AHNAK2 inhibited thyroid carcinoma migration, invasion, and metastasis by reducing activation of the NF-kappa B pathway. This provides a novel target for treating metastatic thyroid carcinoma.
Article
Biochemistry & Molecular Biology
Puhua Zhang, Chaolun Yu, Jianwen Yu, Zhijian Li, Hui-yao Lan, Qin Zhou
Summary: The lncRNA Arid2-IR plays a critical role in kidney diseases by regulating NF-kappa B signaling via a NLRC5-dependent mechanism, which can be inhibited by Filamin A in the cytoplasm. Targeting Arid2-IR may be a novel therapeutic strategy for inflammatory diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Ophthalmology
Min Ji, Qing Sun, Guowei Zhang, Zeyu Huang, Yujian Zhang, Qianyi Shen, Huaijin Guan
Summary: The study revealed that microglia-derived TNF-α plays a crucial role in regulating the activation of Muller cells during retinal neurodegeneration. TNF-α led to increased expression of GFAP and proinflammatory factors in Muller cells, while anti-TNFR1 and NF-κB inhibitor could reverse these changes.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yue Xia, Minghuan Ge, Ling Xia, Guang Shan, Huijun Qian
Summary: This study reveals that the aberrant expression of cathepsin V (CTSV) is associated with a poor outcome in bladder cancer patients. CTSV enhances the inflammatory reaction, thereby promoting the development of bladder cancer. Overexpression of CTSV increases the proliferation and viability of bladder cancer cells, while deletion of CTSV significantly inhibits their proliferation and viability. Furthermore, overexpression of CTSV activates the inflammatory signaling pathway, which can be restored by introducing an NF-kappa B inhibitor.
Article
Nutrition & Dietetics
Shiloh R. Lueschow, Stacy L. Kern, Huiyu Gong, Justin L. Grobe, Jeffrey L. Segar, Susan J. Carlson, Steven J. McElroy
Review
Immunology
Shiloh R. Lueschow, Steven J. McElroy
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Brian A. Juber, Timothy G. Elgin, Erin M. Fricke, Huyiu Gong, Jeffrey Reese, Steven J. McElroy
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Review
Pediatrics
Rita D. Shelby, Ryan Raab, Gail E. Besner, Steven J. McElroy
PEDIATRIC RESEARCH
(2020)
Review
Pediatrics
Ravi Mangal Patel, Joanne Ferguson, Steven J. McElroy, Minesh Khashu, Michael S. Caplan
PEDIATRIC RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Sarah N. Watson, Steven J. McElroy
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2021)
Article
Pediatrics
Shiloh R. Lueschow, Timothy J. Boly, Elizabeth Jasper, Ravi M. Patel, Steven J. McElroy
Summary: This study compared different NEC definitions in evaluating neonatal necrotizing enterocolitis, with newer definitions outperforming Bell's staging. The importance of nine criteria for diagnosis was identified through feature evaluation in decision tree classifiers.
PEDIATRIC RESEARCH
(2022)
Article
Surgery
Marwa Abu El Haija, Yuanchao Ye, Yi Chu, Hussein Herz, Benjamin Linden, Shailesh K. Shahi, Kasra Zarei, Ashutosh K. Mangalam, Steven J. Mcelroy, Mohamad Mokadem
Summary: Toll-like receptor 4 (TLR4) and myeloid differentiation factor 8 (MyD88) play important roles in the metabolic response induced by Roux-en-Y gastric bypass surgery (RYGB), mainly mediated by gut microbiota.
TLR4 knockout mice show attenuated glucose regulatory response to RYGB, while MyD88 knockout mice do not respond to the metabolic effects induced by RYGB.
Fecal microbiota transplant from RYGB-operated mice fails to induce a metabolic phenotype similar to that of the donors in TLR4 and MyD88 KO mice, but is successful in wild-type recipients.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)
Article
Nutrition & Dietetics
Hala Chaaban, Kathryn Burge, Jeffrey Eckert, MaJoi Trammell, David Dyer, Ravi S. Keshari, Robert Silasi, Girija Regmi, Cristina Lupu, Misty Good, Steven J. McElroy, Florea Lupu
Summary: In this study, it was found that oral supplementation of HA 35 KDa to mouse pups led to increased intestinal epithelial cell proliferation, as well as the development of Paneth cells and goblet cell subsets. Additionally, HA 35 KDa impacted the composition of the intestinal microbiota, suggesting potential implications for further research.
Article
Gastroenterology & Hepatology
Michael T. Shanahan, Matt Kanke, Oyebola O. Oyesola, Yu-Han Hung, Kieran Koch-Laskowski, Ajeet P. Singh, Bailey C. E. Peck, Mandy Biraud, Breanna Sheahan, Josca E. Cortes, Huiyu Gong, Dipak K. Sahoo, Rebecca Cubitt, Natasza A. Kurpios, Jonathan P. Mochel, Karin Allenspach, Steven J. McElroy, Shengli Ding, Jakob von Moltke, Christopher M. Dekaney, Elia D. Tait-Wojno, Praveen Sethupathy
Summary: In this study, a microRNA atlas (and searchable web server) across all major small intestinal epithelial cell types is presented. Unique microRNAs marking several lineages, including enteroendocrine and tuft cells, have been identified. A key marker of mouse secretory progenitor cells, miR-672, which is deleted in humans, was discovered. Several in vivo models were used to establish miR-152 as a specific marker of Paneth cells, which are understudied in terms of microRNAs.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Correction
Pediatrics
Shiloh R. Lueschow, Timothy J. Boly, Elizabeth Jasper, Ravi M. Patel, Steven J. McElroy
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Shiloh R. Lueschow, Timothy J. Boly, Steven A. Frese, Giorgio Casaburi, Ryan D. Mitchell, Bethany M. Henrick, Steven J. McElroy
Summary: Necrotizing enterocolitis (NEC) is a disease that primarily affects preterm infants and has limited treatment options. Recent research suggests that the probiotic B. infantis EVC001 can prevent NEC by reducing inflammation and promoting epithelial barrier restoration.
Article
Pediatrics
Brian A. Juber, Timothy J. Boly, Graeme J. Pitcher, Steven J. McElroy
Summary: In this study, a retrospective analysis of infants showed that routine probiotic supplementation did not significantly alter the rates of modified Bell's stage >= 2a NEC or all-cause pre-discharge mortality in very low birth weight (VLBW) infants at the institution.
FRONTIERS IN PEDIATRICS
(2021)
Article
Microbiology
Hala Chaaban, Maulin M. Patel, Kathryn Burge, Jeffrey Eckert, Cristina Lupu, Ravi S. Keshari, Robert Silasi, Girija Regmi, MaJoi Trammell, David Dyer, Steven J. McElroy, Florea Lupu
Summary: Increasing evidence suggests a correlation between prolonged antibiotic therapy in preterm infants and increased mortality and morbidities such as NEC. This study used neonatal mice to test the effects of systemic antibiotic treatment on intestinal development and found that it impaired intestinal development and increased the risk of intestinal injury.
Meeting Abstract
Obstetrics & Gynecology
Nichole Watson, Huiyu Gong, Brian Juber, Steven Mcelroy
REPRODUCTIVE SCIENCES
(2021)