Article
Immunology
Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh
Summary: 15d-PGJ(2) promotes the resolution of intestinal colitis by reducing neutrophils and M1 macrophages, increasing M2 macrophage proportion, and decreasing the expression of pro-inflammatory cytokine IL-6 in macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuping Ning, Wenfei Wang, Paul M. Jordan, Stefanie A. Barth, Robert Klaus Hofstetter, Jinjin Xu, Ximeng Zhang, Yi Cai, Christian Menge, Xinchun Chen, Oliver Werz
Summary: Tuberculosis caused by Mycobacterium tuberculosis is a global health concern. In this study, it is shown that M. tuberculosis induces COX-2 expression in human macrophages and promotes the formation of anti-inflammatory J2-PGs. These J2-PGs have anti-inflammatory effects in M1-MDMs, downregulating proinflammatory cytokines and upregulating anti-inflammatory cytokines and M2 markers.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Yao Jiang, Jia-Mei Liu, Jia-Ping Huang, Ke-Xi Lu, Wei-Lian Sun, Jing-Yi Tan, Bo-Xiu Li, Li-Li Chen, Yan-Min Wu
Summary: This study evaluated the biological properties of decellularized human periodontal ligament cell (dHPDLC) sheets in vitro, showing that dHPDLC sheets can promote periodontal regeneration in an inflammatory environment.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Su-Jung Kim, Nam-Chul Cho, Bitnara Han, Kyeojin Kim, Young-Il Hahn, Kwang Pyo Kim, Young Ger Suh, Bu Young Choi, Hye-Kyung Na, Young-Joon Surh
Summary: The cyclopentenone prostaglandin 15d-PGJ2 functions as an allosteric inhibitor of STAT3 by covalently modifying STAT3 on Cys259, inhibiting its activity in MCF10A-Ras cells. This results in antiproliferative and pro-apoptotic effects similar to mutation of this amino acid.
Article
Chemistry, Multidisciplinary
Airat M. Gimazetdinov, Aidar Z. Al'mukhametov, Mansur S. Miftakhov
Summary: An asymmetric total synthesis of 15-deoxy-Delta(12,14)-prostaglandin J(2) methyl ester is described. The synthesis involves several key steps, including the formation of a cyclopentenone precursor, construction of the prostaglandin alpha-chain, and alkylation followed by the formation of the omega-chain.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Cell Biology
Eun-Hee Kim, Su-Jung Kim, Hye-Kyung Na, Wonshik Han, Nam-Jung Kim, Young-Ger Suh, Young-Joon Surh
Summary: The study found that 15d-PGJ2 activates VEGF expression through NRF2-driven induction of HO-1 in human breast cancer cells, suggesting a novel oncogenic mechanism. Elevated levels of 15d-PGJ2 during the inflammatory response were linked to poor clinical outcomes in breast cancer patients. Levels of 15d-PGJ2, COX-2, NRF2, and HO-1 were found to be increased in human breast cancer tissues.
Article
Chemistry, Multidisciplinary
Zaynutdin R. Makaev, Nikolay S. Vostrikov, Natalya K. Selezneva, Mansur S. Miftakhov
Summary: A simple and efficient synthesis of racemic 15-deoxy- increment 12,14- prostaglandin J2 methyl ester from readily available Corey lactone diol in a total of eleven steps was proposed. Standard methods were used to form a fused co-chain and then converted into PGJ2 methyl ester. The transformation to the target prostaglandin was achieved smoothly in TsOH-CH2Cl2 medium by converting the allylic alcohol moiety to an exocyclic diene substituent conjugated with the endocyclic enone system.
MENDELEEV COMMUNICATIONS
(2023)
Article
Oncology
Su-Jung Kim, Nam-Chul Cho, Young-Il Hahn, Seong Hoon Kim, Xizhu Fang, Young-Joon Surh
Summary: 15d-PGJ(2) inhibits STAT3 signaling and induces apoptosis in human breast tumor cells, particularly effective in triple negative breast cancer cells but less effective in estrogen receptor positive breast cancer cells. This compound may offer a potential therapeutic approach for the treatment of triple negative breast cancer through direct chemical modification of STAT3.
JOURNAL OF CANCER PREVENTION
(2021)
Article
Toxicology
Ahmed Ayyash, Alison C. Holloway
Summary: Fluoxetine, a commonly used SSRI antidepressant, has been found to increase the risk of metabolic diseases such as nonalcoholic fatty liver disease. It affects hepatic lipid accumulation and the production of prostaglandins, which are implicated in the development of liver diseases. Understanding these mechanisms could lead to novel therapeutic strategies to mitigate the adverse effects of fluoxetine treatment.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Immunology
Weiyang Li, Jieshi Xie, Le Yang, Yuanru Yang, Lin Yang, Liying Li
Summary: The study found that 15d-PGJ2 can reduce MIF expression in damaged hepatocytes by activating PPARγ, thereby inhibiting macrophage infiltration and inflammatory response, ultimately alleviating acute liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nikolay S. Vostrikov, Vadim V. Zagitov, Alexander N. Lobov, Diana Ishmetova, Yulia V. Vakhitova, Mansur S. Miftakhov
Summary: A series of novel compounds were synthesized through multiple steps in this study, and their anticancer activities were preliminarily explored.
Article
Endocrinology & Metabolism
Zahirrah BM. Rasheed, Yun S. S. Lee, Sung H. H. Kim, Tg Teoh, David A. A. MacIntyre, Phillip R. R. Bennett, Lynne Sykes
Summary: The study found that 15dPGJ2 has differential effects on inflammatory modulation depending on cell type, and is therefore unlikely to be a useful therapeutic agent for the prevention of preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carl Eguez, Michelle A. Clark, Ann Tenneil O'Connor
Summary: 15-Deoxy-Delta-(12,14)-prostaglandin J2 (15d-PGJ2) has inhibitory effects on proliferation and alters protein expression in vascular smooth muscle cells (VSMCs). Controversy exists over whether it induces PPAR-γ activation, but understanding the mechanisms by which it elicits beneficial actions can aid in developing new therapeutic strategies.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2021)
Article
Multidisciplinary Sciences
Siow-Wey Hee, Yi-Cheng Chang, Lynn Su, Ing-Jung Chen, Yung-Ming Jeng, Meng-Lun Hsieh, Yu-Chia Chang, Fu-An Li, Daniel Liao, Shiau-Mei Chen, Lee-Ming Chuang
Summary: 15-keto-PGE(2) has been shown to have anti-inflammatory properties by modifying the subunits of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). In high-fat and high-sucrose diet and non-alcoholic steatohepatitis models, treatment with 15-keto-PGE(2) reduces inflammation and improves liver damage.
Article
Cell Biology
Anil Khushalrao Shendge, Sourav Panja, Nripendranath Mandal
Summary: The study demonstrated the anticancer activity of tropical lichen DCME against brain and cervical cancer cells, revealing its cytotoxicity and apoptosis induction mechanisms through various experimental approaches.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)