Article
Cell Biology
Chen Song, Yu Zhang, Yutong Li, Juntao Bie, Zhe Wang, Xin Yang, Haishuang Li, Liangyi Zhu, Tianzhuo Zhang, Qing Chang, Jianyuan Luo
Summary: During interphase, the phosphorylation cascade of TrkA-ERK1/2-ABL1-PHF5A plays a critical role in regulating centrosome separation, which involves the disruption of the centrosome linker. The pY36-PHF5A enhances the interaction between CEP250 and Nek2A, leading to premature centrosome separation. This cascade is hyper-regulated in medulloblastoma and inhibiting it can restrict tumor proliferation.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Hyojung Kim, Jeong-Yong Shin, Areum Jo, Ji Hun Kim, Sangwook Park, Jeong-Yun Choi, Ho Chul Kang, Valina L. Dawson, Ted M. Dawson, Joo-Ho Shin, Yunjong Lee
Summary: Aberrant activation of c-Abl kinase is implicated in the development of Parkinson's disease. c-Abl phosphorylation inhibits parkin function, leading to a-synuclein pathology and dopaminergic neurodegeneration. Inhibiting c-Abl or PARIS phosphorylation may be a potential therapeutic strategy.
Article
Biochemistry & Molecular Biology
Alexis Martinez, Cristian M. Lamaizon, Cristian Valls, Fabien Llambi, Nancy Leal, Patrick Fitzgerald, Cliff Guy, Marcin M. Kaminski, Nibaldo C. Inestrosa, Brigitte van Zundert, Gonzalo I. Cancino, Andres E. Dulcey, Silvana Zanlungo, Juan J. Marugan, Claudio Hetz, Douglas R. Green, Alejandra R. Alvarez
Summary: Endoplasmic reticulum stress activates c-Abl tyrosine kinase, which translocates to mitochondria. Activated c-Abl interacts with mitochondrial fusion protein MFN2, leading to mitochondrial fragmentation and apoptosis.
Article
Biochemistry & Molecular Biology
Damian M. Janecki, Agata Swiatkowska, Joanna Szpotkowska, Anna Urbanowicz, Martyna Kabacinska, Kamil Szpotkowski, Jerzy Ciesiolka
Summary: The protein PCBP2 has been shown to directly bind to the 5' terminus of p53 mRNA and is involved in both stability and translation control of p53 mRNA, especially under stress conditions. This dual function factor plays a crucial role in modulating p53 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bernhard Moser, Bernhard Hochreiter, Jose Basilio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen, Johannes A. Schmid
Summary: The IKK complex, consisting of IKK alpha and IKK beta, activates the inflammatory transcription factor NF-kappa B, constitutively active in many cancers. Research has shown that IKK alpha phosphorylates c-Myc on serines 67/71, leading to stabilized c-Myc, increased transcriptional activity, higher cell proliferation, and decreased apoptosis in cancer cells.
Article
Biochemistry & Molecular Biology
Sonja Srdanovic, Madita Wolter, Chi H. Trinh, Christian Ottmann, Stuart L. Warriner, Andrew J. Wilson
Summary: p53 plays a critical role in regulating diverse biological processes and is negatively regulated by hDMX and hDM2. Previous studies have identified 14-3-3 proteins as potential regulators of the interaction between hDMX or hDM2 and p53. This study characterizes the biophysical and structural features of the interaction between 14-3-3 and hDMX or hDM2, providing insights for future drug discovery efforts.
Article
Chemistry, Medicinal
Mi Zhang, Xindong Shui, Xiaoqing Zheng, Jong Eun Lee, Yingxue Mei, Ruomeng Li, Yuan Tian, Xiuzhi Zheng, Quling Wang, Long Wang, Dongmei Chen, Tao Zhang, Byeong Mo Kim, Jungho Kim, Tae Ho Lee
Summary: This study identifies DAPK1 as a novel regulator of MDM2 in breast cancer. DAPK1 phosphorylates MDM2, leading to its protein degradation and upregulation of p53 expression, thereby exerting an antitumorigenic function.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Cell Biology
Kwang-Hoon Chun, Seung-Ju Cho, Ji-Won Lee, Ji Hae Seo, Kyu-Won Kim, Seung-Ki Lee
Summary: The study identified the interaction between PKCδ and mARD1, with PKCδ phosphorylating Ser(80) and Ser(108) of mARD1 as major phosphorylation sites. This suggests that PKCδ may transduce signals by regulating the phosphorylation of ARD1.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Corbin C. Jensen, Amber N. Clements, Hope Liou, Lauren E. Ball, Jennifer R. Bethard, Paul R. Langlais, Rachel K. Toth, Shailender S. Chauhan, Andrea L. Casillas, Sohail R. Daulat, Andrew S. Kraft, Anne E. Cress, Cindy K. Miranti, Ghassan Mouneimne, Greg C. Rogers, Noel A. Warfel
Summary: A novel signaling pathway linking hypoxia and PIM1 kinase to actin cytoskeleton and cell motility was identified. This pathway enhances cell protrusion and motility by increasing ABI2 protein levels and WRC formation. These findings have significant implications for the treatment of prostate cancer patients.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Neurosciences
Jun Zhang, Jian-guang Sun, Xiaowen Xing, Rong Wu, Lujun Zhou, Ying Zhang, Fang Yuan, Shukun Wang, Zengqiang Yuan
Summary: In both developmental myelination and remyelination in the central nervous system, the c-Abl kinase plays a crucial role in the proliferation of OL progenitor cells by directly phosphorylating the transcription factor Olig2. Lack of c-Abl results in insufficient OPC proliferation and reduced expression of myelin-related genes, leading to impaired myelination.
Article
Cell Biology
Saebom Lee, Hye Guk Ryu, Sin Ho Kweon, Hyerynn Kim, Hyeonwoo Park, Kyung-Ha Lee, Sang-Min Jang, Chan Hyun Na, Sangjune Kim, Han Seok Ko
Summary: Non-receptor tyrosine kinase c-Abl is involved in the development of various neurodegenerative disorders. This study reveals that TDP-43 is a novel substrate for c-Abl and its phosphorylation by c-Abl leads to increased levels of TDP-43 in the cytoplasm and the formation of stress granules. In addition, phosphorylation of TDP-43 by c-Abl promotes its aggregation and neuronal cell death.
Article
Biochemistry & Molecular Biology
Krishna M. Chauhan, Yingxiao Chen, Yiyi Chen, Andrew T. Liu, Xiao-Xin Sun, Mu-Shui Dai
Summary: The study reveals that SENP1 is a critical p53 deSUMOylating enzyme, and its depletion induces p53 transactivation activity and synergizes with DNA damage-inducing agent etoposide to activate p53 and inhibit cancer cell growth.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lin Yan, Shuo Gao, Jun Zhu, Jun Zhou
Summary: This study reveals the role of irf2bp2a in inducing apoptosis of hepatic cells through aberrant p53 activation during the early stage of embryonic development. Mechanistic studies show that the lack of IRF2BP2 in hepatic cells sequesters more MDM2 molecules into the IRF2-MDM2 complex, leading to the stabilization of P53 protein. In addition, irf2bp2a is identified as a direct downstream target of c/ebp alpha.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Review
Neurosciences
Adrian Gonzalez-Martin, Tomas Moyano, Daniela A. Gutierrez, Franciso J. Carvajal, Waldo Cerpa, Jonathan G. Hanley, Rodrigo A. Gutierrez, Alejandra R. Alvarez
Summary: Studies have shown that c-Abl kinase deficiency in the brain of mice can improve learning acquisition and memory consolidation, and also affect gene expression patterns in the mouse hippocampus. Trained c-Abl KO mice exhibit upregulation of genes involved in synaptic plasticity and actin cytoskeleton dynamics, and have larger and more densely distributed dendritic spines.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Xun Sun, H. Jane Dyson, Peter E. Wright
Summary: The phosphorylation of Thr55 modulates DNA binding of p53, controlling both activation and termination of p53-mediated transcriptional programs during different stages of the cellular DNA damage response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Filipe Menezes, Grzegorz Maria Popowicz
Summary: In this study, three semi-empirical methods were used to model the interactions between the corannulene pincer and fullerenes. The results showed that these methods provided better agreement with experimental data compared to higher-level methods, at a significantly lower computational cost. Additionally, dynamical simulations were used to gain a more comprehensive understanding of the behavior of the corannulene pincer with fullerenes.
Correction
Multidisciplinary Sciences
Panagiotis Karras, Ignacio Bordeu, Joanna Pozniak, Ada Nowosad, Cecilia Pazzi, Nina Van Raemdonck, Ewout Landeloos, Yannick Van Herck, Dennis Pedri, Greet Bervoets, Samira Makhzami, Jia Hui Khoo, Benjamin Pavie, Jochen Lamote, Oskar Marin-Bejar, Michael Dewaele, Han Liang, Xingju Zhang, Yichao Hua, Jasper Wouters, Robin Browaeys, Gabriele Bergers, Yvan Saeys, Francesca Bosisio, Joost van den Oord, Diether Lambrechts, Anil K. Rustgi, Oliver Bechter, Cedric Blanpain, Benjamin D. Simons, Florian Rambow, Jean-Christophe Marine
Correction
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Article
Oncology
Yichao Hua, Gerlanda Vella, Florian Rambow, Elizabeth Allen, Asier Antoranz Martinez, Marie Duhamel, Akira Takeda, Sirpa Jalkanen, Steffie Junius, Ann Smeets, David Nittner, Stefanie Dimmeler, Thomas Hehlgans, Adrian Liston, Francesca Maria Bosisio, Giuseppe Floris, Damya Laoui, Maija Hollmen, Diether Lambrechts, Pascal Merchiers, Jean-Christophe Marine, Susan Schlenner, Gabriele Bergers
Summary: The lack of T cell infiltrates hinders effective immunotherapy in cancer, while the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs) is associated with a good prognosis. This study reveals that antiangiogenic immune-modulating therapies can induce the transformation of postcapillary venules into inflamed high-endothelial venules (HEVs) through lymphotoxin/lymphotoxin beta receptor (LT/LTbR) signaling. Tumor HEVs enhance intratumoral lymphocyte influx and promote the differentiation of CD8 T cell progenitors into effector cells, contributing to tumor immunotherapy.
Article
Oncology
Sofia Ibanez-Molero, Alex van Vliet, Joanna Pozniak, Karlijn Hummelink, Alexandra M. Terry, Kim Monkhorst, Joyce Sanders, Ingrid Hofland, Ewout Landeloos, Yannick Van Herck, Oliver Bechter, Thomas Kuilman, Weiwei Zhong, Jean-Christophe Marine, Lodewyk Wessels, Daniel S. Peeper
Summary: Immunotherapies, including immune checkpoint blockade, have improved cancer patient outcomes, but many fail to develop a durable response. Researchers have identified SERPINB9 as a potential resistance mechanism that prevents tumor cell apoptosis. Overexpression of SERPINB9 is associated with resistance in NSCLC and poor prognosis in melanoma, while rare SERPINB9-positive cancer cells may contribute to reservoirs of resistant cells.
Article
Oncology
Patricia Altea-Manzano, Ginevra Doglioni, Yawen Liu, Alejandro M. Cuadros, Emma Nolan, Juan Fernandez-Garcia, Qi Wu, Melanie Planque, Kathrin Julia Laue, Florencia Cidre-Aranaz, Xiao-Zheng Liu, Oskar Marin-Bejar, Joke Van Elsen, Ines Vermeire, Dorien Broekaert, Sofie Demeyer, Xander Spotbeen, Jakub Idkowiak, Aurelie Montagne, Margherita Demicco, H. Furkan Alkan, Nick Rabas, Carla Riera-Domingo, Francois Richard, Tatjana Geukens, Maxim De Schepper, Sophia Leduc, Sigrid Hatse, Yentl Lambrechts, Emily Jane Kay, Sergio Lilla, Alisa Alekseenko, Vincent Geldhof, Bram Boeckx, Celia de la Calle Arregui, Giuseppe Floris, Johannes V. Swinnen, Jean-Christophe Marine, Diether Lambrechts, Vicent Pelechano, Massimiliano Mazzone, Sara Zanivan, Jan Cools, Hans Wildiers, Veronique Baud, Thomas G. P. Gruenewald, Uri Ben-David, Christine Desmedt, Ilaria Malanchi, Sarah-Maria Fendt
Summary: The formation of pre-metastatic niche and high-fat diet can increase palmitate availability in future organs of metastases, promoting NF-kappa B acetylation and inducing metastatic signaling. Deletion of acetyltransferase and palmitoyltransferase reduces metastasis formation.
Review
Biochemistry & Molecular Biology
Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A. Aaronson, John M. Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S. Alnemri, Lucia Altucci, Ivano Amelio, David W. Andrews, Rami Aqeilan, Eli Arama, Eric H. Baehrecke, Siddharth Balachandran, Daniele Bano, Nickolai A. Barlev, Jiri Bartek, Nicolas G. Bazan, Christoph Becker, Francesca Bernassola, Mathieu J. M. Bertrand, Marco E. Bianchi, Mikhail V. Blagosklonny, J. Magarian Blander, Giovanni Blandino, Klas Blomgren, Christoph Borner, Carl D. Bortner, Pierluigi Bove, Patricia Boya, Catherine Brenner, Petr Broz, Thomas Brunner, Rune Busk Damgaard, George A. Calin, Michelangelo Campanella, Eleonora Candi, Michele Carbone, Didac Carmona-Gutierrez, Francesco Cecconi, Francis K-M Chan, Guo-Qiang Chen, Quan Chen, Youhai H. Chen, Emily H. Cheng, Jerry E. Chipuk, John A. Cidlowski, Aaron Ciechanover, Gennaro Ciliberto, Marcus Conrad, Juan R. Cubillos-Ruiz, Peter E. Czabotar, Vincenzo D'Angiolella, Mads Daugaard, Ted M. Dawson, Valina L. Dawson, Ruggero De Maria, Bart De Strooper, Klaus-Michael Debatin, Ralph J. Deberardinis, Alexei Degterev, Giannino Del Sal, Mohanish Deshmukh, Francesco Di Virgilio, Marc Diederich, Scott J. Dixon, Brian D. Dynlacht, Wafik S. El-Deiry, John W. Elrod, Kurt Engeland, Gian Maria Fimia, Claudia Galassi, Carlo Ganini, Ana J. Garcia-Saez, Abhishek D. Garg, Carmen Garrido, Evripidis Gavathiotis, Motti Gerlic, Sourav Ghosh, Douglas R. Green, Lloyd A. Greene, Hinrich Gronemeyer, Georg Haecker, Gyorgy Hajnoczky, J. Marie Hardwick, Ygal Haupt, Sudan He, David M. Heery, Michael O. Hengartner, Claudio Hetz, David A. Hildeman, Hidenori Ichijo, Satoshi Inoue, Marja Jaeaettelae, Ana Janic, Bertrand Joseph, Philipp J. Jost, Thirumala-Devi Kanneganti, Michael Karin, Hamid Kashkar, Thomas Kaufmann, Gemma L. Kelly, Oliver Kepp, Adi Kimchi, Richard N. Kitsis, Daniel J. Klionsky, Ruth Kluck, Dmitri Krysko, Dagmar Kulms, Sharad Kumar, Sergio Lavandero, Inna N. Lavrik, John J. Lemasters, Gianmaria Liccardi, Andreas Linkermann, Stuart A. Lipton, Richard A. Lockshin, Carlos Lopez-Otin, Tom Luedde, Marion MacFarlane, Frank Madeo, Walter Malorni, Gwenola Manic, Roberto Mantovani, Saverio Marchi, Jean-Christophe Marine, Seamus J. Martin, Jean-Claude Martinou, Pier G. Mastroberardino, Jan Paul Medema, Patrick Mehlen, Pascal Meier, Gerry Melino, Sonia Melino, Edward A. Miao, Ute M. Moll, Cristina Munoz-Pinedo, Daniel J. Murphy, Maria Victoria Niklison-Chirou, Flavia Novelli, Gabriel Nunez, Andrew Oberst, Dimitry Ofengeim, Joseph T. Opferman, Moshe Oren, Michele Pagano, Theocharis Panaretakis, Manolis Pasparakis, Josef M. Penninger, Francesca Pentimalli, David M. Pereira, Shazib Pervaiz, Marcus E. Peter, Paolo Pinton, Giovanni Porta, Jochen H. M. Prehn, Hamsa Puthalakath, Gabriel A. Rabinovich, Krishnaraj Rajalingam, Kodi S. Ravichandran, Markus Rehm, Jean-Ehrland Ricci, Rosario Rizzuto, Nirmal Robinson, Cecilia M. P. Rodrigues, Barak Rotblat, Carla Rothlin, David C. Rubinsztein, Thomas Rudel, Alessandro Rufini, Kevin M. Ryan, Kristopher A. Sarosiek, Akira Sawa, Emre Sayan, Kate Schroder, Luca Scorrano, Federico Sesti, Feng Shao, Yufang Shi, Giuseppe S. Sica, John Silke, Hans-Uwe Simon, Antonella Sistigu, Anastasis Stephanou, Brent R. Stockwell, Flavie Strapazzon, Andreas Strasser, Liming Sun, Erwei Sun, Qiang Sun, Gyorgy Szabadkai, Stephen W. G. Tait, Daolin Tang, Nektarios Tavernarakis, Carol M. Troy, Boris Turk, Nicoletta Urbano, Peter Vandenabeele, Tom Vanden Berghe, Matthew G. Vander Heiden, Jacqueline L. Vanderluit, Alexei Verkhratsky, Andreas Villunger, Silvia von Karstedt, Anne K. Voss, Karen H. Vousden, Domagoj Vucic, Daniela Vuri, Erwin F. Wagner, Henning Walczak, David Wallach, Ruoning Wang, Ying Wang, Achim Weber, Will Wood, Takahiro Yamazaki, Huang-Tian Yang, Zahra Zakeri, Joanna E. Zawacka-Pankau, Lin Zhang, Haibing Zhang, Boris Zhivotovsky, Wenzhao Zhou, Mauro Piacentini, Guido Kroemer, Lorenzo Galluzzi
Summary: Apoptosis is a regulated cell death process involving caspase family proteases. Inhibiting or delaying apoptosis experimentally through pharmacological and genetic strategies has demonstrated its importance in embryonic development, tissue homeostasis, and the pathogenesis of various human disorders. Defects in apoptotic cell death machinery impair development and promote oncogenesis, while inappropriate activation of apoptosis contributes to cell loss and tissue damage in neurological, cardiovascular, renal, hepatic, infectious, neoplastic, and inflammatory conditions.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Melanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O'Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. V. Swinnen
Summary: This study identifies the role of FASN in therapy resistance in cancer. By inhibiting FASN and inducing ROS, therapy resistance can be delayed. The combination of MAPK inhibitors, FASN inhibitors, and ROS inducers significantly increases survival in therapy-resistant models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Loeffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdoerfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Pozniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hoelzel, Iris Helfrich
Summary: This study identified HSD11B1 as a negative feedback mechanism that limits the efficacy of PD-1 blockade, and showed that HSD11B1 inhibitors can enhance the effectiveness of immunotherapy for melanoma. Additionally, high levels of HSD11B1 were associated with poor responses to immune checkpoint inhibitors in patients with advanced melanoma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Juliana C. N. Kenski, Xinyao Huang, David W. Vredevoogd, Beaunelle de Bruijn, Joleen J. H. Traets, Sofia Ibanez-Molero, Sebastiaan M. Schieven, Alex van Vliet, Oscar Krijgsman, Thomas Kuilman, Joanna Pozniak, Fabricio Loayza-Puch, Alexandra M. Terry, Judith Mueller, Meike E. W. Logtenberg, Marjolein de Bruijn, Pierre Levy, Pierre-Rene Korner, Colin R. Goding, Ton N. Schumacher, Jean-Christophe Marine, Reuven Agami, Daniel S. Peeper
Summary: By restoring tryptophan, IDO1 inhibitors aim to reactivate anti-tumor T cells. However, inhibiting IDO1 can lead to an adverse protection of melanoma cells to T cell-derived IFNg. This is accompanied by impaired translation and a stress response that downregulates MITF, contributing to T cell resistance and potentially impacting patient outcome.
CELL REPORTS MEDICINE
(2023)
Correction
Cell Biology
Adrian P. Bracken, Daniela Kleine-Kohlbrecher, Nikolaj Dietrich, Diego Pasini, Gaetano Gargiulo, Chantal Beekman, Kim Theilgaard-Monch, Saverio Minucci, Bo T. Porse, Jean-Christophe Marine, Klaus H. Hansen, Kristian Helin
GENES & DEVELOPMENT
(2023)
Article
Multidisciplinary Sciences
Hyungsoo Kim, Yongmei Feng, Rabi Murad, Joanna Pozniak, Carl Pelz, Yeqing Chen, Bhavik Dalal, Rosalie Sears, Eduard Sergienko, Michael Jackson, Eytan Ruppin, Meenhard Herlyn, Curtis Harris, Jean-Christophe Marine, Victoria Klepsch, Gottfried Baier, Ze'ev A. Ronai
Summary: The orphan nuclear receptor NR2F6 has a tumor-intrinsic function in regulating antitumor immunity. It plays a role in tumor development and the abundance of CD8(+) T cells. Blocking NR2F6 enhances the efficacy of PD-1 therapy and could be a promising anticancer treatment strategy.
Article
Cell Biology
Franco Caramia, Terence P. Speed, Hui Shen, Ygal Haupt, Sue Haupt
Summary: This study found an association between dysregulation of X-chromosome inactivation and survival rate in breast cancer patients, and identified prognostic gene expression features related to chromosome abnormalities, providing new insights into female cancer risks.
Review
Oncology
Ada Nowosad, Jean-Christophe Marine, Panagiotis Karras
Summary: Tumors are complex ecosystems consisting of cancer cells and immune cells, which communicate bidirectionally and influence tumor growth and metastasis. The tumor vasculature and perivascular niche play important roles in promoting cancer stemness, immune evasion, dormancy, and metastatic spreading. These findings have significant implications for cancer research and therapy.
Article
Computer Science, Interdisciplinary Applications
Zhonghua Xia, Pavel Karpov, Grzegorz Popowicz, Michael Sattler, Igor Tetko
Summary: Small-molecule drug design aims to identify inhibitors that can specifically bind to an enzyme's active site. Traditional methods rely on static structures to identify binding pockets, but small molecules can induce the opening of dynamic pockets. This study assessed the features in molecules that can induce cryptic pocket opening and developed a model to design inducers for undruggable proteins.