Article
Materials Science, Multidisciplinary
Yukun Chen, Mingyin Cui, Chenliang Lin, Bingfu Liu, Noriyo Mitome, Takeo Miyake
Summary: The study demonstrates a protonic biodevice that translates proton signals into enzyme cascade reactions, with proton signals mediated by an external voltage for controlling biological reactions.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Biochemical Research Methods
Raheel Ahmad, Christin Kleineberg, Vahid Nasirimarekani, Yu-Jung Su, Samira Goli Pozveh, Albert Bae, Kai Sundmacher, Eberhard Bodenschatz, Isabella Guido, Tanja Vidakovic-Koch, Azam Gholami
Summary: The study demonstrates the biocompatibility and efficiency of an artificial light-driven energy module and a motility functional unit by integrating light-switchable photosynthetic vesicles with demembranated flagella. The system is able to control the beating frequency of flagella in a light-dependent manner, potentially contributing to the bottom-up synthesis of artificial cells capable of undergoing motor-driven morphological deformations and exhibiting directional motion in a light-controllable fashion.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Seok Jeong, Junmo Seong, Sung Wook Moon, Jaewoong Lim, Seung Bin Baek, Seung Kyu Min, Myoung Soo Lah
Summary: The spatial distribution of mixed building blocks in metal-organic frameworks can be modulated by tuning the reaction temperature, leading to the formation of core-shell and uniform microstructures.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Anayat Bhat, Shuang Li, Daniel Hammler, Martin J. Winterhalder, Andreas Marx, Andreas Zumbusch
Summary: The hydrolysis of nucleotides is important for cellular energy, and the transfer of phosphates to proteins is crucial for post-translational modification. A novel fluorogenic adenosine 5'-tetraphosphate (Ap4) analog has been developed for real-time monitoring of ATP hydrolysis within live cells, with potential applications in studying cellular processes involving Ap4 hydrolysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
John J. Lemasters
Summary: In post-mitotic cells, mitochondrial ATP/ADP exchange occurs via adenine nucleotide translocator (ANT), while cancer cells predominantly utilize non-electrogenic ATP-Mg/phosphate carrier for the exchange, leading to decreased cytosolic ATP/ADP levels. These alterations promote aerobic glycolysis and confer specific growth advantages to cancer cells.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
Article
Cell Biology
Cedric Bressan, Armen Saghatelyan
Summary: Cell migration is regulated by autophagy, with energy levels affecting autophagy regulation through AMPK activation. The dynamic balance between autophagy and energy levels is crucial for maintaining neuronal migration and coping with diverse micro-environmental factors.
Article
Biochemistry & Molecular Biology
Wenyong Ding, Minghua Qi, Li Ma, Xuefei Xu, Yingfei Chen, Wenli Zhang
Summary: The study revealed that ANT1 is potentially involved in the pathogenesis of Parkinson's disease (PD) by promoting the formation of protein aggregates with alpha-synuclein, leading to neurodegenerative injury. Additionally, ANT1 supplementation in neuronal cells showed protective roles against MPP+-induced cytotoxicity. This investigation advances the understanding of ANT1 in PD etiology and provides valuable insights for potential drug targets and biomarkers in PD management.
CELL AND BIOSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Hsiang-Hao Chuang, Yen-Yi Zhen, Yu-Chen Tsai, Cheng-Hao Chuang, Ming-Shyan Huang, Michael Hsiao, Chih-Jen Yang
Summary: Pin1 is a key isomerase that is overexpressed in cancers and plays a crucial role in tumorigenesis. Targeting Pin1 shows promise in inhibiting cancer progression through various mechanisms, making it a desirable pharmaceutical target for cancer therapy with ongoing research in targeted small-molecule compounds.
Review
Biochemistry & Molecular Biology
Paola Turina
Summary: F-type ATP synthases are crucial enzymes in cells, converting the energy from an electrochemical ion gradient into ATP synthesis. In addition to classical regulatory feedback effects, substrate-induced tuning of the H+/ATP coupling ratio may play a key role in cellular energy homeostasis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Computer Science, Information Systems
Ugrasen Singh, Manav R. Bhatnagar, Jamel Nebhen
Summary: This letter proposes a quadrature spatial modulation-assisted full-duplex communication scheme for multiple-input multiple-output systems, utilizing half-duplex antennas and an analog self-interference cancelation model to reduce interference levels. It also presents analytical frameworks for the average bit error rate, ergodic capacity, system throughput, and ergodic spectral efficiency of the scheme, all of which are verified through Monte-Carlo simulation.
IEEE WIRELESS COMMUNICATIONS LETTERS
(2021)
Article
Soil Science
Thomas Ohnemus, Oliver Spott, Enrico Thiel
Summary: A process-driven model was developed to estimate the susceptibility of cropland soils to release ammonia after urea application, revealing that CEC, pH, and SOC are important factors influencing ammonia loss potential. Spatial distribution analysis showed that cropland soils in northern and eastern Germany are more susceptible to ammonia release due to urea fertilization.
Article
Biology
Hannah R. Foster, Thuong Ho, Evgeniy Potapenko, Sophia M. Sdao, Shih Ming Huang, Sophie L. Lewandowski, Halena R. VanDeusen, Shawn M. Davidson, Rebecca L. Cardone, Marc Prentki, Richard G. Kibbey, Matthew J. Merrins
Summary: Pyruvate kinase (PK) and the phosphoenolpyruvate (PEP) cycle are crucial for nutrient-stimulated insulin secretion. The response of PKm1 and PKm2 to glycolytic and mitochondrial sources of PEP influences beta-cell nutrient response and controls the oscillatory cycle regulating insulin secretion.
Article
Multidisciplinary Sciences
Daniel Dar, Nina Dar, Long Cai, Dianne K. Newman
Summary: The par-seqFISH method allows for recording gene expression and spatial context of microbial populations, revealing diverse physiological states coexisting within the same biofilm with high spatial resolution when studying Pseudomonas aeruginosa.
Article
Neurosciences
Guo-Li Zhao, Hong Zhou, Yun-Hui Guo, Shu-Min Zhong, Han Zhou, Fang Li, Bo Lei, Zhongfeng Wang, Yanying Miao
Summary: In this study, the expression of connexin 43 (Cx43) was found to be regulated in glial cells in a glaucoma mouse model, indicating its involvement in the pathogenesis of glaucoma. The Rac1/PAK1/Cx43/ATP pathway was identified as a potential mechanism underlying the interaction between astrocytes and retinal ganglion cells (RGCs), providing insight into potential therapeutic strategies for glaucoma management.
Article
Computer Science, Information Systems
Khadiga Eltira, Abdelhamid Younis, Raed Mesleh
Summary: The paper investigates the theoretical capacity of the amplify and forward (AF)-QSM system, validates derived formulas through Monte Carlo simulation results, and explores the impact of system and channel parameters on capacity and mutual information. The results show that AF-QSM outperforms AF-spatial modulation system in terms of performance gains.
Article
Microbiology
Ekta Lachmandas, Lily Boutens, Jacqueline M. Ratter, Anneke Hijmans, Guido J. Hooiveld, Leo A. B. Joosten, Richard J. Rodenburg, Jack A. M. Fransen, Riekelt H. Houtkooper, Reinout van Crevel, Mihai G. Netea, Rinke Stienstra
NATURE MICROBIOLOGY
(2017)
Review
Neurosciences
Helena Xicoy, Be Wieringa, Gerard J. M. Martens
MOLECULAR NEURODEGENERATION
(2017)
Article
Biotechnology & Applied Microbiology
Ellen L. van Agtmaal, Laurene M. Andre, Marieke Willemse, Sarah A. Cumming, Ingeborg D. G. van Kessel, Walther J. A. A. van den Broek, Genevieve Gourdon, Denis Furling, Vincent Mouly, Darren G. Monckton, Derick G. Wansink, Be Wieringa
Article
Biochemistry & Molecular Biology
Anchel Gonzalez-Barriga, Bram Nillessen, Julia Kranzen, Ingeborg D. G. van Kessel, Huib J. E. Croes, Begona Aguilera, Peter C. de Visser, Nicole A. Datson, Susan A. M. Mulders, Judith C. T. van Deutekom, Be Wieringa, Derick G. Wansink
NUCLEIC ACID THERAPEUTICS
(2017)
Review
Clinical Neurology
Laurene M. Andre, C. Rosanne M. Ausems, Derick G. Wansink, Be Wieringa
FRONTIERS IN NEUROLOGY
(2018)
Article
Immunology
Ben Joosten, Marieke Willemse, Jack Fransen, Alessandra Cambi, Koen van den Dries
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Cell Biology
Helena Xicoy, Be Wieringa, Gerard J. M. Martens
Article
Biochemistry & Molecular Biology
Remco T. P. van Cruchten, Be Wieringa, Derick G. Wansink
Article
Multidisciplinary Sciences
Koen van den Dries, Leila Nahidiazar, Johan A. Slotman, Marjolein B. M. Meddens, Elvis Pandzic, Ben Joosten, Marleen Ansems, Joost Schouwstra, Anke Meijer, Raymond Steen, Mietske Wijers, Jack Fransen, Adriaan B. Houtsmuller, Paul W. Wiseman, Kees Jalink, Alessandra Cambi
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Koen van den Dries, Jack Fransen, Alessandra Cambi
Summary: Correlative light and electron microscopy (CLEM) is a powerful imaging approach that combines light and electron microscopy, and has wide applications in biology. This review summarizes the important developments in CLEM for biological research, with a focus on the combination of fluorescence microscopy and electron microscopy.
Editorial Material
Biochemistry & Molecular Biology
Jan Willem Borst, Jack Fransen, Stefanie Weidtkamp-Peters, Yvonne Stahl
Article
Neurosciences
Malou Zuidscherwoude, Mark K. K. van Goor, Sara R. R. Roig, Niky Thijssen, Merijn van Erp, Jack Fransen, Jenny van der Wijst, Joost G. G. Hoenderop
Summary: This study characterizes the interaction between functional TRPV5 and CaM, demonstrating that they interact in the absence of Ca2+ and the interaction is intensified with increasing Ca2+ concentrations. The CaM C-lobe achieves channel pore blocking, leading to channel inactivation. Furthermore, the study shows a Ca2+-dependent binding stoichiometry at the single channel level. This research proposes a new CaM-dependent regulation model for TRPV5, involving apoCaM interaction and lobe-specific actions, which is of significant physiological relevance given its role in Ca2+ transport in the kidney.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Matteo Bolomini-Vittori, Svenja F. B. Mennens, Ben Joosten, Jack Fransen, Guangwei Du, Koen van den Dries, Alessandra Cambi
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Cell Biology
K. van den Dries, L. Nahidiazar, J. A. Slotman, M. B. Meddens, E. Pandzic, B. Joosten, M. Ansems, J. A. Fransen, A. B. Houtsmuller, P. W. Wiseman, K. Jalink, A. Cambi
MOLECULAR BIOLOGY OF THE CELL
(2018)
Article
Biochemistry & Molecular Biology
Anke E. E. G. Gudde, Ingeborg D. G. van Kessel, Laurene M. Andre, Be Wieringa, Derick G. Wansink
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2017)