Review
Medicine, General & Internal
R. J. Johnson, P. Stenvinkel, P. Andrews, L. G. Sanchez-Lozada, T. Nakagawa, E. Gaucher, A. Andres-Hernando, B. Rodriguez-Iturbe, C. R. Jimenez, G. Garcia, D. -H. Kang, D. R. Tolan, M. A. Lanaspa
JOURNAL OF INTERNAL MEDICINE
(2020)
Review
Urology & Nephrology
Takahiko Nakagawa, Richard J. Johnson, Ana Andres-Hernando, Carlos Roncal-Jimenez, Laura G. Sanchez-Lozada, Dean R. Tolan, Miguel A. Lanaspa
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Editorial Material
Peripheral Vascular Disease
Miguel A. Lanaspa, Ana Andres-Hernando, Masanari Kuwabara
HYPERTENSION RESEARCH
(2020)
Article
Medicine, Research & Experimental
Ana Andres-Hernando, Thomas J. Jensen, Masanari Kuwabara, David J. Orlicky, Christina Cicerchi, Nanxing Li, Carlos A. Roncal-Jimenez, Gabriela E. Garcia, Takuji Ishimoto, Paul S. Maclean, Petter Bjornstad, Laura Gabriela Sanchez-Lozada, Mehmet Kanbay, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Summary: The study found that orally administered fructose, glucose, or high-fructose corn syrup increased vasopressin concentrations, mediated by fructokinase specific to fructose metabolism. Hydration prevented and improved fructose-induced metabolic syndrome, with vasopressin effects mediated by vasopressin 1b receptor. Increased water intake may be beneficial in preventing or treating metabolic syndrome.
Review
Substance Abuse
David Carn, Miguel A. Lanaspa, Steven A. Benner, Peter Andrews, Robert Dudley, Ana Andres-Hernando, Dean R. Tolan, Richard J. Johnson
Summary: This narrative review introduces the hypothesis that two key gene mutations, occurring approximately 15 and 10 million years ago, were beneficial for ancestral humans during periods of starvation but are maladaptive in modern civilization, increasing the risk of obesity and alcoholism. The mutations enhanced survival by aiding in fat storage and ethanol metabolism, yet now may contribute to the risk of alcoholism.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Mehmet Kanbay, Begum Guler, Lale A. Ertuglu, Tuncay Dagel, Baris Afsar, Said Incir, Arzu Baygul, Adrian Covic, Ana Andres-Hernando, Laura Gabriela Sanchez-Lozada, Miguel A. Lanaspa, Richard J. Johnson
Summary: The study found that fast ingestion of 100% apple juice causes a significantly greater metabolic response, which may be associated with negative long-term outcomes. Therefore, the rate of ingestion must be considered when evaluating the metabolic impacts of sweetened beverage consumption.
Review
Immunology
Takahiko Nakagawa, Laura G. Sanchez-Lozada, Ana Andres-Hernando, Hideto Kojima, Masato Kasahara, Bernardo Rodriguez-Iturbe, Petter Bjornstad, Miguel A. Lanaspa, Richard J. Johnson
Summary: Chronic low-grade inflammation is the root cause of non-communicable diseases, including chronic kidney disease, with fructose and uric acid potentially mediating a metabolic switch towards glycolysis in CKD. SGLT2 inhibitors may slow CKD progression by reducing intrarenal glucose and fructose levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Gabriela E. Garcia, Yingjuan J. Lu, Luan D. Truong, Carlos A. Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Gabriel Cara-Fuentes, Ana Andres-Hernando, Miguel Lanaspa, Richard J. Johnson, Christopher P. Leamon
Summary: Targeting activated macrophages expressing FR beta with folate-linked drugs can be a selective approach for treating inflammatory diseases. The novel folic acid-aminopterin conjugate EC2319 showed significant kidney protection in anti-GBM glomerulonephritis through FR beta-mediated mechanisms, reducing macrophage infiltration and pro-inflammatory cytokine expression.
Review
Nutrition & Dietetics
Richard J. Johnson, Fernando E. Garcia-Arroyo, Guillermo Gonzaga-Sanchez, Kevin A. Velez-Orozco, Yamnia Quetzal Alvarez-Alvarez, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Horacio Osorio-Alonso, Ana Andres-Hernando, Takahiko Nakagawa, Masanari Kuwabara, Mehmet Kanbay, Miguel A. Lanaspa, Laura Gabriela Sanchez-Lozada
Summary: Improper hydration habits, including low water intake and substituting sugar-sweetened beverages, are risk factors for the development of chronic diseases. These habits lead to mild hyperosmolarity and stimulate biological processes, resulting in the activation of pathways that mediate various chronic diseases.
Article
Multidisciplinary Sciences
Gabriel Cara-Fuentes, Ana Andres-Hernando, Colin Bauer, Mindy Banks, Gabriela E. Garcia, Christina Cicerchi, Masanari Kuwabara, Michiko Shimada, Richard J. Johnson, Miguel A. Lanaspa
Summary: This study highlights the critical connection between pulmonary inflammation-released surfactants and podocyte receptor SIRP alpha signaling, shedding light on the pathogenesis of SSNS/MCD in children.
Review
Peripheral Vascular Disease
Masanari Kuwabara, Takahide Kodama, Ryusuke Ae, Mehmet Kanbay, Ana Andres-Hernando, Claudio Borghi, Ichiro Hisatome, Miguel A. Lanaspa
Summary: Many studies have reported a direct relationship between serum uric acid levels and hypertension, cardiovascular, renal, and metabolic diseases. While there is a clinical association between uric acid and high blood pressure, it is still unclear whether lowering uric acid is beneficial for preventing cardiovascular and renal metabolic diseases.
HYPERTENSION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ana Andres-Hernando, David J. Orlicky, Christina Cicerchi, Masanari Kuwabara, Gabriela E. Garcia, Takahiko Nakagawa, Laura Gabriela Sanchez-Lozada, Richard J. Johnson, Miguel A. Lanaspa
Summary: Obesity and metabolic syndrome increase the susceptibility to chronic kidney disease (CKD), potentially due to enhanced absorption and utilization of fructose. Pound mice with metabolic syndrome showed increased expression of fructose transporter and fructokinase, leading to enhanced fructose absorption. Administration of high fructose corn syrup (HFCS) rapidly induced CKD in pound mice, whereas pound mice lacking fructokinase were protected from CKD. Lowering added sugar intake may reduce the risk for CKD in subjects with metabolic syndrome.
Article
Multidisciplinary Sciences
Ana Andresa Hernando, Christina Cicerchi, Gabriela E. Gracia, David J. Orlicky, Peter Stenvinkel, Richard J. Johnson, Miguel A. Lanaspa
Summary: In this study, it was found that sarcopenia in patients with CKD is mediated by reduced insulin sensitivity and the activation of muscle-specific AMP deaminase isoform, AMPD1. Urea reduces insulin-dependent glucose and phosphate uptake by skeletal muscle, contributing to hyperphosphatemia observed in CKD. Furthermore, urea depletes intramuscular phosphate, leading to a low-energy state and activation of AMPD1, which in turn worsens muscle energy deficiency and contributes to the progression of kidney disease.
Review
Biology
Richard J. Johnson, Miguel A. Lanaspa, L. Gabriela Sanchez-Lozada, Dean Tolan, Takahiko Nakagawa, Takuji Ishimoto, Ana Andres-Hernando, Bernardo Rodriguez-Iturbe, Peter Stenvinkel
Summary: The fructose survival hypothesis suggests that obesity and metabolic disorders may be caused by excessive stimulation of a biological response triggered by fructose intake. This response involves hunger, thirst, weight gain, fat accumulation, insulin resistance, inflammation, and increased blood pressure. In humans, this response is exaggerated due to genetic factors and a western diet high in fructose. Excessive fructose metabolism not only explains obesity but also various diseases such as diabetes, hypertension, fatty liver disease, obesity-related cancers, vascular and Alzheimer's dementia, and aging. Reducing activation of this pathway and promoting mitochondrial regeneration may improve health-span.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ana Andres-Hernando, Christina Cicerchi, Masanari Kuwabara, David J. Orlicky, Laura Gabriela Sanchez-Lozada, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Summary: Umami foods, containing monosodium glutamate and inosine monophosphate, may induce metabolic syndrome in mice by activating purine degradation pathway in the liver and brain, leading to the formation of uric acid.