Article
Multidisciplinary Sciences
Jie Heng, Yunfei Hu, Guillermo Perez-Hernandez, Asuka Inoue, Jiawei Zhao, Xiuyan Ma, Xiaoou Sun, Kouki Kawakami, Tatsuya Ikuta, Jienv Ding, Yujie Yang, Lujia Zhang, Sijia Peng, Xiaogang Niu, Hongwei Li, Ramon Guixa-Gonzalez, Changwen Jin, Peter W. Hildebrand, Chunlai Chen, Brian K. Kobilka
Summary: Research reveals the dynamic behavior of the beta 2 adrenergic receptor C-terminus and its autoinhibitory function in downstream Gs coupling.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Multidisciplinary Sciences
Tobias Benkel, Mirjam Zimmermann, Julian Zeiner, Sergi Bravo, Nicole Merten, Victor Jun Yu Lim, Edda Sofie Fabienne Matthees, Julia Drube, Elke Miess-Tanneberg, Daniela Malan, Martyna Szpakowska, Stefania Monteleone, Jak Grimes, Zsombor Koszegi, Yann Lanoiselee, Shannon O'Brien, Nikoleta Pavlaki, Nadine Dobberstein, Asuka Inoue, Viacheslav Nikolaev, Davide Calebiro, Andy Chevigne, Philipp Sasse, Stefan Schulz, Carsten Hoffmann, Peter Kolb, Maria Waldhoer, Katharina Simon, Jesus Gomeza, Evi Kostenis
Summary: This study provides an alternative mechanism for carvedilol's cellular signaling, demonstrating that G proteins drive all detectable signals through beta(2)-adrenoceptors.
NATURE COMMUNICATIONS
(2022)
Article
Agriculture, Dairy & Animal Science
Fuqing Huang, Kunling Teng, Yayong Liu, Tianwei Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Nisin Z has potential anti-inflammatory effects on mastitis by inhibiting the activation of the ERK1/2 and p38 MAPK signaling pathway and promoting the blood-milk barrier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biology
Nana Zhang, Haibo Zhu, Zijian Li, Erdan Dong
Summary: The biased ligand Higenamine acts as a novel beta-arrestin-biased ligand by inducing ERK1/2 phosphorylation via EGFR transactivation. Its action is dependent on beta-arrestin1/2 and inhibits Doxorubicin-induced cardiomyocyte apoptosis. These findings provide insight into Higenamine's potential diagnostic and therapeutic applications.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lulu Zhang, Chunmei Yang, Yanran Huang, Huakun Huang, Xiaohui Yuan, Ping Zhang, Caihong Ye, Mengqi Wei, Yuping Wang, Xiaoji Luo, Jinyong Luo
Summary: The study demonstrates that Cardamonin inhibits proliferation, migration, and invasion of osteosarcoma cells, inducing cell cycle arrest. It has minimal effects on normal cells and represses tumor growth in a xenograft mouse model. Mechanistically, Cardamonin activates the P38 and JNK MAPK signaling pathway to promote apoptosis in osteosarcoma cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Shu-qing Ma, Zhen Guo, Fang-yuan Liu, Shahzad-Gul Hasan, Dan Yang, Nan Tang, Peng An, Ming-yu Wang, Hai-ming Wu, Zheng Yang, Di Fan, Qi-zhu Tang
Summary: The study demonstrates that 6-gingerol can protect against pressure overload-induced cardiac remodeling in in vivo models by improving cardiac function and alleviating hypertrophy, fibrosis, inflammation, and dysfunction. In vitro experiments showed that 6-gingerol can block cardiomyocyte hypertrophy and cardiac fibroblast activation in response to specific stimuli.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Paola Matarrese, Sonia Maccari, Barbara Ascione, Rosa Vona, Vanessa Vezzi, Tonino Stati, Maria Cristina Gro, Giuseppe Marano, Caterina Ambrosio, Paola Molinari
Summary: This study found that beta-AR stimulation affects the proliferative activity of B16F10 cells by regulating cAMP levels. Additionally, alpha 2-AR agonists can inhibit cell proliferation, which is disrupted by the inhibitory effect of beta-AR agonists on alpha 2-AR. These findings suggest that the crosstalk between beta-AR and alpha 2-AR signaling pathways plays an important role in regulating melanoma proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Shangling Zhu, Junlong Dang, Yiming Shi, Xiaoxue Feng, Yudan Hu, Lang Lin, Jianlin Huang
Summary: The sonic hedgehog (SHH) signaling pathway plays a crucial role in synovial inflammation and joint destruction in rheumatoid arthritis (RA) by promoting abnormal behavior of activated fibroblast-like synoviocytes (FLS) in a p38-dependent manner. Inhibition of the SHH-p38 MAPK signaling pathway may be a potential target for the treatment of RA.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Integrative & Complementary Medicine
Hu Xijiao, Cheng Yinglong, Kang Huanan, Li Shuoxi, Wang Yawen, Liu Jinzhe, Sun Yiming, Liu Li
Summary: This study investigated the effect of electroacupuncture on chronic fallopian tube inflammation in rats and its potential mechanisms. The results showed that electroacupuncture attenuated chronic salpingitis by down-regulating the TGF-01/MAPK signaling pathway.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Article
Cell Biology
Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: The study identified BMI1 as a positive regulator of testosterone production, with the mechanism involving BMI1-mediated gene silencing to inhibit the p38 MAPK pathway and promote steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Paul H. Taghert
Summary: In this study, the incidence and conservation of beta-arrestin binding sites (BBS's) among the C terminal tails of Drosophila melanogaster neuropeptide GPCRs were evaluated. The results showed great diversity in the profile of BBS's, with some GPCRs lacking conserved BBS sequences. Additionally, certain GPCRs displayed multiple conserved compound BBS's, and BBS-like sequences were found in the intracellular loop domains. This research lays the initial foundation for future genetic analyses to investigate the roles of arrestins in neuropeptide GPCR desensitization, trafficking, and signaling in Drosophila.
Article
Cell Biology
Nohely Abreu, Amanda Acosta-Ruiz, Guoqing Xiang, Joshua Levitz
Summary: This study investigates the distinct regulation of different subtypes of mGluR family using fluorescence imaging and electrophysiology. The research reveals significant differences in rapid desensitization and internalization between subtypes, with a focus on the properties of mGluR3 and its interaction with GPCR kinases and beta-arrestins. The identification of a cancer-associated mutation within mGluR3 highlights the potential for biased variants and provides insight into the functional roles of mGluR subtypes.
Article
Pharmacology & Pharmacy
Janaine P. Oliveira, Fabiula F. Abreu, Jose Marcos M. Bispo, Anderson R. A. Cerqueira, Jose Ronaldo dos Santos, Cristiane B. B. Correa, Soraia K. P. Costa, Enilton A. A. Camargo
Summary: This study evaluated the effect of myrtenol on orofacial pain and inflammation. The results showed that myrtenol can alleviate orofacial pain and inflammation and is associated with the modulation of IL-1β levels in the trigeminal pathway and p38-MAPK in the trigeminal ganglia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Patrick A. Carroll, Daniel Diolaiti, Lisa McFerrin, Haiwei Gu, Danijel Djukovic, Jianhai Du, Pei Feng Cheng, Sarah Anderson, Michelle Ulrich, James B. Hurley, Daniel Raftery, Donald E. Ayer, Robert N. Eisenman
Article
Biochemistry & Molecular Biology
Jianhai Du, Austin Rountree, Whitney M. Cleghorn, Laura Contreras, Ken J. Lindsay, Martin Sadilek, Haiwei Gu, Danijel Djukovic, Dan Raftery, Jorgina Satrustegui, Mark Kanow, Lawrence Chan, Stephen H. Tsang, Ian R. Sweet, James B. Hurley
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Review
Neurosciences
James B. Hurley, Kenneth J. Lindsay, Jianhai Du
JOURNAL OF NEUROSCIENCE RESEARCH
(2015)
Article
Medicine, Research & Experimental
Lijuan Zhang, Jianhai Du, Sally Justus, Chun-Wei Hsu, Luis Bonet-Ponce, Wen-Hsuan Wu, Yi-Ting Tsai, Wei-Pu Wu, Yading Jia, Jimmy K. Duong, Vinit B. Mahajan, Chyuan-Sheng Lin, Shuang Wang, James B. Hurley, Stephen H. Tsang
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Biochemistry & Molecular Biology
Jianhai Du, Whitney M. Cleghorn, Laura Contreras, Ken Lindsay, Austin M. Rountree, Andrei O. Chertov, Sally J. Turner, Ayse Sahaboglu, Jonathan Linton, Martin Sadilek, Jorgina Satrustegui, Ian R. Sweet, Franois Paquet-Durand, James B. Hurley
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Jeffrey Adijanto, Jianhai Du, Cynthia Moffat, Erin L. Seifert, James B. Hurley, Nancy J. Philp
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Hao Zhang, Xigang Jing, Yang Shi, Hao Xu, Jianhai Du, Tongju Guan, Dorothee Weihrauch, Deron W. Jones, Weiling Wang, David Gourlay, Keith T. Oldham, Cheryl A. Hillery, Kirkwood A. Pritchard
JOURNAL OF LIPID RESEARCH
(2013)
Article
Multidisciplinary Sciences
Hsiang-En Wu, Shelley L. Baumgardt, Juan Fang, Mark Paterson, Yanan Liu, Jianhai Du, Yang Shi, Shigang Qiao, Zeljko J. Bosnjak, David C. Warltier, Judy R. Kersten, Zhi-Dong Ge
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Aditi Swarup, Ivy S. Samuels, Brent A. Bell, John Y. S. Han, Jianhai Du, Erik Massenzio, E. Dale Abel, Kathleen Boesze-Battaglia, Neal S. Peachey, Nancy J. Philp
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Biology
Ting Zhang, Ling Zhu, Michele C. Madigan, Wei Liu, Weiyong Shen, Svetlana Cherepanoff, Fanfan Zhou, Shaoxue Zeng, Jianhai Du, Mark C. Gillies
Article
Cell Biology
Rui Zhang, Weiyong Shen, Jianhai Du, Mark C. Gillies
CELL DEATH & DISEASE
(2020)
Article
Neurosciences
Weiyong Shen, So-Ra Lee, Ashish Easow Mathai, Rui Zhang, Jianhai Du, Michelle X. Yam, Victoria Pye, Nigel L. Barnett, Cassie L. Rayner, Ling Zhu, James B. Hurley, Pankaj Seth, Yoshio Hirabayashi, Shigeki Furuya, Mark C. Gillies
Summary: The study showed that selectively knocking down key metabolic genes in Muller glia could lead to photoreceptor degeneration, but supplementation with exogenous L-serine could prevent this degeneration by regulating serine transport and maintaining retinal homeostasis.
Article
Biology
David Sokolov, Emily R. Sechrest, Yekai Wang, Connor Nevin, Jianhai Du, Saravanan Kolandaivelu
Summary: This study reveals the previously unrecognized complexity in NMNAT1-associated retinal degeneration, indicating a potential role for NMNAT1 in gene regulation during photoreceptor terminal differentiation. Deletion of nuclear-localized NAD(+) synthase NMNAT1 in developing murine retina leads to early and severe degeneration of photoreceptors and inner retinal neurons, associated with disruptions in central carbon metabolism, purine nucleotide synthesis, and amino acid pathways. Dysregulation of photoreceptor and synapse-specific genes in NMNAT1 knockout retinas is observed prior to detectable morphological or metabolic alterations.
Article
Biochemistry & Molecular Biology
Lauren L. Daniele, John Y. S. Han, Ivy S. Samuels, Ravikiran Komirisetty, Nikhil Mehta, Jessica L. McCord, Minzhong Yu, Yekai Wang, Kathleen Boesze-Battaglia, Brent A. Bell, Jianhai Du, Neal S. Peachey, Nancy J. Philp
Summary: Glucose supply is crucial for the normal functioning and survival of retinal cells. This study demonstrates the essential role of glucose in maintaining and sustaining rod photoreceptor outer segments (OS), with minimal impact on cone photoreceptor cells.
Article
Medicine, Research & Experimental
Jiancheng Huang, Shun Gu, Meng Chen, Shu-jie Zhang, Zhichun Jiang, Xue Chen, Chao Jiang, Guohua Liu, Roxana A. Radu, Xiantao Sun, Douglas Vollrath, Jianhai Du, Biao Yan, Chen Zhao