Article
Peripheral Vascular Disease
Chen Chen, Pengfei Cui, Kevin Zhao, Gengming Niu, Shiqiang Hou, Dezheng Zhao, Huiyan Zeng
Summary: This study demonstrates the crucial role of DSCR1-1L in tumor angiogenesis and growth, as well as its regulation of both endothelial and tumor cell proliferation and migration.
MICROVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yan Yun, Yun Zhang, Chen Zhang, Liyan Huang, Shichuan Tan, Pin Wang, Carles Vilarino-Guell, Weihong Song, Xiulian Sun
Summary: The study reveals that RCAN1 is a novel RNA-binding protein, and its RNA aptamer can block RCAN1-induced inhibition of NFAT and NF-kappa B signaling pathways, reducing neuronal apoptosis and playing a neuroprotective role.
MOLECULAR PSYCHIATRY
(2021)
Article
Peripheral Vascular Disease
Shiqiang Hou, Gengming Niu, Xin Liu, Pierre M. Bourbon, Dongmei Zhang, Pengfei Cui, Kevin Zhao, Dezheng Zhao, Huiyan Zeng
Summary: DSCR1-1L regulates angiogenesis in vivo by down-regulating VE-cadherin expression in the early stage. DSCR1-1L shRNAs significantly inhibit angiogenesis induced by VEGF in mice, while overexpression of DSCR1-1L cDNA induces angiogenesis in mouse endothelium. Our findings suggest that DSCR1-1L could be a promising therapeutic target for angiogenic diseases.
MICROVASCULAR RESEARCH
(2021)
Article
Immunology
Victoria Maksimova, Susan Smith, Jaideep Seth, Cameron Phelps, Stefan Niewiesk, Yorifumi Satou, Patrick L. Green, Amanda R. Panfil
Summary: The enhancer element of HTLV-1 plays a crucial role in regulating viral gene expression, but does not determine persistent infection or disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Masashi Muramatsu, Tsuyoshi Osawa, Yuri Miyamura, Suguru Nakagawa, Toshiya Tanaka, Tatsuhiko Kodama, Hiroyuki Aburatani, Juro Sakai, Sandra Ryeom, Takashi Minami
Summary: DSCR-1 serves as a feedback modulator for NFAT signals crucial for cell proliferation and inflammation, and plays a critical role in vascular wall remodeling and macrophage phenotypic switch. Loss of both Dscr-1 and ApoE causes metabolic dysfunction in the liver but reduces atherosclerotic plaques, resulting in increased serum cholesterol and vasculopathy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Sandeep Potluri, Salam A. Assi, Paulynn S. Chin, Dan J. L. Coleman, Anna Pickin, Shogo Moriya, Naohiko Seki, Olaf Heidenreich, Peter N. Cockerill, Constanze Bonifer
Summary: WT1 is a key transcription factor in AML, frequently mutated or upregulated in multiple AML subtypes and predictive for relapse. Different isoforms of WT1 exhibit contrasting biological activities, including enhanced proliferation in two main AML subtypes. WT1 is responsive to oncogenic signaling and part of a transcription factor hub controlling AML growth.
Article
Microbiology
Lingdan Lian, Guang Zhang, Jing Zhu, Yunxiao Wang, Lingshuai Wang, Rui Liu, Liang Shi, Ang Ren, Mingwen Zhao
Summary: This study identified two different transcripts of Swi6, with the isoform GlSwi6B participating in regulating the cell wall integrity signaling in Ganoderma lucidum fungi. GlSwi6B was found to bind to the promoters of chitin and glucan synthesis genes, while this binding phenomenon was not observed in the isoform GlSwi6A.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
David R. Sweet, Roshan Padmanabhan, Xudong Liao, Himanshu R. Dashora, Xinmiao Tang, Lalitha Nayak, Rajan Jain, Sarah De Val, Vinesh Vinayachandran, Mukesh K. Jain
Summary: This study investigates the transcriptional control mechanisms of KLF2 and KLF4 in heart and lung endothelium. The results show that KLF2 and KLF4 use open chromatin regions in promoters and enhancers, and bind context-specifically to govern transcription in microvasculature. This work provides insight into the transcriptional and functional heterogeneity seen in vascular populations, and establishes tools for exploring microvascular endothelial dynamics in vivo.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Yukihiro Harada, Toru Tanaka, Yuji Arai, Yoshie Isomoto, Atsushi Nakano, Shu Nakao, Akihiro Urasaki, Yusuke Watanabe, Teruhisa Kawamura, Osamu Nakagawa
Summary: SGK1 is predominantly expressed in endothelial cells of mouse embryos, and its expression is maintained through at least two ETS-regulated enhancers, located in the proximal and distal regions. The presence of these enhancers is essential for the responsiveness to ERG, FLI1, and ETS1 proteins.
Article
Endocrinology & Metabolism
Michael J. MacDonald, Israr-ul H. Ansari, Amy S. Riedemann, Scott W. Stoker, Jens C. Eickhoff, Peter J. Chlebeck, Luis A. Fernandez, Melissa J. Longacre
Summary: Net synthesis of pancreatic beta-cells peaks before 2 years of age and beta-cell mass is set within the first 5 years of life. In-frame translational readthrough of the NRP1 gene generates a truncated neuropilin-1 protein, which lacks downstream sequence necessary for binding VEGF and stimulates beta-cell replication. Decreased insulin cells and a genetic marker in NRP1 intron 9 are associated with early onset of type 1 diabetes.
Article
Biochemistry & Molecular Biology
Fabienne Bejjani, Emilie Evanno, Samantha Mahfoud, Claire Tolza, Kazem Zibara, Marc Piechaczyk, Isabelle Jariel-Encontre
Summary: This study reveals that the transcription factor Fra-1 down-regulates the expression of the TGFB2 gene by decreasing the formation of its transcription-initiating form. Complex long-range chromatin interactions involving multiple heterogeneous Fra-1-bound transcriptional enhancers are involved in this process. The transcriptional output of the TGFB2 gene depends on a balance between the positive and negative effects of Fra-1 at these enhancers.
CELL AND BIOSCIENCE
(2023)
Article
Oncology
Britt A. Sterken, Tobias Ackermann, Christine Mueller, Hidde R. Zuidhof, Gertrud Kortman, Alejandra Hernandez-Segura, Mathilde Broekhuis, Diana Spierings, Victor Guryev, Cornelis F. Calkhoven
Summary: This study found that the ratio of LIP/LAP is associated with cell migration and invasion in breast cancer. Overexpression of LAP and reducing the LIP/LAP ratio can decrease the migration and matrix invasion of triple-negative breast cancer (TNBC) cells. Conversely, overexpression of LIP stimulates migration in untransformed mammary epithelial cells. Knockout of CEBPB in TNBC cells with high LIP expression results in reduced migration and downregulation of genes involved in cell migration, extracellular matrix production, and cytoskeletal remodeling.
Article
Multidisciplinary Sciences
Mario Ruiz, Ranjan Devkota, Dimitra Panagaki, Per-Olof Bergh, Delaney Kaper, Marcus Henricsson, Ali Nik, Kasparas Petkevicius, Johanna L. Hoog, Mohammad Bohlooly-Y, Peter Carlsson, Jan Boren, Marc Pilon
Summary: Cells and organisms require proper membrane composition for their proper functioning and development. The lack of fluidity regulators Adiponectin Receptors 1 and 2 (AdipoR1/2) in mice leads to embryonic lethality due to high saturation of membrane phospholipids. The researchers identified a conserved pathway involving AdipoR1/2 and fatty acid desaturase SCD that helps maintain membrane homeostasis. This study provides insights into how cells and organisms adapt to variable environments by adjusting membrane composition.
NATURE COMMUNICATIONS
(2022)
Article
Agronomy
Ruiting Zhang, Chao Shen, De Zhu, Yu Le, Nian Wang, Yuanxue Li, Xianlong Zhang, Zhongxu Lin
Summary: In this study, a QTL controlling cotton fiber length was fine-mapped to a 96.5-kb region containing an uncharacterized gene. The identified gene, GhFL10, is speculated to interact with NF-YA transcription factors to negatively regulate fiber elongation.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Multidisciplinary Sciences
Reuben Franklin, Yiming Guo, Shiyang He, Meijuan Chen, Fei Ji, Xinyue Zhou, David Frankhouser, Brian T. Do, Carmen Chiem, Mihyun Jang, M. Andres Blanco, Matthew G. Vander Heiden, Russell C. Rockne, Maria Ninova, David B. Sykes, Konrad Hochedlinger, Rui Lu, Ruslan I. Sadreyev, Jernej Murn, Andrew Volk, Sihem Cheloufi
Summary: In this study, the authors demonstrate that CAF-1 maintains lineage fidelity by controlling chromatin accessibility at specific sites. Suppression of CAF-1 leads to differentiation of myeloid stem and progenitor cells into a mixed lineage state. These findings provide important insights into cell fate commitment and transcriptional regulation circuits.
NATURE COMMUNICATIONS
(2022)