Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Article
Ophthalmology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: The study aimed to determine the necessity of HIF-1a on PR cell survival after RD. The findings suggest that rod-derived HIF-1a plays a key role in promoting PR cell survival.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Editorial Material
Biology
Mingyu Shin, Jiwon Shim
Summary: A gene involved in hypoxia response has been found to protect insect muscles during migratory flight in a non-oxygen dependent manner.
Article
Immunology
Gabriela Burczyk, Iwona Cichon, Elzbieta Kolaczkowska
Summary: 4-octyl itaconate (4-OI) diminishes the formation of neutrophil extracellular traps (NETs) in mice, regardless of their health status or metabolic challenges. The inhibition is mediated by downregulating Hif-1 alpha and inducing HO-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Toxicology
Michael Aschner, Anatoly V. Skalny, Rongzhu Lu, Abel Santamaria, Ji-Chang Zhou, Tao Ke, Mikhail Yu. Karganov, Aristides Tsatsakis, Kirill S. Golokhvast, Aaron B. Bowman, Alexey A. Tinkov
Summary: This review summarizes the existing data on the effects of toxic metals on HIF-1 signaling and its underlying mechanisms, with a special focus on the prooxidant effect of metals. The effect of metals on HIF-1 pathway varies depending on the cell type, ranging from down-regulation to up-regulation. Inhibition of HIF-1 signaling may contribute to hypoxic damage in cells, while metal-induced activation may promote tumor growth and contribute to the carcinogenic effects of heavy metals.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Fisheries
Zhihai Huang, Weiliang Guan, Xiaobo Wei, Renchi Chen, Xiamin Lyu, Gaohai Zheng, Linchun Mao
Summary: The study found that HIF-1 alpha can protect whiteleg shrimp hemocytes from apoptosis caused by air exposure through upregulating the expression of HSP70 and decreasing intracellular ROS production.
Article
Biochemistry & Molecular Biology
Jin-Woo Kim, Hyun-Ju An, HyunJeong Yeo, Yunhui Jeong, HyeonHae Lee, Jusung Lee, Kisik Nam, Jongheon Lee, Dong-Eun Shin, Soonchul Lee
Summary: Activation of the HIF-1α signaling pathway can protect intervertebral discs from degeneration and may serve as a potential therapeutic target in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yiwei Liu, Qipeng Luo, Zhanhao Su, Junyue Xing, Jinlin Wu, Li Xiang, Yuan Huang, Haizhou Pan, Xie Wu, Xiaoling Zhang, Jun Li, Fuxia Yan, Hao Zhang
Summary: Cyanotic congenital heart disease (CCHD) leads to maladaptation of cardiac metabolism during puberty, accompanied by impaired cardiac function. The study identified HIF-1 alpha as the key regulator of cardiac metabolic adaptation in CH animal models, with pubertal insulin resistance potentially suppressing its expression.
Review
Pharmacology & Pharmacy
Chunying Xiao, Sheng Liu, Ge Ge, Hao Jiang, Liezhi Wang, Qi Chen, Chong Jin, Jinggang Mo, Jin Li, Kunpeng Wang, Qianqian Zhang, Jianyu Zhou
Summary: Hepatocellular carcinoma (HCC) is a common digestive malignancy and a leading cause of cancer mortality worldwide. Local ablation therapies, such as radiofrequency ablation (RFA) and high-intensity focused ultrasound (HIFU) ablation, have shown effectiveness in treating HCC. However, the molecular mechanisms and HCC recurrence after ablation still need further understanding.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Genetics & Heredity
Mingxiao Luo, Tingting Li, Haiquan Sang
Summary: Chronic liver disease is a prevalent public health problem worldwide, with steatosis driving the progression of the disease to cirrhosis or liver cancer. The hypoxia-inducible factor 1a (HIF-1a) plays a central role in hepatic lipid metabolism by promoting intrahepatic lipid deposition. HIF-1a is also expressed in white adipose tissue, where it contributes to the accumulation of fatty acids in the liver. In contrast, intestinal expression of HIF-1a maintains a healthy microbiota and intestinal barrier, providing protection against hepatic steatosis. This article provides an overview of the role of HIF-1a in hepatic steatosis and highlights the potential for therapeutic interventions targeting the HIF-1a pathway.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Wasinee Tianthong, Vorapong Phupong
Summary: This study demonstrates that serum HIF-1 alpha levels combined with uterine artery Doppler at 11-13(+6) weeks of gestation are effective in predicting preeclampsia.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Correction
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: A correction to the paper has been published.
CANCER GENE THERAPY
(2021)
Correction
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: A correction to the paper has been published at the given DOI link.
CANCER GENE THERAPY
(2021)
Article
Cell & Tissue Engineering
Sandra Petrus-Reurer, Pankaj Kumar, Sara Padrell Sanchez, Monica Aronsson, Helder Andre, Hammurabi Bartuma, Alvaro Plaza Reyes, Emeline F. Nandrot, Anders Kvanta, Fredrik Lanner
STEM CELLS TRANSLATIONAL MEDICINE
(2020)
Article
Biology
Ross O. Smith, Takeshi Ninchoji, Emma Gordon, Helder Andre, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh
Article
Cell & Tissue Engineering
Sandra Petrus-Reurer, Nerges Winblad, Pankaj Kumar, Laia Gorchs, Michael Chrobok, Arnika KathleenWagner, Hammurabi Bartuma, Emma Lardner, Monica Aronsson, Alvaro Plaza Reyes, Helder Andre, Evren Alici, Helen Kaipe, Anders Kvanta, Fredrik Lanner
Review
Cell Biology
Mostafa Khalili, Maryam Asadi, Houman Kahroba, Mohammad Reza Soleyman, Helder Andre, Effat Alizadeh
Summary: The cornea is a transparent avascular tissue that focuses light on the retina. Restoring vision in patients with corneal endothelium dysfunction often requires corneal transplantation, but donor limitations pose challenges. An emerging alternative to transplantation is corneal endothelium tissue engineering, which uses scaffold-based and scaffold-free methods.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Ophthalmology
James R. Tribble, Eirini Kokkali, Amin Otmani, Flavia Plastino, Emma Lardner, Rupali Vohra, Miriam Kolko, Helder Andre, James E. Morgan, Pete A. Williams
Summary: Animal models of glaucoma show that unilateral or bilateral ocular hypertensive glaucoma can lead to increased neuroinflammatory responses, with more marked effects in animals with bilateral glaucoma. Unilateral glaucoma can also activate microglia in the contralateral eye, indicating the need for caution when using the contralateral eye as a control. Neuroinflammatory protein responses identified in this study may serve as potential disease-modifiable targets.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Cell Biology
Noemi Anna Pesce, Alessio Canovai, Emma Lardner, Maurizio Cammalleri, Anders Kvanta, Helder Andre, Massimo Dal Monte
Summary: The study found that autophagy plays a crucial role during retinal development in rats, particularly during the hypoxic phase. Autophagy activity was heightened in the early postnatal days, but decreased in later stages of development, reaching a normal level between post-natal days 14-18.
Article
Ophthalmology
Flavia Plastino, Alvaro Santana-Garrido, Noemi Anna Pesce, Monica Aronsson, Emma Lardner, Alfonso Mate, Anders Kvanta, Carmen Maria Vazquez, Helder Andre
Summary: Our study demonstrates that Echinomycin can inhibit HIF-mediated angiogenesis in vitro and reduce vascular lesions in a mouse model of CNV, suggesting potential implications for the treatment of neovascular age-related macular degeneration in patients.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Ophthalmology
Flavia Plastino, Noemi Anna Pesce, Helder Andre
Summary: Hypoxia-inducible factors and vascular endothelial growth factors play important roles in ocular neovascularization, while microRNAs are being increasingly recognized as regulators of angiogenesis, especially hypoxia-associated miRNAs. The discussed microRNAs have the potential to be diagnostic markers and therapeutic agents for choroidal and retinal angiogenic diseases in various eye conditions.
ACTA OPHTHALMOLOGICA
(2021)
Review
Medicine, Research & Experimental
Maryam Asadi, Mostafa Khalili, Hajie Lotfi, Sevil Vaghefi Moghaddam, Nosratollah Zarghami, Helder Andre, Effat Alizadeh
Summary: Development of novel technologies in tissue engineering has led to the exploration of scaffold-based and scaffold-free tissues for liver regeneration. Innovations such as cell sheet technology and analogs of liver acellular extracellular matrix have shown promise in aiding liver repair and regeneration.
Article
Multidisciplinary Sciences
Philippe A. Melas, Malin Wirf, Helder Andre, Nitya Jayaram-Lindstrom, Aleksander A. Mathe, Pia Steensland
Summary: This study investigated the effects of a drug (OSU) on anxiety-like behaviors following long-term drinking in a genetic rat model, and found that OSU not only attenuated alcohol-mediated behaviors but also significantly reduced anxiety-like behaviors, suggesting further clinical evaluation is warranted.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Alvaro Santana-Garrido, Claudia Reyes-Goya, Santiago Milla-Navarro, Pedro de la Villa, Helder Andre, Carmen M. Vazquez, Alfonso Mate
Summary: The study found that ACE oil has anti-inflammatory effects on the retina in an experimental hypertension model, preventing retinal dysfunction and modulating the expression of inflammatory markers. Dietary supplementation with ACE oil showed better results compared to EVOO in protecting against hypertension-related retinal damage.
Article
Cell Biology
Noemi Anna Pesce, Alessio Canovai, Flavia Plastino, Emma Lardner, Anders Kvanta, Maurizio Cammalleri, Helder Andre, Massimo Dal Monte
Summary: The study found that in oxygen-induced retinopathy (OIR) rats, autophagic mechanisms are dysregulated and associated with necrosis, but not apoptosis. Treatment with the autophagy inhibitor 3-methyladenine (3-MA) can reduce autophagic and necroptotic markers in OIR retinas, but does not improve retinal function.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Erwin Ilegems, Galyna Bryzgalova, Jorge Correia, Burcak Yesildag, Edurne Berra, Jorge L. Ruas, Teresa S. Pereira, Per-Olof Berggren
Summary: This study found the presence of HIF-1 alpha in pancreatic cells during the progression of type 2 diabetes, and demonstrated that treatment with the HIF-1 alpha inhibitor PX-478 can improve beta cell function, prevent diabetes progression, and increase insulin secretion. The results showed that PX-478 treatment has an improving effect on mouse and human islets.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder Andre, Ari Koskelainen
Summary: Cells have stress-response pathways to cope with stress factors for homeostasis maintenance; low doses of stress may be beneficial; HHS was found to enhance autophagy gene expression and activation through HSF1.
Article
Biochemistry & Molecular Biology
Alvaro Santana-Garrido, Claudia Reyes-Goya, Carmen Fernandez-Bobadilla, Antonio J. Blanca, Helder Andre, Alfonso Mate, Carmen M. Vazquez
Summary: This study highlights the importance of oxidative stress in severe hypertension-related eye damage and emphasizes NADPH oxidase as a major ROS-generating enzyme system in the oxidative and inflammatory processes surrounding hypertensive eye diseases.