Article
Biochemistry & Molecular Biology
Thomas J. Gardner, J. Peter Lee, Christopher M. Bourne, Dinali Wijewarnasuriya, Nihar Kinarivala, Keifer G. Kurtz, Broderick C. Corless, Megan M. Dacek, Aaron Y. Chang, George Mo, Kha M. Nguyen, Renier J. Brentjens, Derek S. Tan, David A. Scheinberg
Summary: CAR-T cell therapy is a significant breakthrough in cancer treatment, but currently limited to B cell cancers. Challenges include resistance from antigen-negative tumor cells, immunosuppression in the tumor microenvironment, and T cell exhaustion. A novel class of CAR-T cells has been developed to activate a systemically administered small-molecule prodrug in situ at a tumor site to enhance anticancer activity.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Noelle E. Gillis, Joseph R. Boyd, Jennifer A. Tomczak, Seth Frietze, Frances E. Carr
Summary: Transcriptional regulation in response to thyroid hormone is important for maintaining cellular homeostasis and identity. In this study, we used genomics to analyze TR beta and found that T-3 induces changes in genomic occupancy, chromatin accessibility, and the recruitment of chromatin remodelers. Additionally, we discovered the selective recruitment of BAF and PBAF SWI/SNF complexes to TR beta binding sites. These findings reveal the diverse modes of TR beta interaction with chromatin and the coordination of coregulator activity.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ryota Shizu, Yuta Otsuka, Chizuru Ishii, Kanako Ezaki, Kouichi Yoshinari
Summary: The nuclear receptor PPAR alpha controls fatty acid metabolism and can be inhibited by the xenobiotic receptor CAR, preventing lipid metabolism. Activation of PPAR alpha increases gene expression related to fatty acid metabolism. PPAR alpha binds to the promoter region of the CAR gene and induces its activity. CAR functions as a negative feedback factor for PPAR alpha activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Takeshi Hori, Kosuke Yokobori, Rick Moore, Masahiko Negishi, Tatsuya Sueyoshi
Summary: This study found that Gadd45b plays an important regulatory role in the development of mouse HCC, and regulates the expression of the irisin/Fndc5 and Tgfbr2 genes. In addition, the study also found that PB treatment has different effects on growth and gene expression in wild-type mice compared to Gadd45 beta KO mice.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Likai Wang, Zhiyuan Zhang, Fan Zhang, Zhengyao Shao, Bo Zhao, Austin Huang, Jaclyn Tran, Fernando Vera Hernandez, Hong Qiao
Summary: Ethylene signal transduction and transcriptional regulation play important roles in plant growth, development, and stress responses, with the cooperation of EIN2-C and EIN3 regulating through DNA binding and histone acetylation.
Article
Biochemistry & Molecular Biology
Takaaki Sokabe, Heather B. Bradshaw, Makoto Tominaga, Emma Leishman, Avinash Chandel, Craig Montell
Summary: This study identifies 2-linoleoyl glycerol (2-LG) as a physiologically relevant endocannabinoid that activates TRPC channels in photoreceptor cells. The increase in 2-LG amounts depends on the activity of PLC and diacylglycerol lipase, and it facilitates TRPC-dependent Ca2+ influx and cooperatively activates TRPC channels in response to mechanical stimulation.
Article
Biochemistry & Molecular Biology
Mauricio P. Contreras, Hsuan Pai, Yasin Tumtas, Cian Duggan, Enoch Lok Him Yuen, Angel Vergara Cruces, Jiorgos Kourelis, Hee-Kyung Ahn, Kim-Teng Lee, Chih-Hang Wu, Tolga O. Bozkurt, Lida Derevnina, Sophien Kamoun
Summary: Nucleotide-binding domain leucine-rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity. In asterid plant species, the NLR required for cell death (NRC) immune receptor network is composed of multiple resistance protein sensors and downstream helpers. The study reveals the activation and release model for NLRs in the NRC immune receptor network and provides insights into the activation mechanisms of plant paired NLRs.
Article
Cell Biology
Munerah Hamed, Jihong Chen, Qiao Li
Summary: Dystroglycan, a key component for muscle membrane integrity, is regulated by retinoid X receptor signaling and plays a crucial role in myoblast differentiation. It is a target gene of the muscle master regulator MyoD and its expression is influenced by residue-specific histone acetylation. Our study provides new insights into the regulation and function of dystroglycan in myoblasts and suggests potential therapeutic approaches for muscle pathology.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Julia Minderjahn, Alexander Fischer, Konstantin Maier, Karina Mendes, Margit Nuetzel, Johanna Raithel, Hanna Stanewsky, Ute Ackermann, Robert Mansson, Claudia Gebhard, Michael Rehli
Summary: The study reveals the essential role of cohesin in maintaining genome architecture, controlling long-term differentiation, and activation-associated gene expression programs.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Sarah Da Won Bae, Romario Nguyen, Liang Qiao, Jacob George
Summary: CAR is a receptor that is predominantly expressed in the liver and interacts with key signaling pathways related to drug, energy, and bilirubin metabolism. While studies in animal models suggest a potential role of CAR in tumorigenesis, recent research has shown species differences and a possible tumor-suppressive role of CAR in liver cancer in humans. This review highlights the need for further exploration of CAR's role in human diseases, particularly cancers, with a focus on its emerging functions in liver cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemistry & Molecular Biology
Alex Zaufel, Sandra M. W. van de Wiel, Lu Yin, Gunter Fauler, Daphne Chien, Xinzhong Dong, John F. Gilmer, Jennifer K. Truong, Paul A. Dawson, Stan F. J. van de Graaf, Peter Fickert, Tarek Moustafa
Summary: Secondary (iso) BAs cooperatively activate FXR in the presence of endogenous BAs, which is important to consider in diseases linked to disturbances in BA enterohepatic cycling; the study shows that UDCA is only effective in the presence of endogenous FXR ligands.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Hematology
Michael T. Patterson, Shanzay M. Khan, Natalia S. Nunes, Jing Bian, Ashley D. Hadjis, Michael A. Eckhaus, Suresh K. Mendu, Alessandra de Paula Pohl, David J. Venzon, Hyoyoung Choo-Wosoba, Kazusa Ishii, Haiying Qin, Terry J. Fry, Maggie Cam, Christopher G. Kanakry
Summary: Relapsed malignancy can be prevented or treated by sequentially employing chimeric antigen receptor (CAR) T cells and allogeneic hematopoietic cell transplantation (allo-HCT). This study shows that the integration of allogeneic CAR T cells in a murine allo-HCT model is safe and can effectively eliminate leukemia when given early after posttransplant cyclophosphamide (PTCy) treatment.
Article
Biochemistry & Molecular Biology
Eyal Ben-David, Pinelopi Pliota, Sonya A. Widen, Alevtina Koreshova, Tzitziki Lemus-Vergara, Philipp Verpukhovskiy, Sridhar Mandali, Christian Braendle, Alejandro Burga, Leonid Kruglyak
Summary: The study reveals the presence of maternal-effect TAs in C. tropicalis and C. briggsae, causing significant intraspecific incompatibility. The identification of new TAs genes and their role in larval development suggests TAs are widespread in Caenorhabditis species, and their spreading in populations is affected by balancing selection.
Article
Chemistry, Medicinal
Zuzana Rania Brozova, Jan Dusek, Norbert Palsa, Jana Maixnerova, Rajamanikkam Kamaraj, Lucie Smutna, Petr Matous, Albert Braeuning, Petr Pavek, Jiri Kunes, Nicholas Gathergood, Marcel Spulak, Milan Pour, Alejandro Carazo
Summary: A series of quinazolinone derivatives were synthesized and evaluated for their ability to selectively modulate human CAR activity. Several novel partial agonists and antagonists were identified, including 2-(3-methylphenyl) quinazolinone derivatives 7d and 8d as potent partial agonists. Compound 7l, a 2-(4-bromophenyl)quinazoline-4-thione, showed significant CAR antagonistic activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xinran Cai, Ye Feng, Meishu Xu, Chaohui Yu, Wen Xie
Summary: Activation of the xenobiotic receptor CAR has been shown to inhibit obesity and improve insulin sensitivity, but its metabolic benefits may depend partly on the inducible coactivator Gadd45b.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Endocrinology & Metabolism
Takuyu Hashiguchi, Shingo Arakawa, Shogo Takahashi, Frank J. Gonzalez, Tatsuya Sueyoshi, Masahiko Negishi
MOLECULAR ENDOCRINOLOGY
(2016)
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Biochemistry & Molecular Biology
Ryota Shizu, Jungki Min, Mack Sobhany, Lars C. Pedersen, Shingo Mutoh, Masahiko Negishi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi, Masahiko Negishi
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Pharmacology & Pharmacy
Takuyu Hashiguchi, Sawako Shindo, Shih-Heng Chen, Jau-Shyong Hong, Masahiko Negishi
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Biochemistry & Molecular Biology
Muluneh Fashe, Takuyu Hashiguchi, MyeongJin Yi, Rick Moore, Masahiko Negishi
Article
Oncology
Takeshi Hori, Kosuke Saito, Rick Moore, Gordon P. Flake, Masahiko Negishi
MOLECULAR CANCER RESEARCH
(2018)
Article
Critical Care Medicine
Marumi Ohno, Rick Moore, Page Myers, Masahiko Negishi
Meeting Abstract
Pharmacology & Pharmacy
Masahiko Negishi
DRUG METABOLISM AND PHARMACOKINETICS
(2019)
Article
Cell Biology
Saki Gotoh, Yuu Miyauchi, Rick Moore, Masahiko Negishi
CELLULAR SIGNALLING
(2017)
Meeting Abstract
Biochemistry & Molecular Biology
Tatsuya Sueyoshi, Tsutomu Sakuma, Sawako Shindo, Tomohiko Kanayama, Rick Moore, Masahiko Negishi
Article
Pharmacology & Pharmacy
Lei Li, Xiaochen Bao, Qing-Yu Zhang, Masahiko Negishi, Xinxin Ding
DRUG METABOLISM AND DISPOSITION
(2017)
Article
Pharmacology & Pharmacy
Masahiko Negishi
DRUG METABOLISM AND DISPOSITION
(2017)
Correction
Pharmacology & Pharmacy
T. Hori, R. Moore, M. Negishi
DRUG METABOLISM AND DISPOSITION
(2017)
Article
Pharmacology & Pharmacy
Tomoya Yasujima, Kosuke Saito, Rick Moore, Masahiko Negishi
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2016)
Article
Pharmacology & Pharmacy
Takeshi Hori, Rick Moore, Masahiko Negishi
DRUG METABOLISM AND DISPOSITION
(2016)