Article
Multidisciplinary Sciences
Shrawan Kumar Mageswaran, Wei Yuan Yang, Yogaditya Chakrabarty, Catherine M. Oikonomou, Grant J. Jensen
Summary: The study combines live-cell microscopy, correlative light and electron microscopy, and cryo-ET to investigate shedding in response to plasma membrane damage in HeLa cells, revealing filopodia-like protrusions as scaffolds enriched at damage sites. The shedding process involves F-actin dynamics, myosin-1a, and vacuolar protein sorting 4B, indicating a more complex mechanism than current models of vesiculation. The findings suggest a conserved mechanism with constitutive shedding in enterocytes and the potential for adapting the workflow to study other damage response pathways and dynamic cellular events.
Article
Plant Sciences
Britta Pitann, Hafiz Faiq Bakhat, Ammara Fatima, Stefan Hanstein, Sven Schubert
Summary: The study found that silicon promotes maize shoot growth, potentially through its positive effects on plasma membrane H+-ATPase protein. Silicon also regulates plant growth by altering the relative transcripts of specific PM H+-ATPase isoforms.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
James M. Hutchison, Ricardo Capone, Dustin D. Luu, Karan H. Shah, Arina Hadziselimovic, Wade D. Van Horn, Charles R. Sanders
Summary: The study introduced the recombinant expression and purification of S2-E membrane protein in amphipol-class amphipathic polymer solutions, leading to membrane integration and viroporin cation channel formation. The amphipol-mediated delivery of S2-E to human cells demonstrated integration into plasma membrane, trafficking to the trans-Golgi network and accumulation in lysosomal vesicles, potentially influencing CoV particle release. This work also establishes a paradigm for future studies on SARS-CoV-2 pathogenesis and Trojan horse antiviral therapies through amphipol-mediated delivery of membrane proteins.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Rosanne Wouters, Christine Michiels, Ragna Sannerud, Bertrand Kleizen, Katleen Dillen, Wendy Vermeire, Abril Escamilla Ayala, David Demedts, Randy Schekman, Wim Annaert
Summary: gamma-secretase plays a role in various physiological processes by targeting over 100 substrates, with dysfunction linking it to cancer and Alzheimer's disease. The spatiotemporal regulation of its assembly remains unclear, but evidence suggests a stepwise process controlled by selective sorting mechanisms, leading to final levels in postGolgi compartments.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Cell Biology
Nevena Vicic, Xiaoxin Guo, Darren Chan, John G. Flanagan, Ian A. Sigal, Jeremy M. Sivak
Summary: This study found that moderate biomechanical strain damages cell membranes, increases permeability, and induces the aggregation of A4 protein at injury sites. Loss of A4 protein increases permeability, while exogenous A4 protein reduces it. Furthermore, similar findings were observed in the optic nerve head of glaucoma patients. These studies provide a new model for understanding the pathogenesis of glaucoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiuya Li, Yilin Lian, Yukang Wu, Zihui Ye, Jiabao Feng, Yuan Zhao, Xudong Guo, Jiuhong Kang
Summary: In this study, it was found that intramyocardial delivery of plasma exosomes from neonatal mice could help repair the adult heart after acute myocardial infarction (AMI). Cardiac endothelial cells received the majority of exosomal ligands and the pro-angiogenic effect of exosomes was mediated through the recognition of cardiac endothelial cell receptors. This ligand-receptor network provides inspiration for cardiac regeneration post-MI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
P. R. Sreedevi, K. Suresh
Summary: Delivery of genetic material is an important tool for analyzing and understanding genetic interventions. Traditional methods rely on viral vectors or xenogenic carrier molecules, which can have carcinogenic, immunogenic, and toxic effects. Cold atmospheric plasma-induced transfection is a new physical method that does not require vectors or carriers. It creates temporary pores on cell membranes for gene delivery. This method has been successfully used in various cell lines and mouse models without adverse effects on cell activity and function.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Charles A. Day, Minchul Kang
Summary: The plasma membrane of mammalian cells plays a crucial role in various cellular processes and requires organization and dynamics. Diffusion measurements, such as FRAP, provide insights into the subresolution organization of the plasma membrane. Comparisons with other methods help explore different membrane organization models.
Article
Biochemistry & Molecular Biology
Shagufta Iqbal, Caitlin Flux, Deborah A. Briggs, Evelyne Deplazes, Jiansi Long, Ruth Skrzypek, Alice Rothnie, Ian D. Kerr, Richard Callaghan
Summary: Through the use of mutational analysis and computational modeling, the binding sites for the substrates vinblastine and rhodamine 123 on P-glycoprotein (Pgp) were successfully determined. Binding occurs in the central cavity and the lipid-protein interface, revealing the process of substrate internalization in Pgp.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Pharmacology & Pharmacy
Julian Peter Mueller, Lena Keufgens, Dirk Gruendemann
Summary: This study used a hyperosmolarity assay to differentiate transport mechanisms of drugs, showing that some transporters translocate substrates into the cytosol while others insert them into the plasma membrane.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jiwoo Choi, Dongsu Kim, Ji Eon Chae, Sanghyeok Lee, Sang Moon Kim, Sung Jong Yoo, Hyoung-Juhn Kim, Mansoo Choi, Segeun Jang
Summary: This study modified hydrocarbon-based PEM using oxygen plasma irradiation process, introducing oxygen functional groups and microstructures to improve adhesive force and reduce interfacial resistance between the membrane and electrodes. Additionally, the micropillar structured electrodes significantly decreased oxygen transport resistance in the membrane-electrode assembly.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Erdinc Sezgin
Summary: The plasma membrane is a complex structure intertwined with the actin cytoskeleton and extracellular matrix. Model membrane systems, such as cell-derived giant plasma membrane vesicles (GPMVs), provide a simplified model to study processes at the plasma membrane. GPMVs, being the most physiologically relevant system, have become a key tool in membrane research, but also have limitations.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2022)
Article
Virology
Ghadah A. Karasneh, Divya Kapoor, Navya Bellamkonda, Chandrashekhar D. Patil, Deepak Shukla
Summary: The increased levels of HPSE can reduce syncytial plaque formation and promote viral egress and release. Transiently enhanced expression of HPSE does not affect HSV-1 entry into cells but facilitates extracellular release of mature virions.
Article
Chemistry, Physical
Benedetta Come, Maressa Donato, Lucia Francesca Potenza, Paolo Mariani, Rosangela Itri, Francesco Spinozzi
Summary: Rhamnolipids, produced by Pseudomonas aeruginosa, are glycolipids that act as biosurfactants. Their mechanism of action in biological systems is not well defined, but experimental results suggest that they may alter membrane curvature and structure, potentially affecting endocytic processes in cells.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Chemical
Shun Aoyama, Hiroki Nagasawa, Masakoto Kanezashi, Toshinori Tsuru
Summary: The effects of plasma treatment time on the gas permeation and pervaporation dehydration properties of organosilica membranes were investigated. The study found that increasing plasma modification time resulted in a decrease in pore size, leading to an increased He/N2 permeance ratio. The H2O/EtOH permeance ratio also increased from about 20 to over 1000 as the plasma modification time increased due to changes in pore structure and water adsorption properties.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Agronomy
Zhen-Zhen Li, Fei Deng, Chi Zhang, Li Zhu, Lian-Hua He, Tao Zhou, Hui Lu, Shi-Lin Zhu, Yu-Ling Zeng, Xiao-Yuan Zhong, Wei Zhou, Yong Chen, Wan-Jun Ren, Jian-Feng Hu
Summary: A simple and low-cost index, called relative culm wall thickness (RCWT), is proposed to evaluate the lodging resistance of rice. Through a field experiment, RCWT was found to be significantly correlated with various lodging-related indexes. Rice plants with high RCWT were characterized by lower plant height and center of gravity, as well as shorter basal internodes, thicker culm wall thickness, and smaller pith diameter. These features increased the fullness of the stem, resulting in higher cellulose and lignin content, enhanced bending resistance, and decreased lodging index.
ARCHIVES OF AGRONOMY AND SOIL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yuhua Fu, Hong Liu, Jingwen Dou, Yue Wang, Yong Liao, Xin Huang, Zhenshuang Tang, JingYa Xu, Dong Yin, Shilin Zhu, Yangfan Liu, Xiong Shen, Hengyi Liu, Jiaqi Liu, Xin Yang, Yi Zhang, Yue Xiang, Jingjin Li, Zhuqing Zheng, Yunxia Zhao, Yunlong Ma, Haiyan Wang, Xiaoyong Du, Shengsong Xie, Xuewen Xu, Haohao Zhang, Lilin Yin, Mengjin Zhu, Mei Yu, Xinyun Li, Xiaolei Liu, Shuhong Zhao
Summary: IAnimal is a cross-species, multi-omics knowledgebase that aims to improve the utilization of multi-omics data and simplify data integration for better understanding of gene regulation mechanisms and comprehensive analyses of biological systems.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Engineering, Chemical
Hongli Zhang, Yiling Zheng, Hongwei Zhou, Shilin Zhu, Jie Yang
Summary: Two-dimensional (2D) nanomaterial-based membranes hold great promise for various applications due to their attractive properties in molecular separation and transport. However, the swelling problem of 2D membranes has hindered their performance. In this study, the insertion of flexible and hydrophilic carboxylated cellulose nanofibers (CNFs) effectively stabilized the Ti3C2Tx MXene laminar architecture, enhancing mechanical strength, fixing interlayer distance, and improving anti-swelling properties. Furthermore, the intercalation of nanocelluloses increased interlayer spacing and created open gaps for fast and selective molecular transport. When applied in antibiotics separative filtration process, the resulting membrane exhibited excellent anti-swelling properties and high selectivity of antibiotics, making it ideal for various applications.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Guo, Hong Zhao, Xiaohu Qiang, Chengwei Ouyang, Zhehui Wang, Dajian Huang
Summary: Biomass-based aerogel materials have great development potential in packaging, cushioning and green building insulation due to their low thermal conductivity and non-toxicity. However, their application is limited by low mechanical strength and poor fire safety. This study developed a composite aerogel modified by the magnesium hydroxide/sodium alginate composite flame retardant system, which significantly enhanced mechanical and thermal stability. The composite showed improved fire resistance and achieved a more complete carbon structure after burning.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Physics, Multidisciplinary
Hua-Xing Chen, Wei Chen, Xiang Liu, Yan-Rui Liu, Shi-Lin Zhu
Summary: The past decades have seen significant advancements in hadron physics, particularly in the observation of excited open heavy flavor mesons and baryons since 2017. This review provides updated information on the recent experimental and theoretical developments in this field, including the observation of unconventional heavy hadrons, tetraquark states, and hidden heavy flavor multiquark states. Additionally, the review covers progress in understanding glueballs and light hybrid mesons, which are manifestations of the non-Abelian SU(3) gauge interaction in Quantum Chromodynamics at low energies.
REPORTS ON PROGRESS IN PHYSICS
(2023)
Review
Environmental Sciences
Tong Wu, Shan-Shan Yang, Le Zhong, Ji-Wei Pang, Luyan Zhang, Xue-Fen Xia, Fan Yang, Guo-Jun Xie, Bing-Feng Liu, Nan-Qi Ren, Jie Ding
Summary: This paper provides a comprehensive review of studies on simultaneous nitrogen and phosphorus removal. The most promising process is found to be simultaneous nitrification, denitrification, and phosphorus removal (SNDPR). Factors influencing SNDPR are analyzed and future research directions are suggested, including balancing microbial competition, achieving continuous flow operation, and maximizing phosphorus recovery.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Cell & Tissue Engineering
Xin Mao, Zhehui Wang
Summary: Cardiovascular disease is a major threat to human life and health, and heart transplantation is the most effective treatment. However, the shortage of living heart organs has always been an issue. With the development of bioprinting technology, 3D bioprinted hearts have become a promising solution, and research in this field has become a hot topic.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2023)
Article
Physics, Particles & Fields
Zhi Yang, Guang-Juan Wang, Jia-Jun Wu, Makoto Oka, Shi-Lin Zhu
Summary: In this study, we investigated the near-threshold P-wave B-s states using the Hamiltonian effective field theory, combining the quark model, the quark-pair-creation mechanism and B-(*)(K) over bar interaction. By fitting the lattice data and applying the heavy quark flavor symmetry, we determined all the parameters in the D-s sector. The predicted masses of the bottom-strange partners of the D-30*(2317) and D-31*(2460) are consistent with lattice QCD simulation. We also observed a crossing point in the finite volume spectrum, which corresponds to a CDD zero in the B(K) over bar scattering T-matrix, providing further insights into the near-threshold states.
JOURNAL OF HIGH ENERGY PHYSICS
(2023)
Article
Mathematics
Guosheng Jiang, Zhehui Wang, Jintian Zhu
Summary: In this study, we investigate the minimal surface equation in the unbounded convex domain 12 C Rn (n >= 2) with boundary value given by the sum of a linear function and a bounded uniformly continuous function in Rn. We prove that the solution is unique if 12 is not a half space and the graphs of all solutions form a foliation of 12 x R if 12 is a half space. This result can be considered as a stability type theorem for Edelen-Wang's Bernstein type theorem in [10]. Additionally, we establish a comparison principle for the minimal surface equation in 12.
JOURNAL OF FUNCTIONAL ANALYSIS
(2023)
Article
Physics, Fluids & Plasmas
Y. C. Hu, L. Ye, X. Z. Gong, A. M. Garofalo, J. P. Qian, J. Huang, B. Zhang, P. F. Zhao, Y. J. Hu, Q. L. Ren, J. Y. Zhang, X. X. Zhang, R. R. Liang, Z. H. Wang
Summary: The properties of core turbulence and thermal transport are investigated for EAST high-beta(P) plasmas with dominant electron heating via gyrokinetic simulation. Linear simulations demonstrate the dominance of electrostatic eta(e)-driven trapped electron mode in the core region and the ion temperature gradient mode in the outer region, consistent with linear threshold analysis. Nonlinear simulations show that the electron thermal internal transport barrier in EAST high-beta(P) plasma is determined by the TEM-induced turbulence. A higher zonal flow shearing rate facilitates the formation of e-ITB.
PLASMA PHYSICS AND CONTROLLED FUSION
(2023)
Proceedings Paper
Physics, Particles & Fields
Bo Wang, Lu Meng, Shi-Lin Zhu
Summary: In this study, we investigated di-hadron interactions including D (D) over bar*/D*(D) over bar, D*(D) over bar, DsD*/D*D-s, BB*/BB* and B*B* in chiral effective field theory (chi EFT) up to next-to-leading (NLO) order. The tetraquark states Z(c)(3900), Z(c)(4020), Z(cs)(3985), Z(b)(10610), Z(b)(10650) above threshold can be explained as corresponding di-hadron resonances. We also studied the interactions of Sigma(()(c)*) (D) over bar(*) to investigate the three hidden-charm pentaquarks Pc(4312), Pc(4440) and Pc(4457). Using the parameters fixed from the Pc states, we predicted possible molecular states in Xi D-c* Xi cD* and Xi & lowast; c recently observed by the LHCb Collaboration. Our predictions of the Xi D-c(*) bound states are in good agreement with two new near-threshold structures.
NUCLEAR AND PARTICLE PHYSICS PROCEEDINGS
(2023)
Article
Astronomy & Astrophysics
Niu Su, Hua-Xing Chen, Wei Chen, Shi-Lin Zhu
Summary: We investigate the double-gluon hybrid states composed of quark-gluon contents q over bar qgg (q = u/d) and s over bar sgg. Twelve double-gluon hybrid currents with various quantum numbers are constructed, and five of them are found to be zero due to some internal symmetries. The remaining seven currents are used for QCD sum rule analyses. In particular, the masses of the double-gluon hybrid states with exotic quantum number JPC = 2+- are calculated to be Mlq over bar qgg;2+-) = 2.26+0.20 -0.25 GeV and Mls over bar sgg;2+-) = 2.38+0.19 -0.25 GeV. Their two-and three-meson decay patterns are also studied.
Article
Astronomy & Astrophysics
Jian-Bo Cheng, Du-xin Zheng, Zi-Yang Lin, Shi-Lin Zhu
Summary: We investigate the double-charm and hidden-charm hexaquarks as molecular states using the one-boson-exchange potential model. We consider multichannel coupling and S-D wave mixing and use the complex scaling method to study quasibound states. We find a quasibound state in the double-charm system, but not in the hidden-charm system.
Article
Physics, Particles & Fields
Bo-Lin Huang, Zi-Yang Lin, Kan Chen, Shi-Lin Zhu
Summary: We calculate the complete T matrices of elastic light pseudoscalar meson and heavy meson scattering to the third order in heavy meson chiral perturbation theory. We determine the low-energy constants by fitting the phase shifts and scattering lengths from lattice QCD simulations simultaneously, and predict the phase shifts at the physical meson masses. The strong phase shifts in various channels suggest the presence of bound states or resonances, including the well-known exotic state D-s0*(2317).
EUROPEAN PHYSICAL JOURNAL C
(2023)
Article
Astronomy & Astrophysics
Lu Meng, Bo Wang, Shi-Lin Zhu
Summary: The LHCb Collaboration has recently observed the first hidden-charm pentaquark with strangeness, P?,yso4338 thorn 0. The state is close to the Xi 0c over bar D0 and Xi thorn c D- thresholds, raising concerns about the bias of the Breit-Wigner parametrization and its coupling to these double thresholds. Through qualitative and formalism-based analyses, it is shown that the peak of P?,yso4338 thorn 0 could originate from either an o-; thorn thorn sheet pole above the Xi thorn c D- threshold or an o-; - thorn sheet pole below the Xi 0c over bar D0 threshold. The authors suggest a refined experimental analysis considering unitarity and analyticity.
