Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Immunology
Susanna Esposito, Giulia Antoniol, Marialuisa Labate, Lucrezia Passadore, Patrizia Alvisi, Valeria Dacco, Chiara Ghizzi, Carla Colombo, Nicola Principi
Summary: The incidence of inflammatory bowel diseases (IBDs) is rising globally, leading to a higher risk of infections in children with dysfunctional immune systems. Vaccines are essential for preventing these infections, and should be administered according to specific immunization guidelines for IBD patients. Compliance with vaccination recommendations is generally low, highlighting the need for multidisciplinary educational programs to improve vaccination coverage and protect children with IBD from vaccine-preventable diseases.
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Review
Biochemistry & Molecular Biology
Maria Jose Sanchez-Quintero, Cristina Rodriguez-Diaz, Francisco J. Rodriguez-Gonzalez, Alejandra Fernandez-Castaner, Eduardo Garcia-Fuentes, Carlos Lopez-Gomez
Summary: Mitochondria play a crucial role in maintaining cellular functions and are involved in various cellular processes. Dysfunction of mitochondria has been linked to complex disorders, including inflammatory bowel diseases (IBD). The impact of mitochondrial dysfunction on IBD, including its role in intestinal mucosa, immune cell populations, mucosal repair, microbiota-brain-gut axes, and the development of colitis-associated colorectal cancer, is discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Flavia Baccini, Federica Micheli, Giovanni Di Nardo, Caterina Lombardo
Summary: This study found that patients with inflammatory bowel disease have poorer subjective sleep quality compared to controls, with even worse sleep quality in those with active IBD. However, there were no differences within IBD subtypes. These results highlight the importance of considering sleep quality as a relevant comorbidity in IBD.
SLEEP MEDICINE REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna Krystyna Zielinska, Maciej Salaga, Pawel Siwinski, Marcin Wlodarczyk, Adam Dziki, Jakub Fichna
Summary: The study found that IBD patients had significantly decreased SOD activity, GSH and GSSG levels, and GPX activity was significantly diminished only in CD patients. CAT and COX-1 activity was increased, while COX-2 was significantly decreased in IBD patients. TBARS were significantly higher in CD patients compared to the control group. There was no correlation between pain scores, inflammatory status, disease activity, disease duration, or dietary habits and OS markers.
Review
Gastroenterology & Hepatology
Alexa N. Sasson, Ashwin N. Ananthakrishnan, Maitreyi Raman
Summary: The global incidence of inflammatory bowel diseases (IBDs) has increased significantly in the past few decades, with genetic and environmental factors playing a role in the pathogenesis. Diet is a potentially modifiable environmental risk factor for IBD, as it can promote intestinal inflammation through various mechanisms such as dysregulating the immune system and altering intestinal permeability. Dietary changes may be integrated into therapeutic strategies for IBD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Medicine, General & Internal
Eduard Brunet Mas, Xavier Calvet Calvo
Summary: Combination of two biological therapies (CoT) appears to be a safe and effective treatment option for refractory and severely ill patients with inflammatory bowel disease (IBD). Ustekinumab plus vedolizumab and vedolizumab plus anti-TNF are the most commonly used CoTs for Crohn's disease. For ulcerative colitis, vedolizumab plus anti-TNF and vedolizumab plus tofacitinib are the most commonly used CoTs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Matthias Zilbauer, Robert Heuschkel
Summary: Inflammatory bowel diseases like Crohn's disease and ulcerative colitis are complex conditions that require personalized treatment approaches. Developing biomarkers to predict disease course and treatment response is challenging.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Biochemistry & Molecular Biology
Lidiya V. Boldyreva, Maryana V. Morozova, Snezhanna S. Saydakova, Elena N. Kozhevnikova
Summary: Inflammatory bowel diseases (IBD) are chronic conditions characterized by inflammation in the gastrointestinal tract, with metabolic deregulation and changes in phospholipids being common features. Alterations in phospholipid composition, especially in phosphatidylcholine and lysophosphatidylcholine, are associated with the severity of inflammation in IBD patients. New strategies for treating IBD may involve controlling phospholipid and fatty acid levels through diet or pharmacological interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sijing Cheng, Jun Hu, Xianrui Wu, Ji-An Pan, Na Jiao, Yichen Li, Yibo Huang, Xutao Lin, Yifeng Zou, Yuan Chen, Lixin Zhu, Min Zhi, Ping Lan
Summary: The study shows that FUT2 loss-of-function mutation alters the gut microbiota composition in IBD patients, reducing adherent bacteria while increasing butyrate-producing bacteria, leading to intestinal inflammation.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Biochemistry & Molecular Biology
Andrea Picchianti-Diamanti, Francesca Romana Spinelli, Maria Manuela Rosado, Fabrizio Conti, Bruno Lagana
Summary: Phosphodiesterases (PDEs) are a diverse family of enzymes that regulate intracellular second messengers, with PDE4 being the most studied isoenzyme known for its role in down-regulating inflammatory responses. Inhibition of PDE4 can increase levels of cAMP, leading to decreased expression of inflammatory factors and increased regulatory cytokines, making it a potential therapeutic target for chronic inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Sergi Casado-Llombart, Maria Velasco-de Andres, Cristina Catala, Alejandra Leyton-Pereira, Rebeca Gutierrez-Cozar, Belen Suarez, Noelia Armiger, Esther Carreras, Miriam Esteller, Elena Ricart, Ingrid Ordas, Javier P. Gisbert, Maria Chaparro, Maria Esteve, Lucia Marquez, David Busquets, Eva Iglesias, Esther Garcia-Planella, Maria Dolores Martin-Arranz, Juliane Lohmann, C. Korcan Ayata, Jan Hendrik Niess, Pablo Engel, Julian Panes, Azucena Salas, Eugeni Domenech, Francisco Lozano
Summary: The expression and variation of CD5 and CD6 may play a role in the pathophysiology of inflammatory bowel diseases, affecting their clinical manifestations and therapeutic requirements.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Milosz Caban, Urszula Lewandowska
Summary: Posterior segment eye diseases are a major cause of visual impairment worldwide, and polyphenolic compounds may be an effective and safe component used to limit the development and progression of these ocular disorders.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Tomasz Mackiewicz, Jakub Wlodarczyk, Marta Zielinska, Marcin Wlodarczyk, Adam Durczynski, Piotr Hogendorf, Lukasz Dziki, Jakub Fichna
Summary: This study measured the expression of GPR35 in colorectal cancer (CRC) and pancreatic adenocarcinoma (PDAC) patients using real-time polymerase chain reaction (RT-PCR). The results showed significantly higher GPR35 expression in tumor samples compared to paired healthy samples, and correlations with tumor characteristics were observed. These findings suggest the potential prognostic value of GPR35 testing in CRC and PDAC patients.
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Editorial Material
Environmental Sciences
Patricia P. P. Wadowski, Aleksandra Piechota-Polanczyk, Martin Andreas, Christoph W. W. Kopp
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Jakub Wlodarczyk, Jacek Burzynski, Bartlomiej Czerwinski, Mateusz Prusisz, Katarzyna Socala, Ewa Poleszak, Jakub Fichna, Kasper Marynczak, Marcin Wlodarczyk, Lukasz Dziki
Summary: Crohn's disease is a subtype of chronic inflammatory bowel diseases characterized by skip lesions and transmural inflammation. It can affect the entire gastrointestinal tract and persistent pain is one of the main symptoms. This study aims to provide an abbreviated summary of the current knowledge on the origins and treatment of pelvic pain in Crohn's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Marek Pajak, Magdalena Wozniczka, Miroslawa Swiatek, Bartlomiej Czerwinski, Jakub Wlodarczyk, Jakub Fichna
Summary: The complexation properties of two synthetic nucleosides, beta-D-ribofuranoside-4-pyrimidinone (ribo) and beta-D-deoxyribofuranoside-4-pyrimidinone (deoxy), with Ag(I) ions in aqueous solution were investigated. The stability constants of the coordination entities formed were calculated and the percentage of each entity in solution was estimated. The results suggest that these coordination entities have potential antiviral, antibacterial, and antitumor properties, as well as potential applications in nanobiotechnology.
ACTA POLONIAE PHARMACEUTICA
(2023)
Review
Pharmacology & Pharmacy
Karolina Merecz, Mikolaj Hirsa, Olga Biniszewska, Jakub Fichna, Aleksandra Tarasiuk
Summary: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that affects approximately 10% of the global population. Recent studies have shown that antagonism of the serotonin 5-HT3 receptor is an effective treatment for IBS-D. The modulation of serotonin function plays a crucial role in maintaining intestinal homeostasis.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jakub Wlodarczyk, Julia Krajewska, Lukasz Szeleszczuk, Patrycja Szalwinska, Agata Gurba, Szymon Lipiec, Przemyslaw Taciak, Remigiusz Szczepaniak, Izabela Mlynarczuk-Bialy, Jakub Fichna
Summary: Inflammatory bowel diseases (IBD), such as Crohn's disease and ulcerative colitis, are global health problems with increasing frequency and unclear pathogenesis. Current treatment involves drugs like corticosteroids and derivative compounds, but more specific and effective therapies are desired. In this study, novel gold complexes were tested and found to have anti-inflammatory potential both in vitro and in vivo, particularly TGS 703, which was able to alleviate inflammation in a mouse model of colitis and showed a link to antioxidant systems. These findings suggest that gold(III) complexes may have therapeutic applications in the treatment of IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Milosz Caban, Urszula Lewandowska
Summary: Inflammatory bowel diseases (IBD) and colorectal cancer (CRC) are difficult to treat and often have limited efficacy. Polyphenols show promise in treating these diseases due to their anti-inflammatory, antioxidant, and anticancer properties. However, their bioavailability is affected by processing and gastrointestinal interactions. Hemicellulose-based encapsulations of polyphenols may offer a solution by providing a stable and bioavailable carrier for these compounds.
Review
Pharmacology & Pharmacy
Jacek Burzynski, Jakub Fichna, Aleksandra Tarasiuk
Summary: Acute pancreatitis (AP) and chronic pancreatitis (CP) are severe diseases that pose a great threat to human health in high-income countries. Oxidative stress plays a significant role in the development of AP and CP, and there is growing interest in the use of antioxidant therapy to manage these conditions. Vitamin A, a well-known antioxidant, has been understudied in relation to its impact on oxidative stress in AP and CP. This review aims to evaluate the molecular targets of vitamin A and its potential role in attenuating oxidative stress in AP and CP. The findings suggest that vitamin A may influence several molecular pathways involved in antioxidative defense and cytoprotection, indicating its potential to alter the disease course of AP and CP.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Toxicology
Szymon Lipiec, Agata Gurba, Izabela M. Agnieszczak, Andrzej Antoni Szczepankiewicz, Przemyslaw Szymanski, Przemyslaw Taciak, Remigiusz Szczepaniak, Lukasz Szeleszczuk, Hanna Nieznanska, Jakub Wlodarczyk, Jakub Fichna, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Metal-based agents in cancer therapy, like cisplatin and its derivates, have established clinical applications but also can induce serious side effects. Thus, metallotherapeutic alternatives for platinum derivatives are developed and intensively studied. Platinum is replaced by several transition metals including gold. Especially gold (III) complexes can have the same square-planar structure and are isoelectric with platinum (II).
TOXICOLOGY IN VITRO
(2023)
Article
Immunology
Adam Makaro, Mikolaj Swierczynski, Kacper Pokora, Barbara Sarniak, Radzislaw Kordek, Jakub Fichna, Maciej Salaga
Summary: Inflammatory bowel diseases (IBD) is a chronic and relapsing inflammation in the gastrointestinal tract. The incidence and prevalence of IBD are high and increasing, and current therapeutic strategies are suboptimal. This study focused on gliflozins, a group of anti-diabetic drugs, and found that they have anti-inflammatory properties. In vitro experiments showed that two gliflozins, EMPA and DAPA, suppressed nitric oxide production in macrophages, and in vivo experiments demonstrated that EMPA alleviated colitis in mice. Our findings suggest that SGLT-2 inhibitors have anti-inflammatory effects independent of their hypoglycemic effects.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marcin Sochal, Marta Ditmer, Agata Binienda, Agata Gabryelska, Piotr Bialasiewicz, Renata Talar-Wojnarowska, Jakub Fichna, Ewa Malecka-Wojciesko
Summary: Inflammatory bowel disease (IBD) patients often experience sleep and mood disorders which may be related to the disruption of the brain-gut axis. This study found that IBD patients had lower expression of BDNF mRNA but higher concentrations of proBDNF and BDNF protein compared to healthy controls. BDNF protein levels were positively correlated with sleep efficiency in the IBD group and depression severity was associated with BDNF mRNA and protein levels in the remission group.
Article
Biochemistry & Molecular Biology
Aleksandra Kopacz, Damian Kloska, Dominik Cysewski, Izabela Kraszewska, Karolina Przepiorska, Malgorzata Lenartowicz, Agnieszka Loboda, Anna Grochot-Przecezek, Witold Nowak, Alicja Jozkowicz, Aleksandra Piechota-Polanczyk
Summary: The study found that hemolysis and statin treatment in patients with hypertension may lead to heme degradation and iron accumulation in the kidneys, resulting in kidney failure. The study also identified mucin-1 as a protective factor against oxidative stress caused by heme and iron. Overall, the results suggest that hypertensive patients with less active HMOX1 alleles may have a higher risk of kidney injury after statin treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Marcin Sochal, Alicja Witkowska, Agata Binienda, Agata Gabryelska, Piotr Bialasiewicz, Jakub Fichna, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: The study investigates the impact of the serotonergic pathway on the pathogenesis and course of inflammatory bowel diseases (IBDs), and its relationship with sleep and mood disorders. The results show that patients with active IBD have higher levels of 5-HT and SERT protein expression, which are positively correlated with insomnia severity. After treatment, only 5-HT levels are decreased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Marcin Wlodarczyk, Adam Makaro, Mateusz Prusisz, Jakub Wlodarczyk, Marta Nowocien, Kasper Marynczak, Jakub Fichna, Lukasz Dziki
Summary: Crohn's disease (CD) is a chronic, relapsing inflammatory bowel disease characterized by transmural inflammation in the gastrointestinal tract. Chronic fatigue is a common and often underestimated symptom in CD patients, with a higher prevalence compared to the general population. Its underlying causes and mechanisms are complex and not fully understood. Routine screening and a comprehensive, multidisciplinary approach, including psychological support, may play a crucial role in managing CD patients with chronic fatigue. Further research is needed to predict, prevent, identify, and treat fatigue associated with CD. This review aims to summarize the current knowledge on the etiology, diagnosis, and treatment of chronic fatigue in CD patients.