Article
Biochemistry & Molecular Biology
Yang Chen, Nanjing Li, Jun Yang, Ke Li, Mei Tang, Xinyu Zhao, Wenhao Guo, Aiping Tong, Chunlai Nie, Yong Peng, Zhu Yuan
Summary: This study reveals a novel mechanism of PUMA in promoting apoptosis in ovarian cancer by activating ASK1 and subsequently activating the ASK1-JNK axis. Additionally, in vivo experiments demonstrate that PUMA combined with chemotherapy can effectively inhibit the growth of cisplatin-resistant ovarian cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biology
Amrutha Kizhedathu, Piyush Chhajed, Lahari Yeramala, Deblina Sain Basu, Tina Mukherjee, Kutti R. Vinothkumar, Arjun Guha
Summary: The study reveals that high levels of reactive oxygen species (ROS) play a crucial role in the G2 arrest and mitotic re-entry of progenitors of the thoracic tracheal system in adult Drosophila, with Duox expression being a key regulator of ROS levels.
Article
Engineering, Environmental
Ashmi Mishra, Steven Lelieveld, Ulrich Poeschl, Thomas Berkemeier
Summary: Exposure to ambient air pollution can lead to oxidative stress and damage in the respiratory tract. This study investigates the chemical modification of proteins by reactive species from air pollution and biological sources. Fine particulate matter and nitrogen dioxide synergistically increase the formation of a biomarker of oxidative stress, nitrotyrosine. Ozone affects the antioxidant defense system but does not significantly influence nitrotyrosine concentration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Mengxue Xi, Dan Shen, Pengyuan Dai, Guofeng Han, Chunmei Li
Summary: This study found that fine particulate matter (PM2.5) from poultry houses caused damage to chicken primary alveolar epithelial cells, but tert-butylhydroquinone (TBHQ) can alleviate this damage and provide a basis for overcoming the health risks posed by air pollutants from broiler houses.
Article
Environmental Sciences
Nguyen Thanh Tung, Kin-Fai Ho, Xinyi Niu, Jian Sun, Zhenxing Shen, Feng Wu, Junji Cao, Hoang Ba Dung, Tran Phan Chung Thuy, Ta-Chih Hsiao, Wen-Te Liu, Hsiao-Chi Chuang
Summary: Exposure to road dust PM2.5 can lead to E-cadherin disruption in human pharyngeal epithelial cells, potentially affecting EGFR activation and barrier function of the upper airway epithelium.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Chia-Hua Lin, Shih-Chun Candice Lung, Yi-Chun Chen, Lung-Chun Wang
Summary: This study found that exposure to ultrafine particulate matter (UFPM) can lead to decreased cell viability, increased oxidative stress, and upregulated expression of interleukin-8 (IL-8). Additionally, UFPM can reduce pulmonary trans-epithelial electrical resistance by depleting zonula occludens (ZO) proteins. Furthermore, UFPM was shown to decrease the expression of alpha 1-antitrypsin (A1AT), indicating a higher risk of chronic obstructive pulmonary disease (COPD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Jakub Styburski, Kaja Skubala
Summary: This study investigated the effect of nitrogen oxides and suspended particulate matter on the anatomical structure and photosynthetic efficiency of Physcia adscendens lichen. The results showed that lichens from polluted sites had different anatomical structures and higher photosynthetic efficiency, indicating their adaptation to air pollution stress and successful colonization in polluted areas.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Shouheng Lin, Xuchao Zhang, Guohua Huang, Lin Cheng, Jiang Lv, Diwei Zheng, Simiao Lin, Suna Wang, Qiting Wu, Youguo Long, Baiheng Li, Wei Wei, Pentao Liu, Duanqing Pei, Yangqiu Li, Zhesheng Wen, Shuzhong Cui, Peng Li, Xiaofang Sun, Yilong Wu, Yao Yao
Summary: This study revealed that intratumoral MDSC infiltration is associated with NSCLC progression and promotes metastasis through producing CCL11, which activates ERK and AKT signaling pathways and induces EMT. High expression of CCL11 is correlated with poor prognosis in lung cancer and other cancer types.
Article
Medicine, Research & Experimental
Jennifer L. Larson-Casey, Shanrun Liu, Jennifer M. Pyles, Suzanne E. Lapi, Komal Saleem, Veena B. Antony, Manuel Lora Gonzalez, David K. Crossman, A. Brent Carter
Summary: It has been found that environmental heavy metal exposure is associated with lung diseases, including lower respiratory tract infections. Through single-cell RNA sequencing, an increase in Pparg gene expression in lung macrophages from mice exposed to cadmium and/or infected with Streptococcus pneumoniae was observed. However, it was discovered that the heavy metal cadmium or infection led to an inhibitory posttranslational modification of the peroxisome proliferator-activated receptor gamma (PPAR gamma), exacerbating lower respiratory tract infections.
Article
Environmental Sciences
Byoung-Seok Lee, Younhee Kim, Heejin Park, Wan-Jung Im, Hyoung-Yun Han, Yong-Bum Kim, SunHwa Lim, Min Heui Yoo
Summary: Exposure to high levels of perfluorooctanoate (PFOA) may be correlated with kidney cancer incidence. However, little is known about the mechanism behind the influence of perfluoroalkyl carboxylates (PFACs) on renal cell carcinoma (RCC) development. This study investigates the effects of different types of PFACs on RCC using in vitro and in vivo models, revealing that long-chain PFACs induce epithelial-mesenchymal transition (EMT) and exhibit greater toxicity compared to short-chain PFACs. These findings contribute to our understanding of PFACs' impact on RCC development and their potential risks to public health.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Toxicology
Vegard Saeter Grytting, Prem Chand, Marit Lag, Johan Ovrevik, Magne Refsnes
Summary: This study investigated the pro-inflammatory effects of combined exposure to diesel exhaust particles (DEP) and mineral particles in human lung epithelial cells. The results showed that combined exposure induced enhanced pro-inflammatory responses compared to individual exposure. These effects were partially mediated through the AhR pathway and lipophilic organic chemicals in DEP.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Seyed Ahmad Reza Dibaji, Berk Oktem, Lee Williamson, Jenna DuMond, Todd Cecil, Jimin P. Kim, Samanthi Wickramasekara, Matthew Myers, Suvajyoti Guha
Summary: This study investigates the effects of various ENDS design parameters on aerosol characteristics and finds that ultra-fine particle concentrations are higher at higher temperatures, while decreasing propylene glycol content increases the aerosol mass of fine and coarse particles.
Article
Environmental Sciences
Jen-Hsiung Tsai, Shui-Jen Chen, Sheng-Lun Lin, Zheng-You Xu, Kuo-Lin Huang, Chih-Chung Lin
Summary: This study investigated the effects of various two-stroke engine oils on the emission characteristics of a P2SGE engine, finding that the PM mass concentrations in the exhaust were highest with MS oil and lowest with LS oil. As the engine load increased, both PM mass concentrations and emission factors decreased.
AEROSOL AND AIR QUALITY RESEARCH
(2021)
Article
Engineering, Chemical
Hanhan Li, Mingwei Tang, Xiaosan Luo, Weijun Li, Yuting Pang, Weijie Huang, Zhen Zhao, Yaqian Wei, Tengda Long, Tariq Mehmood
Summary: Inhalable particulate matters (PM10) from biomass combustion are harmful to human health and contribute significantly to aerosol pollution in China. PM10 samples were collected from 10 representative biomass fuel combustion sources, and their chemical compositions and cytotoxicity to human lung epithelial cells were analyzed. The dominant components of PM10 are organic carbon (OC), followed by water-soluble ICE and Cl, and metals Fe, Zn, Cr, and Ni. Biomass fuel combustion emissions can weaken cells' antioxidant capacity, especially emissions from rape and peanut straws, due to the toxic effects of Cr, Ni, and Co. Reducing specific source emissions of PM10 from crop straw combustion rich in heavy metals could be an effective strategy to improve air quality and control aerosol pollution for public health protection.
Article
Multidisciplinary Sciences
Magdalena Paplinska-Goryca, Paulina Misiukiewicz-Stepien, Malgorzata Proboszcz, Patrycja Nejman-Gryz, Katarzyna Gorska, Elwira Zajusz-Zubek, Rafal Krenke
Summary: Urban particulate matter (UPM) plays a crucial role in triggering airway inflammation, particularly in obstructive lung diseases like asthma and COPD. By studying the immune processes induced by epithelium after UPM exposure and interactions with monocyte-derived dendritic cells (moDCs) and monocyte-derived macrophages (moM phi s), researchers found that cell-cell interactions, especially with DCs, have a significant impact on the inflammatory response of epithelial cells. Epithelial remodeling and DCs dysfunction may contribute to the acceleration of inflammation after exposure to air pollution in asthma and COPD patients.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Veronica Montesinos-Cruz, Jordan Rose, Aglaia Pappa, Mihalis Panayiotidis, Andrea De Vizcaya-Ruiz, Rodrigo Franco
CHEMICAL RESEARCH IN TOXICOLOGY
(2020)
Article
Physiology
Kimberly E. Stelzig, Fabrizio Canepa-Escaro, Marta Schiliro, Sergejs Berdnikovs, Y. S. Prakash, Sergio E. Chiarella
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Editorial Material
Critical Care Medicine
Sanjay H. Chotirmall, Fernando J. Martinez, Paul T. Schumacker, Colin R. Cooke, Nitin Seam, Laurent Brochard, Robert M. Tighe, Bruce D. Levy, Diane Gern, Jadwiga A. Wedzicha
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Reproductive Biology
Ramses Santacruz-Marquez, Aidee Solorio-Rodriguez, Sirenia Gonzalez-Posos, Sihomara Patricia Garcia-Zepeda, Jaime Santoyo-Salazar, Andrea De Vizcaya-Ruiz, Isabel Hernandez-Ochoa
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Environmental Sciences
Octavio Gamaliel Aztatzi-Aguilar, Gabriela Andrea Pardo-Osorio, Marisela Uribe-Ramirez, Juana Narvaez-Morales, Andrea De Vizcaya-Ruiz, Olivier Christophe Barbier
Summary: Exposure to PM2.5 is associated with acute kidney damage, oxidative stress, inflammation, and potential loss of renal function, as evidenced by increased early kidney damage biomarkers and inflammatory markers.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Chemistry, Organic
Naxieli Santiago-De la Rosa, Violeta Mugica-Alvarez, Griselda Gonzalez-Cardoso, Andrea De Vizcaya-Ruiz, Marisela Uribe-Ramirez, Brenda L. Valle-Hernandez
Summary: Mexico's agricultural activities are closely linked to undesirable burning practices of crop residues, resulting in emissions of harmful PM2.5 particles that can impact climate change and human health. Study findings indicate that the concentration of organic carbon (OC) fractions is associated with combustion efficiency, with significant variation in emission factors between different crops, suggesting diverse levels of PAHs and carcinogenic compounds produced during biomass burning.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Toxicology
A. Solorio-Rodriguez, V Escamilla-Rivera, M. Uribe-Ramirez, S. Gonzalez-Pozos, J. Hernandez-Soto, L. Rafael-Vazquez, A. De Vizcaya-Ruiz
Summary: This study evaluated the impact of exposure to crystalline Fe3O4 NP and amorphous SiO2 NP on pneumocytes organelles in alveolar epithelial cells. The results showed that SiO2 NP had a greater effect on organelles responsible for energy, secretion, degradation, and metabolism in pneumocytes, potentially leading to the development of respiratory disorders or exacerbation of preexisting conditions. The established biocompatibility for amorphous NP needs to be reconsidered based on these findings.
TOXICOLOGY IN VITRO
(2021)
Editorial Material
Biochemistry & Molecular Biology
Paul T. Schumacker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Environmental Sciences
A. Jimenez-Chavez, A. Solorio-Rodriguez, V Escamilla-Rivera, D. Leseman, R. Morales-Rubio, M. Uribe-Ramirez, L. Campos-Villegas, I. E. Medina-Ramirez, L. Arreola-Mendoza, F. R. Cassee, A. De Vizcaya-Ruiz
Summary: The increasing use of metal oxide nanoparticles, such as TiO2 NPs or ZnO NPs, has led to environmental release and human exposure. Research shows differential responses in human alveolar epithelial cells when exposed to these nanoparticles, with TiO2 showing higher persistence on cell surfaces and inducing sustained inflammatory responses, while ZnO shows a modest response. Exposure to TiO2 NPs or ZnO NPs also results in a reduction of SP-A levels, impacting lung function.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Environmental Sciences
M. Palacios-Arreola, A. De Vizcaya-Ruiz, J. Morales-Montor, O. Amador-Munoz
Summary: This study investigated the inhalatory absorption of Diisobutyl phthalate (DiBP) and found that it exhibited two peaks in plasma concentration, indicating two absorption events after inhalation with a first order elimination stage.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Russell Morales-Rubio, Omar Amador-Munoz, Irma Rosas-Perez, Yesennia Sanchez-Perez, Claudia Garcia-Cuellar, Patricia Segura-Medina, Alvaro Osornio-Vargas, Andrea De Vizcaya-Ruiz
Summary: This study investigated the effects of resveratrol on airway hyperresponsiveness and inflammation induced by exposure to fine particulate matter, showing that resveratrol can inhibit these adverse effects.
Article
Toxicology
Maria-de-los-Angeles Andrade-Oliva, Yazmin Debray-Garcia, Guadalupe-Elide Morales-Figueroa, Juan Escamilla-Sanchez, Omar Amador-Munoz, Raul Diaz-Godoy, Michael Kleinman, Benjamin Floran, Jose-Antonio Arias-Montano, Andrea De Vizcaya-Ruiz
Summary: Exposure to ambient particulate matter reduces locomotion in rats, which could be related to altered striatal dopaminergic transmission.
INHALATION TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Simran S. Sabharwal, V. Joseph Dudley, Charlene Landwerlin, Paul T. Schumacker
Summary: Cancer cells experience increased levels of oxidant stress due to oncogene activation, nucleotide biosynthesis, and growth factor receptor signaling. Mitochondrial ROS contribute to this stress. Assessing the importance of mitochondrial ROS in cancer cells is difficult due to the effects of electron transport chain inhibitors. This study showed that mitochondrial H2O2 signaling contributes to tumor cell proliferation and survival through HIF-dependent and HIF-independent mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Environmental Sciences
Maria-de-los-Angeles Andrade-Oliva, Juan Escamilla-Sanchez, Yazmin Debray-Garcia, Russell A. Morales-Rubio, Raul Gonzalez-Pantoja, Marisela Uribe-Ramirez, Omar Amador-Munoz, Raul Diaz-Godoy, Andrea De Vizcaya-Ruiz, Jose-Antonio Arias-Montano
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2020)
Letter
Allergy
Pragya Shrestha, Maximiliano Diaz-Menindez, Sergio E. Chiarella, Alexei Gonzalez-Estrada
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2020)