Review
Endocrinology & Metabolism
Graeme B. Bolger
Summary: cAMP-signaling cancers are driven by somatic mutations in the cAMP signaling pathway genes, resulting in a wide range of cell origins, clinical manifestations, and potential therapeutic options. The tumor phenotype is influenced by the specific gene mutations, allele effects, mutational context, tissue-specific expression, and biochemical regulation of the pathway components. Understanding these oncogenic mechanisms can lead to the discovery of novel drug targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thi Mong Diep Nguyen, Laura Filliatreau, Daniele Klett, Nong Van Hai, Nguyen Thuy Duong, Yves Combarnous
Summary: The research reveals that ADCY10 is located in the cytoplasm and responds to four different inhibitors. These inhibitors can reduce cAMP accumulation in MTLC-1 cells and various Leydig cells, emphasizing the importance of ADCY10 in response to the hormone LH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Xuefeng Zhang, Alejandro Pizzoni, Kyoungja Hong, Nyla Naim, Chao Qi, Volodymyr Korkhov, Daniel L. Altschuler
Summary: CAP1 is a highly conserved protein involved in regulating cAMP dynamics in mammalian cells by binding and activating adenylyl cyclase, modulating cAMP levels in a Rap1-dependent manner, and affecting cAMP-dependent proliferation. The interaction between CAP1, cyclase, and Rap1 forms a regulatory unit that may be involved in establishing cAMP microdomains and localized signaling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Endocrinology & Metabolism
T. John Martin
Summary: Parathyroid hormone (PTH) activates adenylyl cyclase in cells of the osteoblast lineage, indirectly regulating osteoclast formation. PTH1R, shared by PTH and PTHrP, activates adenylyl cyclase with similar potency. PTH1R is translocated from the plasma membrane to the endosome, but the influence of endosomal translocation on PTH1R activity is not yet known.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dermatology
Jaewon You, Michael D. Reilly, Mahmoud Eljalby, Rohan Bareja, Maftuna Yusupova, Nikki S. Vyas, Jakyung Bang, Wanhong Ding, Garrett Desman, Lloyd S. Miller, Olivier Elemento, Richard D. Granstein, Jonathan H. Zippin
Summary: This study demonstrates the importance of soluble adenylate cyclase (sAC) in psoriasis pathogenesis and identifies it as a potential therapeutic target. The absence of Adcy10 gene significantly reduces the symptoms of psoriasiform dermatitis in mice and inhibits the differentiation and gene expression of Th17 cells. Moreover, topical application of sAC inhibitors shows promise in reducing psoriasiform dermatitis and IL17 gene expression in the skin, suggesting their potential as topical therapeutics for Th17-mediated skin diseases.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Cell Biology
Gabriel Komla Adzika, Hongjian Hou, Adebayo Oluwafemi Adekunle, Ruqayya Rizvi, Seyram Yao Adzraku, Kexue Li, Qi-Ming Deng, Richard Mprah, Marie Louise Ndzie Noah, Joseph Adu-Amankwaah, Jeremiah Ong'achwa Machuki, Wenkang Shang, Tongtong Ma, Stephane Koda, Xianluo Ma, Hong Sun
Summary: The study aimed to prevent pathological cardiac hypertrophy during chronic stress by modulating cardiac and inflammatory responses. The combination of Amlexanox and Forskolin showed the highest efficacy in regulating adaptive inflammatory responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Katrina F. Ostrom, Justin E. LaVigne, Tarsis F. Brust, Roland Seifert, Carmen W. Dessauer, Val J. Watts, Rennolds S. Ostrom
Summary: Adenylyl cyclases (ACs) catalyze the conversion of ATP to cAMP, serving as major effectors of G protein-coupled receptors (GPCRs) with varying expression patterns across tissues. Understanding the potential roles of each isoform holds promise for uncovering new therapeutic approaches.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Cell Biology
Mina Hwang, Hyo-Sup Kim, Sang-Man Jin, Kyoo-Yeon Hur, Jae-Hyeon Kim, Moon-Kyu Lee
Summary: Thiazolidinediones are synthetic PPAR gamma ligands that can enhance insulin sensitivity and potentially increase insulin secretion from pancreatic beta-cells, but the functional role and mechanism of action in beta-cells have not been thoroughly investigated.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jun Xu, Nobuo Koizumi, Yusuke V. Morimoto, Ryo Ozuru, Toshiyuki Masuzawa, Shuichi Nakamura
Summary: Nucleotide second messengers play crucial roles in signal transduction in various organisms. A study has found that the swimming motility of the soil bacterium Leptospira kobayashii can be rapidly modulated by light stimulation. Through analysis of a loss-of-photoresponsivity mutant, a novel sensory gene was identified, and the light-dependent synthesis of cyclic adenosine monophosphate (cAMP) was elucidated. These findings reveal a new role for cAMP in controlling the flagella-dependent motility of Leptospira and highlight the global distribution of the newly discovered photoactivated cyclase among diverse microbial species.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Muhammad Aslam, Yury Ladilov
Summary: This article discusses the role of mitochondria not only as a source of cellular energy, but also as key regulators of various cellular processes. Research shows that cAMP signaling plays a significant role in mitochondrial biology and homeostasis, with sAC being a crucial enzyme for cAMP synthesis within mitochondria. Disruption of sAC-dependent cAMP pools in mitochondria can lead to mitochondrial dysfunction and pathologies.
Article
Neurosciences
Ming Zhang, Hongbing Wang
Summary: The type 1 and 8 adenylyl cyclase (ADCY1 and ADCY8) are responsible for Ca2+-stimulated cyclic AMP (cAMP) production and play a role in activity-dependent synaptic modification. This study found that Adcy8(-/-) mice showed normal long-term potentiation (LTP), while Adcy1(-/-) mice showed deficits in LTP depending on the induction protocol. ADCY1 was found to be necessary for long-term depression (LTD), whereas ADCY8 was not. Both Adcy1(-/-) and Adcy8(-/-) mice showed defects in synaptic depotentiation, with Adcy8(-/-) mice's deficits depending on the induction protocol. ADCY1 was required for both initial and reversal memory formation, while ADCY8 was only necessary for reversal memory formation. These findings demonstrate that ADCY1 and ADCY8 have distinct roles in regulating synaptic and cognitive flexibility through bidirectional modulation of synaptic function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Cell Biology
Muhammad Aslam, Yury Ladilov
Summary: AMPK plays a crucial role in cellular and systemic energy homeostasis. There is a link between cAMP and AMPK signaling. In addition to its physiological role, the cAMP/AMPK axis also plays a significant role in pathologies such as inflammation, ischemia, diabetes, obesity, and aging.
Article
Plant Sciences
Yuta Hayashida, Chiaki Yamamoto, Fumio Takahashi, Aika Shibata, Masahiro Kasahara
Summary: The study characterized the PDE domain of the cAMP-synthesis/hydrolysis enzyme CAPE from Marchantia polymorpha, showing that Ca2+ enhances PDE activity and only dipyridamole moderately inhibits PDE activity by approximately 40% at high concentrations.
JOURNAL OF PLANT RESEARCH
(2022)
Article
Neurosciences
Emil Jakobsen, Jens V. Andersen, Sofie K. Christensen, Olga Siamka, Martin R. Larsen, Helle S. Waagepetersen, Blanca I. Aldana, Lasse K. Bak
Summary: Pharmacologically induced inhibition of sAC activity lowers mitochondrial respiration, induces phosphorylation of AMP-activated protein kinase (AMPK), and decreases glycogen stores in cultured primary murine astrocytes. Mitochondrial sAC emerges as a key regulator of astrocyte bioenergetics, despite challenges in investigating the roles of cytosolic versus mitochondrial sAC in astrocytes using current pharmacological tools.
Article
Biochemistry & Molecular Biology
Michael P. Duffy, McKenzie E. Sup, X. Edward Guo
Summary: The study demonstrates the role of AC3 in osteocyte mechanotransduction, particularly through a signaling axis involving primary cilia and GSK3 beta. Inhibiting AC3 leads to decreased cAMP signaling and enhanced osteogenic response to longer durations of fluid flow stimulation. Further investigation is warranted to explore AC3 as a potential therapeutic target for bone diseases like osteoporosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Immunology
Kyu-Seon Oh, Heta Patel, Rachel A. Gottschalk, Wai Shing Lee, Songjoon Baek, Iain D. C. Fraser, Gordon L. Hager, Myong-Hee Sung
Article
Biochemical Research Methods
Marijke Koppenol-Raab, Virginie Sjoelund, Nathan P. Manes, Rachel A. Gottschalk, Bhaskar Dutta, Zachary L. Benet, Iain D. C. Fraser, Aleksandra Nita-Lazar
MOLECULAR & CELLULAR PROTEOMICS
(2017)
Article
Neurosciences
Derek S. Welsbie, Katherine L. Mitchell, Vinod Jaskula-Ranga, Valentin M. Sluch, Zhiyong Yang, Jessica Kim, Eugen Buehler, Amit Patel, Scott E. Martin, Ping-Wu Zhang, Yan Ge, Yukan Duan, John Fuller, Byung-Jin Kim, Eman Hamed, Xitiz Chamling, Lei Lei, Iain D. C. Fraser, Ze'ev A. Ronai, Cynthia A. Berlinicke, Donald J. Zack
Article
Biochemistry & Molecular Biology
Bin Lin, Bhaskar Dutta, Iain D. C. Fraser
Article
Immunology
Kyu-Seon Oh, Rachel A. Gottschalk, Nicolas W. Lounsbury, Jing Sun, Michael G. Dorrington, Songjoon Baek, Guangping Sun, Ze Wang, Kathleen S. Krauss, Joshua D. Milner, Bhaskar Dutta, Gordon L. Hager, Myong-Hee Sung, Iain D. C. Fraser
JOURNAL OF IMMUNOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Mohd M. Khan, Orna Ernst, Jing Sun, Iain D. C. Fraser, Robert K. Ernst, David R. Goodlett, Aleksandra Nita-Lazar
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Gastroenterology & Hepatology
Joram Wardi, Orna Ernst, Anna Lilja, Hussein Aeed, Sebastian Katz, Idan Ben-Nachum, Iris Ben-Dror, Dolev Katz, Olga Bernadsky, Rajendar Kandhikonda, Yona Avni, Iain D. C. Fraser, Roy Weinstain, Alexander Biro, Tsaffrir Zor
DIGESTIVE DISEASES AND SCIENCES
(2018)
Article
Cell Biology
Sinu P. John, Jing Sun, Rebecca J. Carlson, Binh Cao, Clinton J. Bradfield, Jian Song, Margery Smelkinson, Iain D. C. Fraser
Article
Immunology
Luis M. Franco, Manasi Gadkari, Katherine N. Howe, Jing Sun, Lela Kardava, Parag Kumar, Sangeeta Kumari, Zonghui Hu, Iain D. C. Fraser, Susan Moir, John S. Tsang, Ronald N. Germain
JOURNAL OF EXPERIMENTAL MEDICINE
(2019)
Meeting Abstract
Immunology
Naeha Subramanian, Leah M. Rommereim, Bhaskar Dutta, Ajay Suresh Akhade, Carolyn Hutcheon, Clifford Rostomily, Nicolas Lounsbury, Ram Savan, Iain D. C. Fraser, Ronald N. Germain
JOURNAL OF IMMUNOLOGY
(2018)
Meeting Abstract
Immunology
Luis Miguel Franco, Manasi Gadkari, Katherine Howe, Jing Sun, Parag Kumar, Lela Kardava, Angelique Biancotto, Zonghui Hu, Iain D. C. Fraser, Susan Moir, Ronald N. Germain, John S. Tsang
JOURNAL OF IMMUNOLOGY
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Aleksandra Nita-Lazar, Nathan P. Manes, Jessica M. Mann, Pauline Kaplan, Martin Meier-Schellersheim, Iain D. C. Fraser, Ronald N. Germain
Meeting Abstract
Immunology
Michael G. Dorrington, Sinu John, Iain D. C. Fraser
JOURNAL OF IMMUNOLOGY
(2017)
Meeting Abstract
Immunology
Aleksandra Nita-Lazar, Virginie Helle Sjoelund, Marijke Koppenol-Raab, Nathan P. Manes, Iain D. Fraser, Zachary Benet, Bhaskar Dutta, Mohd M. Khan
JOURNAL OF IMMUNOLOGY
(2017)
Meeting Abstract
Immunology
Rachel A. Gottschalk, Bhaskar Dutta, Kathleen Krauss, Michael G. Dorrington, Andrew J. Martins, Stefan Uderhardt, John S. Tsang, Parizad Torabi-Parizi, Iain D. C. Fraser, Ronald N. Germain
JOURNAL OF IMMUNOLOGY
(2017)